LOCUS       NM_005130               1351 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1),
            mRNA.
ACCESSION   NM_005130
VERSION     NM_005130.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1351)
  AUTHORS   Lu,D.D., Huang,N., Li,S.A., Fang,J.R., Lai,C.H., Wang,J.K.,
            Chan,K.S., Johnson,M.D. and Lin,C.Y.
  TITLE     HAI-1 is required for the novel role of FGFBP1 in maintenance of
            cell morphology and F-actin rearrangement in human keratinocytes
  JOURNAL   Hum Cell 36 (4), 1403-1415 (2023)
   PUBMED   37076641
  REMARK    GeneRIF: HAI-1 is required for the novel role of FGFBP1 in
            maintenance of cell morphology and F-actin rearrangement in human
            keratinocytes.
REFERENCE   2  (bases 1 to 1351)
  AUTHORS   Chen,X., Miao,M., Zhou,M., Chen,J., Li,D., Zhang,L., Sun,A.,
            Guan,M., Wang,Z., Liu,P., Zhang,S., Zha,X. and Fan,X.
  TITLE     Poly-L-arginine promotes asthma angiogenesis through induction of
            FGFBP1 in airway epithelial cells via activation of the
            mTORC1-STAT3 pathway
  JOURNAL   Cell Death Dis 12 (8), 761 (2021)
   PUBMED   34341336
  REMARK    GeneRIF: Poly-L-arginine promotes asthma angiogenesis through
            induction of FGFBP1 in airway epithelial cells via activation of
            the mTORC1-STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1351)
  AUTHORS   Zhang,Z., Qin,Y., Ji,S., Xu,W., Liu,M., Hu,Q., Ye,Z., Fan,G.,
            Yu,X., Liu,W. and Xu,X.
  TITLE     FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer
            cells via FGF22/FGFR2 promotes invasion and metastasis of
            pancreatic cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (8), 997-1008 (2021)
   PUBMED   34117747
  REMARK    GeneRIF: FGFBP1-mediated crosstalk between fibroblasts and
            pancreatic cancer cells via FGF22/FGFR2 promotes invasion and
            metastasis of pancreatic cancer.
REFERENCE   4  (bases 1 to 1351)
  AUTHORS   Zhang,W., Zhou,Y., Li,C., Xu,S., Li,M., Liu,W., Ma,Y. and Wang,H.
  TITLE     The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in
            Esophageal Squamous Cell Carcinoma
  JOURNAL   Anal Cell Pathol (Amst) 2020, 2872479 (2020)
   PUBMED   33381388
  REMARK    GeneRIF: The Expression and Prognostic Value of FGF2, FGFR3, and
            FGFBP1 in Esophageal Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1351)
  AUTHORS   Tassi,E. and Wellstein,A.
  TITLE     The angiogenic switch molecule, secreted FGF-binding protein, an
            indicator of early stages of pancreatic and colorectal
            adenocarcinoma
  JOURNAL   Semin Oncol 33 (6 Suppl 11), S50-S56 (2006)
   PUBMED   17178288
  REMARK    Review article
REFERENCE   6  (bases 1 to 1351)
  AUTHORS   Mongiat,M., Otto,J., Oldershaw,R., Ferrer,F., Sato,J.D. and
            Iozzo,R.V.
  TITLE     Fibroblast growth factor-binding protein is a novel partner for
            perlecan protein core
  JOURNAL   J Biol Chem 276 (13), 10263-10271 (2001)
   PUBMED   11148217
REFERENCE   7  (bases 1 to 1351)
  AUTHORS   Harris,V.K., Coticchia,C.M., Kagan,B.L., Ahmad,S., Wellstein,A. and
            Riegel,A.T.
  TITLE     Induction of the angiogenic modulator fibroblast growth
            factor-binding protein by epidermal growth factor is mediated
            through both MEK/ERK and p38 signal transduction pathways
  JOURNAL   J Biol Chem 275 (15), 10802-10811 (2000)
   PUBMED   10753873
REFERENCE   8  (bases 1 to 1351)
  AUTHORS   Wang,X.C., Chen,J.H., Crab,J.W. and Sato,J.D.
  TITLE     Purification of heparin-binding protein HBp17 and identification of
            HBp17 heparin binding site
  JOURNAL   Biochem Mol Biol Int 46 (1), 81-87 (1998)
   PUBMED   9784842
REFERENCE   9  (bases 1 to 1351)
  AUTHORS   Czubayko,F., Liaudet-Coopman,E.D., Aigner,A., Tuveson,A.T.,
            Berchem,G.J. and Wellstein,A.
  TITLE     A secreted FGF-binding protein can serve as the angiogenic switch
            in human cancer
  JOURNAL   Nat Med 3 (10), 1137-1140 (1997)
   PUBMED   9334727
REFERENCE   10 (bases 1 to 1351)
  AUTHORS   Wu,D.Q., Kan,M.K., Sato,G.H., Okamoto,T. and Sato,J.D.
