LOCUS       NM_033165               1049 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens fibroblast growth factor 8 (FGF8), transcript variant
            A, mRNA.
ACCESSION   NM_033165
VERSION     NM_033165.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Chandra,K.B., Kumar,V., Ranjan,S., Saini,A., Tomar,A.K.,
            Sharma,J.B., Mathur,S.R. and Yadav,S.
  TITLE     Unveiling the Significance of FGF8 Overexpression in Orchestrating
            the Progression of Ovarian Cancer
  JOURNAL   Int J Mol Sci 24 (18), 14239 (2023)
   PUBMED   37762545
  REMARK    GeneRIF: Unveiling the Significance of FGF8 Overexpression in
            Orchestrating the Progression of Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1049)
  AUTHORS   Hargittay,B., Mineev,K.S., Richter,C., Sreeramulu,S.,
            Jonker,H.R.A., Saxena,K. and Schwalbe,H.
  TITLE     NMR resonance assignment of a fibroblast growth factor 8 splicing
            isoform b
  JOURNAL   Biomol NMR Assign 17 (1), 135-142 (2023)
   PUBMED   37118562
  REMARK    GeneRIF: NMR resonance assignment of a fibroblast growth factor 8
            splicing isoform b.
REFERENCE   3  (bases 1 to 1049)
  AUTHORS   Yoshiura,K., Leysens,N.J., Chang,J., Ward,D., Murray,J.C. and
            Muenke,M.
  TITLE     Genomic structure, sequence, and mapping of human FGF8 with no
            evidence for its role in craniosynostosis/limb defect syndromes
  JOURNAL   Am J Med Genet 72 (3), 354-362 (1997)
   PUBMED   9332670
REFERENCE   4  (bases 1 to 1049)
  AUTHORS   Ghosh,A.K., Shankar,D.B., Shackleford,G.M., Wu,K., T'Ang,A.,
            Miller,G.J., Zheng,J. and Roy-Burman,P.
  TITLE     Molecular cloning and characterization of human FGF8 alternative
            messenger RNA forms
  JOURNAL   Cell Growth Differ 7 (10), 1425-1434 (1996)
   PUBMED   8891346
REFERENCE   5  (bases 1 to 1049)
  AUTHORS   Gemel,J., Gorry,M., Ehrlich,G.D. and MacArthur,C.A.
  TITLE     Structure and sequence of human FGF8
  JOURNAL   Genomics 35 (1), 253-257 (1996)
   PUBMED   8661131
REFERENCE   6  (bases 1 to 1049)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   7  (bases 1 to 1049)
  AUTHORS   White,R.A., Dowler,L.L., Angeloni,S.V., Pasztor,L.M. and
            MacArthur,C.A.
  TITLE     Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8
            may be responsible for some types of acrocephalosyndactyly linked
            to this region
  JOURNAL   Genomics 30 (1), 109-111 (1995)
   PUBMED   8595889
REFERENCE   8  (bases 1 to 1049)
  AUTHORS   Tanaka,A., Miyamoto,K., Matsuo,H., Matsumoto,K. and Yoshida,H.
  TITLE     Human androgen-induced growth factor in prostate and breast cancer
            cells: its molecular cloning and growth properties
  JOURNAL   FEBS Lett 363 (3), 226-230 (1995)
   PUBMED   7737407
REFERENCE   9  (bases 1 to 1049)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
REFERENCE   10 (bases 1 to 1049)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010789.9 and BC128236.1.
            
            On May 21, 2020 this sequence version replaced NM_033165.4.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein is known to be a factor that supports
            androgen and anchorage independent growth of mammary tumor cells.
            Overexpression of this gene has been shown to increase tumor growth
            and angiogensis. The adult expression of this gene is restricted to
            testes and ovaries. Temporal and spatial pattern of this gene
            expression suggests its function as an embryonic epithelial factor.
            Studies of the mouse and chick homologs revealed roles in midbrain
            and limb development, organogenesis, embryo gastrulation and
            left-right axis determination. The alternative splicing of this
            gene results in four transcript variants. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (A) lacks an in-frame exon and
            uses an alternate splice site, compared to variant F. The encoded
            isoform (A) is shorter than isoform F.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128236.1, U46211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC010789.9         104700-104811       c
            113-695             BC128236.1         1-583
            696-1049            AC010789.9         98806-99159         c
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..1049
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /note="fibroblast growth factor 8"
                     /db_xref="GeneID:2253"
                     /db_xref="HGNC:HGNC:3686"
                     /db_xref="MIM:600483"
     exon            1..246
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..829
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /note="isoform A precursor is encoded by transcript
                     variant A; heparin-binding growth factor 8; fibroblast
                     growth factor 8 (androgen-induced); androgen-induced
                     growth factor"
                     /codon_start=1
                     /product="fibroblast growth factor 8 isoform A precursor"
                     /protein_id="NP_149355.1"
                     /db_xref="CCDS:CCDS7518.1"
                     /db_xref="GeneID:2253"
                     /db_xref="HGNC:HGNC:3686"
                     /db_xref="MIM:600483"
                     /translation="MGSPRSALSCLLLHLLVLCLQAQHVREQSLVTDQLSRRLIRTYQ
                     LYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKK
                     GKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQRE
                     VHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR"
     exon            247..283
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            284..431
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            432..538
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            539..1049
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1019..1024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /note="hexamer: AACAAA"
     polyA_site      1049
                     /gene="FGF8"
                     /gene_synonym="AIGF; FGF-8; HBGF-8; HH6; KAL6"
                     /note="major polyA site"
ORIGIN      
        1 agccagcggc caccggctcc ggcagcggcg cacagcgatt cggtgcggcg cggcgagcac
       61 gacgttccac gggacccgcg gagccgcgtc gtgatcgccg ccggcctccc gcacccgcac
      121 cctctccgct cgcgccctgc tcagcgcgtc ctcccgcggc ggcccgcggg acggcgtgac
      181 ccgccgggct ctcggtgccc cggggccgcg cgccatgggc agcccccgct ccgcgctgag
      241 ctgcctgctg ttgcacttgc tggtcctctg cctccaagcc cagcatgtga gggagcagag
      301 cctggtgacg gatcagctca gccgccgcct catccggacc taccaactct acagccgcac
      361 cagcgggaag cacgtgcagg tcctggccaa caagcgcatc aacgccatgg cagaggacgg
      421 cgaccccttc gcaaagctca tcgtggagac ggacaccttt ggaagcagag ttcgagtccg
      481 aggagccgag acgggcctct acatctgcat gaacaagaag gggaagctga tcgccaagag
      541 caacggcaaa ggcaaggact gcgtcttcac ggagattgtg ctggagaaca actacacagc
      601 gctgcagaat gccaagtacg agggctggta catggccttc acccgcaagg gccggccccg
      661 caagggctcc aagacgcggc agcaccagcg tgaggtccac ttcatgaagc ggctgccccg
      721 gggccaccac accaccgagc agagcctgcg cttcgagttc ctcaactacc cgcccttcac
      781 gcgcagcctg cgcggcagcc agaggacttg ggcccccgag ccccgatagg tgctgcctgg
      841 ccctccccac aatgccagac cgcagagagg ctcatcctgt agggcaccca aaactcaagc
      901 aagatgagct gtgcgctgct ctgcaggctg gggaggtgct gggggagccc tgggttccgg
      961 ttgttgatat tgtttgctgt tgggtttttg ctgttttttt tttttttttt ttttttaaaa
     1021 caaaagagag gctctatttt tgtattcca
//
