LOCUS       NM_020637               1329 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens fibroblast growth factor 22 (FGF22), transcript
            variant 1, mRNA.
ACCESSION   NM_020637
VERSION     NM_020637.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Zhang,Z., Qin,Y., Ji,S., Xu,W., Liu,M., Hu,Q., Ye,Z., Fan,G.,
            Yu,X., Liu,W. and Xu,X.
  TITLE     FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer
            cells via FGF22/FGFR2 promotes invasion and metastasis of
            pancreatic cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (8), 997-1008 (2021)
   PUBMED   34117747
  REMARK    GeneRIF: FGFBP1-mediated crosstalk between fibroblasts and
            pancreatic cancer cells via FGF22/FGFR2 promotes invasion and
            metastasis of pancreatic cancer.
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Liu,H.Y., Zhao,H. and Li,W.X.
  TITLE     Integrated Analysis of Transcriptome and Prognosis Data Identifies
            FGF22 as a Prognostic Marker of Lung Adenocarcinoma
  JOURNAL   Technol Cancer Res Treat 18, 1533033819827317 (2019)
   PUBMED   30803369
  REMARK    GeneRIF: High FGF22 expression is associated with Lung
            Adenocarcinoma.
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Yang,H., Tian,H., Cheng,J., Zheng,J., Wang,D., Sun,C., Fernig,D.,
            Chen,T., Gong,W., Wang,S., Li,X. and Jiang,C.
  TITLE     Highly efficient production of functional recombinant human
            fibroblast growth factor 22 in E. coli and its protective effects
            on H2O2-lesioned L02cells
  JOURNAL   Protein Expr Purif 152, 114-121 (2018)
   PUBMED   29627393
  REMARK    GeneRIF: FGF22 displays protective, antioxidant, and mitogenic
            effect on mammalian cells.
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Xu,Y.H., Yu,M., Wei,H., Yao,S., Chen,S.Y., Zhu,X.L. and Li,Y.F.
  TITLE     Fibroblast growth factor 22 is a novel modulator of depression
            through interleukin-1beta
  JOURNAL   CNS Neurosci Ther 23 (11), 907-916 (2017)
   PUBMED   28948716
  REMARK    GeneRIF: This study showed that serum FGF22 levels in depressive
            patients were negatively correlated with serum IL-1beta levels. In
            animal and cell experiments, enhancing the levels of FGF22 in rat
            hippocampus was demonstrated to alleviate the chronic unpredictable
            mild stress-induced depression. The increase in FGF22 was found to
            be associated with reduced IL-1beta expression and hippocampal
            apoptosis.
REFERENCE   5  (bases 1 to 1329)
  AUTHORS   Moffa,A.B. and Ethier,S.P.
  TITLE     Differential signal transduction of alternatively spliced FGFR2
            variants expressed in human mammary epithelial cells
  JOURNAL   J Cell Physiol 210 (3), 720-731 (2007)
   PUBMED   17133345
REFERENCE   6  (bases 1 to 1329)
  AUTHORS   Koyasu,S.
  TITLE     The role of PI3K in immune cells
  JOURNAL   Nat Immunol 4 (4), 313-319 (2003)
   PUBMED   12660731
  REMARK    Review article
REFERENCE   7  (bases 1 to 1329)
  AUTHORS   Hart,K.C., Robertson,S.C. and Donoghue,D.J.
  TITLE     Identification of tyrosine residues in constitutively activated
            fibroblast growth factor receptor 3 involved in mitogenesis, Stat
            activation, and phosphatidylinositol 3-kinase activation
  JOURNAL   Mol Biol Cell 12 (4), 931-942 (2001)
   PUBMED   11294897
REFERENCE   8  (bases 1 to 1329)
  AUTHORS   Nakatake,Y., Hoshikawa,M., Asaki,T., Kassai,Y. and Itoh,N.
  TITLE     Identification of a novel fibroblast growth factor, FGF-22,
            preferentially expressed in the inner root sheath of the hair
            follicle
  JOURNAL   Biochim Biophys Acta 1517 (3), 460-463 (2001)
   PUBMED   11342227
REFERENCE   9  (bases 1 to 1329)
  AUTHORS   Carpenter,G. and Ji,Qs.
  TITLE     Phospholipase C-gamma as a signal-transducing element
  JOURNAL   Exp Cell Res 253 (1), 15-24 (1999)
   PUBMED   10579907
  REMARK    Review article
REFERENCE   10 (bases 1 to 1329)
  AUTHORS   Mohammadi,M., Dikic,I., Sorokin,A., Burgess,W.H., Jaye,M. and
            Schlessinger,J.
