LOCUS       NM_000141               4624 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens fibroblast growth factor receptor 2 (FGFR2),
            transcript variant 1, mRNA.
ACCESSION   NM_000141
VERSION     NM_000141.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4624)
  AUTHORS   Chen,C.P., Huang,J.P., Huang,K.S., Chen,Y.Y., Wu,F.T., Pan,Y.T.,
            Chiu,C.L. and Wang,W.
  TITLE     Perinatal imaging findings of a fetus with Pfeiffer syndrome and a
            heterozygous c.1019A>G, p.Tyr340Cys (Y340C) mutation in FGFR2
            presenting a cloverleaf skull, craniosynostosis and short limbs on
            prenatal ultrasound mimicking thanatophoric dysplasia type II
  JOURNAL   Taiwan J Obstet Gynecol 63 (3), 387-390 (2024)
   PUBMED   38802203
  REMARK    GeneRIF: Perinatal imaging findings of a fetus with Pfeiffer
            syndrome and a heterozygous c.1019A>G, p.Tyr340Cys (Y340C) mutation
            in FGFR2 presenting a cloverleaf skull, craniosynostosis and short
            limbs on prenatal ultrasound mimicking thanatophoric dysplasia type
            II.
REFERENCE   2  (bases 1 to 4624)
  AUTHORS   Lian,Y., Bodian,D. and Shehu,A.
  TITLE     Elucidating the Role of Wildtype and Variant FGFR2 Structural
            Dynamics in (Dys)Function and Disorder
  JOURNAL   Int J Mol Sci 25 (8), 4523 (2024)
   PUBMED   38674107
  REMARK    GeneRIF: Elucidating the Role of Wildtype and Variant FGFR2
            Structural Dynamics in (Dys)Function and Disorder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4624)
  AUTHORS   Xu,N., Hung,K.L., Gong,X., Fan,D., Tian,Y., Yan,M., Wei,Y. and
            Wang,S.
  TITLE     Genetic insights into the 'sandwich fusion' subtype of Klippel-Feil
            syndrome: novel FGFR2 mutations identified by 21 cases of
            whole-exome sequencing
  JOURNAL   Orphanet J Rare Dis 19 (1), 141 (2024)
   PUBMED   38561822
  REMARK    GeneRIF: Genetic insights into the 'sandwich fusion' subtype of
            Klippel-Feil syndrome: novel FGFR2 mutations identified by 21 cases
            of whole-exome sequencing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4624)
  AUTHORS   Wenger,T.L., Hing,A.V. and Evans,K.N.
  TITLE     Apert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31145570
REFERENCE   5  (bases 1 to 4624)
  AUTHORS   Wenger,T., Miller,D. and Evans,K.
  TITLE     FGFR Craniosynostosis Syndromes Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301628
REFERENCE   6  (bases 1 to 4624)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   7  (bases 1 to 4624)
  AUTHORS   Dell,K.R. and Williams,L.T.
  TITLE     A novel form of fibroblast growth factor receptor 2. Alternative
            splicing of the third immunoglobulin-like domain confers ligand
            binding specificity
  JOURNAL   J Biol Chem 267 (29), 21225-21229 (1992)
   PUBMED   1400433
REFERENCE   8  (bases 1 to 4624)
  AUTHORS   Luqmani,Y.A., Graham,M. and Coombes,R.C.
  TITLE     Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in
            normal and malignant human breast, and comparison with other normal
            tissues
  JOURNAL   Br J Cancer 66 (2), 273-280 (1992)
   PUBMED   1380281
REFERENCE   9  (bases 1 to 4624)
  AUTHORS   Katoh,M., Hattori,Y., Sasaki,H., Tanaka,M., Sugano,K., Yazaki,Y.,
            Sugimura,T. and Terada,M.
  TITLE     K-sam gene encodes secreted as well as transmembrane receptor
            tyrosine kinase
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2960-2964 (1992)
   PUBMED   1313574
REFERENCE   10 (bases 1 to 4624)
  AUTHORS   Miki,T., Bottaro,D.P., Fleming,T.P., Smith,C.L., Burgess,W.H.,
            Chan,A.M. and Aaronson,S.A.
  TITLE     Determination of ligand-binding specificity by alternative
            splicing: two distinct growth factor receptors encoded by a single
            gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 246-250 (1992)
   PUBMED   1309608
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC039243.1, CN345547.1,
            M87770.1, CX873387.1, BC037338.2 and CB305736.1.
