LOCUS       NM_004464               5313 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 5 (FGF5), transcript variant
            1, mRNA.
ACCESSION   NM_004464
VERSION     NM_004464.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5313)
  AUTHORS   Gao,C., Wang,W. and Jia,H.
  TITLE     Fibroblast growth factor 5 as a target for atrial fibrillation
            treatment: Evidence from mendelian randomization
  JOURNAL   Int J Cardiol 413, 132393 (2024)
   PUBMED   39059473
  REMARK    GeneRIF: Fibroblast growth factor 5 as a target for atrial
            fibrillation treatment: Evidence from mendelian randomization.
REFERENCE   2  (bases 1 to 5313)
  AUTHORS   Zhang,Q., Ding,F., Zhang,C., Han,X. and Cheng,H.
  TITLE     Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the
            Progression of Non-small Cell Lung Cancer via Upregulating the
            Level of FGF5
  JOURNAL   Biochem Genet 61 (5), 1807-1826 (2023)
   PUBMED   36808266
  REMARK    GeneRIF: Circ_0001715 Functions as a miR-1249-3p Sponge to
            Accelerate the Progression of Non-small Cell Lung Cancer via
            Upregulating the Level of FGF5.
REFERENCE   3  (bases 1 to 5313)
  AUTHORS   Wang,J.H., Wu,S.J., Li,Y., Zhao,Y., Liu,Z.M., Deng,S.L. and
            Lian,Z.X.
  TITLE     Improving the Efficiency of Precise Genome Editing with CRISPR/Cas9
            to Generate Goats Overexpressing Human Butyrylcholinesterase
  JOURNAL   Cells 12 (14), 1818 (2023)
   PUBMED   37508483
  REMARK    GeneRIF: Improving the Efficiency of Precise Genome Editing with
            CRISPR/Cas9 to Generate Goats Overexpressing Human
            Butyrylcholinesterase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5313)
  AUTHORS   Cui,S., Li,Y., Zhang,X., Wu,B., Li,M., Gao,J., Xia,H. and Xu,L.
  TITLE     FGF5 protects heart from sepsis injury by attenuating cardiomyocyte
            pyroptosis through inhibiting CaMKII/NFkappaB signaling
  JOURNAL   Biochem Biophys Res Commun 636 (Pt 2), 104-112 (2022)
   PUBMED   36368152
  REMARK    GeneRIF: FGF5 protects heart from sepsis injury by attenuating
            cardiomyocyte pyroptosis through inhibiting CaMKII/NFkappaB
            signaling.
REFERENCE   5  (bases 1 to 5313)
  AUTHORS   Zhang,G., Zheng,H. and Wang,L.
  TITLE     miR-491-3p functions as a tumor suppressor in non-small cell lung
            cancer by targeting fibroblast growth factor 5
  JOURNAL   Oncol Rep 48 (3) (2022)
   PUBMED   35866594
  REMARK    GeneRIF: miR4913p functions as a tumor suppressor in nonsmall cell
            lung cancer by targeting fibroblast growth factor 5.
REFERENCE   6  (bases 1 to 5313)
  AUTHORS   Werner,S., Roth,W.K., Bates,B., Goldfarb,M. and Hofschneider,P.H.
  TITLE     Fibroblast growth factor 5 proto-oncogene is expressed in normal
            human fibroblasts and induced by serum growth factors
  JOURNAL   Oncogene 6 (11), 2137-2144 (1991)
   PUBMED   1658709
REFERENCE   7  (bases 1 to 5313)
  AUTHORS   Bates,B., Hardin,J., Zhan,X., Drickamer,K. and Goldfarb,M.
  TITLE     Biosynthesis of human fibroblast growth factor-5
  JOURNAL   Mol Cell Biol 11 (4), 1840-1845 (1991)
   PUBMED   2005884
REFERENCE   8  (bases 1 to 5313)
  AUTHORS   Haub,O., Drucker,B. and Goldfarb,M.
  TITLE     Expression of the murine fibroblast growth factor 5 gene in the
            adult central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 8022-8026 (1990)
   PUBMED   1700424
REFERENCE   9  (bases 1 to 5313)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 5313)
  AUTHORS   Nguyen,C., Roux,D., Mattei,M.G., de Lapeyriere,O., Goldfarb,M.,
            Birnbaum,D. and Jordan,B.R.
