LOCUS       NM_023110               5697 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens fibroblast growth factor receptor 1 (FGFR1),
            transcript variant 1, mRNA.
ACCESSION   NM_023110 NM_000604
VERSION     NM_023110.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5697)
  AUTHORS   Lin,H., Hassan Safdar,M., Washburn,S., S Akhand,S., Dickerhoff,J.,
            Ayers,M., Monteiro,M., Solorio,L., Yang,D. and Wendt,M.K.
  TITLE     Fibroblast growth receptor 1 is regulated by G-quadruplex in
            metastatic breast cancer
  JOURNAL   Commun Biol 7 (1), 963 (2024)
   PUBMED   39122837
  REMARK    GeneRIF: Fibroblast growth receptor 1 is regulated by G-quadruplex
            in metastatic breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5697)
  AUTHORS   Twigg,S.R., Burns,H.D., Oldridge,M., Heath,J.K. and Wilkie,A.O.
  TITLE     Conserved use of a non-canonical 5' splice site (/GA) in
            alternative splicing by fibroblast growth factor receptors 1, 2 and
            3
  JOURNAL   Hum Mol Genet 7 (4), 685-691 (1998)
   PUBMED   9499422
REFERENCE   3  (bases 1 to 5697)
  AUTHORS   Wang,L.Y., Edenson,S.P., Yu,Y.L., Senderowicz,L. and Turck,C.W.
  TITLE     A natural kinase-deficient variant of fibroblast growth factor
            receptor 1
  JOURNAL   Biochemistry 35 (31), 10134-10142 (1996)
   PUBMED   8756477
REFERENCE   4  (bases 1 to 5697)
  AUTHORS   Othman,A.A., Babcock,H.E. and Ferreira,C.R.
  TITLE     Osteoglophonic Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38648328
REFERENCE   5  (bases 1 to 5697)
  AUTHORS   Moog,U. and Dobyns,W.B.
  TITLE     Encephalocraniocutaneous Lipomatosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35099867
REFERENCE   6  (bases 1 to 5697)
  AUTHORS   Dhamija,R. and Babovic-Vuksanovic,D.
  TITLE     FGFR1-Related Hartsfield Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26937548
REFERENCE   7  (bases 1 to 5697)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
REFERENCE   8  (bases 1 to 5697)
  AUTHORS   Wenger,T., Miller,D. and Evans,K.
  TITLE     FGFR Craniosynostosis Syndromes Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301628
REFERENCE   9  (bases 1 to 5697)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
REFERENCE   10 (bases 1 to 5697)
  AUTHORS   Hattori,Y., Odagiri,H., Katoh,O., Sakamoto,H., Morita,T.,
            Shimotohno,K., Tobinai,K., Sugimura,T. and Terada,M.
  TITLE     K-sam-related gene, N-sam, encodes fibroblast growth factor
            receptor and is expressed in T-lymphocytic tumors
  JOURNAL   Cancer Res 52 (12), 3367-3371 (1992)
   PUBMED   1317750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087623.21, BC018128.1,
            X66945.1, CX757985.1, BQ774633.1, AK130555.1 and AW206093.1.
            
            On Aug 29, 2019 this sequence version replaced NM_023110.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor receptor (FGFR) family, where amino acid
            sequence is highly conserved between members and throughout
            evolution. FGFR family members differ from one another in their
            ligand affinities and tissue distribution. A full-length
            representative protein consists of an extracellular region,
            composed of three immunoglobulin-like domains, a single hydrophobic
            membrane-spanning segment and a cytoplasmic tyrosine kinase domain.
