LOCUS       NM_002007               3165 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.
ACCESSION   NM_002007
VERSION     NM_002007.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3165)
  AUTHORS   Lin,J., Lin,H.W., Wang,Y.X., Fang,Y., Jiang,H.M., Li,T., Huang,J.,
            Zhang,H.D., Chen,D.Z. and Chen,Y.P.
  TITLE     FGF4 ameliorates the liver inflammation by reducing M1 macrophage
            polarization in experimental autoimmune hepatitis
  JOURNAL   J Transl Med 22 (1), 717 (2024)
   PUBMED   39095789
  REMARK    GeneRIF: FGF4 ameliorates the liver inflammation by reducing M1
            macrophage polarization in experimental autoimmune hepatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3165)
  AUTHORS   Sun,J., Zhou,J., Zhou,J., Xu,W., Du,Y., Jia,Z., Shen,Y., Lin,X.,
            Wang,X., Bao,Y., Rao,Z., Dong,S., Luo,Y., Cong,W., Jin,L. and Li,X.
  TITLE     FGF4 Promotes Skin Wound Repair through p38 MAPK and
            GSK3beta-Mediated Stabilization of Slug
  JOURNAL   J Invest Dermatol 143 (6), 1073-1084 (2023)
   PUBMED   36521556
  REMARK    GeneRIF: FGF4 Promotes Skin Wound Repair through p38 MAPK and
            GSK3beta-Mediated Stabilization of Slug.
REFERENCE   3  (bases 1 to 3165)
  AUTHORS   Jiang,H., Fang,Y., Wang,Y., Li,T., Lin,H., Lin,J., Pan,T., Liu,Q.,
            Lv,J., Chen,D. and Chen,Y.
  TITLE     FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice
            via activation of CISD3
  JOURNAL   Int Immunopharmacol 116, 109762 (2023)
   PUBMED   36702076
  REMARK    GeneRIF: FGF4 improves hepatocytes ferroptosis in autoimmune
            hepatitis mice via activation of CISD3.
REFERENCE   4  (bases 1 to 3165)
  AUTHORS   Urbini,M., Astolfi,A., Indio,V., Nannini,M., Schipani,A.,
            Bacalini,M.G., Angelini,S., Ravegnini,G., Calice,G., Del Gaudio,M.,
            Secchiero,P., Ulivi,P., Gruppioni,E. and Pantaleo,M.A.
  TITLE     Gene duplication, rather than epigenetic changes, drives FGF4
            overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST
  JOURNAL   Sci Rep 10 (1), 19829 (2020)
   PUBMED   33199729
  REMARK    GeneRIF: Gene duplication, rather than epigenetic changes, drives
            FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3165)
  AUTHORS   Zhang,C., Yang,T. and Jiang,H.
  TITLE     miR-511 inhibits proliferation and metastasis of breast cancer
            cells by targeting FGF4
  JOURNAL   J Gene Med 22 (9), e3168 (2020)
   PUBMED   32023352
  REMARK    GeneRIF: miR-511 inhibits proliferation and metastasis of breast
            cancer cells by targeting FGF4.
REFERENCE   6  (bases 1 to 3165)
  AUTHORS   Galland,F., Stefanova,M., Lafage,M. and Birnbaum,D.
  TITLE     Localization of the 5' end of the MCF2 oncogene to human chromosome
            15q15----q23
  JOURNAL   Cytogenet Cell Genet 60 (2), 114-116 (1992)
   PUBMED   1611909
REFERENCE   7  (bases 1 to 3165)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   8  (bases 1 to 3165)
  AUTHORS   Yoshida,T., Miyagawa,K., Odagiri,H., Sakamoto,H., Little,P.F.,
            Terada,M. and Sugimura,T.
  TITLE     Genomic sequence of hst, a transforming gene encoding a protein
            homologous to fibroblast growth factors and the int-2-encoded
            protein
  JOURNAL   Proc Natl Acad Sci U S A 84 (20), 7305-7309 (1987)
   PUBMED   2959959
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1988 Mar;85(6):1967]
REFERENCE   9  (bases 1 to 3165)
  AUTHORS   Delli Bovi,P., Curatola,A.M., Kern,F.G., Greco,A., Ittmann,M. and
            Basilico,C.
  TITLE     An oncogene isolated by transfection of Kaposi's sarcoma DNA
            encodes a growth factor that is a member of the FGF family
  JOURNAL   Cell 50 (5), 729-737 (1987)
   PUBMED   2957062
REFERENCE   10 (bases 1 to 3165)
  AUTHORS   Taira,M., Yoshida,T., Miyagawa,K., Sakamoto,H., Terada,M. and
            Sugimura,T.