  TITLE     The FGF-related oncogenes hst and int.2, and the bcl.1 locus are
            contained within one megabase in band q13 of chromosome 11, while
            the fgf.5 oncogene maps to 4q21
  JOURNAL   Oncogene 3 (6), 703-708 (1988)
   PUBMED   2577873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021127.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 8, 2020 this sequence version replaced NM_004464.3.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This gene was identified as an oncogene, which confers
            transforming potential when transfected into mammalian cells.
            Targeted disruption of the homolog of this gene in mouse resulted
            in the phenotype of abnormally long hair, which suggested a
            function as an inhibitor of hair elongation. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131502.1, SRR14038192.1263568.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312465.12/ ENSP00000311697.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 2005884
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               AC021127.9         90616-91131
            517-620             AC021127.9         98861-98964
            621-5313            AC021127.9         110277-114969
FEATURES             Location/Qualifiers
     source          1..5313
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..5313
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="fibroblast growth factor 5"
                     /db_xref="GeneID:2250"
                     /db_xref="HGNC:HGNC:3683"
                     /db_xref="MIM:165190"
     exon            1..516
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      49..165
                     /regulatory_class="uORF"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:2005884]"
                     /note="this uORF is predicted to encode a 38 aa peptide
                     (PMID:2005884)"
     regulatory      133..165
                     /regulatory_class="uORF"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:2005884]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:2005884)"
     CDS             162..968
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; heparin-binding growth factor 5"
                     /codon_start=1
                     /product="fibroblast growth factor 5 isoform 1 precursor"
                     /protein_id="NP_004455.2"
                     /db_xref="CCDS:CCDS34021.1"
                     /db_xref="GeneID:2250"
                     /db_xref="HGNC:HGNC:3683"
                     /db_xref="MIM:165190"
                     /translation="MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGS
                     SSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQ
                     IYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDC
                     KFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPR
                     FKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG"
     exon            517..620
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /inference="alignment:Splign:2.1.0"
     exon            621..5313
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1634
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="major polyA site"
     regulatory      4150..4155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: TATAAA"
     regulatory      4157..4162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: ATTACA"
     polyA_site      4171
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="major polyA site"
     polyA_site      4175
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
