LOCUS       NM_213647               3093 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens fibroblast growth factor receptor 4 (FGFR4),
            transcript variant 3, mRNA.
ACCESSION   NM_213647
VERSION     NM_213647.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3093)
  AUTHORS   Wu,Q., Liao,R., Miao,C., Hasnat,M., Li,L., Sun,L., Wang,X.,
            Yuan,Z., Jiang,Z., Zhang,L. and Yu,Q.
  TITLE     Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4
            expression through alternative splicing
  JOURNAL   Br J Cancer 131 (1), 77-89 (2024)
   PUBMED   38796598
  REMARK    GeneRIF: Oncofetal SNRPE promotes HCC tumorigenesis by regulating
            the FGFR4 expression through alternative splicing.
REFERENCE   2  (bases 1 to 3093)
  AUTHORS   Di Giorgio,C., Bellini,R., Lupia,A., Massa,C., Urbani,G.,
            Bordoni,M., Marchiano,S., Rosselli,R., De Gregorio,R.,
            Rapacciuolo,P., Sepe,V., Morretta,E., Monti,M.C., Moraca,F.,
            Cari,L., Ullah,K.R.S., Natalizi,N., Graziosi,L., Distrutti,E.,
            Biagioli,M., Catalanotti,B., Donini,A., Zampella,A. and Fiorucci,S.
  TITLE     The leukemia inhibitory factor regulates fibroblast growth factor
            receptor 4 transcription in gastric cancer
  JOURNAL   Cell Oncol (Dordr) 47 (2), 695-710 (2024)
   PUBMED   37945798
  REMARK    GeneRIF: The leukemia inhibitory factor regulates fibroblast growth
            factor receptor 4 transcription in gastric cancer.
REFERENCE   3  (bases 1 to 3093)
  AUTHORS   Liu,N., Zhang,J., Chen,W., Ma,W. and Wu,T.
  TITLE     The RNA methyltransferase METTL16 enhances cholangiocarcinoma
            growth through PRDM15-mediated FGFR4 expression
  JOURNAL   J Exp Clin Cancer Res 42 (1), 263 (2023)
   PUBMED   37817227
  REMARK    GeneRIF: The RNA methyltransferase METTL16 enhances
            cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3093)
  AUTHORS   Chen,X., Chen,J., Feng,W., Huang,W., Wang,G., Sun,M., Luo,X.,
            Wang,Y., Nie,Y., Fan,D., Wu,K. and Xia,L.
  TITLE     FGF19-mediated ELF4 overexpression promotes colorectal cancer
            metastasis through transactivating FGFR4 and SRC
  JOURNAL   Theranostics 13 (4), 1401-1418 (2023)
   PUBMED   36923538
  REMARK    GeneRIF: FGF19-mediated ELF4 overexpression promotes colorectal
            cancer metastasis through transactivating FGFR4 and SRC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3093)
  AUTHORS   Moes-Sosnowska,J., Skupinska,M., Lechowicz,U.,
            Szczepulska-Wojcik,E., Skronska,P., Rozy,A., Stepniewska,A.,
            Langfort,R., Rudzinski,P., Orlowski,T., Popiel,D., Stanczak,A.,
            Wieczorek,M. and Chorostowska-Wynimko,J.
  TITLE     FGFR1-4 RNA-Based Gene Alteration and Expression Analysis in
            Squamous Non-Small Cell Lung Cancer
  JOURNAL   Int J Mol Sci 23 (18), 10506 (2022)
   PUBMED   36142417
  REMARK    GeneRIF: FGFR1-4 RNA-Based Gene Alteration and Expression Analysis
            in Squamous Non-Small Cell Lung Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3093)
  AUTHORS   Vainikka,S., Partanen,J., Bellosta,P., Coulier,F., Birnbaum,D.,
            Basilico,C., Jaye,M. and Alitalo,K.
  TITLE     Fibroblast growth factor receptor-4 shows novel features in genomic
            structure, ligand binding and signal transduction
  JOURNAL   EMBO J 11 (12), 4273-4280 (1992)
   PUBMED   1385111
  REMARK    Erratum:[EMBO J 1993 Feb;12(2):810]
REFERENCE   7  (bases 1 to 3093)
  AUTHORS   Warrington,J.A., Bailey,S.K., Armstrong,E., Aprelikova,O.,
            Alitalo,K., Dolganov,G.M., Wilcox,A.S., Sikela,J.M., Wolfe,S.F.,
            Lovett,M. et al.
  TITLE     A radiation hybrid map of 18 growth factor, growth factor receptor,
            hormone receptor, or neurotransmitter receptor genes on the distal
            region of the long arm of chromosome 5
  JOURNAL   Genomics 13 (3), 803-808 (1992)
   PUBMED   1322355
REFERENCE   8  (bases 1 to 3093)
  AUTHORS   Armstrong,E., Partanen,J., Cannizzaro,L., Huebner,K. and Alitalo,K.