  TITLE     cDNA sequence of human transforming gene hst and identification of
            the coding sequence required for transforming activity
  JOURNAL   Proc Natl Acad Sci U S A 84 (9), 2980-2984 (1987)
   PUBMED   2953031
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M17446.1, CN429959.1,
            AW340506.1, AP001888.4, BF510715.1 and AA974433.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002007.3.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities and are involved in a
            variety of biological processes including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This gene was identified by its oncogenic transforming
            activity. This gene and FGF3, another oncogenic growth factor, are
            located closely on chromosome 11. Co-amplification of both genes
            was found in various kinds of human tumors. Studies on the mouse
            homolog suggested a function in bone morphogenesis and limb
            development through the sonic hedgehog (SHH) signaling pathway.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M17446.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2148093 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000168712.3/ ENSP00000168712.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               M17446.1           64-213
            151-520             CN429959.1         138-507
            521-930             M17446.1           583-992
            931-1017            AW340506.1         325-411
            1018-1158           M17446.1           1079-1219
            1159-2550           AP001888.4         133125-134516       c
            2551-3157           BF510715.1         18-624              c
            3158-3165           AA974433.1         37-44               c
FEATURES             Location/Qualifiers
     source          1..3165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..3165
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
                     /note="fibroblast growth factor 4"
                     /db_xref="GeneID:2249"
                     /db_xref="HGNC:HGNC:3682"
                     /db_xref="MIM:164980"
     exon            1..597
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..878
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
                     /note="heparin secretory transforming protein 1; oncogene
                     HST; human stomach cancer, transforming factor from
                     FGF-related oncogene; kaposi sarcoma oncogene;
                     transforming protein KS3; heparin-binding growth factor 4"
                     /codon_start=1
                     /product="fibroblast growth factor 4 precursor"
                     /protein_id="NP_001998.1"
                     /db_xref="CCDS:CCDS8194.1"
                     /db_xref="GeneID:2249"
                     /db_xref="HGNC:HGNC:3682"
                     /db_xref="MIM:164980"
                     /translation="MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELE
                     RRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDG
                     RIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEI
                     LLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL"
     exon            598..701
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
                     /inference="alignment:Splign:2.1.0"
     exon            702..3165
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3136..3141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
                     /note="hexamer: ATTAAA"
     regulatory      3146..3151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
                     /note="hexamer: ATTAAA"
     polyA_site      3157
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
     polyA_site      3165
                     /gene="FGF4"
                     /gene_synonym="FGF-4; HBGF-4; HST; HST-1; HSTF-1; HSTF1;
                     K-FGF; KFGF"
                     /note="major polyA site"
