LOCUS       NM_002010               4530 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens fibroblast growth factor 9 (FGF9), mRNA.
ACCESSION   NM_002010
VERSION     NM_002010.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4530)
  AUTHORS   Gu,J. and Zhou,D.
  TITLE     Long non-coding RNA MEG3 knockdown represses airway smooth muscle
            cells proliferation and migration via sponging miR-143-3p/FGF9 in
            asthma
  JOURNAL   J Cardiothorac Surg 19 (1), 314 (2024)
   PUBMED   38824534
  REMARK    GeneRIF: Long non-coding RNA MEG3 knockdown represses airway smooth
            muscle cells proliferation and migration via sponging
            miR-143-3p/FGF9 in asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4530)
  AUTHORS   Zhang,B., Liu,Y., Yu,J. and Lin,X.
  TITLE     Upregulation of FGF9 and NOVA1 in cancer-associated fibroblasts
            promotes cell proliferation, invasion and migration of triple
            negative breast cancer
  JOURNAL   Drug Dev Res 85 (3), e22185 (2024)
   PUBMED   38657094
  REMARK    GeneRIF: Upregulation of FGF9 and NOVA1 in cancer-associated
            fibroblasts promotes cell proliferation, invasion and migration of
            triple negative breast cancer.
REFERENCE   3  (bases 1 to 4530)
  AUTHORS   Sun,Y., Ying,X., Li,R., Weng,M., Shi,J. and Chen,Z.
  TITLE     FGF9 Promotes Expression of HAS2 in Palatal Elevation via the
            Wnt/beta-Catenin/TCF7L2 Pathway
  JOURNAL   Biomolecules 12 (11), 1639 (2022)
   PUBMED   36358989
  REMARK    GeneRIF: FGF9 Promotes Expression of HAS2 in Palatal Elevation via
            the Wnt/beta-Catenin/TCF7L2 Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4530)
  AUTHORS   Hiller,B.E., Yin,Y., Perng,Y.C., de Araujo Castro,I., Fox,L.E.,
            Locke,M.C., Monte,K.J., Lopez,C.B., Ornitz,D.M. and Lenschow,D.J.
  TITLE     Fibroblast growth factor-9 expression in airway epithelial cells
            amplifies the type I interferon response and alters influenza A
            virus pathogenesis
  JOURNAL   PLoS Pathog 18 (6), e1010228 (2022)
   PUBMED   35675358
  REMARK    GeneRIF: Fibroblast growth factor-9 expression in airway epithelial
            cells amplifies the type I interferon response and alters influenza
            A virus pathogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4530)
  AUTHORS   Xu,Z., Cai,Y., Liu,W., Kang,F., He,Q., Hong,Q., Zhang,W., Li,J.,
            Yan,Y. and Peng,J.
  TITLE     Downregulated exosome-associated gene FGF9 as a novel diagnostic
            and prognostic target for ovarian cancer and its underlying roles
            in immune regulation
  JOURNAL   Aging (Albany NY) 14 (4), 1822-1835 (2022)
   PUBMED   35190498
  REMARK    GeneRIF: Downregulated exosome-associated gene FGF9 as a novel
            diagnostic and prognostic target for ovarian cancer and its
            underlying roles in immune regulation.
REFERENCE   6  (bases 1 to 4530)
  AUTHORS   Santos-Ocampo,S., Colvin,J.S., Chellaiah,A. and Ornitz,D.M.
  TITLE     Expression and biological activity of mouse fibroblast growth
            factor-9
  JOURNAL   J Biol Chem 271 (3), 1726-1731 (1996)
   PUBMED   8576175
REFERENCE   7  (bases 1 to 4530)
  AUTHORS   Mattei,M.G., Penault-Llorca,F., Coulier,F. and Birnbaum,D.
  TITLE     The human FGF9 gene maps to chromosomal region 13q11-q12
  JOURNAL   Genomics 29 (3), 811-812 (1995)
   PUBMED   8575785
REFERENCE   8  (bases 1 to 4530)
  AUTHORS   Miyamoto,M., Naruo,K., Seko,C., Matsumoto,S., Kondo,T. and
            Kurokawa,T.
  TITLE     Molecular cloning of a novel cytokine cDNA encoding the ninth
            member of the fibroblast growth factor family, which has a unique
            secretion property
  JOURNAL   Mol Cell Biol 13 (7), 4251-4259 (1993)
   PUBMED   8321227
REFERENCE   9  (bases 1 to 4530)
  AUTHORS   Naruo,K., Seko,C., Kuroshima,K., Matsutani,E., Sasada,R., Kondo,T.
            and Kurokawa,T.
  TITLE     Novel secretory heparin-binding factors from human glioma cells
            (glia-activating factors) involved in glial cell growth.
