LOCUS       NM_031950               1105 bp    mRNA    linear   PRI 06-JAN-2025
DEFINITION  Homo sapiens fibroblast growth factor binding protein 2 (FGFBP2),
            mRNA.
ACCESSION   NM_031950
VERSION     NM_031950.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1105)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1105)
  AUTHORS   Liu,Z., Ma,C., Gu,J. and Yu,M.
  TITLE     Potential biomarkers of acute myocardial infarction based on
            weighted gene co-expression network analysis
  JOURNAL   Biomed Eng Online 18 (1), 9 (2019)
   PUBMED   30683112
  REMARK    GeneRIF: three overlapping genes (FGFBP2, GFOD1 and MLC1) between
            two modules could potentially have a role in acute myocardial
            infarction and have diagnostic potential
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1105)
  AUTHORS   Salemi,M., Barone,C., Morale,M.C., Caniglia,S., Romano,C.,
            Salluzzo,M.G., Rando,R.G., Ragalmuto,A., Bosco,P. and Romano,C.
  TITLE     Killer-specific secretory (Ksp37) gene expression in subjects with
            Down's syndrome
  JOURNAL   Neurol Sci 37 (5), 793-795 (2016)
   PUBMED   27032399
  REMARK    GeneRIF: results of this study suggest that the expression of Ksp37
            gene might be associated with increased susceptibility of
            individuals with Down syndrome to EBV infections and autoimmune
            problems.
REFERENCE   4  (bases 1 to 1105)
  AUTHORS   Jeff,J.M., Ritchie,M.D., Denny,J.C., Kho,A.N., Ramirez,A.H.,
            Crosslin,D., Armstrong,L., Basford,M.A., Wolf,W.A., Pacheco,J.A.,
            Chisholm,R.L., Roden,D.M., Hayes,M.G. and Crawford,D.C.
  TITLE     Generalization of variants identified by genome-wide association
            studies for electrocardiographic traits in African Americans
  JOURNAL   Ann Hum Genet 77 (4), 321-332 (2013)
   PUBMED   23534349
REFERENCE   5  (bases 1 to 1105)
  AUTHORS   Elgaaen,B.V., Haug,K.B., Wang,J., Olstad,O.K., Fortunati,D.,
            Onsrud,M., Staff,A.C., Sauer,T. and Gautvik,K.M.
  TITLE     POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage
            and outcome in ovarian carcinomas
  JOURNAL   PLoS One 5 (11), e13837 (2010)
   PUBMED   21079801
  REMARK    GeneRIF: Results suggest that POLD2 and KSP37 might be potential
            prognostic biomarkers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1105)
  AUTHORS   Yamanaka,R., Arao,T., Yajima,N., Tsuchiya,N., Homma,J., Tanaka,R.,
            Sano,M., Oide,A., Sekijima,M. and Nishio,K.
  TITLE     Identification of expressed genes characterizing long-term survival
            in malignant glioma patients
  JOURNAL   Oncogene 25 (44), 5994-6002 (2006)
   PUBMED   16652150
REFERENCE   7  (bases 1 to 1105)
  AUTHORS   Kuepper,M., Bratke,K., Julius,P., Ogawa,K., Nagata,K., Luttmann,W.
            and Virchow,J.C. Jr.
  TITLE     Increase in killer-specific secretory protein of 37 kDa in
            bronchoalveolar lavage fluid of allergen-challenged patients with
            atopic asthma
  JOURNAL   Clin Exp Allergy 35 (5), 643-649 (2005)
   PUBMED   15898988
REFERENCE   8  (bases 1 to 1105)
  AUTHORS   Hayano,C., Koi,H., Ogawa,K., Nagata,K., Matsumoto,Y., Nakamura,M.
            and Aso,T.
  TITLE     Accumulation of CD16+ cells with secretion of Ksp37 in decidua at
            the end of pregnancy
  JOURNAL   Am J Reprod Immunol 48 (1), 57-62 (2002)
   PUBMED   12322897
  REMARK    GeneRIF: Secreted from NK cells in decidua, elevated at late
            gestational period.
REFERENCE   9  (bases 1 to 1105)
  AUTHORS   Ogawa,K., Tanaka,K., Ishii,A., Nakamura,Y., Kondo,S., Sugamura,K.,
            Takano,S., Nakamura,M. and Nagata,K.
  TITLE     A novel serum protein that is selectively produced by cytotoxic
            lymphocytes
  JOURNAL   J Immunol 166 (10), 6404-6412 (2001)
   PUBMED   11342666
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358978.1, AC005598.6 and
            CN480296.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031950.3.
