LOCUS       NM_019851               1840 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 20 (FGF20), mRNA.
ACCESSION   NM_019851
VERSION     NM_019851.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Van Greenen,J.D. and Hockman,D.
  TITLE     FGF20.
  JOURNAL   Differentiation 139, 100737 (2024)
   PUBMED   38007375
  REMARK    GeneRIF: FGF20.
            Review article
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Hecker,J., Chun,S., Samiei,A., Liu,C., Laurie,C., Kachroo,P.,
            Lutz,S.M., Lee,S., Smith,A.V., Lasky-Su,J., Cho,M.H., Sharma,S.,
            Soto Quiros,M.E., Avila,L., Celedon,J.C., Raby,B., Zhou,X.,
            Silverman,E.K., DeMeo,D.L., Lange,C. and Weiss,S.T.
  CONSRTM   NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
  TITLE     FGF20 and PGM2 variants are associated with childhood asthma in
            family-based whole-genome sequencing studies
  JOURNAL   Hum Mol Genet 32 (4), 696-707 (2023)
   PUBMED   36255742
  REMARK    GeneRIF: FGF20 and PGM2 variants are associated with childhood
            asthma in family-based whole-genome sequencing studies.
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Cai,X., Tao,W. and Li,L.
  TITLE     Glioma cell-derived FGF20 suppresses macrophage function by
            activating beta-catenin
  JOURNAL   Cell Signal 89, 110181 (2022)
   PUBMED   34757019
  REMARK    GeneRIF: Glioma cell-derived FGF20 suppresses macrophage function
            by activating beta-catenin.
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Pu,J.L., Lin,Z.H., Zheng,R., Yan,Y.Q., Xue,N.J., Yin,X.Z. and
            Zhang,B.R.
  TITLE     Association analysis of SYT11, FGF20, GCH1 rare variants in
            Parkinson's disease
  JOURNAL   CNS Neurosci Ther 28 (1), 175-177 (2022)
   PUBMED   34674384
  REMARK    GeneRIF: Association analysis of SYT11, FGF20, GCH1 rare variants
            in Parkinson's disease.
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   Chiang,H.L., Wu,Y.R., Chen,Y.C., Fung,H.C. and Chen,C.M.
  TITLE     Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson's
            Disease in Asian Population: A Meta-Analysis
  JOURNAL   Genes (Basel) 12 (5), 674 (2021)
   PUBMED   33947140
  REMARK    GeneRIF: Fibroblast Growth Factor 20 Gene Polymorphism in
            Parkinson's Disease in Asian Population: A Meta-Analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Ornitz,D.M. and Itoh,N.
  TITLE     Fibroblast growth factors
  JOURNAL   Genome Biol 2 (3), REVIEWS3005 (2001)
   PUBMED   11276432
  REMARK    Review article
REFERENCE   7  (bases 1 to 1840)
  AUTHORS   Ohmachi,S., Watanabe,Y., Mikami,T., Kusu,N., Ibi,T., Akaike,A. and
            Itoh,N.
  TITLE     FGF-20, a novel neurotrophic factor, preferentially expressed in
            the substantia nigra pars compacta of rat brain
  JOURNAL   Biochem Biophys Res Commun 277 (2), 355-360 (2000)
   PUBMED   11032730
REFERENCE   8  (bases 1 to 1840)
  AUTHORS   Kirikoshi,H., Sagara,N., Saitoh,T., Tanaka,K., Sekihara,H.,
            Shiokawa,K. and Katoh,M.
  TITLE     Molecular cloning and characterization of human FGF-20 on
            chromosome 8p21.3-p22
  JOURNAL   Biochem Biophys Res Commun 274 (2), 337-343 (2000)
   PUBMED   10913340
  REMARK    GeneRIF: FGF20, FGF9, and FGF16 constitute a subfamily among FGFs.
            FGF20 is preferentially expressed in colorectal cancer.
REFERENCE   9  (bases 1 to 1840)
  AUTHORS   Ong,S.H., Guy,G.R., Hadari,Y.R., Laks,S., Gotoh,N., Schlessinger,J.
            and Lax,I.
  TITLE     FRS2 proteins recruit intracellular signaling pathways by binding
            to diverse targets on fibroblast growth factor and nerve growth
            factor receptors
  JOURNAL   Mol Cell Biol 20 (3), 979-989 (2000)
   PUBMED   10629055
REFERENCE   10 (bases 1 to 1840)
  AUTHORS   Carpenter,G. and Ji,Qs.