            
            On Nov 1, 2019 this sequence version replaced NM_000141.4.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor receptor family, where amino acid sequence
            is highly conserved between members and throughout evolution. FGFR
            family members differ from one another in their ligand affinities
            and tissue distribution. A full-length representative protein
            consists of an extracellular region, composed of three
            immunoglobulin-like domains, a single hydrophobic membrane-spanning
            segment and a cytoplasmic tyrosine kinase domain. The extracellular
            portion of the protein interacts with fibroblast growth factors,
            setting in motion a cascade of downstream signals, ultimately
            influencing mitogenesis and differentiation. This particular family
            member is a high-affinity receptor for acidic, basic and/or
            keratinocyte growth factor, depending on the isoform. Mutations in
            this gene are associated with Crouzon syndrome, Pfeiffer syndrome,
            Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome,
            Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome,
            and syndromic craniosynostosis. Multiple alternatively spliced
            transcript variants encoding different isoforms have been noted for
            this gene. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1, also
            referred to as isoform BEK and K-sam.
            
            Sequence Note: A downstream AUG translation start codon is selected
            for this RefSeq based on the presence of a strong Kozak consensus
            signal, a strong community standard for the use of the downstream
            start codon, and on a higher probability of an N-terminal signal
            peptide being present in the resulting protein. The use of an
            alternative in-frame upstream AUG start codon would result in a
            protein that is 19 aa longer at the N-terminus. Translation from
            the annotated downstream start codon is likely to occur via leaky
            scanning and/or reinitiation.
            
            CCDS Note: A downstream AUG translation start codon is selected for
            this CCDS representation based on a strong community standard for
            its use, and on a higher probability of a signal peptide being
            present in the protein N-terminus. The use of an alternative
            upstream AUG start codon would result in a protein that is 19 aa
            longer at the N-terminus. The upstream AUG has a weak Kozak signal
            while the downstream AUG has a strong Kozak signal. Due to leaky
            scanning by ribosomes, it is possible that some ribosomes may
            initiate translation from the downstream AUG codon while others
            start from the upstream AUG. The presence of multiple upstream ORFs
            suggests that a combination of leaky scanning and translational
            reinitiation may be necessary to achieve translation of the
            annotated ORF.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M87770.1, X52832.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: community standard (PMID:
                                                15863034)
            MANE Ensembl match               :: ENST00000358487.10/
                                                ENSP00000351276.6
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               BC039243.1         15-411
            398-483             CN345547.1         290-375
            484-1328            M87770.1           124-968
            1329-1381           CX873387.1         106-158
            1382-3356           M87770.1           1022-2996
            3357-4498           BC037338.2         2755-3896
            4499-4624           CB305736.1         17-142              c
FEATURES             Location/Qualifiers
     source          1..4624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..4624
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="fibroblast growth factor receptor 2"
                     /db_xref="GeneID:2263"
                     /db_xref="HGNC:HGNC:3689"
                     /db_xref="MIM:176943"
     exon            1..483
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            484..742
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     CDS             634..3099
