LOCUS       NM_002009               5321 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 7 (FGF7), mRNA.
ACCESSION   NM_002009
VERSION     NM_002009.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5321)
  AUTHORS   Zheng,Y., Liu,W.H., Yang,B. and Milman Krentsis,I.
  TITLE     Primer on fibroblast growth factor 7 (FGF 7)
  JOURNAL   Differentiation 139, 100801 (2024)
   PUBMED   39048474
  REMARK    GeneRIF: Primer on fibroblast growth factor 7 (FGF 7).
            Review article
REFERENCE   2  (bases 1 to 5321)
  AUTHORS   Zhao,J., Zhang,L., Zhang,Y., Cao,M., Wang,C., Hu,A., Cao,L.,
            Luo,Q., You,Z., Ma,X., Gong,L., Zhang,C. and Li,H.
  TITLE     FGF7 and FGF10 Promote Fate Transition of Human Epidermal
            Cell-derived Organoids to an Eccrine Gland Phenotype
  JOURNAL   Int J Biol Sci 20 (11), 4162-4177 (2024)
   PUBMED   39247826
  REMARK    GeneRIF: FGF7 and FGF10 Promote Fate Transition of Human Epidermal
            Cell-derived Organoids to an Eccrine Gland Phenotype.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5321)
  AUTHORS   Meng,H., Liao,Z., Ji,Y., Wang,D., Han,Y., Huang,C., Hu,X., Chen,J.,
            Zhang,H., Li,Z., Wang,C., Sun,H., Sun,J., Chen,L., Yin,J., Zhao,J.,
            Xu,T. and Liu,H.
  TITLE     FGF7 enhances the expression of ACE2 in human islet organoids
            aggravating SARS-CoV-2 infection
  JOURNAL   Signal Transduct Target Ther 9 (1), 104 (2024)
   PUBMED   38654010
  REMARK    GeneRIF: FGF7 enhances the expression of ACE2 in human islet
            organoids aggravating SARS-CoV-2 infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5321)
  AUTHORS   Geervliet,E., Terstappen,L.W.M.M. and Bansal,R.
  TITLE     Hepatocyte survival and proliferation by fibroblast growth factor 7
            attenuates liver inflammation, and fibrogenesis during acute liver
            injury via paracrine mechanisms
  JOURNAL   Biomed Pharmacother 167, 115612 (2023)
   PUBMED   37797460
  REMARK    GeneRIF: Hepatocyte survival and proliferation by fibroblast growth
            factor 7 attenuates liver inflammation, and fibrogenesis during
            acute liver injury via paracrine mechanisms.
REFERENCE   5  (bases 1 to 5321)
  AUTHORS   Zhou,Z., Wu,L., Zhao,S., Xia,S.J., Pan,L., Chen,M., Zhu,Y.P.,
            Jiang,J.T. and Shi,F.
  TITLE     Upregulation of FGF7 Induced Intravesical Prostatic Protrusion of
            Benign Prostatic Hyperplasia via the ERK1/2 Signaling Pathway
  JOURNAL   Gerontology 69 (5), 615-627 (2023)
   PUBMED   36693332
  REMARK    GeneRIF: Upregulation of FGF7 Induced Intravesical Prostatic
            Protrusion of Benign Prostatic Hyperplasia via the ERK1/2 Signaling
            Pathway.
REFERENCE   6  (bases 1 to 5321)
  AUTHORS   Ishibashi,T., Bottaro,D.P., Chan,A., Miki,T. and Aaronson,S.A.
  TITLE     Expression cloning of a human dual-specificity phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12170-12174 (1992)
   PUBMED   1281549
REFERENCE   7  (bases 1 to 5321)
  AUTHORS   Kelley,M.J., Pech,M., Seuanez,H.N., Rubin,J.S., O'Brien,S.J. and
            Aaronson,S.A.
  TITLE     Emergence of the keratinocyte growth factor multigene family during
            the great ape radiation
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9287-9291 (1992)
   PUBMED   1409637
REFERENCE   8  (bases 1 to 5321)
  AUTHORS   Miki,T., Bottaro,D.P., Fleming,T.P., Smith,C.L., Burgess,W.H.,
            Chan,A.M. and Aaronson,S.A.