  TITLE     Localization of the fibroblast growth factor receptor-4 gene to
            chromosome region 5q33-qter
  JOURNAL   Genes Chromosomes Cancer 4 (1), 94-98 (1992)
   PUBMED   1377018
REFERENCE   9  (bases 1 to 3093)
  AUTHORS   Holtrich,U., Brauninger,A., Strebhardt,K. and Rubsamen-Waigmann,H.
  TITLE     Two additional protein-tyrosine kinases expressed in human lung:
            fourth member of the fibroblast growth factor receptor family and
            an intracellular protein-tyrosine kinase
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10411-10415 (1991)
   PUBMED   1720539
REFERENCE   10 (bases 1 to 3093)
  AUTHORS   Partanen,J., Makela,T.P., Eerola,E., Korhonen,J., Hirvonen,H.,
            Claesson-Welsh,L. and Alitalo,K.
  TITLE     FGFR-4, a novel acidic fibroblast growth factor receptor with a
            distinct expression pattern
  JOURNAL   EMBO J 10 (6), 1347-1354 (1991)
   PUBMED   1709094
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC011847.2, AK225909.1 and
            AC027314.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_213647.2.
            
            Summary: The protein encoded by this gene is a tyrosine kinase and
            cell surface receptor for fibroblast growth factors. The encoded
            protein is involved in the regulation of several pathways,
            including cell proliferation, cell differentiation, cell migration,
            lipid metabolism, bile acid biosynthesis, vitamin D metabolism,
            glucose uptake, and phosphate homeostasis. This protein consists of
            an extracellular region, composed of three immunoglobulin-like
            domains, a single hydrophobic membrane-spanning segment, and a
            cytoplasmic tyrosine kinase domain. The extracellular portion
            interacts with fibroblast growth factors, setting in motion a
            cascade of downstream signals, ultimately influencing mitogenesis
            and differentiation. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (3) uses an alternative splice
            site for the first exon compared to variant 1. Variants 1, 3 and 5
            all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011847.2, SRR9304715.459080.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292408.9/ ENSP00000292408.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3075              BC011847.2         30-3104
            3076-3091           AK225909.1         3033-3048
            3092-3093           AC027314.5         84278-84279         c
FEATURES             Location/Qualifiers
     source          1..3093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..3093
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /note="fibroblast growth factor receptor 4"
                     /db_xref="GeneID:2264"
                     /db_xref="HGNC:HGNC:3691"
                     /db_xref="MIM:134935"
     exon            1..163
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            164..307
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2625
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; hydroxyaryl-protein kinase; tyrosine kinase
                     related to fibroblast growth factor receptor;
                     protein-tyrosine kinase; tyrosylprotein kinase"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 4 isoform 1
                     precursor"
                     /protein_id="NP_998812.1"
                     /db_xref="CCDS:CCDS4410.1"
                     /db_xref="GeneID:2264"
                     /db_xref="HGNC:HGNC:3691"
                     /db_xref="MIM:134935"
                     /translation="MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQE
                     LTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCL
                     ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLH
                     AVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSD
                     RGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSD
                     AQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCL
                     AGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRG
                     QALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLV
                     SLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDN
                     ASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR
                     PPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN
                     VMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEI
                     FTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLV
                     EALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGS
                     GVQT"
     exon            308..571
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            572..652
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            653..819
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            820..943
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1134