            The extracellular portion of the protein interacts with fibroblast
            growth factors, setting in motion a cascade of downstream signals,
            ultimately influencing mitogenesis and differentiation. This
            particular family member binds both acidic and basic fibroblast
            growth factors and is involved in limb induction. Mutations in this
            gene have been associated with Pfeiffer syndrome, Jackson-Weiss
            syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and
            autosomal dominant Kallmann syndrome 2. Chromosomal aberrations
            involving this gene are associated with stem cell
            myeloproliferative disorder and stem cell leukemia lymphoma
            syndrome. Alternatively spliced variants which encode different
            protein isoforms have been described; however, not all variants
            have been fully characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1, also known
            as isoform Alpha A1, IV and the 3-Ig domain+2 AA insert form.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66945.1, X57121.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447712.7/ ENSP00000400162.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               AC087623.21        43689-43955
            268-1185            BC018128.1         231-1148
            1186-3992           X66945.1           1169-3975
            3993-4675           CX757985.1         44-726
            4676-4960           BQ774633.1         275-559             c
            4961-5397           AK130555.1         194-630
            5398-5697           AW206093.1         22-321              c
FEATURES             Location/Qualifiers
     source          1..5697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..5697
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /note="fibroblast growth factor receptor 1"
                     /db_xref="GeneID:2260"
                     /db_xref="HGNC:HGNC:3688"
                     /db_xref="MIM:136350"
     exon            1..655
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            656..834
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             744..3212
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hydroxyaryl-protein kinase; fms-related
                     tyrosine kinase 2; heparin-binding growth factor receptor;
                     FMS-like tyrosine kinase 2; basic fibroblast growth factor
                     receptor 1; proto-oncogene c-Fgr; FGFR1/PLAG1 fusion"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 1 isoform 1
                     precursor"
                     /protein_id="NP_075598.2"
                     /db_xref="CCDS:CCDS6107.2"
                     /db_xref="GeneID:2260"
                     /db_xref="HGNC:HGNC:3688"
                     /db_xref="MIM:136350"
                     /translation="MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFL
                     VHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACV
                     TSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK
                     MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMD
                     SVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFM
                     CKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE
                     DAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVG
                     SVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLS
                     SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV
                     TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
                     GNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDL
                     AARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSD
                     VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV
                     PSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSH
                     EPLPEEPCLPRHPAQLANGGLKRR"
     exon            835..1101
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1191
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1364
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1488
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1679
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1824
