LOCUS       NP_065688                170 aa            linear   PRI 30-APR-2025
DEFINITION  fibroblast growth factor 22 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_065688
VERSION     NP_065688.1
DBSOURCE    REFSEQ: accession NM_020637.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 170)
  AUTHORS   Zhang,Z., Qin,Y., Ji,S., Xu,W., Liu,M., Hu,Q., Ye,Z., Fan,G.,
            Yu,X., Liu,W. and Xu,X.
  TITLE     FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer
            cells via FGF22/FGFR2 promotes invasion and metastasis of
            pancreatic cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (8), 997-1008 (2021)
   PUBMED   34117747
  REMARK    GeneRIF: FGFBP1-mediated crosstalk between fibroblasts and
            pancreatic cancer cells via FGF22/FGFR2 promotes invasion and
            metastasis of pancreatic cancer.
REFERENCE   2  (residues 1 to 170)
  AUTHORS   Liu,H.Y., Zhao,H. and Li,W.X.
  TITLE     Integrated Analysis of Transcriptome and Prognosis Data Identifies
            FGF22 as a Prognostic Marker of Lung Adenocarcinoma
  JOURNAL   Technol Cancer Res Treat 18, 1533033819827317 (2019)
   PUBMED   30803369
  REMARK    GeneRIF: High FGF22 expression is associated with Lung
            Adenocarcinoma.
REFERENCE   3  (residues 1 to 170)
  AUTHORS   Yang,H., Tian,H., Cheng,J., Zheng,J., Wang,D., Sun,C., Fernig,D.,
            Chen,T., Gong,W., Wang,S., Li,X. and Jiang,C.
  TITLE     Highly efficient production of functional recombinant human
            fibroblast growth factor 22 in E. coli and its protective effects
            on H2O2-lesioned L02cells
  JOURNAL   Protein Expr Purif 152, 114-121 (2018)
   PUBMED   29627393
  REMARK    GeneRIF: FGF22 displays protective, antioxidant, and mitogenic
            effect on mammalian cells.
REFERENCE   4  (residues 1 to 170)
  AUTHORS   Xu,Y.H., Yu,M., Wei,H., Yao,S., Chen,S.Y., Zhu,X.L. and Li,Y.F.
  TITLE     Fibroblast growth factor 22 is a novel modulator of depression
            through interleukin-1beta
  JOURNAL   CNS Neurosci Ther 23 (11), 907-916 (2017)
   PUBMED   28948716
  REMARK    GeneRIF: This study showed that serum FGF22 levels in depressive
            patients were negatively correlated with serum IL-1beta levels. In
            animal and cell experiments, enhancing the levels of FGF22 in rat
            hippocampus was demonstrated to alleviate the chronic unpredictable
            mild stress-induced depression. The increase in FGF22 was found to
            be associated with reduced IL-1beta expression and hippocampal
            apoptosis.
REFERENCE   5  (residues 1 to 170)
  AUTHORS   Moffa,A.B. and Ethier,S.P.
  TITLE     Differential signal transduction of alternatively spliced FGFR2
            variants expressed in human mammary epithelial cells
  JOURNAL   J Cell Physiol 210 (3), 720-731 (2007)
   PUBMED   17133345
REFERENCE   6  (residues 1 to 170)
  AUTHORS   Koyasu,S.
  TITLE     The role of PI3K in immune cells
  JOURNAL   Nat Immunol 4 (4), 313-319 (2003)
   PUBMED   12660731
  REMARK    Review article
REFERENCE   7  (residues 1 to 170)
  AUTHORS   Hart,K.C., Robertson,S.C. and Donoghue,D.J.
  TITLE     Identification of tyrosine residues in constitutively activated
            fibroblast growth factor receptor 3 involved in mitogenesis, Stat
            activation, and phosphatidylinositol 3-kinase activation
  JOURNAL   Mol Biol Cell 12 (4), 931-942 (2001)
   PUBMED   11294897
REFERENCE   8  (residues 1 to 170)
  AUTHORS   Nakatake,Y., Hoshikawa,M., Asaki,T., Kassai,Y. and Itoh,N.
  TITLE     Identification of a novel fibroblast growth factor, FGF-22,
            preferentially expressed in the inner root sheath of the hair
            follicle
  JOURNAL   Biochim Biophys Acta 1517 (3), 460-463 (2001)
   PUBMED   11342227
REFERENCE   9  (residues 1 to 170)
  AUTHORS   Carpenter,G. and Ji,Qs.
  TITLE     Phospholipase C-gamma as a signal-transducing element
  JOURNAL   Exp Cell Res 253 (1), 15-24 (1999)
   PUBMED   10579907
  REMARK    Review article
REFERENCE   10 (residues 1 to 170)
  AUTHORS   Mohammadi,M., Dikic,I., Sorokin,A., Burgess,W.H., Jaye,M. and
            Schlessinger,J.
  TITLE     Identification of six novel autophosphorylation sites on fibroblast
            growth factor receptor 1 and elucidation of their importance in
            receptor activation and signal transduction
  JOURNAL   Mol Cell Biol 16 (3), 977-989 (1996)
   PUBMED   8622701
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004449.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities and are involved in a
            variety of biological processes including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. The mouse homolog of this gene was found to be
            preferentially expressed in the inner root sheath of the hair
            follicle, which suggested a role in hair development. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137445.1, AY359084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215530.7/ ENSP00000215530.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..170
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     Protein         1..170
                     /product="fibroblast growth factor 22 isoform 1 precursor"
                     /note="FGF-22"
                     /calculated_mol_wt=17174
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2507
     Region          35..168
                     /region_name="beta-trefoil_FGF"
                     /note="FGF domain, beta-trefoil fold, found in acidic and
                     basic fibroblast growth factor (FGF) superfamily; cl00060"
                     /db_xref="CDD:469595"
     CDS             1..170
                     /gene="FGF22"
                     /coded_by="NM_020637.2:48..560"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS12037.1"
                     /db_xref="GeneID:27006"
                     /db_xref="HGNC:HGNC:3679"
                     /db_xref="MIM:605831"
ORIGIN      
        1 mrrrlwlgla wlllarapda agtpsasrgp rsyphlegdv rwrrlfssth fflrvdpggr
       61 vqgtrwrhgq dsileirsvh vgvvvikavs sgfyvamnrr grlygsrlyt vdcrfrerie
      121 enghntyasq rwrrrgqpmf laldrrggpr pggrtrryhl sahflpvlvs
//