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1273
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1467
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1613
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1735
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1846
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2037
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2160
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2231
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2369
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2475
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..3093
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3052..3057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /note="hexamer: TATAAA"
     regulatory      3070..3075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /note="hexamer: AATAAA"
     polyA_site      3075
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
                     /note="major polyA site"
     polyA_site      3093
                     /gene="FGFR4"
                     /gene_synonym="CD334; JTK2; TKF"
ORIGIN      
        1 cattcctcgc tcccggccga ggagcgctcg ggctgtctgc ggaccctgcc gcgtgcaggg
       61 gtcgcggccg gctggagctg ggagtgaggc ggcggaggag ccaggtgagg aggagccagg
      121 tgagcaggac cctgtgctgg gcgcggagtc acgcaggctc gaggaaggca gttggtggga
      181 agtccagctt gggtccctga gagctgtgag aaggagatgc ggctgctgct ggccctgttg
      241 ggggtcctgc tgagtgtgcc tgggcctcca gtcttgtccc tggaggcctc tgaggaagtg
      301 gagcttgagc cctgcctggc tcccagcctg gagcagcaag agcaggagct gacagtagcc
      361 cttgggcagc ctgtgcgtct gtgctgtggg cgggctgagc gtggtggcca ctggtacaag
      421 gagggcagtc gcctggcacc tgctggccgt gtacggggct ggaggggccg cctagagatt
      481 gccagcttcc tacctgagga tgctggccgc tacctctgcc tggcacgagg ctccatgatc
      541 gtcctgcaga atctcacctt gattacaggt gactccttga cctccagcaa cgatgatgag
      601 gaccccaagt cccataggga cccctcgaat aggcacagtt acccccagca agcaccctac
      661 tggacacacc cccagcgcat ggagaagaaa ctgcatgcag tacctgcggg gaacaccgtc
      721 aagttccgct gtccagctgc aggcaacccc acgcccacca tccgctggct taaggatgga
      781 caggcctttc atggggagaa ccgcattgga ggcattcggc tgcgccatca gcactggagt
      841 ctcgtgatgg agagcgtggt gccctcggac cgcggcacat acacctgcct ggtagagaac
      901 gctgtgggca gcatccgcta taactacctg ctagatgtgc tggagcggtc cccgcaccgg
      961 cccatcctgc aggccgggct cccggccaac accacagccg tggtgggcag cgacgtggag
     1021 ctgctgtgca aggtgtacag cgatgcccag ccccacatcc agtggctgaa gcacatcgtc
     1081 atcaacggca gcagcttcgg agccgacggt ttcccctatg tgcaagtcct aaagactgca
     1141 gacatcaata gctcagaggt ggaggtcctg tacctgcgga acgtgtcagc cgaggacgca
     1201 ggcgagtaca cctgcctcgc aggcaattcc atcggcctct cctaccagtc tgcctggctc
     1261 acggtgctgc cagaggagga ccccacatgg accgcagcag cgcccgaggc caggtatacg
     1321 gacatcatcc tgtacgcgtc gggctccctg gccttggctg tgctcctgct gctggccggg
     1381 ctgtatcgag ggcaggcgct ccacggccgg cacccccgcc cgcccgccac tgtgcagaag
     1441 ctctcccgct tccctctggc ccgacagttc tccctggagt caggctcttc cggcaagtca
     1501 agctcatccc tggtacgagg cgtgcgtctc tcctccagcg gccccgcctt gctcgccggc
     1561 ctcgtgagtc tagatctacc tctcgaccca ctatgggagt tcccccggga caggctggtg
     1621 cttgggaagc ccctaggcga gggctgcttt ggccaggtag tacgtgcaga ggcctttggc
     1681 atggaccctg cccggcctga ccaagccagc actgtggccg tcaagatgct caaagacaac
     1741 gcctctgaca aggacctggc cgacctggtc tcggagatgg aggtgatgaa gctgatcggc
     1801 cgacacaaga acatcatcaa cctgcttggt gtctgcaccc aggaagggcc cctgtacgtg
     1861 atcgtggagt gcgccgccaa gggaaacctg cgggagttcc tgcgggcccg gcgcccccca
     1921 ggccccgacc tcagccccga cggtcctcgg agcagtgagg ggccgctctc cttcccagtc
     1981 ctggtctcct gcgcctacca ggtggcccga ggcatgcagt atctggagtc ccggaagtgt
     2041 atccaccggg acctggctgc ccgcaatgtg ctggtgactg aggacaatgt gatgaagatt
     2101 gctgactttg ggctggcccg cggcgtccac cacattgact actataagaa aaccagcaac
     2161 ggccgcctgc ctgtgaagtg gatggcgccc gaggccttgt ttgaccgggt gtacacacac
     2221 cagagtgacg tgtggtcttt tgggatcctg ctatgggaga tcttcaccct cgggggctcc
     2281 ccgtatcctg gcatcccggt ggaggagctg ttctcgctgc tgcgggaggg acatcggatg
     2341 gaccgacccc cacactgccc cccagagctg tacgggctga tgcgtgagtg ctggcacgca
     2401 gcgccctccc agaggcctac cttcaagcag ctggtggagg cgctggacaa ggtcctgctg
     2461 gccgtctctg aggagtacct cgacctccgc ctgaccttcg gaccctattc cccctctggt
     2521 ggggacgcca gcagcacctg ctcctccagc gattctgtct tcagccacga ccccctgcca
     2581 ttgggatcca gctccttccc cttcgggtct ggggtgcaga catgagcaag gctcaaggct
     2641 gtgcaggcac ataggctggt ggccttgggc cttggggctc agccacagcc tgacacagtg
     2701 ctcgaccttg atagcatggg gcccctggcc cagagttgct gtgccgtgtc caagggccgt
     2761 gcccttgccc ttggagctgc cgtgcctgtg tcctgatggc ccaaatgtca gggttctgct
     2821 cggcttcttg gaccttggcg cttagtcccc atcccgggtt tggctgagcc tggctggaga
     2881 gctgctatgc taaacctcct gcctcccaat accagcagga ggttctgggc ctctgaaccc
     2941 cctttcccca cacctccccc tgctgctgct gccccagcgt cttgacggga gcattggccc
     3001 ctgagcccag agaagctgga agcctgccga aaacaggagc aaatggcgtt ttataaatta
     3061 tttttttgaa ataaagctct gtgtgcctgg gtc
//
