LOCUS       NM_020996                945 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens fibroblast growth factor 6 (FGF6), mRNA.
ACCESSION   NM_020996
VERSION     NM_020996.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Zhang,X., Xu,Y., Shi,L., Chen,X., Hu,M., Zhang,M., Nie,M. and
            Liu,X.
  TITLE     FGF6 inhibits oral squamous cell carcinoma progression by
            regulating PI3K/AKT and MAPK pathways
  JOURNAL   Sci Rep 14 (1), 26877 (2024)
   PUBMED   39506091
  REMARK    GeneRIF: FGF6 inhibits oral squamous cell carcinoma progression by
            regulating PI3K/AKT and MAPK pathways.
            Erratum:[Sci Rep. 2024 Dec 5;14(1):30375. doi:
            10.1038/s41598-024-81416-9.. PMID: 39639102]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Smith,J. and Jerome-Majewska,L.A.
  TITLE     Reprint of: Fibroblast Growth Factor 6
  JOURNAL   Differentiation 139, 100805 (2024)
   PUBMED   39214748
  REMARK    GeneRIF: Reprint of: Fibroblast Growth Factor 6.
            Review article
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Hu,Z., Chen,P., Wang,L., Zhu,Y., Chen,G., Chen,Y., Hu,Z., Mei,L.,
            You,W., Cong,W., Jin,L., Wang,X., Wang,Y. and Guan,X.
  TITLE     FGF6 promotes cardiac repair after myocardial infarction by
            inhibiting the Hippo pathway
  JOURNAL   Cell Prolif 55 (5), e13221 (2022)
   PUBMED   35355356
  REMARK    GeneRIF: FGF6 promotes cardiac repair after myocardial infarction
            by inhibiting the Hippo pathway.
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Zhi,Y., Sun,F., Cai,C., Li,H., Wang,K., Sun,J., He,T., Ji,Z.,
            Liu,Z., Wang,H. and Cheng,R.
  TITLE     LINC00265 promotes the viability, proliferation, and migration of
            bladder cancer cells via the miR-4677-3p/FGF6 axis
  JOURNAL   Hum Exp Toxicol 40 (12_suppl), S434-S446 (2021)
   PUBMED   34591706
  REMARK    GeneRIF: LINC00265 promotes the viability, proliferation, and
            migration of bladder cancer cells via the miR-4677-3p/FGF6 axis.
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Xu,B., Liu,C., Zhang,H., Zhang,R., Tang,M., Huang,Y., Jin,L.,
            Xu,L., Hu,C. and Jia,W.
  TITLE     Skeletal muscle-targeted delivery of Fgf6 protects mice from
            diet-induced obesity and insulin resistance
  JOURNAL   JCI Insight 6 (19), e149969 (2021)
   PUBMED   34491915
  REMARK    GeneRIF: Skeletal muscle-targeted delivery of Fgf6 protects mice
            from diet-induced obesity and insulin resistance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Vainikka,S., Partanen,J., Bellosta,P., Coulier,F., Birnbaum,D.,
            Basilico,C., Jaye,M. and Alitalo,K.
  TITLE     Fibroblast growth factor receptor-4 shows novel features in genomic
            structure, ligand binding and signal transduction
  JOURNAL   EMBO J 11 (12), 4273-4280 (1992)
   PUBMED   1385111
  REMARK    Erratum:[EMBO J 1993 Feb;12(2):810]
REFERENCE   7  (bases 1 to 945)
  AUTHORS   Iida,S., Yoshida,T., Naito,K., Sakamoto,H., Katoh,O., Hirohashi,S.,
            Sato,T., Onda,M., Sugimura,T. and Terada,M.
  TITLE     Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization
  JOURNAL   Oncogene 7 (2), 303-309 (1992)
   PUBMED   1549352
REFERENCE   8  (bases 1 to 945)
  AUTHORS   Coulier,F., Batoz,M., Marics,I., de Lapeyriere,O. and Birnbaum,D.