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein tyrosine kinase, receptor like 14;
                     bacteria-expressed kinase; keratinocyte growth factor
                     receptor; BEK fibroblast growth factor receptor"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 2 isoform 1
                     precursor"
                     /protein_id="NP_000132.3"
                     /db_xref="CCDS:CCDS31298.1"
                     /db_xref="GeneID:2263"
                     /db_xref="HGNC:HGNC:3689"
                     /db_xref="MIM:176943"
                     /translation="MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQI
                     SQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDS
                     GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE
                     KMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM
                     ESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEF
                     VCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF
                     EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV
                     VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTR
                     LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP
                     KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
                     ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH
                     RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH
                     QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCW
                     HAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVF
                     SPDPMPYEPCLPQYPHINGSVKT"
     exon            743..1009
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1087
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1257
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1381
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1572
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1717
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1920
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2072
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2194
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2305
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2496
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2619
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2690
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2828
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2934
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..4624
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3714..3719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="hexamer: AATAAA"
     polyA_site      3738
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="major polyA site"
     regulatory      4556..4561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="hexamer: AATAAA"
     regulatory      4596..4601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="hexamer: AATAAA"
     polyA_site      4597
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="major polyA site"
     polyA_site      4624
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
ORIGIN      
        1 gagagcgcgg tggagagccg agcgggcggg cggcgggtgc ggagcgggcg agggagcgcg
       61 cgcggccgcc acaaagctcg ggcgccgcgg ggctgcatgc ggcgtacctg gcccggcgcg
      121 gcgactgctc tccgggctgg cgggggccgg ccgcgagccc cgggggcccc gaggccgcag
      181 cttgcctgcg cgctctgagc cttcgcaact cgcgagcaaa gtttggtgga ggcaacgcca
      241 agcctgagtc ctttcttcct ctcgttcccc aaatccgagg gcagcccgcg ggcgtcatgc
      301 ccgcgctcct ccgcagcctg gggtacgcgt gaagcccggg aggcttggcg ccggcgaaga
      361 cccaaggacc actcttctgc gtttggagtt gctccccgca accccgggct cgtcgctttc
      421 tccatcccga cccacgcggg gcgcggggac aacacaggtc gcggaggagc gttgccattc
      481 aagtgactgc agcagcagcg gcagcgcctc ggttcctgag cccaccgcag gctgaaggca
      541 ttgcgcgtag tccatgcccg tagaggaagt gtgcagatgg gattaacgtc cacatggaga
      601 tatggaagag gaccggggat tggtaccgta accatggtca gctggggtcg tttcatctgc
      661 ctggtcgtgg tcaccatggc aaccttgtcc ctggcccggc cctccttcag tttagttgag
      721 gataccacat tagagccaga agagccacca accaaatacc aaatctctca accagaagtg
      781 tacgtggctg cgccagggga gtcgctagag gtgcgctgcc tgttgaaaga tgccgccgtg
      841 atcagttgga ctaaggatgg ggtgcacttg gggcccaaca ataggacagt gcttattggg
      901 gagtacttgc agataaaggg cgccacgcct agagactccg gcctctatgc ttgtactgcc
      961 agtaggactg tagacagtga aacttggtac ttcatggtga atgtcacaga tgccatctca
