LOCUS       NM_019113               1347 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens fibroblast growth factor 21 (FGF21), mRNA.
ACCESSION   NM_019113 XM_005258731
VERSION     NM_019113.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Kim,E., Moore,A.E., Dulnoan,D. and Hampson,G.
  TITLE     Effect of Fibroblast Growth Factor (FGF) 19 and 21 on Hip Geometry
            and Strength in Post-menopausal Osteoporosis (PMO)
  JOURNAL   Calcif Tissue Int 115 (5), 562-569 (2024)
   PUBMED   39341924
  REMARK    GeneRIF: Effect of Fibroblast Growth Factor (FGF) 19 and 21 on Hip
            Geometry and Strength in Post-menopausal Osteoporosis (PMO).
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Zhou,D., Shi,Y., Zhang,D., Zuo,J., Zeng,C., Mamtawla,G., Huang,L.,
            Gao,X., Zhang,L. and Wang,X.
  TITLE     Liver-secreted FGF21 induces sarcopenia by inhibiting satellite
            cell myogenesis via klotho beta in decompensated cirrhosis
  JOURNAL   Redox Biol 76, 103333 (2024)
   PUBMED   39226764
  REMARK    GeneRIF: Liver-secreted FGF21 induces sarcopenia by inhibiting
            satellite cell myogenesis via klotho beta in decompensated
            cirrhosis.
REFERENCE   3  (bases 1 to 1347)
  AUTHORS   Trusz,G.J.
  TITLE     Fibroblast growth factor 21
  JOURNAL   Differentiation 139, 100793 (2024)
   PUBMED   38991938
  REMARK    GeneRIF: Fibroblast growth factor 21.
            Review article
REFERENCE   4  (bases 1 to 1347)
  AUTHORS   Fiorenza,M., Checa,A., Sandsdal,R.M., Jensen,S.B.K., Juhl,C.R.,
            Noer,M.H., Bogh,N.P., Lundgren,J.R., Janus,C., Stallknecht,B.M.,
            Holst,J.J., Madsbad,S., Wheelock,C.E. and Torekov,S.S.
  TITLE     Weight-loss maintenance is accompanied by interconnected
            alterations in circulating FGF21-adiponectin-leptin and bioactive
            sphingolipids
  JOURNAL   Cell Rep Med 5 (7), 101629 (2024)
   PUBMED   38959886
  REMARK    GeneRIF: Weight-loss maintenance is accompanied by interconnected
            alterations in circulating FGF21-adiponectin-leptin and bioactive
            sphingolipids.
REFERENCE   5  (bases 1 to 1347)
  AUTHORS   Ogawa,Y., Kurosu,H., Yamamoto,M., Nandi,A., Rosenblatt,K.P.,
            Goetz,R., Eliseenkova,A.V., Mohammadi,M. and Kuro-o,M.
  TITLE     BetaKlotho is required for metabolic activity of fibroblast growth
            factor 21
  JOURNAL   Proc Natl Acad Sci U S A 104 (18), 7432-7437 (2007)
   PUBMED   17452648
  REMARK    GeneRIF: klotho beta functions as a cofactor essential for FGF21
            activity
REFERENCE   6  (bases 1 to 1347)
  AUTHORS   Kharitonenkov,A., Wroblewski,V.J., Koester,A., Chen,Y.F.,
            Clutinger,C.K., Tigno,X.T., Hansen,B.C., Shanafelt,A.B. and
            Etgen,G.J.
  TITLE     The metabolic state of diabetic monkeys is regulated by fibroblast
            growth factor-21
  JOURNAL   Endocrinology 148 (2), 774-781 (2007)
   PUBMED   17068132
  REMARK    GeneRIF: When administered daily for 6 wk to diabetic rhesus
            monkeys, FGF-21 caused a dramatic decline in fasting plasma
            glucose, fructosamine, triglycerides, insulin, and glucagon.
REFERENCE   7  (bases 1 to 1347)
  AUTHORS   Kharitonenkov,A., Shiyanova,T.L., Koester,A., Ford,A.M.,
            Micanovic,R., Galbreath,E.J., Sandusky,G.E., Hammond,L.J.,
            Moyers,J.S., Owens,R.A., Gromada,J., Brozinick,J.T., Hawkins,E.D.,
            Wroblewski,V.J., Li,D.S., Mehrbod,F., Jaskunas,S.R. and
            Shanafelt,A.B.
  TITLE     FGF-21 as a novel metabolic regulator
  JOURNAL   J Clin Invest 115 (6), 1627-1635 (2005)
   PUBMED   15902306
REFERENCE   8  (bases 1 to 1347)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 1347)
  AUTHORS   Popovici,C., Conchonaud,F., Birnbaum,D. and Roubin,R.
  TITLE     Functional phylogeny relates LET-756 to fibroblast growth factor 9
  JOURNAL   J Biol Chem 279 (38), 40146-40152 (2004)
   PUBMED   15199049
REFERENCE   10 (bases 1 to 1347)
  AUTHORS   Nishimura,T., Nakatake,Y., Konishi,M. and Itoh,N.