  TITLE     Identification of six novel autophosphorylation sites on fibroblast
            growth factor receptor 1 and elucidation of their importance in
            receptor activation and signal transduction
  JOURNAL   Mol Cell Biol 16 (3), 977-989 (1996)
   PUBMED   8622701
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004449.1.
            
            On Dec 3, 2019 this sequence version replaced NM_020637.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities and are involved in a
            variety of biological processes including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. The mouse homolog of this gene was found to be
            preferentially expressed in the inner root sheath of the hair
            follicle, which suggested a role in hair development. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137445.1, AY359084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215530.7/ ENSP00000215530.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC004449.1         28943-29203
            262-365             AC004449.1         32299-32402
            366-1329            AC004449.1         32474-33437
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1329
                     /gene="FGF22"
                     /note="fibroblast growth factor 22"
                     /db_xref="GeneID:27006"
                     /db_xref="HGNC:HGNC:3679"
                     /db_xref="MIM:605831"
     exon            1..261
                     /gene="FGF22"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..560
                     /gene="FGF22"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; FGF-22"
                     /codon_start=1
                     /product="fibroblast growth factor 22 isoform 1 precursor"
                     /protein_id="NP_065688.1"
                     /db_xref="CCDS:CCDS12037.1"
                     /db_xref="GeneID:27006"
                     /db_xref="HGNC:HGNC:3679"
                     /db_xref="MIM:605831"
                     /translation="MRRRLWLGLAWLLLARAPDAAGTPSASRGPRSYPHLEGDVRWRR
                     LFSSTHFFLRVDPGGRVQGTRWRHGQDSILEIRSVHVGVVVIKAVSSGFYVAMNRRGR
                     LYGSRLYTVDCRFRERIEENGHNTYASQRWRRRGQPMFLALDRRGGPRPGGRTRRYHL
                     SAHFLPVLVS"
     exon            262..365
                     /gene="FGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            366..1329
                     /gene="FGF22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1308..1313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF22"
                     /note="hexamer: AATAAA"
     polyA_site      1329
                     /gene="FGF22"
                     /note="major polyA site"
ORIGIN      
        1 gcggacgccc gggagcgacg agcgcgcagc gaaccgggtg ccgggtcatg cgccgccgcc
       61 tgtggctggg cctggcctgg ctgctgctgg cgcgggcgcc ggacgccgcg ggaaccccga
      121 gcgcgtcgcg gggaccgcgc agctacccgc acctggaggg cgacgtgcgc tggcggcgcc
      181 tcttctcctc cactcacttc ttcctgcgcg tggatcccgg cggccgcgtg cagggcaccc
      241 gctggcgcca cggccaggac agcatcctgg agatccgctc tgtacacgtg ggcgtcgtgg
      301 tcatcaaagc agtgtcctca ggcttctacg tggccatgaa ccgccggggc cgcctctacg
      361 ggtcgcgact ctacaccgtg gactgcaggt tccgggagcg catcgaagag aacggccaca
      421 acacctacgc ctcacagcgc tggcgccgcc gcggccagcc catgttcctg gcgctggaca
      481 ggaggggggg gccccggcca ggcggccgga cgcggcggta ccacctgtcc gcccacttcc
      541 tgcccgtcct ggtctcctga ggccctgaga ggccggcggc tccccaaggt gcctgggctg
      601 gtggcgaggg gcccggccac gcttgttctt ccccctgcgg gctctgtaag cgctgagtgc
      661 ccaccgtgtg cgggcgctgt ggacacagcc caggagccct ccaggggggt cccagcctga
      721 gggggtggtg gccaccaagc aggttcaatc ctgagttggg gacctcgagg acccaacagg
      781 gcgcctctcg ggctgaagga cgcagacgtc gaaaggtcga gggggacgtc ccaggcaggg
      841 cccggcagag gcaggggctc ggggtgggga gcacgttggg agtgggggca ggagcggagg
      901 ggaggggagg gggccgggga gacggtgaca gacgccgcag aacaccagcc tcgaagccgg
      961 tcccgtcccg ggaatctgca aatacaacgc cttgcgagga caaaggcacc tgcaggtggg
     1021 acggagatgg aggagcatcc agggtggggg gtccagggcc ccagtgtcct cacagggtcc
     1081 tcacgacagg aggcgggaca gtgagagcca gagagagatg gggatgggcc gcgctgtggc
     1141 cgtgaagggg aggaagggcc ctaagctgag ggacgtgggt gcctccagat gctggggaag
     1201 gcgggaacgg ttccgcactg gagcccccgg gagggaccgg cctgctcctg ccttgatatg
     1261 agcccagtgg gacccagttt ggactctggc ctccagaacc gccagaaaat aaacgtagta
     1321 agccatcaa
//
