LOCUS       NM_001004356            3411 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens fibroblast growth factor receptor like 1 (FGFRL1),
            transcript variant 1, mRNA.
ACCESSION   NM_001004356
VERSION     NM_001004356.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Sharma,P., Kaushik,V., Saraya,A. and Sharma,R.
  TITLE     Aberrant Expression of FGFRL1 in Esophageal Cancer and Its
            Regulation by miR-107
  JOURNAL   Asian Pac J Cancer Prev 24 (4), 1331-1341 (2023)
   PUBMED   37116156
  REMARK    GeneRIF: Aberrant Expression of FGFRL1 in Esophageal Cancer and Its
            Regulation by miR-107.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Wen,T., Hong,Y., Cui,Y., Pan,J., Wang,Y. and Luo,Y.
  TITLE     Downregulation of miR-210-3p Attenuates High Glucose-Induced
            Angiogenesis of Vascular Endothelial Cells via Targeting FGFRL1
  JOURNAL   Ophthalmic Res 66 (1), 913-920 (2023)
   PUBMED   37062273
  REMARK    GeneRIF: Downregulation of miR-210-3p Attenuates High
            Glucose-Induced Angiogenesis of Vascular Endothelial Cells via
            Targeting FGFRL1.
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Cho,H.W., Jin,H.S. and Eom,Y.B.
  TITLE     FGFRL1 and FGF genes are associated with height, hypertension, and
            osteoporosis
  JOURNAL   PLoS One 17 (8), e0273237 (2022)
   PUBMED   35980984
  REMARK    GeneRIF: FGFRL1 and FGF genes are associated with height,
            hypertension, and osteoporosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3411)
  AUTHORS   Gofin,Y., Mackay,L.P., Machol,K., Keswani,S., Potocki,L., Di
            Gregorio,E., Naretto,V.G., Brusco,A., Hernandez-Garcia,A. and
            Scott,D.A.
  TITLE     Evidence that FGFRL1 contributes to congenital diaphragmatic hernia
            development in humans
  JOURNAL   Am J Med Genet A 185 (3), 836-840 (2021)
   PUBMED   33443296
  REMARK    GeneRIF: Evidence that FGFRL1 contributes to congenital
            diaphragmatic hernia development in humans.
REFERENCE   5  (bases 1 to 3411)
  AUTHORS   Zheng,C., Shi,C.J., Du,L.J., Jiang,Y.H. and Su,J.M.
  TITLE     [Expression of fibroblast growth factor receptor like 1 protein in
            oral squamous cell carcinoma and its influence on tumor cell
            proliferation and migration]
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 38 (5), 558-565 (2020)
   PUBMED   33085242
  REMARK    GeneRIF: [Expression of fibroblast growth factor receptor like 1
            protein in oral squamous cell carcinoma and its influence on tumor
            cell proliferation and migration].
REFERENCE   6  (bases 1 to 3411)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 3411)
  AUTHORS   Trueb,B., Zhuang,L., Taeschler,S. and Wiedemann,M.
  TITLE     Characterization of FGFRL1, a novel fibroblast growth factor (FGF)
            receptor preferentially expressed in skeletal tissues
  JOURNAL   J Biol Chem 278 (36), 33857-33865 (2003)
   PUBMED   12813049
REFERENCE   8  (bases 1 to 3411)
  AUTHORS   Sleeman,M., Fraser,J., McDonald,M., Yuan,S., White,D.,
            Grandison,P., Kumble,K., Watson,J.D. and Murison,J.G.
  TITLE     Identification of a new fibroblast growth factor receptor, FGFR5
  JOURNAL   Gene 271 (2), 171-182 (2001)
   PUBMED   11418238
REFERENCE   9  (bases 1 to 3411)
  AUTHORS   Kim,I., Moon,S., Yu,K., Kim,U. and Koh,G.Y.
  TITLE     A novel fibroblast growth factor receptor-5 preferentially
            expressed in the pancreas(1)
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 152-156 (2001)
   PUBMED   11267671
REFERENCE   10 (bases 1 to 3411)
  AUTHORS   Wiedemann,M. and Trueb,B.
  TITLE     Characterization of a novel protein (FGFRL1) from human cartilage
            related to FGF receptors
  JOURNAL   Genomics 69 (2), 275-279 (2000)
   PUBMED   11031111
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019103.8, AY358303.1,
            BQ689625.1 and BC015228.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001004356.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor receptor (FGFR) family, where amino acid
            sequence is highly conserved between members and throughout
            evolution. FGFR family members differ from one another in their
            ligand affinities and tissue distribution. A full-length
            representative protein would consist of an extracellular region,
            composed of three immunoglobulin-like domains, a single hydrophobic
            membrane-spanning segment and a cytoplasmic tyrosine kinase domain.