  TITLE     Putative structure of the FGF6 gene product and role of the signal
            peptide
  JOURNAL   Oncogene 6 (8), 1437-1444 (1991)
   PUBMED   1886714
REFERENCE   9  (bases 1 to 945)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 945)
  AUTHORS   Marics,I., Adelaide,J., Raybaud,F., Mattei,M.G., Coulier,F.,
            Planche,J., de Lapeyriere,O. and Birnbaum,D.
  TITLE     Characterization of the HST-related FGF.6 gene, a new member of the
            fibroblast growth factor gene family
  JOURNAL   Oncogene 4 (3), 335-340 (1989)
   PUBMED   2649847
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008012.8.
            
            On Sep 16, 2020 this sequence version replaced NM_020996.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This gene displayed oncogenic transforming activity when
            transfected into mammalian cells. The mouse homolog of this gene
            exhibits a restricted expression profile predominantly in the
            myogenic lineage, which suggested a role in muscle regeneration or
            differentiation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63454.1, BC121098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMN03465413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228837.3/ ENSP00000228837.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               AC008012.8         58612-59202
            592-695             AC008012.8         60191-60294
            696-945             AC008012.8         70036-70285
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.32"
     gene            1..945
                     /gene="FGF6"
                     /gene_synonym="HBGF-6; HST2"
                     /note="fibroblast growth factor 6"
                     /db_xref="GeneID:2251"
                     /db_xref="HGNC:HGNC:3684"
                     /db_xref="MIM:134921"
     exon            1..591
                     /gene="FGF6"
                     /gene_synonym="HBGF-6; HST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..872
                     /gene="FGF6"
                     /gene_synonym="HBGF-6; HST2"
                     /note="FGF-6; HST-2; HSTF-2; heparin-binding growth factor
                     6; heparin secretory-transforming protein 2"
                     /codon_start=1
                     /product="fibroblast growth factor 6 precursor"
                     /protein_id="NP_066276.2"
                     /db_xref="CCDS:CCDS8527.1"
                     /db_xref="GeneID:2251"
                     /db_xref="HGNC:HGNC:3684"
                     /db_xref="MIM:134921"
                     /translation="MALGQKLFITMSRGAGRLQGTLWALVFLGILVGMVVPSPAGTRA
                     NNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLP
                     DGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFR
                     ETLLPNNYNAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI"
     exon            592..695
                     /gene="FGF6"
                     /gene_synonym="HBGF-6; HST2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..945
                     /gene="FGF6"
                     /gene_synonym="HBGF-6; HST2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactagggac ggagcaagcg ggcgagctag agagcgtccc cgagccatgg tctctaccgg
       61 ccgcggctca gcctgggtcc ctctgctctc aacccgagtg cccgatggag gctttggttt
      121 catgtcagca gccttcatct gccttccaaa aataagcccc tgccgccatg ccggagggag
      181 aaaaacaaga agggcggtat ttttagggcc attaattctg accacgtgcc tgagaggcaa
      241 ggtggatggc cctgggacag aaactgttca tcactatgtc ccggggagca ggacgtctgc
      301 agggcacgct gtgggctctc gtcttcctag gcatcctagt gggcatggtg gtgccctcgc
      361 ctgcaggcac ccgtgccaac aacacgctgc tggactcgag gggctggggc accctgctgt
      421 ccaggtctcg cgccgggcta gctggagaga ttgccggggt gaactgggaa agtggctatt
      481 tggtggggat caagcggcag cggaggctct actgcaacgt gggcatcggc tttcacctcc
      541 aggtgctccc cgacggccgg atcagcggga cccacgagga gaacccctac agcctgctgg
      601 aaatttccac tgtggagcga ggcgtggtga gtctctttgg agtgagaagt gccctcttcg
      661 ttgccatgaa cagtaaagga agattgtacg caacgcccag cttccaagaa gaatgcaagt
      721 tcagagaaac cctcctgccc aacaattaca atgcctacga gtcagacttg taccaaggga
      781 cctacattgc cctgagcaaa tacggacggg taaagcgggg cagcaaggtg tccccgatca
      841 tgactgtcac tcatttcctt cccaggatct aaggacccac aaaagaaggc tcacagattt
      901 aaagcatcat ctgttcgatt gaaattttgc accagcgaag aattc
//