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2027
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2173
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2295
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2406
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2597
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2720
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2791
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2929
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3035
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..5697
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /note="hexamer: AATAAA"
     polyA_site      4110
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /note="major polyA site"
     regulatory      5182..5187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /note="hexamer: ATTAAA"
     polyA_site      5222
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /note="major polyA site"
     regulatory      5420..5425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /note="hexamer: AATGAA"
     polyA_site      5461
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
     regulatory      5677..5682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
                     /note="hexamer: AATAAA"
     polyA_site      5697
                     /gene="FGFR1"
                     /gene_synonym="bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR;
                     FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM;
                     OGD"
ORIGIN      
        1 gcatagcgct cggagcgctc ttgcggccac aggcgcggcg tcctcggcgg cgggcggcag
       61 ctagcgggag ccgggacgcc ggtgcagccg cagcgcgcgg aggaacccgg gtgtgccggg
      121 agctgggcgg ccacgtccgg acgggaccga gacccctcgt agcgcattgc ggcgacctcg
      181 ccttccccgg ccgcgagcgc gccgctgctt gaaaagccgc ggaacccaag gacttttctc
      241 cggtccgagc tcggggcgcc ccgcagggcg cacggtaccc gtgctgcagt cgggcacgcc
      301 gcggcgccgg ggcctccgca gggcgatgga gcccggtctg caaggaaagt gaggcgccgc
      361 cgctgcgttc tggaggaggg gggcacaagg tctggagacc ccgggtggcg gacgggagcc
      421 ctccccccgc cccgcctccg gggcaccagc tccggctcca ttgttcccgc ccgggctgga
      481 ggcgccgagc accgagcgcc gccgggagtc gagcgccggc cgcggagctc ttgcgacccc
      541 gccaggaccc gaacagagcc cgggggcggc gggccggagc cggggacgcg ggcacacgcc
      601 cgctcgcaca agccacggcg gactctcccg aggcggaacc tccacgccga gcgagggtca
      661 gtttgaaaag gaggatcgag ctcactgtgg agtatccatg gagatgtgga gccttgtcac
      721 caacctctaa ctgcagaact gggatgtgga gctggaagtg cctcctcttc tgggctgtgc
      781 tggtcacagc cacactctgc accgctaggc cgtccccgac cttgcctgaa caagcccagc
      841 cctggggagc ccctgtggaa gtggagtcct tcctggtcca ccccggtgac ctgctgcagc
      901 ttcgctgtcg gctgcgggac gatgtgcaga gcatcaactg gctgcgggac ggggtgcagc
      961 tggcggaaag caaccgcacc cgcatcacag gggaggaggt ggaggtgcag gactccgtgc
     1021 ccgcagactc cggcctctat gcttgcgtaa ccagcagccc ctcgggcagt gacaccacct
     1081 acttctccgt caatgtttca gatgctctcc cctcctcgga ggatgatgat gatgatgatg
     1141 actcctcttc agaggagaaa gaaacagata acaccaaacc aaaccgtatg cccgtagctc
     1201 catattggac atccccagaa aagatggaaa agaaattgca tgcagtgccg gctgccaaga
     1261 cagtgaagtt caaatgccct tccagtggga ccccaaaccc cacactgcgc tggttgaaaa
     1321 atggcaaaga attcaaacct gaccacagaa ttggaggcta caaggtccgt tatgccacct
     1381 ggagcatcat aatggactct gtggtgccct ctgacaaggg caactacacc tgcattgtgg
     1441 agaatgagta cggcagcatc aaccacacat accagctgga tgtcgtggag cggtcccctc
     1501 accggcccat cctgcaagca gggttgcccg ccaacaaaac agtggccctg ggtagcaacg
     1561 tggagttcat gtgtaaggtg tacagtgacc cgcagccgca catccagtgg ctaaagcaca
     1621 tcgaggtgaa tgggagcaag attggcccag acaacctgcc ttatgtccag atcttgaaga
     1681 ctgctggagt taataccacc gacaaagaga tggaggtgct tcacttaaga aatgtctcct
     1741 ttgaggacgc aggggagtat acgtgcttgg cgggtaactc tatcggactc tcccatcact
     1801 ctgcatggtt gaccgttctg gaagccctgg aagagaggcc ggcagtgatg acctcgcccc
     1861 tgtacctgga gatcatcatc tattgcacag gggccttcct catctcctgc atggtggggt
     1921 cggtcatcgt ctacaagatg aagagtggta ccaagaagag tgacttccac agccagatgg
     1981 ctgtgcacaa gctggccaag agcatccctc tgcgcagaca ggtaacagtg tctgctgact
     2041 ccagtgcatc catgaactct ggggttcttc tggttcggcc atcacggctc tcctccagtg
     2101 ggactcccat gctagcaggg gtctctgagt atgagcttcc cgaagaccct cgctgggagc
     2161 tgcctcggga cagactggtc ttaggcaaac ccctgggaga gggctgcttt gggcaggtgg
