LOCUS       NM_152429               2553 bp    mRNA    linear   PRI 10-JUL-2024
DEFINITION  Homo sapiens fibroblast growth factor binding protein 3 (FGFBP3),
            mRNA.
ACCESSION   NM_152429
VERSION     NM_152429.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Zhang,W., Chen,Y., Swift,M.R., Tassi,E., Stylianou,D.C.,
            Gibby,K.A., Riegel,A.T. and Wellstein,A.
  TITLE     Effect of FGF-binding protein 3 on vascular permeability
  JOURNAL   J Biol Chem 283 (42), 28329-28337 (2008)
   PUBMED   18669637
  REMARK    GeneRIF: the FGF binding domain and the heparin binding domain are
            necessary for the hBP3 interaction with endogenous FGF and the
            activation of FGFR signaling in vivo
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR759872.1 and AL359198.38.
            
            On May 17, 2019 this sequence version replaced NM_152429.4.
            
            Sequence Note: This RefSeq record was created from genomic and
            transcript sequence data because transcript sequence consistent
            with the reference genome assembly was not available for all
            regions of the RefSeq transcript. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075410.1, BX440581.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311575.6/ ENSP00000339067.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-699               DR759872.1         27-725
            700-2553            AL359198.38        31774-33627         c
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.32"
     gene            1..2553
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /note="fibroblast growth factor binding protein 3"
                     /db_xref="GeneID:143282"
                     /db_xref="HGNC:HGNC:23428"
                     /db_xref="MIM:620879"
     exon            1..89
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /inference="alignment:Splign:2.1.0"
     exon            90..2553
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..944
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /note="FGFBP-3; FGF-binding protein 3"
                     /codon_start=1
                     /product="fibroblast growth factor-binding protein 3
                     precursor"
                     /protein_id="NP_689642.3"
                     /db_xref="CCDS:CCDS7418.1"
                     /db_xref="GeneID:143282"
                     /db_xref="HGNC:HGNC:23428"
                     /db_xref="MIM:620879"
                     /translation="MTPPKLRASLSPSLLLLLSGCLLAAARREKGAASNVAEPVPGPT
                     GGSSGRFLSPEQHACSWQLLLPAPEAAAGSELALRCQSPDGARHQCAYRGHPERCAAY
                     AARRAHFWKQVLGGLRKKRRPCHDPAPLQARLCAGKKGHGAELRLVPRASPPARPTVA
                     GFAGESKPRARNRGRTRERASGPAAGTPPPQSAPPKENPSERKTNEGKRKAALVPNEE
                     RPMGTGPDPDGLDGNAELTETYCAEKWHSLCNFFVNFWNG"
     regulatory      1350..1355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /note="hexamer: ATTAAA"
     polyA_site      1382
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
     regulatory      2207..2212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /note="hexamer: AATAAA"
     polyA_site      2233
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /note="major polyA site"
     polyA_site      2254
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
     regulatory      2350..2355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /note="hexamer: CATAAA"
     polyA_site      2375