  TITLE     Characterization and molecular cloning of a putative binding
            protein for heparin-binding growth factors
  JOURNAL   J Biol Chem 266 (25), 16778-16785 (1991)
   PUBMED   1885605
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW959908.1, AK291307.1,
            AC005798.10 and BC008910.2.
            
            On May 17, 2019 this sequence version replaced NM_005130.4.
            
            Summary: This gene encodes a secreted fibroblast growth factor
            carrier protein. The encoded protein plays a critical role in cell
            proliferation, differentiation and migration by binding to
            fibroblast growth factors and potentiating their biological effects
            on target cells. The encoded protein may also play a role in tumor
            growth as an angiogenic switch molecule, and expression of this
            gene has been associated with several types of cancer including
            pancreatic and colorectal adenocarcinoma. A pseudogene of this gene
            is also located on the short arm of chromosome 4. [provided by
            RefSeq, Nov 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW959908.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382333.2/ ENSP00000371770.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               AW959908.1         1-516
            517-819             AK291307.1         339-641
            820-820             AC005798.10        5252-5252
            821-1350            AK291307.1         643-1172
            1351-1351           BC008910.2         1164-1164
FEATURES             Location/Qualifiers
     source          1..1351
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..1351
                     /gene="FGFBP1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17"
                     /note="fibroblast growth factor binding protein 1"
                     /db_xref="GeneID:9982"
                     /db_xref="HGNC:HGNC:19695"
                     /db_xref="MIM:607737"
     exon            1..54
                     /gene="FGFBP1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            55..275
                     /gene="FGFBP1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            276..1351
                     /gene="FGFBP1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1000
                     /gene="FGFBP1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17"
                     /note="heparin-binding growth factor binding protein;
                     FGF-binding protein 1; 17 kDa HBGF-binding protein; 17 kDa
                     heparin-binding growth factor-binding protein"
                     /codon_start=1
                     /product="fibroblast growth factor-binding protein 1
                     precursor"
                     /protein_id="NP_005121.1"
                     /db_xref="CCDS:CCDS3418.1"
                     /db_xref="GeneID:9982"
                     /db_xref="HGNC:HGNC:19695"
                     /db_xref="MIM:607737"
                     /translation="MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLG
                     NTQIKQKSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTS
                     CLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTK
                     PRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETW
                     SSLCTFFLSIVQDTSC"
     regulatory      1323..1328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGFBP1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17"
                     /note="hexamer: AATAAA"
     polyA_site      1351
                     /gene="FGFBP1"
                     /gene_synonym="FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17"
                     /note="major polyA site"
ORIGIN      
        1 gaatcattgc actccctact agagcggatg tgatgaggga aaaggagaac tcagcacttt
       61 ccctgcagga accggctccc tcggaggggc gtggctggga ggagctgtga gtaacgtgcc
      121 acagtgttgt aaaaacccag tgagtgttat aaaaacccag tcagcctggc tcctgttgaa
      181 tagtctaccc cccttgcact ctacctgaca cagctgcagc ctgcaattca ctcgcactgc
      241 ctgggattgc actggatccg tgtgctcaga acaaggtgaa cgcccagctg cagccatgaa
      301 gatctgtagc ctcaccctgc tctccttcct cctactggct gctcaggtgc tcctggtgga
      361 ggggaaaaaa aaagtgaaga atggacttca cagcaaagtg gtctcagaac aaaaggacac
      421 tctgggcaac acccagatta agcagaaaag caggcccggg aacaaaggca agtttgtcac
      481 caaagaccaa gccaactgca gatgggctgc tactgagcag gaggagggca tctctctcaa
      541 ggttgagtgc actcaattgg accatgaatt ttcctgtgtc tttgctggca atccaacctc
      601 atgcctaaag ctcaaggatg agagagtcta ttggaaacaa gttgcccgga atctgcgctc
      661 acagaaagac atctgtagat attccaagac agctgtgaaa accagagtgt gcagaaagga
      721 ttttccagaa tccagtctta agctagtcag ctccactcta tttgggaaca caaagcccag
      781 gaaggagaaa acagagatgt cccccaggga gcacatcaaa ggcaaagaga ccaccccctc
      841 tagcctagca gtgacccaga ccatggccac caaagctccc gagtgtgtgg aggacccaga
      901 tatggcaaac cagaggaaga ctgccctgga gttctgtgga gagacttgga gctctctctg
      961 cacattcttc ctcagcatag tgcaggacac gtcatgctaa tgaggtcaaa agagaacggg
     1021 ttcccttaag agatgtcatg tcgtaagtcc ctctgtatac tttaaagctc tctacagtcc
     1081 ccccaaaata tgaacttttg tgcttagtga gtgcaacgaa atatttaaac aagttttgta
     1141 ttttttgctt ttgtgttttg gaatttgcct tatttttctt ggatgcgatg ttcagaggct
     1201 gtttcctgca gcatgtattt ccatggccca cacagctatg tgtttgagca gcgaagagtc
     1261 tttgagctga atgagccaga gtgataattt cagtgcaacg aactttctgc tgaattaatg
     1321 gtaataaaac tctgggtgtt tttcagaaat a
//