  TITLE     Determination of ligand-binding specificity by alternative
            splicing: two distinct growth factor receptors encoded by a single
            gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 246-250 (1992)
   PUBMED   1309608
REFERENCE   9  (bases 1 to 5321)
  AUTHORS   Aaronson,S.A., Bottaro,D.P., Miki,T., Ron,D., Finch,P.W.,
            Fleming,T.P., Ahn,J., Taylor,W.G. and Rubin,J.S.
  TITLE     Keratinocyte growth factor. A fibroblast growth factor family
            member with unusual target cell specificity
  JOURNAL   Ann N Y Acad Sci 638, 62-77 (1991)
   PUBMED   1664700
REFERENCE   10 (bases 1 to 5321)
  AUTHORS   Finch,P.W., Rubin,J.S., Miki,T., Ron,D. and Aaronson,S.A.
  TITLE     Human KGF is FGF-related with properties of a paracrine effector of
            epithelial cell growth
  JOURNAL   Science 245 (4919), 752-755 (1989)
   PUBMED   2475908
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB206350.1, M60828.1 and
            AC025919.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002009.3.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein is a potent epithelial cell-specific growth
            factor, whose mitogenic activity is predominantly exhibited in
            keratinocytes but not in fibroblasts and endothelial cells. Studies
            of mouse and rat homologs of this gene implicated roles in
            morphogenesis of epithelium, reepithelialization of wounds, hair
            development and early lung organogenesis. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.9434.1, M60828.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267843.9/ ENSP00000267843.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               DB206350.1         148-590
            444-1073            M60828.1           424-1053
            1074-5321           AC025919.8         63318-67565
FEATURES             Location/Qualifiers
     source          1..5321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..5321
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /note="fibroblast growth factor 7"
                     /db_xref="GeneID:2252"
                     /db_xref="HGNC:HGNC:3685"
                     /db_xref="MIM:148180"
     exon            1..199
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /inference="alignment:Splign:2.1.0"
     exon            200..751
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..1050
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /note="keratinocyte growth factor; heparin-binding growth
                     factor 7; FGF-7"
                     /codon_start=1
                     /product="fibroblast growth factor 7 precursor"
                     /protein_id="NP_002000.1"
                     /db_xref="CCDS:CCDS10131.1"
                     /db_xref="GeneID:2252"
                     /db_xref="HGNC:HGNC:3685"
                     /db_xref="MIM:148180"
                     /translation="MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNV
                     NCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRT
                     VAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNG
                     GEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT"
     exon            752..855
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /inference="alignment:Splign:2.1.0"
     exon            856..5321
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1955..1960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /note="hexamer: ATTAAA"
     polyA_site      1983
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /note="major polyA site"