            
            Summary: This gene encodes a member of the fibroblast growth factor
            binding protein family. The encoded protein is a serum protein that
            is selectively secreted by cytotoxic lymphocytes and may be
            involved in cytotoxic lymphocyte-mediated immunity. An increase in
            the amount of gene product may be associated with atopic asthma and
            mild extrinsic asthma.[provided by RefSeq, Jan 2025].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358978.1, BC025720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259989.7/ ENSP00000259989.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AY358978.1         62-96
            36-497              AC005598.6         66141-66602
            498-1105            CN480296.1         23-630              c
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..1105
                     /gene="FGFBP2"
                     /gene_synonym="HBP17RP; KSP37"
                     /note="fibroblast growth factor binding protein 2"
                     /db_xref="GeneID:83888"
                     /db_xref="HGNC:HGNC:29451"
                     /db_xref="MIM:607713"
     exon            1..738
                     /gene="FGFBP2"
                     /gene_synonym="HBP17RP; KSP37"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..718
                     /gene="FGFBP2"
                     /gene_synonym="HBP17RP; KSP37"
                     /note="killer-specific secretory protein of 37 kDa;
                     FGF-binding protein 2; HBp17-related protein; FGF-BP2;
                     FGFBP-2; HBp17-RP; 37 kDa killer-specific secretory
                     protein"
                     /codon_start=1
                     /product="fibroblast growth factor-binding protein 2
                     precursor"
                     /protein_id="NP_114156.1"
                     /db_xref="CCDS:CCDS3419.1"
                     /db_xref="GeneID:83888"
                     /db_xref="HGNC:HGNC:29451"
                     /db_xref="MIM:607713"
                     /translation="MKFVPCLLLVTLSCLGTLGQAPRQKQGSTGEEFHFQTGGRDSCT
                     MRPSSLGQGAGEVWLRVDCRNTDQTYWCEYRGQPSMCQAFAADPKPYWNQALQELRRL
                     HHACQGAPVLRPSVCREAGPQAHMQQVTSSLKGSPEPNQQPEAGTPSLRPKATVKLTE
                     ATQLGKDSMEELGKAKPTTRPTAKPTQPGPRPGGNEEAKKKAWEHCWKPFQALCAFLI
                     SFFRG"
     exon            739..1105
                     /gene="FGFBP2"
                     /gene_synonym="HBP17RP; KSP37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1084..1089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFBP2"
                     /gene_synonym="HBP17RP; KSP37"
                     /note="hexamer: AATAAA"
     polyA_site      1105
                     /gene="FGFBP2"
                     /gene_synonym="HBP17RP; KSP37"
                     /note="major polyA site"
ORIGIN      
        1 ctctctcctg gtgcagagtt gcaagcaagt ttatcggagt atcgccatga agttcgtccc
       61 ctgcctcctg ctggtgacct tgtcctgcct ggggactttg ggtcaggccc cgaggcaaaa
      121 gcaaggaagc actggggagg aattccattt ccagactgga gggagagatt cctgcactat
      181 gcgtcccagc agcttggggc aaggtgctgg agaagtctgg cttcgtgtcg actgccgcaa
      241 cacagaccag acctactggt gtgagtacag ggggcagccc agcatgtgcc aggctttcgc
      301 tgctgacccc aaaccttact ggaatcaagc cctgcaggag ctgaggcgcc ttcaccatgc
      361 gtgccagggg gccccggtgc ttaggccatc cgtgtgcagg gaggctggac cccaggccca
      421 tatgcagcag gtgacttcca gcctcaaggg cagcccagag cccaaccagc agcctgaggc
      481 tgggacgcca tctctgaggc ccaaggccac agtgaaactc acagaagcaa cacagctggg
      541 aaaggactcg atggaagagc tgggaaaagc caaacccacc acccgaccca cagccaaacc
      601 tacccagcct ggacccaggc ccggagggaa tgaggaagca aagaagaagg cctgggaaca
      661 ttgttggaaa cccttccagg ccctgtgcgc ctttctcatc agcttcttcc gagggtgaca
      721 ggtgaaagac ccctacagat ctgacctctc cctgacagac aaccatctct ttttatatta
      781 tgccgctttc aatccaacgt tctcacactg gaagaagaga gtttctaatc agatgcaacg
      841 gcccaaattc ttgatctgca gcttctctga agtttggaaa agaaaccttc ctttctggag
      901 tttgcagagt tcagcaatat gatagggaac aggtgctgat gggcccaaga gtgacaagca
      961 tacacaacta cttattatct gtagaagttt tgctttgttg atctgagcct tctatgaaag
     1021 tttaaatatg taacgcattc atgaatttcc agtgttcagt aaatagcagc tatgtgtgtg
     1081 caaaataaaa gaatgatttc agaaa
//
