LOCUS       NM_033143               5295 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant
            2, mRNA.
ACCESSION   NM_033143
VERSION     NM_033143.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5295)
  AUTHORS   Gao,C., Wang,W. and Jia,H.
  TITLE     Fibroblast growth factor 5 as a target for atrial fibrillation
            treatment: Evidence from mendelian randomization
  JOURNAL   Int J Cardiol 413, 132393 (2024)
   PUBMED   39059473
  REMARK    GeneRIF: Fibroblast growth factor 5 as a target for atrial
            fibrillation treatment: Evidence from mendelian randomization.
REFERENCE   2  (bases 1 to 5295)
  AUTHORS   Zhang,Q., Ding,F., Zhang,C., Han,X. and Cheng,H.
  TITLE     Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the
            Progression of Non-small Cell Lung Cancer via Upregulating the
            Level of FGF5
  JOURNAL   Biochem Genet 61 (5), 1807-1826 (2023)
   PUBMED   36808266
  REMARK    GeneRIF: Circ_0001715 Functions as a miR-1249-3p Sponge to
            Accelerate the Progression of Non-small Cell Lung Cancer via
            Upregulating the Level of FGF5.
REFERENCE   3  (bases 1 to 5295)
  AUTHORS   Wang,J.H., Wu,S.J., Li,Y., Zhao,Y., Liu,Z.M., Deng,S.L. and
            Lian,Z.X.
  TITLE     Improving the Efficiency of Precise Genome Editing with CRISPR/Cas9
            to Generate Goats Overexpressing Human Butyrylcholinesterase
  JOURNAL   Cells 12 (14), 1818 (2023)
   PUBMED   37508483
  REMARK    GeneRIF: Improving the Efficiency of Precise Genome Editing with
            CRISPR/Cas9 to Generate Goats Overexpressing Human
            Butyrylcholinesterase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5295)
  AUTHORS   Cui,S., Li,Y., Zhang,X., Wu,B., Li,M., Gao,J., Xia,H. and Xu,L.
  TITLE     FGF5 protects heart from sepsis injury by attenuating cardiomyocyte
            pyroptosis through inhibiting CaMKII/NFkappaB signaling
  JOURNAL   Biochem Biophys Res Commun 636 (Pt 2), 104-112 (2022)
   PUBMED   36368152
  REMARK    GeneRIF: FGF5 protects heart from sepsis injury by attenuating
            cardiomyocyte pyroptosis through inhibiting CaMKII/NFkappaB
            signaling.
REFERENCE   5  (bases 1 to 5295)
  AUTHORS   Zhang,G., Zheng,H. and Wang,L.
  TITLE     miR-491-3p functions as a tumor suppressor in non-small cell lung
            cancer by targeting fibroblast growth factor 5
  JOURNAL   Oncol Rep 48 (3) (2022)
   PUBMED   35866594
  REMARK    GeneRIF: miR4913p functions as a tumor suppressor in nonsmall cell
            lung cancer by targeting fibroblast growth factor 5.
REFERENCE   6  (bases 1 to 5295)
  AUTHORS   Werner,S., Roth,W.K., Bates,B., Goldfarb,M. and Hofschneider,P.H.
  TITLE     Fibroblast growth factor 5 proto-oncogene is expressed in normal
            human fibroblasts and induced by serum growth factors
  JOURNAL   Oncogene 6 (11), 2137-2144 (1991)
   PUBMED   1658709
REFERENCE   7  (bases 1 to 5295)
  AUTHORS   Bates,B., Hardin,J., Zhan,X., Drickamer,K. and Goldfarb,M.
  TITLE     Biosynthesis of human fibroblast growth factor-5
  JOURNAL   Mol Cell Biol 11 (4), 1840-1845 (1991)
   PUBMED   2005884
REFERENCE   8  (bases 1 to 5295)
  AUTHORS   Haub,O., Drucker,B. and Goldfarb,M.
  TITLE     Expression of the murine fibroblast growth factor 5 gene in the
            adult central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 8022-8026 (1990)
   PUBMED   1700424
REFERENCE   9  (bases 1 to 5295)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 5295)
  AUTHORS   Nguyen,C., Roux,D., Mattei,M.G., de Lapeyriere,O., Goldfarb,M.,
            Birnbaum,D. and Jordan,B.R.