     regulatory      2017..2022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /note="hexamer: TATAAA"
     polyA_site      2042
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /note="major polyA site"
     regulatory      5296..5301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
                     /note="hexamer: ATTAAA"
     polyA_site      5321
                     /gene="FGF7"
                     /gene_synonym="HBGF-7; KGF"
ORIGIN      
        1 acacacacac acaagcacac acgcgctcac acacagagag aaaatccttc tgcctgttga
       61 tttatggaaa caattatgat tctgctggag aacttttcag ctgagaaata gtttgtagct
      121 acagtagaaa ggctcaagtt gcaccaggca gacaacagac atggaattct tatatatcca
      181 gctgttagca acaaaacaaa agtcaaatag caaacagcgt cacagcaact gaacttacta
      241 cgaactgttt ttatgaggat ttatcaacag agttatttaa ggaggaatcc tgtgttgtta
      301 tcaggaacta aaaggataag gctaacaatt tggaaagagc aactactctt tcttaaatca
      361 atctacaatt cacagatagg aagaggtcaa tgacctagga gtaacaatca actcaagatt
      421 cattttcatt atgttattca tgaacacccg gagcactaca ctataatgca caaatggata
      481 ctgacatgga tcctgccaac tttgctctac agatcatgct ttcacattat ctgtctagtg
      541 ggtactatat ctttagcttg caatgacatg actccagagc aaatggctac aaatgtgaac
      601 tgttccagcc ctgagcgaca cacaagaagt tatgattaca tggaaggagg ggatataaga
      661 gtgagaagac tcttctgtcg aacacagtgg tacctgagga tcgataaaag aggcaaagta
      721 aaagggaccc aagagatgaa gaataattac aatatcatgg aaatcaggac agtggcagtt
      781 ggaattgtgg caatcaaagg ggtggaaagt gaattctatc ttgcaatgaa caaggaagga
      841 aaactctatg caaagaaaga atgcaatgaa gattgtaact tcaaagaact aattctggaa
      901 aaccattaca acacatatgc atcagctaaa tggacacaca acggagggga aatgtttgtt
      961 gccttaaatc aaaaggggat tcctgtaaga ggaaaaaaaa cgaagaaaga acaaaaaaca
     1021 gcccactttc ttcctatggc aataacttaa ttgcatatgg tatataaaga accagttcca
     1081 gcagggagat ttctttaagt ggactgtttt ctttcttctc aaaattttct ttccttttat
     1141 tttttagtaa tcaagaaagg ctggaaaact actgaaaaac tgatcaagct ggacttgtgc
     1201 atttatgttt gttttaagac actgcattaa agaaagattt gaaaagtata cacaaaaatc
     1261 agatttagta actaaaggtt gtaaaaaatt gtaaaactgg ttgtacaatc atgatgttag
     1321 taacagtaat ttttttctta aattaattta cccttaagag tatgttagat ttgattatct
     1381 gataatgatt atttaaatat tcctatctgc ttataaaatg gctgctataa taataataat
     1441 acagatgttg ttatataagg tatatcagac ctacaggctt ctggcaggat ttgtcagata
     1501 atcaagccac actaactatg gaaaatgagc agcattttaa atgctttcta gtgaaaaatt
     1561 ataatctact taaactctaa tcagaaaaaa aattctcaaa aaaactatta tgaaagtcaa
     1621 taaaatagat aatttaacaa aagtacagga ttagaacatg cttataccta taaataagaa
     1681 caaaatttct aatgctgctc aagtggaaag ggtattgcta aaaggatgtt tccaaaaatc
     1741 ttgtatataa gatagcaaca gtgattgatg ataatactgt acttcatctt acttgccaca
     1801 aaataacatt ttataaatcc tcaaagtaaa attgagaaat ctttaagttt ttttcaagta
     1861 acataatcta tctttgtata attcatattt gggaatatgg cttttaataa tgttcttccc
     1921 acaaataatc atgctttttt cctatggtta cagcattaaa ctctatttta agttgttttt
     1981 gaactttatt gttttgttat ttaagtttat gttatttata aaaaaaaaac cttaataagc
     2041 tgtatctgtt tcatatgctt ttaattttaa aggaataaca aaactgtctg gctcaacggc
     2101 aagtttccct cccttttctg actgacacta agtctagcac acagcacttg ggccagcaaa
     2161 tcctggaagg cagacaaaaa taagagcctg aagcaatgct tacaatagat gtctcacaca
     2221 gaacaataca aatatgtaaa aaatctttca ccacatattc ttgccaatta attggatcat
     2281 ataagtaaaa tcattacaaa tataagtatt tacaggattt taaagttaga atatatttga
     2341 atgcatgggt agaaaatatc atattttaaa actatgtata tttaaattta gtaattttct
     2401 aatctctaga aatctctgct gttcaaaagg tggcagcact gaaagttgtt ttcctgttag