     2221 tgttggcaga ggctatcggg ctggacaagg acaaacccaa ccgtgtgacc aaagtggctg
     2281 tgaagatgtt gaagtcggac gcaacagaga aagacttgtc agacctgatc tcagaaatgg
     2341 agatgatgaa gatgatcggg aagcataaga atatcatcaa cctgctgggg gcctgcacgc
     2401 aggatggtcc cttgtatgtc atcgtggagt atgcctccaa gggcaacctg cgggagtacc
     2461 tgcaggcccg gaggccccca gggctggaat actgctacaa ccccagccac aacccagagg
     2521 agcagctctc ctccaaggac ctggtgtcct gcgcctacca ggtggcccga ggcatggagt
     2581 atctggcctc caagaagtgc atacaccgag acctggcagc caggaatgtc ctggtgacag
     2641 aggacaatgt gatgaagata gcagactttg gcctcgcacg ggacattcac cacatcgact
     2701 actataaaaa gacaaccaac ggccgactgc ctgtgaagtg gatggcaccc gaggcattat
     2761 ttgaccggat ctacacccac cagagtgatg tgtggtcttt cggggtgctc ctgtgggaga
     2821 tcttcactct gggcggctcc ccataccccg gtgtgcctgt ggaggaactt ttcaagctgc
     2881 tgaaggaggg tcaccgcatg gacaagccca gtaactgcac caacgagctg tacatgatga
     2941 tgcgggactg ctggcatgca gtgccctcac agagacccac cttcaagcag ctggtggaag
     3001 acctggaccg catcgtggcc ttgacctcca accaggagta cctggacctg tccatgcccc
     3061 tggaccagta ctcccccagc tttcccgaca cccggagctc tacgtgctcc tcaggggagg
     3121 attccgtctt ctctcatgag ccgctgcccg aggagccctg cctgccccga cacccagccc
     3181 agcttgccaa tggcggactc aaacgccgct gactgccacc cacacgccct ccccagactc
     3241 caccgtcagc tgtaaccctc acccacagcc cctgctgggc ccaccacctg tccgtccctg
     3301 tcccctttcc tgctggcagg agccggctgc ctaccagggg ccttcctgtg tggcctgcct
     3361 tcaccccact cagctcacct ctccctccac ctcctctcca cctgctggtg agaggtgcaa
     3421 agaggcagat ctttgctgcc agccacttca tcccctccca gatgttggac caacacccct
     3481 ccctgccacc aggcactgcc tggagggcag ggagtgggag ccaatgaaca ggcatgcaag
     3541 tgagagcttc ctgagctttc tcctgtcggt ttggtctgtt ttgccttcac ccataagccc
     3601 ctcgcactct ggtggcaggt gccttgtcct cagggctaca gcagtaggga ggtcagtgct
     3661 tcgtgcctcg attgaaggtg acctctgccc cagataggtg gtgccagtgg cttattaatt
     3721 ccgatactag tttgctttgc tgaccaaatg cctggtacca gaggatggtg aggcgaaggc
     3781 caggttgggg gcagtgttgt ggccctgggg cccagcccca aactgggggc tctgtatata
     3841 gctatgaaga aaacacaaag tgtataaatc tgagtatata tttacatgtc tttttaaaag
     3901 ggtcgttacc agagatttac ccatcgggta agatgctcct ggtggctggg aggcatcagt
     3961 tgctatatat taaaaacaaa aaagaaaaaa aaggaaaatg tttttaaaaa ggtcatatat
     4021 tttttgctac ttttgctgtt ttattttttt aaattatgtt ctaaacctat tttcagttta
     4081 ggtccctcaa taaaaattgc tgctgcttca tttatctatg ggctgtatga aaagggtggg
     4141 aatgtccact ggaaagaagg gacacccacg ggccctgggg ctaggtctgt cccgagggca
     4201 ccgcatgctc ccggcgcagg ttccttgtaa cctcttcttc ctaggtcctg cacccagacc
     4261 tcacgacgca cctcctgcct ctccgctgct tttggaaagt cagaaaaaga agatgtctgc
     4321 ttcgagggca ggaaccccat ccatgcagta gaggcgctgg gcagagagtc aaggcccagc
     4381 agccatcgac catggatggt ttcctccaag gaaaccggtg gggttgggct ggggaggggg
     4441 cacctaccta ggaatagcca cggggtagag ctacagtgat taagaggaaa gcaagggcgc
     4501 ggttgctcac gcctgtaatc ccagcacttt gggacaccga ggtgggcaga tcacttcagg
     4561 tcaggagttt gagaccagcc tggccaactt agtgaaaccc catctctact aaaaatgcaa
     4621 aaattatcca ggcatggtgg cacacgcctg taatcccagc tccacaggag gctgaggcag
     4681 aatcccttga agctgggagg cggaggttgc agtgagccga gattgcgcca ttgcactcca
     4741 gcctgggcaa cagagaaaac aaaaaggaaa acaaatgatg aaggtctgca gaaactgaaa
     4801 cccagacatg tgtctgcccc ctctatgtgg gcatggtttt gccagtgctt ctaagtgcag
     4861 gagaacatgt cacctgaggc tagttttgca ttcaggtccc tggcttcgtt tcttgttggt
     4921 atgcctcccc agatcgtcct tcctgtatcc atgtgaccag actgtatttg ttgggactgt
     4981 cgcagatctt ggcttcttac agttcttcct gtccaaactc catcctgtcc ctcaggaacg
     5041 gggggaaaat tctccgaatg tttttggttt tttggctgct tggaatttac ttctgccacc
     5101 tgctggtcat cactgtcctc actaagtgga ttctggctcc cccgtacctc atggctcaaa
     5161 ctaccactcc tcagtcgcta tattaaagct tatattttgc tggattactg ctaaatacaa
     5221 aagaaagttc aatatgtttt catttctgta gggaaaatgg gattgctgct ttaaatttct
     5281 gagctaggga ttttttggca gctgcagtgt tggcgactat tgtaaaattc tctttgtttc
     5341 tctctgtaaa tagcacctgc taacattaca atttgtattt atgtttaaag aaggcatcat
     5401 ttggtgaaca gaactaggaa atgaattttt agctcttaaa agcatttgct ttgagaccgc
     5461 acaggagtgt ctttccttgt aaaacagtga tgataatttc tgccttggcc ctaccttgaa
     5521 gcaatgttgt gtgaagggat gaagaatcta aaagtcttca taagtccttg ggagaggtgc
     5581 tagaaaaata taaggcacta tcataattac agtgatgtcc ttgctgttac tactcaaatc
     5641 acccacaaat ttccccaaag actgcgctag ctgtcaaata aaagacagtg aaattga
//