            The extracellular portion of the protein interacts with fibroblast
            growth factors, setting in motion a cascade of downstream signals,
            ultimately influencing mitogenesis and differentiation. A marked
            difference between this gene product and the other family members
            is its lack of a cytoplasmic tyrosine kinase domain. The result is
            a transmembrane receptor that could interact with other family
            members and potentially inhibit signaling. Multiple alternatively
            spliced transcript variants encoding the same isoform have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358303.1, AF312678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000510644.6/ ENSP00000425025.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC019103.8         88629-88824
            197-404             AY358303.1         1-208
            405-889             BQ689625.1         37-521
            890-2036            AY358303.1         694-1840
            2037-3411           BC015228.1         1125-2499
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..3411
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /note="fibroblast growth factor receptor like 1"
                     /db_xref="GeneID:53834"
                     /db_xref="HGNC:HGNC:3693"
                     /db_xref="MIM:605830"
     exon            1..329
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            330..424
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1860
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /EC_number="3.2.1.76"
                     /note="fibroblast growth factor receptor 5; FGF homologous
                     factor receptor; FGFR-like protein; FGF receptor-like
                     protein 1"
                     /codon_start=1
                     /product="fibroblast growth factor receptor-like 1
                     precursor"
                     /protein_id="NP_001004356.1"
                     /db_xref="CCDS:CCDS3344.1"
                     /db_xref="GeneID:53834"
                     /db_xref="HGNC:HGNC:3693"
                     /db_xref="MIM:605830"
                     /translation="MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLG
                     RTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKAT
                     NGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI
                     ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGK
                     YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKP
                     VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAG
                     MYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILG
                     TLLLWLCQAQKKPCTPAPAPPLPGHRPPGTARDRSGDKDLPSLAALSAGPGVGLCEEH
                     GSPAAPQHLLGPGPVAGPKLYPKLYTDIHTHTHTHSHTHSHVEGKVHQHIHYQC"
     exon            425..697
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            698..778
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1063
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1417
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..3411
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3411
                     /gene="FGFRL1"
                     /gene_synonym="FGFR-5; FGFR5; FHFR"
                     /note="major polyA site"
ORIGIN      
        1 agagttgaca aagccccgca gggaaggacg cctcgcggcg cggcgccccg ggcccctcgc
       61 cccgccgccc cgggatcccg gccccggccc ccggccccgc ggactcgccc ccgccgcctg
      121 cccggtccgg gaccccgcgc cccgagcgcc cgagcccgga ccccgacccg gcccgagccg
      181 cccgcgccca ggtagcgccg ccccgccccg agaccgggcc cgggggcgcg gggcggcggg
      241 atgcggcgcc cggggcggcg atgaccgcgg agcgcacgcc gcgggcccgg ccctgacccc
      301 gccgcccgcc cgctgagccc cccgccgagg tccggacagg ccgagatgac gccgagcccc