     regulatory      4222..4227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: AATAAA"
     regulatory      4232..4237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: CATAAA"
     polyA_site      4242
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
     polyA_site      4250
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
     regulatory      4257..4262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
                     /note="hexamer: ATTAAA"
     polyA_site      4281
                     /gene="FGF5"
                     /gene_synonym="HBGF-5; Smag-82; TCMGLY"
ORIGIN      
        1 gctcgggtgg cctctctctt cccctctccc cttctcttcc ccgaggctat gtccacccgg
       61 tgcggcgagg cgggcagagc cagaggcacg cagccgcaca ggggctacag agcccagaat
      121 cagccctaca agatgcactt aggacccccg cggctggaag aatgagcttg tccttcctcc
      181 tcctcctctt cttcagccac ctgatcctca gcgcctgggc tcacggggag aagcgtctcg
      241 cccccaaagg gcaacccgga cccgctgcca ctgataggaa ccctagaggc tccagcagca
      301 gacagagcag cagtagcgct atgtcttcct cttctgcctc ctcctccccc gcagcttctc
      361 tgggcagcca aggaagtggc ttggagcaga gcagtttcca gtggagcccc tcggggcgcc
      421 ggaccggcag cctctactgc agagtgggca tcggtttcca tctgcagatc tacccggatg
      481 gcaaagtcaa tggatcccac gaagccaata tgttaagtgt tttggaaata tttgctgtgt
      541 ctcaggggat tgtaggaata cgaggagttt tcagcaacaa atttttagcg atgtcaaaaa
      601 aaggaaaact ccatgcaagt gccaagttca cagatgactg caagttcagg gagcgttttc
      661 aagaaaatag ctataatacc tatgcctcag caatacatag aactgaaaaa acagggcggg
      721 agtggtatgt ggccctgaat aaaagaggaa aagccaaacg agggtgcagc ccccgggtta
      781 aaccccagca tatctctacc cattttctgc caagattcaa gcagtcggag cagccagaac
      841 tttctttcac ggttactgtt cctgaaaaga aaaagccacc tagccctatc aagccaaaga
      901 ttcccctttc tgcacctcgg aaaaatacca actcagtgaa atacagactc aagtttcgct
      961 ttggataata ttcctcttgg ccttgtgaga aaccattctt tcccctcagg agtttctata
     1021 ggtgtcttca gagttctgaa gaaaaattac tggacacagc ttcagctata cttacactgt
     1081 attgaagtca cgtcatttgt ttcaatgtga ctgaaacaaa atgttttttg ataggaagga
     1141 aactggaatt ctttgtacta atacagggag cacactcctt cagttcagca agacataaag
     1201 ccttttgctt tatgcttgag ggatatttag aactttgtat tttcggaaag ttaaataaca
     1261 gggactacgt atttttctga cttttacaga ttaacctgaa agaacataca tgatacattt
     1321 ttatttttgg tttccaaaga atattttgat gcagataaaa tattttgtta acttttgttt
     1381 ttttttgttt gttttcttaa aagtacctct gcattgagca tattttctta cttttattat
     1441 tttaattaat atgacataag caatcatttt atgctgttta tgaattataa atgtgtttat
     1501 agctcatttg taatatggaa atcttttaca tttttcctat tcactgcact tttttattgt
     1561 ttttatttct agccatacct cagataatat gtttagtttt acattttaaa atgtttaaat
     1621 tctctttcac agcaccaaag gctcagcttg gatttgtgtg tatgtgtatg tcaattcatg
     1681 acattatgtg gaatcctaaa cctttggtgg ctgggatatg atgggttaga agcaaggaga
     1741 aaatataagg actttttgat ggaattaaat gtgggaggta aggaaaagga tttagaggta
     1801 aaagtacact aagtttgcaa catttattga gatctaagtc tgtcttgcct tcatttctct
     1861 ttttatctcc cccttgccct cattcttgaa cagctggagg aatacatttt attctgtcca
     1921 tgaagcatac actatgaaat tcaagtgctt aaaaatactt ctatgactct ctgctatccc
     1981 actgtataga tccacaggga gcaaacactt agaaatgata gagaactgaa ggagatcaat
     2041 ggtttaacag ttatccatgc caagtcccat tgtcagaaat attcttatta ctcagtcaaa
     2101 cactctttga gcttcccttc ctaaaggtaa ccaatccagt gaatagatgt gcccttttat
     2161 aaggaaactt ctgatgttta ttaaaaaaac tggccttttg atagaggtaa cttaatttgg
     2221 gaatttgttg tgttgaaatg gcatttaatt tcaacctaaa tactgactgc tggacataaa
     2281 tcacagaaaa tttaacttaa gaaaatttac aaaatttatt ctcaggtaat cattttaata
     2341 aagttctgca aaatacacgt ttatcttaca ttcagaaatg tggcaaaaaa ggcatagcta