  TITLE     Phospholipase C-gamma as a signal-transducing element
  JOURNAL   Exp Cell Res 253 (1), 15-24 (1999)
   PUBMED   10579907
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC136305.6, AB044277.1,
            AB030648.1, DT220794.1 and AC025218.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_019851.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor family. The fibroblast growth factors
            possess broad mitogenic and cell survival activities, and are
            involved in a variety of biological processes including embryonic
            development, cell growth, morphogenesis, tissue repair, tumor
            growth and invasion. This gene product is a secreted neurotrophic
            factor but lacks a typical signal peptide. It is expressed in
            normal brain, particularly the cerebellum, and may regulate central
            nervous system development and function. Homodimerization of this
            protein was shown to regulate its receptor binding activity and
            concentration gradient in the extracellular matrix. Genetic
            variations of this gene have been associated with Parkinson disease
            susceptibility. [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.607830.1, AB044277.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000180166.6/ ENSP00000180166.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC136305.6         106409-106588
            181-456             AB044277.1         1-276
            457-949             AB030648.1         144-636
            950-1031            AB044277.1         770-851
            1032-1066           DT220794.1         649-683
            1067-1113           AB044277.1         887-933
            1114-1114           AC025218.8         2844-2844
            1115-1196           AB044277.1         935-1016
            1197-1840           AC025218.8         2927-3570
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..1840
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
                     /note="fibroblast growth factor 20"
                     /db_xref="GeneID:26281"
                     /db_xref="HGNC:HGNC:3677"
                     /db_xref="MIM:605558"
     exon            1..599
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..949
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
                     /codon_start=1
                     /product="fibroblast growth factor 20"
                     /protein_id="NP_062825.1"
                     /db_xref="CCDS:CCDS5998.1"
                     /db_xref="GeneID:26281"
                     /db_xref="HGNC:HGNC:3677"
                     /db_xref="MIM:605558"
                     /translation="MAPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAA
                     ERSARGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFIS
                     VAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGD
                     TGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPERVPELYKDLLMYT"
     exon            600..703
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1840
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
                     /note="hexamer: AGTAAA"
     polyA_site      1605
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
                     /note="hexamer: ATTAAA"
     polyA_site      1825
                     /gene="FGF20"
                     /gene_synonym="FGF-20; RHDA2"
                     /note="major polyA site"
ORIGIN      
        1 actctgatct gatcagtttg cggaattgga gccccagcca acagccctag tcctagtatt
       61 ggcagcggca gctatagata tttctgcaga gccagcagcc ggctcccacc tacccaagga
      121 gagaagatcg ctccaagaca gtgagagctt ccctgccatt tcagtgcaaa gtccctccgg
      181 agcgacctca gaggagtaac cgggccttaa ctttttgcgc tcgttttgct ataatttttc
      241 tctatccacc tccatcccac ccccacaaca ctctttactg ggggggtctt ttgtgttccg
      301 gatctccccc tccatggctc ccttagccga agtcgggggc tttctgggcg gcctggaggg
      361 cttgggccag caggtgggtt cgcatttcct gttgcctcct gccggggagc ggccgccgct
      421 gctgggcgag cgcaggagcg cggcggagcg gagcgcgcgc ggcgggccgg gggctgcgca
      481 gctggcgcac ctgcacggca tcctgcgccg ccggcagctc tattgccgca ccggcttcca
      541 cctgcagatc ctgcccgacg gcagcgtgca gggcacccgg caggaccaca gcctcttcgg
      601 tatcttggaa ttcatcagtg tggcagtggg actggtcagt attagaggtg tggacagtgg
      661 tctctatctt ggaatgaatg acaaaggaga actctatgga tcagagaaac ttacttccga
      721 atgcatcttt agggagcagt ttgaagagaa ctggtataac acctattcat ctaacatata
      781 taaacatgga gacactggcc gcaggtattt tgtggcactt aacaaagacg gaactccaag
      841 agatggcgcc aggtccaaga ggcatcagaa atttacacat ttcttaccta gaccagtgga
      901 tccagaaaga gttccagaat tgtacaagga cctactgatg tacacttgaa gtgcgatagt
      961 gacattatgg aagagtcaaa ccacaaccat tctttcttgt catagttccc atcataaaat
     1021 aatgacccaa ggagacgttc aaaatattaa agtctatttt ctactgagag actggatttg
     1081 gaaagaatat tgagaaaaaa aaccaaaaaa aattttgact agaaatagat catgatcact
     1141 ctttatatgt ggattaagtt cccttagata cattggatta gtccttacca gtagactgaa
     1201 gccaaaaatc tgttaaactg tggataatgg gaaccctcac atggttgctg ctggtgcctc
     1261 acctctctgg attatgttta ctttaaaatt tatgttaaaa atagagactt catgttgaag
     1321 aaatggattg acttagccaa gagcattgct acataaattc tgaggacctt gtagaattca
     1381 caggttatgg cattatatgt tttaagaaaa aaaaaaacta aacaacacct gggtgaaaca
     1441 tgaactatga aacatgccac accaagacag aacacttttt aaaagaatgg acctatttat
     1501 acactttcaa tttgaaaata tttattatat atatttattt attaaagagt ttatttttta
     1561 ctgggatatg aagataatac aaagagtaaa aaacaacaaa acttccgtta ttgtgccatt
     1621 actttattgt ggtgtcttgc tctgtaaaga ggacattatt ataccacctt aaccatagaa
     1681 tcagattttg aatttctttt taaaatatag tatagattat attttttatg cagtcaattg
     1741 ccttctaaat gtaacgttgg tttcttttgg cctagaaaaa tgcctcattg atttgtatta
     1801 aattcaacac acattcaaaa gggaattaaa cattttcatg
//