      361 ctgttgctgc tcctgctgcc gccgctgctg ctgggggcct tcccgccggc cgccgccgcc
      421 cgaggccccc caaagatggc ggacaaggtg gtcccacggc aggtggcccg gctgggccgc
      481 actgtgcggc tgcagtgccc agtggagggg gacccgccgc cgctgaccat gtggaccaag
      541 gatggccgca ccatccacag cggctggagc cgcttccgcg tgctgccgca ggggctgaag
      601 gtgaagcagg tggagcggga ggatgccggc gtgtacgtgt gcaaggccac caacggcttc
      661 ggcagcctga gcgtcaacta caccctcgtc gtgctggatg acattagccc agggaaggag
      721 agcctggggc ccgacagctc ctctgggggt caagaggacc ccgccagcca gcagtgggca
      781 cgaccgcgct tcacacagcc ctccaagatg aggcgccggg tgatcgcacg gcccgtgggt
      841 agctccgtgc ggctcaagtg cgtggccagc gggcaccctc ggcccgacat cacgtggatg
      901 aaggacgacc aggccttgac gcgcccagag gccgctgagc ccaggaagaa gaagtggaca
      961 ctgagcctga agaacctgcg gccggaggac agcggcaaat acacctgccg cgtgtcgaac
     1021 cgcgcgggcg ccatcaacgc cacctacaag gtggatgtga tccagcggac ccgttccaag
     1081 cccgtgctca caggcacgca ccccgtgaac acgacggtgg acttcggggg gaccacgtcc
     1141 ttccagtgca aggtgcgcag cgacgtgaag ccggtgatcc agtggctgaa gcgcgtggag
     1201 tacggcgccg agggccgcca caactccacc atcgatgtgg gcggccagaa gtttgtggtg
     1261 ctgcccacgg gtgacgtgtg gtcgcggccc gacggctcct acctcaataa gctgctcatc
     1321 acccgtgccc gccaggacga tgcgggcatg tacatctgcc ttggcgccaa caccatgggc
     1381 tacagcttcc gcagcgcctt cctcaccgtg ctgccagacc caaaaccgcc agggccacct
     1441 gtggcctcct cgtcctcggc cactagcctg ccgtggcccg tggtcatcgg catcccagcc
     1501 ggcgctgtct tcatcctggg caccctgctc ctgtggcttt gccaggccca gaagaagccg
     1561 tgcacccccg cgcctgcccc tcccctgcct gggcaccgcc cgccggggac ggcccgcgac
     1621 cgcagcggag acaaggacct tccctcgttg gccgccctca gcgctggccc tggtgtgggg
     1681 ctgtgtgagg agcatgggtc tccggcagcc ccccagcact tactgggccc aggcccagtt
     1741 gctggcccta agttgtaccc caaactctac acagacatcc acacacacac acacacacac
     1801 tctcacacac actcacacgt ggagggcaag gtccaccagc acatccacta tcagtgctag
     1861 acggcaccgt atctgcagtg ggcacggggg ggccggccag acaggcagac tgggaggatg
     1921 gaggacggag ctgcagacga aggcagggga cccatggcga ggaggaatgg ccagcacccc
     1981 aggcagtctg tgtgtgaggc atagcccctg gacacacaca cacagacaca cacactgcct
     2041 ggatgcatgt atgcacacac atgcgcgcac acgtgctccc tgaaggcaca cgtacgcaca
     2101 cacgcacatg cacagatatg ccgcctgggc acacagataa gctgcccaaa tgcacgcaca
     2161 cgcacagaga catgccagaa catacaagga catgctgcct gaacatacac acgcacaccc
     2221 atgcgcagat gtgctgcctg gacacacaca cacacacgga tatgctgtct ggacgcacac
     2281 acgtgcagat atggtatccg gacacacacg tgcacagata tgctgcctgg acacacagat
     2341 aatgctgcct tgacacacac atgcacggat attgcctgga cacacacaca cacacgtgtg
     2401 cacagatatg ctgtctggac acgcacacac atgcagatat gctgcctgga cacacacttc
     2461 cagacacacg tgcacaggcg cagatatgct gcctggacac acgcagatat gctgtctagt
     2521 cacacacaca cgcagacatg ctgtccggac acacacacgc atgcacagat atgctgtccg
     2581 gacacacaca cgcacgcaga tatgctgcct ggacacacac acagataatg ctgcctcaac
     2641 actcacacac gtgcagatat tgcctggaca cacacatgtg cacagatatg ctgtctggac
     2701 atgcacacac gtgcagatat gctgtccgga tacacacgca cgcacacatg cagatatgct
     2761 gcctgggcac acacttccgg acacacatgc acacacaggt gcagatatgc tgcctggaca
     2821 cacgcagact gacgtgcttt tgggagggtg tgccgtgaag cctgcagtac gtgtgccgtg
     2881 aggctcatag ttgatgaggg actttccctg ctccaccgtc actcccccaa ctctgcccgc
     2941 ctctgtcccc gcctcagtcc ccgcctccat ccccgcctct gtcccctggc cttggcggct
     3001 atttttgcca cctgccttgg gtgcccagga gtcccctact gctgtgggct ggggttgggg
     3061 gcacagcagc cccaagcctg agaggctgga gcccatggct agtggctcat ccccactgca
     3121 ttctccccct gacacagaga aggggccttg gtatttatat ttaagaaatg aagataatat
     3181 taataatgat ggaaggaaga ctgggttgca gggactgtgg tctctcctgg ggcccgggac
     3241 ccgcctggtc tttcagccat gctgatgacc acaccccgtc caggccagac accacccccc
     3301 accccactgt cgtggtggcc ccagatctct gtaattttat gtagagtttg agctgaagcc
     3361 ccgtatattt aatttatttt gttaaacatg aaagtgcatc ctttccctcc a
//