     1021 tccggagatg atgaggatga caccgatggt gcggaagatt ttgtcagtga gaacagtaac
     1081 aacaagagag caccatactg gaccaacaca gaaaagatgg aaaagcggct ccatgctgtg
     1141 cctgcggcca acactgtcaa gtttcgctgc ccagccgggg ggaacccaat gccaaccatg
     1201 cggtggctga aaaacgggaa ggagtttaag caggagcatc gcattggagg ctacaaggta
     1261 cgaaaccagc actggagcct cattatggaa agtgtggtcc catctgacaa gggaaattat
     1321 acctgtgtag tggagaatga atacgggtcc atcaatcaca cgtaccacct ggatgttgtg
     1381 gagcgatcgc ctcaccggcc catcctccaa gccggactgc cggcaaatgc ctccacagtg
     1441 gtcggaggag acgtagagtt tgtctgcaag gtttacagtg atgcccagcc ccacatccag
     1501 tggatcaagc acgtggaaaa gaacggcagt aaatacgggc ccgacgggct gccctacctc
     1561 aaggttctca aggccgccgg tgttaacacc acggacaaag agattgaggt tctctatatt
     1621 cggaatgtaa cttttgagga cgctggggaa tatacgtgct tggcgggtaa ttctattggg
     1681 atatcctttc actctgcatg gttgacagtt ctgccagcgc ctggaagaga aaaggagatt
     1741 acagcttccc cagactacct ggagatagcc atttactgca taggggtctt cttaatcgcc
     1801 tgtatggtgg taacagtcat cctgtgccga atgaagaaca cgaccaagaa gccagacttc
     1861 agcagccagc cggctgtgca caagctgacc aaacgtatcc ccctgcggag acaggtaaca
     1921 gtttcggctg agtccagctc ctccatgaac tccaacaccc cgctggtgag gataacaaca
     1981 cgcctctctt caacggcaga cacccccatg ctggcagggg tctccgagta tgaacttcca
     2041 gaggacccaa aatgggagtt tccaagagat aagctgacac tgggcaagcc cctgggagaa
     2101 ggttgctttg ggcaagtggt catggcggaa gcagtgggaa ttgacaaaga caagcccaag
     2161 gaggcggtca ccgtggccgt gaagatgttg aaagatgatg ccacagagaa agacctttct
     2221 gatctggtgt cagagatgga gatgatgaag atgattggga aacacaagaa tatcataaat
     2281 cttcttggag cctgcacaca ggatgggcct ctctatgtca tagttgagta tgcctctaaa
     2341 ggcaacctcc gagaatacct ccgagcccgg aggccacccg ggatggagta ctcctatgac
     2401 attaaccgtg ttcctgagga gcagatgacc ttcaaggact tggtgtcatg cacctaccag
     2461 ctggccagag gcatggagta cttggcttcc caaaaatgta ttcatcgaga tttagcagcc
     2521 agaaatgttt tggtaacaga aaacaatgtg atgaaaatag cagactttgg actcgccaga
     2581 gatatcaaca atatagacta ttacaaaaag accaccaatg ggcggcttcc agtcaagtgg
     2641 atggctccag aagccctgtt tgatagagta tacactcatc agagtgatgt ctggtccttc
     2701 ggggtgttaa tgtgggagat cttcacttta gggggctcgc cctacccagg gattcccgtg
     2761 gaggaacttt ttaagctgct gaaggaagga cacagaatgg ataagccagc caactgcacc
     2821 aacgaactgt acatgatgat gagggactgt tggcatgcag tgccctccca gagaccaacg
     2881 ttcaagcagt tggtagaaga cttggatcga attctcactc tcacaaccaa tgaggaatac
     2941 ttggacctca gccaacctct cgaacagtat tcacctagtt accctgacac aagaagttct
     3001 tgttcttcag gagatgattc tgttttttct ccagacccca tgccttacga accatgcctt
     3061 cctcagtatc cacacataaa cggcagtgtt aaaacatgaa tgactgtgtc tgcctgtccc
     3121 caaacaggac agcactggga acctagctac actgagcagg gagaccatgc ctcccagagc
     3181 ttgttgtctc cacttgtata tatggatcag aggagtaaat aattggaaaa gtaatcagca
     3241 tatgtgtaaa gatttataca gttgaaaact tgtaatcttc cccaggagga gaagaaggtt
     3301 tctggagcag tggactgcca caagccacca tgtaacccct ctcacctgcc gtgcgtactg
     3361 gctgtggacc agtaggactc aaggtggacg tgcgttctgc cttccttgtt aattttgtaa
     3421 taattggaga agatttatgt cagcacacac ttacagagca caaatgcagt atataggtgc
     3481 tggatgtatg taaatatatt caaattatgt ataaatatat attatatatt tacaaggagt
     3541 tattttttgt attgatttta aatggatgtc ccaatgcacc tagaaaattg gtctctcttt
     3601 ttttaatagc tatttgctaa atgctgttct tacacataat ttcttaattt tcaccgagca
     3661 gaggtggaaa aatacttttg ctttcaggga aaatggtata acgttaattt attaataaat
     3721 tggtaatata caaaacaatt aatcatttat agtttttttt gtaatttaag tggcatttct
     3781 atgcaggcag cacagcagac tagttaatct attgcttgga cttaactagt tatcagatcc
     3841 tttgaaaaga gaatatttac aatatatgac taatttgggg aaaatgaagt tttgatttat
     3901 ttgtgtttaa atgctgctgt cagacgattg ttcttagacc tcctaaatgc cccatattaa
     3961 aagaactcat tcataggaag gtgtttcatt ttggtgtgca accctgtcat tacgtcaacg
     4021 caacgtctaa ctggacttcc caagataaat ggtaccagcg tcctcttaaa agatgcctta
     4081 atccattcct tgaggacaga ccttagttga aatgatagca gaatgtgctt ctctctggca
     4141 gctggccttc tgcttctgag ttgcacatta atcagattag cctgtattct cttcagtgaa
     4201 ttttgataat ggcttccaga ctctttggcg ttggagacgc ctgttaggat cttcaagtcc
     4261 catcatagaa aattgaaaca cagagttgtt ctgctgatag ttttggggat acgtccatct
     4321 ttttaaggga ttgctttcat ctaattctgg caggacctca ccaaaagatc cagcctcata
     4381 cctacatcag acaaaatatc gccgttgttc cttctgtact aaagtattgt gttttgcttt
     4441 ggaaacaccc actcactttg caatagccgt gcaagatgaa tgcagattac actgatctta
     4501 tgtgttacaa aattggagaa agtatttaat aaaacctgtt aatttttata ctgacaataa
     4561 aaatgtttct acagatatta atgttaacaa gacaaaataa atgtcacgca acttattttt
     4621 ttaa
//