     2461 atggcaagag cacaatgccc aaaatagaag atgcagttaa gaataagggg ccctgaatgt
     2521 catgaaggct tgaggtcagc ctacagataa caggattatt acaaggatga atttccactt
     2581 caaaagtctt tcattggcag atcttggtag cactttatat gttcaccaat gggaggtcaa
     2641 tatttatcta atttaaaagg tatgctaacc actgtggttt taatttcaaa atatttgtca
     2701 ttcaagtccc tttacataaa tagtatttgg taatacattt atagatgaga gttatatgaa
     2761 aaggctaggt caacaaaaac aatagattca tttaattttc ctgtggttga cctatacgac
     2821 caggatgtag aaaactagaa agaactgccc ttcctcagat atactcttgg gagagagcat
     2881 gaatggtatt ctgaactatc acctgattca aggactttgc tagctaggtt ttgaggtcag
     2941 gcttcagtaa ctgtagtctt gtgagcatat tgagggcaga ggaggactta gtttttcata
     3001 tgtgtttcct tagtgcctag cagactatct gttcataatc agttttcagt gtgaattcac
     3061 tgaatgttta tagacaaaag aaaatacaca ctaaaactaa tcttcatttt aaaagggtaa
     3121 aacatgacta tacagaaatt taaatagaaa tagtgtatat acatataaaa tacaagctat
     3181 gttaggacca aatgctcttt gtctatggag ttatacttcc atcaaattac atagcaatgc
     3241 tgaattaggc aaaaccaaca tttagtggta aatccattcc tggtagtata agtcacctaa
     3301 aaaagacttc tagaaatatg tactttaatt atttgttttt ctcctatttt taaatttatt
     3361 atgcaaattt tagaaaataa aatttgctct agttacacac ctttagaatt ctagaatatt
     3421 aaaactgtaa ggggcctcca tccctcttac tcatttgtag tctaggaaat tgagattttg
     3481 atacacctaa ggtcacgcag ctgggtagat atacagctgt cacaagagtc tagatcagtt
     3541 agcacatgct ttctactctt cgattattag tattattagc taatggtctt tggcatgttt
     3601 ttgtttttta tttctgttga gatatagcct ttacatttgt acacaaatgt gactatgtct
     3661 tggcaatgca cttcatacac aatgactaat ctatactgtg atgatttgac tcaaaaggag
     3721 aaaagaaatt atgtagtttt caattctgat tcctattcac cttttgttta tgaatggaaa
     3781 gctttgtgca aaatatacat ataagcagag taagcctttt aaaaatgttc tttgaaagat
     3841 aaaattaaat acatgagttt ctaacaatta gaaaagaaaa aattaaaaca tgaaatgata
     3901 acaaaagtaa acaaaagata ctttcaaagc agtgaacaaa acattttgac ataagccata
     3961 atataaatta taatataaaa aataaaaacc atagtataaa ttgtcagcct ttgagttggc
     4021 tacaaattca atttaatgac agaagagaag ggatgctgga ggtaaattct tagggtttct
     4081 atctcataga gtttgctctt ctggttctct agactgccaa agaacataaa gatgtgcgag
     4141 gggacctagc tgtagtaaaa gcaatcctat aacaagaaaa actctaaaac agtgcccctt
     4201 acgattttct actgaaattt ctctaatagt agaggtgtaa aataagaagt tagagaataa
     4261 tgcaaagggg gcccaccaca gacggaacat ttcttttctc ttaagactca tgtgattttt
     4321 gcatcttact ccataatata tttgtggttg cgttaatatg acaatgtctg caattaaaca
     4381 ccagtaagca aaattgatac atcagaatga cttgcagggc ttatcatgca gtttggttta
     4441 catccctact ccactgccat ttacttgagc gtgaatgaga cacaaaagat tatttgcctc
     4501 ccataatcca actttacaca taaataacac aaggctaaag aaaaccagaa ctcaaattca
     4561 ccacgcatag gagtgataac aaaaatattt aacagtcagt atgggtgatt actggccaat
     4621 cagaatacat cactgataca tcgaaatgga tgcaggccac tatgactaac ttgtgggtat
     4681 catttctatg atcaccctaa aacagagttg ggaaaatatc tattaactgg tctctctggt
     4741 ttgaattctc aatatgtatc ttaatatgaa atagctcatt aaaacttcat gtgtaactat
     4801 ttcagcattg ttgtcagcta ctctttattc cacttctgta cagtatttat tcaaccaagc
     4861 tgctgctttc aatgaaggtc acttgttcct tcagggacac atatactccc acctatcctt
     4921 taattttgaa tggtttgtca ggaaaattta ctttctcttg agttgaaaaa cttgacagga
     4981 agcaagaaat aatacagtcc tagcctcttt ccaataacat ctgatttctc cattctcaaa
     5041 ctacacttct caaggaacca gatatttact ctcatctggg aagatgcctc ttatgttttc
     5101 cttttacttc ctggttatca tgtggttgca ttttccaagt tcttatcatt gaatttatga
     5161 gagcctatca aaatttattt tctttcattt atattctaat aattgaaatg tgagatgaaa
     5221 ataacatttc acttatgaaa aacccttctc ttgatgaatc cttccatgtg ttagttatct
     5281 attgctgtgt aacaaattaa aacttaatgg cttgaaacaa a
//