  TITLE     The FGF-related oncogenes hst and int.2, and the bcl.1 locus are
            contained within one megabase in band q13 of chromosome 11, while
            the fgf.5 oncogene maps to 4q21
  JOURNAL   Oncogene 3 (6), 703-708 (1988)
   PUBMED   2577873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA461028.1, DR004226.1,
            AF171928.1, AK090557.1, BG252761.1 and BQ001160.1.
            
            On Aug 17, 2005 this sequence version replaced NM_033143.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This gene was identified as an oncogene, which confers
            transforming potential when transfected into mammalian cells.
            Targeted disruption of the homolog of this gene in mouse resulted
            in the phenotype of abnormally long hair, which suggested a
            function as an inhibitor of hair elongation. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, which results in a frameshift and an early stop codon,
            compared to variant 1. The encoded isoform (2, also referred to as
            'FGF-5S' or 'short isoform') is shorter and has a distinct
            C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF171928.1, SRR1660809.188920.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            regulatory uORF :: PMID: 2005884
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AA461028.1         1-16
            17-87               DR004226.1         67-137
            88-2105             AF171928.1         1-2018
            2106-2489           AK090557.1         1922-2305
            2490-3088           AF171928.1         2403-3001
            3089-3226           AK090557.1         2905-3042
            3227-4212           AF171928.1         3139-4124
            4213-4426           BG252761.1         217-430
            4427-5077           AF171928.1         4328-4978
            5078-5295           BQ001160.1         8-225               c
FEATURES             Location/Qualifiers
     source          1..5295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..5295
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="fibroblast growth factor 5"
                     /db_xref="GeneID:2250"
                     /db_xref="HGNC:HGNC:3683"
                     /db_xref="MIM:165190"
     exon            1..592
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      125..241
                     /regulatory_class="uORF"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:2005884]"
                     /note="this uORF is predicted to encode a 38 aa peptide
                     (PMID:2005884)"
     regulatory      209..241
                     /regulatory_class="uORF"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:2005884]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:2005884)"
     CDS             238..609
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; heparin-binding growth factor 5"
                     /codon_start=1
                     /product="fibroblast growth factor 5 isoform 2 precursor"
                     /protein_id="NP_149134.1"
                     /db_xref="CCDS:CCDS3586.1"
                     /db_xref="GeneID:2250"
                     /db_xref="HGNC:HGNC:3683"
                     /db_xref="MIM:165190"
                     /translation="MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGS
                     SSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQ
                     IYPDGKVNGSHEANMLSQVHR"
     exon            593..5285
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1606
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="major polyA site"
     regulatory      4122..4127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: TATAAA"