  TITLE     Identification of a novel FGF, FGF-21, preferentially expressed in
            the liver
  JOURNAL   Biochim Biophys Acta 1492 (1), 203-206 (2000)
   PUBMED   10858549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009002.5 and BC018404.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_019113.3.
            
            Summary: Theis gene encodes a member of the fibroblast growth
            factor (FGF) family. FGF family members possess broad mitogenic and
            cell survival activities and are involved in a variety of
            biological processes. This protein is a secreted endocrine factor
            that functions as a major metabolic regulator. The encoded protein
            stimulates the uptake of glucose in adipose tissue. [provided by
            RefSeq, Mar 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018404.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000593756.6/ ENSP00000471477.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC009002.5         12370-12404         c
            36-642              BC018404.1         1-607
            643-643             AC009002.5         11656-11656         c
            644-1127            BC018404.1         609-1092
            1128-1128           AC009002.5         9817-9817           c
            1129-1334           BC018404.1         1094-1299
            1335-1335           AC009002.5         9610-9610           c
            1336-1347           BC018404.1         1301-1312
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1347
                     /gene="FGF21"
                     /note="fibroblast growth factor 21"
                     /db_xref="GeneID:26291"
                     /db_xref="HGNC:HGNC:3678"
                     /db_xref="MIM:609436"
     exon            1..261
                     /gene="FGF21"
                     /inference="alignment:Splign:2.1.0"
     exon            262..842
                     /gene="FGF21"
                     /inference="alignment:Splign:2.1.0"
     CDS             608..1237
                     /gene="FGF21"
                     /codon_start=1
                     /product="fibroblast growth factor 21 precursor"
                     /protein_id="NP_061986.1"
                     /db_xref="CCDS:CCDS12734.1"
                     /db_xref="GeneID:26291"
                     /db_xref="HGNC:HGNC:3678"
                     /db_xref="MIM:609436"
                     /translation="MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQV
                     RQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFL
                     CQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRG
                     PARFLPLPGLPPALPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS"
     exon            843..946
                     /gene="FGF21"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1347
                     /gene="FGF21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1323..1328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF21"
                     /note="hexamer: AATAAA"
     polyA_site      1347
                     /gene="FGF21"
                     /note="major polyA site"
ORIGIN      
        1 acagatgagg ttgaggttgg cccacggcca ggtgagaggc ttccaaggca ggatacttgt
       61 gtctcagatg cggtcgcttc tttcatacag caattgccgc cttgctgagg atcaaggaac
      121 ctcagtgtca gatcacgccc tccccccaaa cttagaaatt cagatggggc gcagaaattt
      181 ctcttgttct gcgtgatctg catagatggt ccaagaggtg gtttttccag gagcccagca
      241 cccctcctcc ctccgactca gacccaggag tctggccctc cattgaaagg accccaggtt
      301 acatcatcca ttcaggctgc ccttgccacg atggaattct gtagctcctg ccaaatgggt
      361 caaatatcat ggttcaggcg cagggagggt gattgggcgg gcctgtctgg gtataaattc
      421 tggagcttct gcatctatcc caaaaaacaa gggtgttctg tcagctgagg atccagccga
      481 aagaggagcc aggcactcag gccacctgag tctactcacc tggacaactg gaatctggca
      541 ccaattctaa accactcagc ttctccgagc tcacaccccg gagatcacct gaggacccga
      601 gccattgatg gactcggacg agaccgggtt cgagcactca ggactgtggg tttctgtgct
      661 ggctggtctt ctgctgggag cctgccaggc acaccccatc cctgactcca gtcctctcct
      721 gcaattcggg ggccaagtcc ggcagcggta cctctacaca gatgatgccc agcagacaga
      781 agcccacctg gagatcaggg aggatgggac ggtggggggc gctgctgacc agagccccga
      841 aagtctcctg cagctgaaag ccttgaagcc gggagttatt caaatcttgg gagtcaagac
      901 atccaggttc ctgtgccagc ggccagatgg ggccctgtat ggatcgctcc actttgaccc
      961 tgaggcctgc agcttccggg agctgcttct tgaggacgga tacaatgttt accagtccga
     1021 agcccacggc ctcccgctgc acctgccagg gaacaagtcc ccacaccggg accctgcacc
     1081 ccgaggacca gctcgcttcc tgccactacc aggcctgccc cccgcactcc cggagccacc
     1141 cggaatcctg gccccccagc cccccgatgt gggctcctcg gaccctctga gcatggtggg
     1201 accttcccag ggccgaagcc ccagctacgc ttcctgaagc cagaggctgt ttactatgac
     1261 atctcctctt tatttattag gttatttatc ttatttattt ttttattttt cttacttgag
     1321 ataataaaga gttccagagg aggataa
//