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
                     /note="hexamer: TATAAA"
     polyA_site      2553
                     /gene="FGFBP3"
                     /gene_synonym="C10orf13; FGF-BP3"
ORIGIN      
        1 attcacaggg agccggctaa aacagactac tcccccgtgc agtcgttccc tctaccctaa
       61 taaggctttg gcgcctctcc cagaactcgg tcctggggaa tgctctttgc ctggtccagc
      121 cccgacaaac gtggtctgag aacagcggag cgcggaaacc gcggagcatg actcctccga
      181 agctgcgagc gtcgctgtcg ccgtcgctgc tgctgctgct gagtggttgc ctcctcgcgg
      241 ctgctcggag ggagaaaggg gcggctagca acgtggcgga gccggtcccc gggcccactg
      301 gcggctcctc gggtcgcttc ctcagccccg agcagcacgc gtgcagctgg cagctcctgc
      361 tgcccgcccc ggaggccgca gcgggcagcg agctggcgct gcgctgccag agcccggacg
      421 gggcgcgcca ccagtgcgcc taccgcgggc atccggagcg ctgcgcagcc tacgccgctc
      481 gccgcgcgca cttctggaag caggtgctgg gagggctgcg caagaagcgg aggccctgtc
      541 acgaccccgc gccgctccag gcccgcttgt gcgcgggcaa gaagggccac ggcgccgagc
      601 tgcggctagt gccccgcgcg tccccgcccg cacgccccac cgtcgcggga ttcgcggggg
      661 agtccaagcc ccgggcccgg aaccgggggc ggacccggga gcgtgcgtcc ggcccagccg
      721 ctgggacccc gcctccccaa agcgcaccgc ccaaagaaaa cccctcagag aggaagacca
      781 acgagggcaa gaggaaggcg gccttggtcc ccaacgagga gcgacccatg gggaccgggc
      841 ccgaccccga cgggctggac gggaacgcgg agctcacgga gacctactgc gctgagaagt
      901 ggcactccct ctgcaacttc tttgtcaatt tctggaacgg ctgagactgc ctgccggctt
      961 agggagggtt gatgggggag gcgtggggaa gggaaagcta agggcgtctt agaccggggg
     1021 gtactgtgat agagattggg gagaagtcca ggttctcgaa tgggggtggg ggcaagggta
     1081 agggtgagat gcttgggatg agagtgtaag gggtatggag aatctctggg atagcagaga
     1141 agttaaaaat tttgaaaagt ctcagtcctg attaagagca ggaaaaataa tggaaacaga
     1201 aataggcgta ctttaaatgt gcaaaaactg gagactgggg agagaaatcg atgcagaggg
     1261 aggctgagaa taagggggag atagagtgac taaagtgatg tgagtcccat gtggggaggg
     1321 ggatgcaatg tttattgttt aacatttcta ttaaatgcag ccatgagcaa ttgccaacct
     1381 gagccaggtt gaatcaatgt cttctcactt aatcagctaa caagactgca gacttttttt
     1441 ccgtttctga attggtataa acttggatgc ggcgtggtgg gtgtcataga taacctctat
     1501 agggacagaa gcctcacagg tcaaaactgg ctccaaggaa agttttgcag aatgatttcc
     1561 tttccattct tttagaagag ctaccttttt tttttttttt ccctgacagg gtctggcttg
     1621 cccaggctgg agtgcggtgg ctagtcacag gtgtaataat aggcactgca gtctccaact
     1681 cctggcctca agggatcctc acatcttagc ctccagaata gctaggagta ggagtagctg
     1741 ggactacaag catgcacagc tgcacttggc ttagaagtgc tactttattt ttatttttga
     1801 gacagggtct tgtgtcatcc agactggagc agtggtgcaa ttatggctca ctgcggcctc
     1861 gacattccag tctcaagtga tcctctgcct cagcctccgg agtagccagg actacagggg
     1921 tgtgccacta gaagtgctac tttttaacga aatggtgact aatgttctgg aactttccca
     1981 ttaaccttct gcatttagaa ggaattatag atgttgagtg ctccagtaaa cagtgattct
     2041 ctttatatct gatttttttt tttaaacagc taaaatgtaa gtatgtatct cagagtcatt
     2101 ttgaccatta tggaagttgt atctctctgt ttcatgtaac taattattaa tatatttcat
     2161 ttttagtgtg atgtaatgag agactgtgtg tgtatgttag gtgctcaata aaaactgtat
     2221 ggttagattt aaagaagtgg caaggcaatg gaaattctac ctgcatttga tctacttcca
     2281 agtacacctt gaattaagtt cttaaacaca tcttgaattg ctgggaaaag acagaaacta
     2341 agaagttgac ataaagcaag agtcacaaac tggcagccac ctggccttat cattgttcta
     2401 tttgatttgc accctggttc tctttctttt tcccttcctc cccaccttcc tcccatccat
     2461 tgttgaatct gtggatgcag agcccacgga tgtggagggg caactatata tatgtttttc
     2521 cattatatat ataaatgtgt gtgtgtgtat ata
//