     regulatory      4129..4134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: ATTACA"
     polyA_site      4143
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="major polyA site"
     polyA_site      4147
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
     regulatory      4194..4199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: AATAAA"
     regulatory      4204..4209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: CATAAA"
     polyA_site      4214
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
     polyA_site      4222
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: ATTAAA"
     polyA_site      4253
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
ORIGIN      
        1 ggggaagctt cgcaggcgtg cacggagcag tgagatcact ggcgttataa atatcccggt
       61 gccagcgcgg agatccgctc gggtggcctc tctcttcccc tctccccttc tcttccccga
      121 ggctatgtcc acccggtgcg gcgaggcggg cagagccaga ggcacgcagc cgcacagggg
      181 ctacagagcc cagaatcagc cctacaagat gcacttagga cccccgcggc tggaagaatg
      241 agcttgtcct tcctcctcct cctcttcttc agccacctga tcctcagcgc ctgggctcac
      301 ggggagaagc gtctcgcccc caaagggcaa cccggacccg ctgccactga taggaaccct
      361 agaggctcca gcagcagaca gagcagcagt agcgctatgt cttcctcttc tgcctcctcc
      421 tcccccgcag cttctctggg cagccaagga agtggcttgg agcagagcag tttccagtgg
      481 agcccctcgg ggcgccggac cggcagcctc tactgcagag tgggcatcgg tttccatctg
      541 cagatctacc cggatggcaa agtcaatgga tcccacgaag ccaatatgtt aagccaagtt
      601 cacagatgac tgcaagttca gggagcgttt tcaagaaaat agctataata cctatgcctc
      661 agcaatacat agaactgaaa aaacagggcg ggagtggtat gtggccctga ataaaagagg
      721 aaaagccaaa cgagggtgca gcccccgggt taaaccccag catatctcta cccattttct
      781 gccaagattc aagcagtcgg agcagccaga actttctttc acggttactg ttcctgaaaa
      841 gaaaaagcca cctagcccta tcaagccaaa gattcccctt tctgcacctc ggaaaaatac
      901 caactcagtg aaatacagac tcaagtttcg ctttggataa tattcctctt ggccttgtga
      961 gaaaccattc tttcccctca ggagtttcta taggtgtctt cagagttctg aagaaaaatt
     1021 actggacaca gcttcagcta tacttacact gtattgaagt cacgtcattt gtttcaatgt
     1081 gactgaaaca aaatgttttt tgataggaag gaaactggaa ttctttgtac taatacaggg
     1141 agcacactcc ttcagttcag caagacataa agccttttgc tttatgcttg agggatattt
     1201 agaactttgt attttcggaa agttaaataa cagggactac gtatttttct gacttttaca
     1261 gattaacctg aaagaacata catgatacat ttttattttt ggtttccaaa gaatattttg
     1321 atgcagataa aatattttgt taacttttgt ttttttttgt ttgttttctt aaaagtacct
     1381 ctgcattgag catattttct tacttttatt attttaatta atatgacata agcaatcatt
     1441 ttatgctgtt tatgaattat aaatgtgttt atagctcatt tgtaatatgg aaatctttta
     1501 catttttcct attcactgca cttttttatt gtttttattt ctagccatac ctcagataat
     1561 atgtttagtt ttacatttta aaatgtttaa attctctttc acagcaccaa aggctcagct
     1621 tggatttgtg tgtatgtgta tgtcaattca tgacattatg tggaatccta aacctttggt
     1681 ggctgggata tgatgggtta gaagcaagga gaaaatataa ggactttttg atggaattaa
     1741 atgtgggagg taaggaaaag gatttagagg taaaagtaca ctaagtttgc aacatttatt
     1801 gagatctaag tctgtcttgc cttcatttct ctttttatct cccccttgcc ctcattcttg
     1861 aacagctgga ggaatacatt ttattctgtc catgaagcat acactatgaa attcaagtgc
     1921 ttaaaaatac ttctatgact ctctgctatc ccactgtata gatccacagg gagcaaacac
     1981 ttagaaatga tagagaactg aaggagatca atggtttaac agttatccat gccaagtccc
     2041 attgtcagaa atattcttat tactcagtca aacactcttt gagcttccct tcctaaaggt
     2101 aaccaatcca gtgaatagat gtgccctttt ataaggaaac ttctgatgtt tattaaaaaa
     2161 actggccttt tgatagaggt aacttaattt gggaatttgt tgtgttgaaa tggcatttaa
     2221 tttcaaccta aatactgact gctggacata aatcacagaa aatttaactt aagaaaattt
     2281 acaaaattta ttctcaggta atcattttaa taaagttctg caaaatacac gtttatctta
