LOCUS       NM_015633               2932 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens FGFR1 oncogene partner 2 (FGFR1OP2), transcript
            variant 1, mRNA.
ACCESSION   NM_015633
VERSION     NM_015633.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2932)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2932)
  AUTHORS   Kim,J.H., Oh,M.Y., Paek,J. and Lee,J.
  TITLE     Association between FGFR1OP2/wit3.0 polymorphisms and residual
            ridge resorption of mandible in Korean population
  JOURNAL   PLoS One 7 (8), e42734 (2012)
   PUBMED   22880093
  REMARK    GeneRIF: The patient with minor allele of ss518063493 may be
            associated with excessive atrophy of edentulous mandible whereas
            the patients with that of rs840869 are not associated in Korean
            population.
REFERENCE   3  (bases 1 to 2932)
  AUTHORS   Suwanwela,J., Lee,J., Lin,A., Ucer,T.C., Devlin,H., Sinsheimer,J.,
            Garrett,N.R. and Nishimura,I.
  TITLE     A genetic association study of single nucleotide polymorphisms in
            FGFR1OP2/wit3.0 and long-term atrophy of edentulous mandible
  JOURNAL   PLoS One 6 (1), e16204 (2011)
   PUBMED   21283824
  REMARK    GeneRIF: patients with the minor allele of rs840869 or rs859024 of
            FGFR1OP2 were associated with excessive atrophy of edentulous
            mandible
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2932)
  AUTHORS   Lin,A., Hokugo,A., Choi,J. and Nishimura,I.
  TITLE     Small cytoskeleton-associated molecule, fibroblast growth factor
            receptor 1 oncogene partner 2/wound inducible transcript-3.0
            (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure
  JOURNAL   Am J Pathol 176 (1), 108-121 (2010)
   PUBMED   19959814
  REMARK    GeneRIF: FGFR1OP2/wit3.0 may regulate cell motility and stimulate
            wound closure.
REFERENCE   5  (bases 1 to 2932)
  AUTHORS   Gu,T.L., Goss,V.L., Reeves,C., Popova,L., Nardone,J., Macneill,J.,
            Walters,D.K., Wang,Y., Rush,J., Comb,M.J., Druker,B.J. and
            Polakiewicz,R.D.
  TITLE     Phosphotyrosine profiling identifies the KG-1 cell line as a model
            for the study of FGFR1 fusions in acute myeloid leukemia
  JOURNAL   Blood 108 (13), 4202-4204 (2006)
   PUBMED   16946300
REFERENCE   6  (bases 1 to 2932)
  AUTHORS   Grand,E.K., Grand,F.H., Chase,A.J., Ross,F.M., Corcoran,M.M.,
            Oscier,D.G. and Cross,N.C.
  TITLE     Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11
            myeloproliferative syndrome
  JOURNAL   Genes Chromosomes Cancer 40 (1), 78-83 (2004)
   PUBMED   15034873
  REMARK    GeneRIF: FGFR1OP2 is a new FGFR1 fusion gene involving a
            chromosomes 12X8 translocation in a 8p11 myeloproliferative
            syndrome patient.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001534.1 and AC024896.23.
            
            On Nov 23, 2018 this sequence version replaced NM_015633.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.74899.1,
                                           SRR1803614.245914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229395.8/ ENSP00000229395.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1963              AK001534.1         88-2050
            1964-2932           AC024896.23        8008-8976
FEATURES             Location/Qualifiers
     source          1..2932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..2932
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /note="FGFR1 oncogene partner 2"
                     /db_xref="GeneID:26127"
                     /db_xref="HGNC:HGNC:23098"
                     /db_xref="MIM:608858"
     exon            1..241
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /inference="alignment:Splign:2.1.0"
     exon            242..390
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1017
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fibroblast growth factor receptor 1 oncogene partner 2;
                     wound inducible transcript 3.0"
                     /codon_start=1
                     /product="FGFR1 oncogene partner 2 isoform 1"
                     /protein_id="NP_056448.1"
                     /db_xref="CCDS:CCDS8709.1"
                     /db_xref="GeneID:26127"
                     /db_xref="HGNC:HGNC:23098"
                     /db_xref="MIM:608858"
                     /translation="MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMK
                     QYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMS
                     KYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRNKSEGFFLDASRHILEAPQHGL
                     ERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREIL
                     QITRESFLNLRKDDASESTSLSALVTNSDLSLRKS"
     exon            391..508
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /inference="alignment:Splign:2.1.0"
     exon            509..651
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /inference="alignment:Splign:2.1.0"
     exon            652..765
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /inference="alignment:Splign:2.1.0"
     exon            766..879
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /inference="alignment:Splign:2.1.0"
     exon            880..2932
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2275..2280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /note="hexamer: ATTAAA"
     polyA_site      2301
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /note="major polyA site"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /note="hexamer: ATTAAA"
     polyA_site      2932
                     /gene="FGFR1OP2"
                     /gene_synonym="HSPC123-like; WIT3.0"
                     /note="major polyA site"
ORIGIN      
        1 agttctccgg gagcgccggt cggaggcggt cggcggaggt gtctaccccg ccggtgatgg
       61 cgttgaacgc cactggcttc ccggccttcc gtccgctgcc tccgtccgat tctgcgtctg
      121 cttgctgagg aggcggatta ggggggcgcg gagtctcttc ccttgagtgc ataggtcccg
      181 gttggtagag ggtttgagtc cgcatcgcca cagctgaagg ctgcgaggga ctaagagcag
      241 aatatatctt tagaaatgag ttgcacaatt gagaaggcac ttgccgacgc taaagctctt
      301 gttgaaagat taagagatca tgacgatgca gcagaatctc tgattgagca aaccacagct
      361 ctcaacaagc gagtagaagc catgaaacag tatcaggaag aaattcaaga acttaatgaa
      421 gtcgcgagac atcggccacg gtccacgtta gttatgggaa tccagcaaga aaacagacaa
      481 atcagagagt tgcaacaaga aaacaaagaa ttacgtacat ctctggaaga acatcagtcg
      541 gccttggaac ttataatgag caagtaccga gaacaaatgt ttagattgct aatggctagc
      601 aaaaaagatg atccgggtat aataatgaag ttaaaagagc agcactccaa gattgacatg
      661 gtacatcgta acaagtccga aggattcttc cttgatgcat ctcgacacat ccttgaagca
      721 cctcaacatg gactggagag aaggcacttg gaagcaaatc agaatgaact gcaagcacat
      781 gttgaccaga taactgaaat ggcagcagta atgaggaaag ccattgaaat tgacgagcaa
      841 cagggttgca aggaacaaga acgaatattt caacttgaac aagaaaacaa aggcttgaga
      901 gagatccttc aaataactcg agaatcattt ttgaacctaa ggaaagatga tgcgtcggaa
      961 agtacttctt tgtcagcatt agtgaccaac agtgatttga gtctgaggaa gagctgaaga
     1021 gtttctgagt ctgtgagctt cttacatggc tccaaatggt caaataagtg aatgaatgaa
     1081 tggacagaaa attcaatcct ttattttttt ctctgtaaat atgtacagtg cacgggctat
     1141 gagatagcaa caaaaaatgc atagttaatg gtcatagact ttattccaaa acataattgg
     1201 aaaatagaaa ctgagccatt gccaaatggt aaagaaatga aaagttttca cagtgactac
     1261 tgaatatacc aagagctttt ggcagtactg ctggctttct gggtgattaa ttaggtaaac
     1321 ttgaatattc ccagtaaatg tttgagaatg cataaaatta taccaattta aaaatataaa
     1381 tttttgccac tgttttgtga acggaggatt tgtacgctaa atttcatcct tatttggcgt
     1441 caaagttgat gcaaagttta tgtaccatga gacttctagt gattgcctac tttcacattt
     1501 atttaaattt ttgtgaaaga aaatacagtt ttaaaggcta taggaatgtg ttatatgtac
     1561 cttaaacaga taatttaatt ttagcaattt atcataactg atacttagct aacaattgtc
     1621 cataacttgt ttaagtgtaa gaaataccat ttcaggaatg aaaaagaagg aatactactt
     1681 tctaagaaag aagatcttat aatagacata tttagtaggt taaactactc ctttgaaaga
     1741 ataagttttg gttcaaagtc aataatgaag acgagatttg tttttctctt ctctggctga
     1801 tttttaagga tattatgtag ttcatttagt taacagaatt gaaatgtttg atatggcaag
     1861 ataggtatgg taatttcaaa gtgaattggg aattcctctg gctcatagaa cccttttttt
     1921 tttcctttaa gtattcttga gatacaaaaa aaaaaagtaa atacaatttc aaaaaaaaag
     1981 ttccggatct gtttttaagc tccatctggt cctcataacc tgcaagattt ttcttaaaac
     2041 ctttcagctg aaagtggggg taaaggtgga gtaatctgtg gatttgtttc tgttgtcttt
     2101 taaaatgtca aatatataat atgtaatttt tttaaaaacc accagataca gaaatgtgct
     2161 ttaacatcag ttgaaaccta aattttctta tgttgtggtg attgtattaa aaagggataa
     2221 aagaagagtg tcaaacatgg ttaaatatat tgtactcatt tatgttgaat acgtattaaa
     2281 attaagacaa atggaaaatt atactttgag tatataattt gttaaatatt actttatatg
     2341 gtaattttat gtataatttc atatattggt aaaattcaaa actacacttg agaatttttt
     2401 tatcttaagt ttggggtgaa tggggtggat gagactgatt gaatagaaaa gggctaatgg
     2461 cccaaacatt atatagattt ctttttttca gtcagaggcc ttatttgata ttttataaat
     2521 aaatgacagt ttttattttt aaacttttta ttgtttttgg gaaagtattc cttaatttaa
     2581 tgacacattc attcagatac ttcttatccc tgctaataaa ggaaatctat ttcaagctac
     2641 accattgaga ttaagtctga ggcagttcat tgaggcagct ctactataaa agcttacttg
     2701 ataaataatt atttttgtaa acaagttggg ttaacttatt cttcgtcttt ttgcttggat
     2761 atgaatttaa ggtcttcatg tttaaagaca tttactttgt tatttagtga cacatttcca
     2821 tcctattttt tttttttttt tggttgttgt taaacagaac cttaagttta tgtttgaggt
     2881 atgtactgca taggaaccta ttttattatt aaagatgaat gattaaaatt gg
//