            Purification and biological properties
  JOURNAL   J Biol Chem 268 (4), 2857-2864 (1993)
   PUBMED   8428960
REFERENCE   10 (bases 1 to 4530)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139378.15, AK290792.1,
            D14838.1 and CR746503.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002010.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein was isolated as a secreted factor that
            exhibits a growth-stimulating effect on cultured glial cells. In
            nervous system, this protein is produced mainly by neurons and may
            be important for glial cell development. Expression of the mouse
            homolog of this gene was found to be dependent on Sonic hedgehog
            (Shh) signaling. Mice lacking the homolog gene displayed a
            male-to-female sex reversal phenotype, which suggested a role in
            testicular embryogenesis. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.15734.1,
                                           SRR1803612.142973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382353.6/ ENSP00000371790.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL139378.15        53613-53615
            4-813               AK290792.1         1-810
            814-1286            D14838.1           152-624
            1287-4286           AL139378.15        83795-86794
            4287-4530           CR746503.1         1-244
FEATURES             Location/Qualifiers
     source          1..4530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..4530
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /note="fibroblast growth factor 9"
                     /db_xref="GeneID:2254"
                     /db_xref="HGNC:HGNC:3687"
                     /db_xref="MIM:600921"
     exon            1..1117
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             841..1467
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /note="heparin-binding growth factor 9; fibroblast growth
                     factor 9 (glia-activating factor)"
                     /codon_start=1
                     /product="fibroblast growth factor 9 precursor"
                     /protein_id="NP_002001.1"
                     /db_xref="CCDS:CCDS9298.1"
                     /db_xref="GeneID:2254"
                     /db_xref="HGNC:HGNC:3687"
                     /db_xref="MIM:600921"
                     /translation="MAPLGEVGNYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGG
                     LPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAV
                     GLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGR
                     RYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKDILSQS"
     exon            1118..1221
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..4530
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3970..3975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /note="hexamer: AATAAA"
     regulatory      3995..4000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /note="hexamer: AATAAA"
     polyA_site      4000
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /note="major polyA site"
     polyA_site      4015
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
     regulatory      4513..4518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /note="hexamer: ATTACA"
     polyA_site      4530
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
ORIGIN      
        1 gccactctgc gcgccggcgg gggctgcgca ggaggagcgc tccgcccggc tacaacgctc
       61 cgcgagccgg cgcggcaaca cctgttcgcg gcagcctggg cggcacgcga gctcccggac
      121 gcggctctcc tcgctcgccg ctcgccaccc gttctaagcc aatggacatc tgccgagcct
      181 ctggagaatc ctggatacta gctttggacg cctaaagttt cttcttcttt ttgttttatt
      241 attattatca ttttttggag gggggaccgg gaggggagat ttgtcgccgc caccaacgtg
      301 agattttttt ttccccttga aggattcatg ctgatgtctg cagagtcggt tagagagtaa
      361 aaacagcgca tgccttcctg gagtcaggat ccgtaaattc tgacgtagcc cgtgcatctt
      421 aaaaatccct ataataacgc ctaggcattt aagttgctat ggtcattctg atctcaaacc
      481 aaatggagaa actacggatt ttttttcctt attacggtcg gatgggatga agaccttcct
      541 gcctgctaag agctggggat ctatctatag agatacatag atatgtttat caatatgtca
      601 gtgtgtgagt ataaagtggt ggtttcttag actatcagtg gtttgacctt gaacctgtgc
      661 cagtgaaaca gcagattact tttatttatg catttaatgg attgaagaaa agaacctttt
      721 ttttctctct ctctctgcaa ctgcagtaag ggaggggagt tggatatacc tcgcctaata
      781 tctcctgggt tgacaccatc attattgttt attcttgtgc tccaaaagcc gagtcctctg
      841 atggctccct taggtgaagt tgggaactat ttcggtgtgc aggatgcggt accgtttggg