     2341 cattcagaaa tgtggcaaaa aaggcatagc taaaggctaa acatatggct ttagtagtaa
     2401 caaaagggtt catagaaact tcatggtttg catttaaaca tgtttaaagt gtacttataa
     2461 actatttttt tcttaaagca aactatgatt tattttggtg cacaaataca aagtggaaac
     2521 ttaccaaaat tgaactagct accatataag cagattgctt taatttgatg ggaaaatagt
     2581 acacacatat atataacaaa taatatatta aaaaacccat ccatcaacta aaacattata
     2641 tgtatacatc agtatagtgt tttattataa agccaattat ctgattaagc attctttcca
     2701 ctgaatgcat aatgtttaaa tagcataaaa tgaaatgcta caaaaattga actaatttat
     2761 actttaaagt atttctgggt taaatgaaac aatgaaattt tttagtatgt tcaactctca
     2821 tccaaatggc atatgaccct gtttacacag cctaaagcta aaaatattac tctagtttat
     2881 tctaatctat tgttaagtat tgtgcactgt ataccaagtt cttagggcac atgaaaaatt
     2941 ttagctgcca aacaggaact agtaaacata tgttcctaat aagtgaaggg aaagataata
     3001 atgatggtca acaataagcc acgtcaatgc ataagttgta taggctaaat gttgcttgta
     3061 ggctacatta aactcaaatg taatagttta tcttatactc ctggtttgat ttgattagca
     3121 tattaacgtg aaagtaggat agctactaaa tatatattat gcaagtcagg aatcattaat
     3181 ttcaaaattt aaagccatgc taaaattaaa aagaaaatat taaattacac aattacactt
     3241 gtctttactg gccatacaaa atgatttttt tttttttttt gagacagagt cttgctctgt
     3301 caccaggctg gagtgcagtg gcatgatctc ggctcactgc aacctccaac tccctggttt
     3361 aagggattct cctgcctcag cctcccaagt agctgggatt acagactcat gccaccacgc
     3421 cagctaattt ttgtattttt agtagagacg gggtttcacc atgttggtca ggatggtctc
     3481 aatcctggcc tcttgatagt cctgacctca tgatctgccc acctcggcct ccccaaagtg
     3541 ctgggattac aggtacaatg atgtataatt aatgcttagt gaagcataaa gttacctaca
     3601 tcaattaatt aaatgaactt atgtacagaa aacatgtata aatataagtc tatactaatg
     3661 cttacaactt tctaagaggg ttcttgctta tgtagctttt tattatttta agtaactaga
     3721 accaccaaat atcaaataaa attatttggt tatggttatg ttcatctaaa cacaacaata
     3781 acttttatat taatatttag gagtctattt tgtctatagg tgacaaacat ctccagacta
     3841 acatgtcagt tttatcaatt atattatgtt taattattta agatttcttt atgtggaaca
     3901 tctatagaga taaatagaaa ttttcaataa gatgtagtaa cactgtgatt tatctttcaa
     3961 gagtctctct tcacttcctt ctaaagagac taatttgaga gtacaggtgc atattaattt
     4021 tcttggttct ttcagctgaa ttatattggt ccagaagttc aaaatcatgt gacaataata
     4081 agggatactg acagaagtta tttccaagtt tgtgtatata ttataaaaat tacatatata
     4141 aaactaaggc ttttatttct gttattttta agcttttatt tcttgtagct aaaaataaaa
     4201 catcataaat ctggtaggta aatttcttat taaatcaatc ttgaaataga aaatgtaata
     4261 actttcttac cattaacatt ttttaccctt ccatagaagg gagggaataa atcatgactt
     4321 atcccatttt caataacaaa acgaaactat ggcactaacc aaaaacttgc attctggcat
     4381 aatttttaca gttgcagaga attgtttctg ggctcattaa aaaaagtagt attgcagaca
     4441 ttgctgcaat gggaagcaga caataacttc ttaaaggaat tctacacctc ctttaagatt
     4501 tacttaattg ctacatctaa attctgataa tttaaaatcc attttaggtg ataaaatttt
     4561 ttaaaagttt tgaaggaaac ctctggataa atggacaagg cctaattttt ttttgtagtc
     4621 aatccaactg tactggccaa tttttgaaat aagattatat gattaggtat tagcagagac
     4681 aaagagttac ctcctccatc ttactctgcc ctatttgaaa gtctcagggg agaaaaggga
     4741 acaagatgct gatccaacct gagtggagtc aggtgaggca tctttacatc taagaatttt
     4801 tttttaaatt ttattattat tatacttcaa gttctagggt acatgtccac aatgcacatg
     4861 tctgtcacac atgcacacat gtgccatgct ggtgtgctgc acccaccaac ctgtcatcca
     4921 gcattaggta tatctcctaa tgctatccct cccctctcca cccaccccac agcaggcccc
     4981 ggtatgtgat gttccccttc gtgtgtccat gtgttcttat tgttcaattc ccacctatga
     5041 gtgagaatat gtggtgtttg gtttttggtc cttgcaatag tttgctgaga atgatggttt
     5101 ccagcttcat ccatgtccct acaaagaaca tgaactcatc attttttatg gctgcatagt
     5161 attccatggt gtatatgtgc cacattttct taatccagtc tatcattgtt ggacatttgg
     5221 gttggttcca agtctttgct attgtgaata gtgctgcaat aaacatatgt gtgcatgtgt
     5281 ctttaaaaaa aaaaa
//