     2401 aaggctaaac atatggcttt agtagtaaca aaagggttca tagaaacttc atggtttgca
     2461 tttaaacatg tttaaagtgt acttataaac tatttttttc ttaaagcaaa ctatgattta
     2521 ttttggtgca caaatacaaa gtggaaactt accaaaattg aactagctac catataagca
     2581 gattgcttta atttgatggg aaaatagtac acacatatat ataacaaata atatattaaa
     2641 aaacccatcc atcaactaaa acattatatg tatacatcag tatagtgttt tattataaag
     2701 ccaattatct gattaagcat tctttccact gaatgcataa tgtttaaata gcataaaatg
     2761 aaatgctaca aaaattgaac taatttatac tttaaagtat ttctgggtta aatgaaacaa
     2821 tgaaattttt tagtatgttc aactctcatc caaatggcat atgaccctgt ttacacagcc
     2881 taaagctaaa aatattactc tagtttattc taatctattg ttaagtattg tgcactgtat
     2941 accaagttct tagggcacat gaaaaatttt agctgccaaa caggaactag taaacatatg
     3001 ttcctaataa gtgaagggaa agataataat gatggtcaac aataagccac gtcaatgcat
     3061 aagttgtata ggctaaatgt tgcttgtagg ctacattaaa ctcaaatgta atagtttatc
     3121 ttatactcct ggtttgattt gattagcata ttaacgtgaa agtaggatag ctactaaata
     3181 tatattatgc aagtcaggaa tcattaattt caaaatttaa agccatgcta aaattaaaaa
     3241 gaaaatatta aattacacaa ttacacttgt ctttactggc catacaaaat gatttttttt
     3301 ttttttttga gacagagtct tgctctgtca ccaggctgga gtgcagtggc atgatctcgg
     3361 ctcactgcaa cctccaactc cctggtttaa gggattctcc tgcctcagcc tcccaagtag
     3421 ctgggattac agactcatgc caccacgcca gctaattttt gtatttttag tagagacggg
     3481 gtttcaccat gttggtcagg atggtctcaa tcctggcctc ttgatagtcc tgacctcatg
     3541 atctgcccac ctcggcctcc ccaaagtgct gggattacag gtacaatgat gtataattaa
     3601 tgcttagtga agcataaagt tacctacatc aattaattaa atgaacttat gtacagaaaa
     3661 catgtataaa tataagtcta tactaatgct tacaactttc taagagggtt cttgcttatg
     3721 tagcttttta ttattttaag taactagaac caccaaatat caaataaaat tatttggtta
     3781 tggttatgtt catctaaaca caacaataac ttttatatta atatttagga gtctattttg
     3841 tctataggtg acaaacatct ccagactaac atgtcagttt tatcaattat attatgttta
     3901 attatttaag atttctttat gtggaacatc tatagagata aatagaaatt ttcaataaga
     3961 tgtagtaaca ctgtgattta tctttcaaga gtctctcttc acttccttct aaagagacta
     4021 atttgagagt acaggtgcat attaattttc ttggttcttt cagctgaatt atattggtcc
     4081 agaagttcaa aatcatgtga caataataag ggatactgac agaagttatt tccaagtttg
     4141 tgtatatatt ataaaaatta catatataaa actaaggctt ttatttctgt tatttttaag
     4201 cttttatttc ttgtagctaa aaataaaaca tcataaatct ggtaggtaaa tttcttatta
     4261 aatcaatctt gaaatagaaa atgtaataac tttcttacca ttaacatttt ttacccttcc
     4321 atagaaggga gggaataaat catgacttat cccattttca ataacaaaac gaaactatgg
     4381 cactaaccaa aaacttgcat tctggcataa tttttacagt tgcagagaat tgtttctggg
     4441 ctcattaaaa aaagtagtat tgcagacatt gctgcaatgg gaagcagaca ataacttctt
     4501 aaaggaattc tacacctcct ttaagattta cttaattgct acatctaaat tctgataatt
     4561 taaaatccat tttaggtgat aaaatttttt aaaagttttg aaggaaacct ctggataaat
     4621 ggacaaggcc taattttttt ttgtagtcaa tccaactgta ctggccaatt tttgaaataa
     4681 gattatatga ttaggtatta gcagagacaa agagttacct cctccatctt actctgccct
     4741 atttgaaagt ctcaggggag aaaagggaac aagatgctga tccaacctga gtggagtcag
     4801 gtgaggcatc tttacatcta agaatttttt tttaaatttt attattatta tacttcaagt
     4861 tctagggtac atgtccacaa tgcacatgtc tgtcacacat gcacacatgt gccatgctgg
     4921 tgtgctgcac ccaccaacct gtcatccagc attaggtata tctcctaatg ctatccctcc
     4981 cctctccacc caccccacag caggccccgg tatgtgatgt tccccttcgt gtgtccatgt
     5041 gttcttattg ttcaattccc acctatgagt gagaatatgt ggtgtttggt ttttggtcct
     5101 tgcaatagtt tgctgagaat gatggtttcc agcttcatcc atgtccctac aaagaacatg
     5161 aactcatcat tttttatggc tgcatagtat tccatggtgt atatgtgcca cattttctta
     5221 atccagtcta tcattgttgg acatttgggt tggttccaag tctttgctat tgtgaatagt
     5281 gctgcaataa acatatgtgt gcatgtgtct tta
//