      901 aatgtgcccg tgttgccggt ggacagcccg gttttgttaa gtgaccacct gggtcagtcc
      961 gaagcagggg ggctccccag gggacccgca gtcacggact tggatcattt aaaggggatt
     1021 ctcaggcgga ggcagctata ctgcaggact ggatttcact tagaaatctt ccccaatggt
     1081 actatccagg gaaccaggaa agaccacagc cgatttggca ttctggaatt tatcagtata
     1141 gcagtgggcc tggtcagcat tcgaggcgtg gacagtggac tctacctcgg gatgaatgag
     1201 aagggggagc tgtatggatc agaaaaacta acccaagagt gtgtattcag agaacagttc
     1261 gaagaaaact ggtataatac gtactcatca aacctatata agcacgtgga cactggaagg
     1321 cgatactatg ttgcattaaa taaagatggg accccgagag aagggactag gactaaacgg
     1381 caccagaaat tcacacattt tttacctaga ccagtggacc ccgacaaagt acctgaactg
     1441 tataaggata ttctaagcca aagttgacaa agacagtttc ttcacttgag cccttaaaaa
     1501 agtaaccact ataaaggttt cacgcggtgg gttcttattg attcgctgtg tcatcacatc
     1561 agctccactg ttgccaaact ttgtcgcatg cataatgtat gatggaggct tggatgggaa
     1621 tatgctgatt ttgttctgca cttaaaggct tctcctcctg gagggctgcc tagggccact
     1681 tgcttgattt atcatgagag aagaggagag agagagagac tgagcgctag gagtgtgtgt
     1741 atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtatgtgtgt agcgggagat gtgggcggag
     1801 cgagagcaaa aggactgcgg cctgatgcat gctggaaaaa gacacgcttt tcatttctga
     1861 tcagttgtac ttcatcctat atcagcacag ctgccatact tcgacttatc aggattctgg
     1921 ctggtggcct gcgcgagggt gcagtcttac ttaaaagact ttcagttaat tctcactggt
     1981 atcatcgcag tgaacttaaa gcaaagacct cttagtaaaa aataaaaaaa aataaaaaat
     2041 aaaaataaaa aaagttaaat ttatttatag aaattccaaa ggcaacattt tatttatttt
     2101 atatatttat ttattatata gagtttattt ttaatgaaac atgtacaggc cagataggca
     2161 ttttggaagc tttaggctct gtaagcatta aatggcaaag tccgctatga acctgtggta
     2221 aattcatgca agtagatata atggtgcatg gatataagaa attctaatga ccctaatgta
     2281 ctaaaggcga caatctcttt tgtgcccata ttattgtaaa cttatgcaca tcgctcatga
     2341 cactgagtat tcactcttca gactgcttgt ttcatagctt atcccagagg attaaagata
     2401 aactgggtct caaactttga ttctgtgtct gcaatatttc ctctctcata agtgactcca
     2461 ctattgtaac ttcatggttg gaaaatatga gggttgatat atgtcttact tgtttaaatc
     2521 tgtcgcagaa tataccaaag ctaaataata actatgcttt cattttagcc gatctccaga
     2581 atgacagtat taacatcaaa cattgtattg atttagaatt ctcaaaaaag gaaaaaaaag
     2641 tacatagcac agactatttt ttttaaagac gtaagaatca gattaacagg atcatacttg
     2701 taaacttttt ttggttcact tggctatcaa atatgaaatt atagaagtat cataggggtc
     2761 attgtaacat cttttagaga aaatggctat cagtgtgaac tgtcataatt acgtggtaat
     2821 agcaccctta gtaaaacttg caaaatgaaa ctaataaatc gttatcaata atgacaatga
     2881 gggggaaagt attatacttg ttgactgtgt tttgtttttt aaaatggtct ccacaagcgc
     2941 tcaatttttt tagaggggat attactatat agaatatctt ttacaaggct tttataacat
     3001 tttatgctga aaagcataag aatacgtatt tctttagtag caataatttt ggaacttgcc
     3061 cttgggcaag cgagactatt tcttactata tactaaggag aaaagagcca aattcttaaa
     3121 gcaatattta agaaaaaagg aatttataac aaattctcat ctacatatga cactttctag
     3181 ccagttgtgt tgagaagtgc aaagtgacgg tttaaacatg tgttgggatt tattgaacta
     3241 attttaaaat ttactattca aactttattt tgctctgatg cacattctct atgaaaaata
     3301 aaagtgtgtc actggtgagt gacagctgtt atgagctaga agcgcatgac ttattgtgac
     3361 gatgtcttgc ctttctgtgg tccaagttgg agtacatggc aatgccctcc tgctgatgtg
     3421 cattaaggaa aatctaagtc taatatttgg aattaagata tattttaggg ggaggggaca
     3481 gaagcaatgt aaaatagttg atttatgata aagctcagaa tgtcctcttc atttattttc
     3541 ttgttttatt ttcctttcta aacagaaact gcatttaatt ccaaaaagta gtattcttat
     3601 ttattattta accctttgct gctgctaaaa tgtgcacata ttcaggcttt agtttttcca
     3661 aaaggcattt tttttttggc tgaaaaatat taaacatttg accacaggga agaatcaagt
     3721 ttctaggatg tcataggtat actatgtagc actgaaaaaa ttgattttag gtgacagcca
     3781 aaagtagtct taaagtagca tgagacctta gataatcgac ctaaaagaaa gaaaattgtg
     3841 aaaaagacaa aaatcttcat gcattcctat aaaacgctac tttaaggtct acttttggag
     3901 ttaattttgt ttggtacttt tttttttttt aagacgagca aattgttata tgcttttggc
     3961 aattgataca ataaactgta atggtctgta aataaataaa tattgactca tgcgatttat
     4021 gtaaatagtg gaactgggag agtggatggc tcagggtttc ggtgtgggca ttgtctcttg
     4081 ggcagtagag tgagtcatcc ccagctcatg ggtttgcatc cagttcttgt cttaagagac
     4141 ccaaagccca gtgaatggca gccctgagcc actgtggaat gggggttctg gtttcacaaa
     4201 cagatgctta gatagccaaa ccactgtctt gttggtgcca acacttgcac tgtggtcaaa
     4261 gacttaccga gcatgggctg aacaaccttc ccatctgtca tgtgaatgtc cccaagcagt
     4321 ggtgaaggac atgctaggtc agtgttgggg aacctgccct gccaggtcct gttttgtaga
     4381 taaacaaatg gctgccttct ggtgttttta ttctatttca tctcattaac actacaacct
     4441 tgtgttattt acttgataat ctgtaattgt atgtaaatac atacaggatt atgtaatttg
     4501 tgtaaataca taattacaga gttttgaaaa
//