ORIGIN      
        1 ctggcgctca gggaggcgcg cactgctcct cagagtccca gctccagccg cgcgctttcc
       61 gcccggctcg ccgctccatg cagccggggt agagcccggc gcccgggggc cccgtcgctt
      121 gcctcccgca cctcctcggt tgcgcactcc tgcccgaggt cggccgtgcg ctcccgcggg
      181 acgccacagg cgcagctctg ccccccagct tcccgggcgc actgaccgcc tgaccgacgc
      241 acggccctcg ggccgggatg tcggggcccg ggacggccgc ggtagcgctg ctcccggcgg
      301 tcctgctggc cttgctggcg ccctgggcgg gccgaggggg cgccgccgca cccactgcac
      361 ccaacggcac gctggaggcc gagctggagc gccgctggga gagcctggtg gcgctctcgt
      421 tggcgcgcct gccggtggca gcgcagccca aggaggcggc cgtccagagc ggcgccggcg
      481 actacctgct gggcatcaag cggctgcggc ggctctactg caacgtgggc atcggcttcc
      541 acctccaggc gctccccgac ggccgcatcg gcggcgcgca cgcggacacc cgcgacagcc
      601 tgctggagct ctcgcccgtg gagcggggcg tggtgagcat cttcggcgtg gccagccggt
      661 tcttcgtggc catgagcagc aagggcaagc tctatggctc gcccttcttc accgatgagt
      721 gcacgttcaa ggagattctc cttcccaaca actacaacgc ctacgagtcc tacaagtacc
      781 ccggcatgtt catcgccctg agcaagaatg ggaagaccaa gaaggggaac cgagtgtcgc
      841 ccaccatgaa ggtcacccac ttcctcccca ggctgtgacc ctccagagga cccttgcctc
      901 agcctcggga agcccctggg agggcagtgc cgagggtcac cttggtgcac tttcttcgga
      961 tgaagagttt aatgcaagag taggtgtaag atatttaaat taattattta aatgtgtata
     1021 tattgccacc aaattattta tagttctgcg ggtgtgtttt ttaattttct ggggggaaaa
     1081 aaagacaaaa caaaaaacca actctgactt ttctggtgca acagtggaga atcttaccat
     1141 tggatttctt taacttgtca aaagttgtca cgagtgtgct gctattctgt gttttaaaaa
     1201 aaggtgacat tggattccga tgtcatcccc tgtagtatgg cgtggagcat ctctgtctgg
     1261 aaaggcccgc ctgaggcttg ggcagccagt tcagggagct cccaggcttg gctctcggct
     1321 agcatcctca gaggcccact ccctttgtgc cctgttgcta ttaatcggga catatcggtt
     1381 tacttcgggt acagaaagtg cggtgttgaa gtcctcgctg ccactctgtt tttagatctg
     1441 ccaagactga cctttgaact ttcctgtagt caatcttcct cgatctacca gatgggagag
     1501 acccttggac aactttataa actcctgttt gccttttttg gatcagcgac agcccccatc
     1561 gctgtgacta ttggggaaaa gacgaagctc tttcataaat tccatggaga ggaatcaata
     1621 tcccactgga aggctagaaa tggacaagat agtgtatttg caatcacaaa caaaacccta
     1681 gtgatgaaaa ataatttgtg atggcagatg cttctgatgg tgtgatagaa tatgtttttg
     1741 aaaacaaacc atcgaacccc ccgccccacc cccaaaacgg gcttccctgt gtttagggag
     1801 ctttgggcta gaactagcta cgatttttag gtgaaatgtc cttgtaattg tacaaagcac
     1861 ttggtgcagt gtttgcgtgg agcagcctgc tgctttctga tgcattccct gtttaagtgc
     1921 gtttaacatc tacctcacaa gccctgaaac cccaggcaaa acccacagaa agctcatacc
     1981 cggtgcagga gtttgccatc ccaagtggct ttttttccat atgtagccaa aaaggattgc
     2041 agatagcgtc ggtgcgtccc attcgaacct tgtcacgttt gagctatctt taccctgtga
     2101 tttactttta gtaagggtga tcatggtgaa aatatttgca gacagctgtt acagtacact
     2161 atatggtcac caagtaacct tatatttttc tttatatatt ttacaaatgt aacccctgtc
     2221 attgaagcaa ccgtggaaga ggcagggtcg gtgatgttta aaaaaagttc cgaggtgatg
     2281 gcaaacattt aattttaatg aatgactttt tagagtttat acaaaatgac cttagcttgc
     2341 taccagaaat gctccgaatg tttcgtcaag actttaatac tctcctagga tgtttctgaa
     2401 ctgtctcccg aattaacttt atgggagtct acagacagca agactggaaa atctgattgg
     2461 agtttttgtc tttcacattc cttttgaaaa ctctttgttc gaatgcaaat catcgactta
     2521 aaatactatt cttaaccaag gcctggaaga aagaagacac ttgcaaagcc gctaagacag
     2581 gaccacacat cttaaactgc tgttcctacc atgcactaaa ctgtttttaa gttttaaacc
     2641 acaccctagg ctccaggagt gttcaggaaa gatggtgttt gtaggtctcc atgctgtttg
     2701 gcgttggggg gtgtggaggg atcatccgtc gactttctga attttaatgt attcacttag
     2761 taacaaacca tgattgtctt aaatgcctta aattattatg agatttcttg tctcagagcc
     2821 caatcagatt gtcaggaatt aacatgtgtt aggtttgatc acccttgacc acttcttata
     2881 gatatttctt caacaaatca tgtgtgatgc ctgtaggaac acaactgtac ctttaaaata
     2941 ttgttttcat attgctgtga tggggattcg aggttcctgt atgtgccact gttttcagaa
     3001 tctgtagttt tatacaggtg ccgaccctcg ttgtgatgta tgtgctgtgc acattgacat
     3061 gctgaccgac aatgataagc gtttatcgtg tataaaaaga caccactgga ctggatgtac
     3121 acaactggga aaggaattaa aagctattaa aattgtgcct tgaaa
//
