LOCUS       NM_002006               6801 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens fibroblast growth factor 2 (FGF2), transcript variant
            1a, mRNA.
ACCESSION   NM_002006
VERSION     NM_002006.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6801)
  AUTHORS   Zhang,C., Yuan,L., Wen,W., Shao,C., Liao,Y., Jia,Y., Zhao,X.,
            Liao,Y., Xu,D., Chen,L., Yang,G., Jiang,H., Wang,W. and Yao,S.
  TITLE     LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic
            Metastasis via Epigenetic Regulation of FGF2-Induced
            Lymphangiogenesis
  JOURNAL   Adv Sci (Weinh) 11 (38), e2404645 (2024)
   PUBMED   39119899
  REMARK    GeneRIF: LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic
            Metastasis via Epigenetic Regulation of FGF2-Induced
            Lymphangiogenesis.
REFERENCE   2  (bases 1 to 6801)
  AUTHORS   Li,Z., Liu,Y., Li,X., Yang,S., Feng,S., Li,G., Jin,F. and Nie,S.
  TITLE     Knockdown the moyamoya disease susceptibility gene, RNF213,
            upregulates the expression of basic fibroblast growth factor and
            matrix metalloproteinase-9 in bone marrow derived mesenchymal stem
            cells
  JOURNAL   Neurosurg Rev 47 (1), 246 (2024)
   PUBMED   38811382
  REMARK    GeneRIF: Knockdown the moyamoya disease susceptibility gene,
            RNF213, upregulates the expression of basic fibroblast growth
            factor and matrix metalloproteinase-9 in bone marrow derived
            mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6801)
  AUTHORS   Li,D., Huang,P., Xia,L., Leng,W. and Qin,S.
  TITLE     Cancer-associated fibroblasts promote gastric cancer cell
            proliferation by paracrine FGF2-driven ribosome biogenesis
  JOURNAL   Int Immunopharmacol 131, 111836 (2024)
   PUBMED   38479160
  REMARK    GeneRIF: Cancer-associated fibroblasts promote gastric cancer cell
            proliferation by paracrine FGF2-driven ribosome biogenesis.
REFERENCE   4  (bases 1 to 6801)
  AUTHORS   Ream,M.W., Randolph,L.N., Jiang,Y., Chang,Y., Bao,X. and Lian,X.L.
  TITLE     Direct programming of human pluripotent stem cells into endothelial
            progenitors with SOX17 and FGF2
  JOURNAL   Stem Cell Reports 19 (4), 579-595 (2024)
   PUBMED   38518781
  REMARK    GeneRIF: Direct programming of human pluripotent stem cells into
            endothelial progenitors with SOX17 and FGF2.
REFERENCE   5  (bases 1 to 6801)
  AUTHORS   Yu,P.J., Ferrari,G., Galloway,A.C., Mignatti,P. and Pintucci,G.
  TITLE     Basic fibroblast growth factor (FGF-2): the high molecular weight
            forms come of age
  JOURNAL   J Cell Biochem 100 (5), 1100-1108 (2007)
   PUBMED   17131363
  REMARK    Review article
REFERENCE   6  (bases 1 to 6801)
  AUTHORS   Arnaud,E., Touriol,C., Boutonnet,C., Gensac,M.C., Vagner,S.,
            Prats,H. and Prats,A.C.
  TITLE     A new 34-kilodalton isoform of human fibroblast growth factor 2 is
            cap dependently synthesized by using a non-AUG start codon and
            behaves as a survival factor
  JOURNAL   Mol Cell Biol 19 (1), 505-514 (1999)
   PUBMED   9858574
  REMARK    GeneRIF: A new FGF2 isoform results from the use of a non-AUG (CUG)
            translation initiation codon.
REFERENCE   7  (bases 1 to 6801)
  AUTHORS   Watson,R., Anthony,F., Pickett,M., Lambden,P., Masson,G.M. and
            Thomas,E.J.
  TITLE     Reverse transcription with nested polymerase chain reaction shows
            expression of basic fibroblast growth factor transcripts in human
            granulosa and cumulus cells from in vitro fertilisation patients
  JOURNAL   Biochem Biophys Res Commun 187 (3), 1227-1231 (1992)
   PUBMED   1417798
REFERENCE   8  (bases 1 to 6801)
  AUTHORS   Zhu,X., Komiya,H., Chirino,A., Faham,S., Fox,G.M., Arakawa,T.,
            Hsu,B.T. and Rees,D.C.
  TITLE     Three-dimensional structures of acidic and basic fibroblast growth
            factors
  JOURNAL   Science 251 (4989), 90-93 (1991)
   PUBMED   1702556
REFERENCE   9  (bases 1 to 6801)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 6801)
  AUTHORS   Prats,H., Kaghad,M., Prats,A.C., Klagsbrun,M., Lelias,J.M.,
            Liauzun,P., Chalon,P., Tauber,J.P., Amalric,F., Smith,J.A. et al.
  TITLE     High molecular mass forms of basic fibroblast growth factor are
            initiated by alternative CUG codons
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1836-1840 (1989)
   PUBMED   2538817
  REMARK    GeneRIF: Alternate protein isoforms arise through the use of AUG
            and non-AUG (CUG) translation initiation codons.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021205.6.
            
            On Feb 23, 2022 this sequence version replaced NM_002006.5.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members bind
            heparin and possess broad mitogenic and angiogenic activities. This
            protein has been implicated in diverse biological processes, such
            as limb and nervous system development, wound healing, and tumor
            growth. The mRNA for this gene contains multiple polyadenylation
            sites, and is alternatively translated from non-AUG (CUG) and AUG
            initiation codons, resulting in five different isoforms with
            distinct properties. The CUG-initiated isoforms are localized in
            the nucleus and are responsible for the intracrine effect, whereas,
            the AUG-initiated form is mostly cytosolic and is responsible for
            the paracrine and autocrine effects of this FGF. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1a) may encode multiple distinct
            isoforms through the use of alternative translation start codons
            (PMID: 17131363). This record represents use of the 5' most non-AUG
            start codon and encodes the longest (34-kDa) isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04513.1, M27968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 2538817
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-671               AC021205.6         16598-17268
            672-775             AC021205.6         66237-66340
            776-6801            AC021205.6         82127-88152
FEATURES             Location/Qualifiers
     source          1..6801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..6801
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="fibroblast growth factor 2"
                     /db_xref="GeneID:2247"
                     /db_xref="HGNC:HGNC:3676"
                     /db_xref="MIM:134920"
     exon            1..671
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..961
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="isoform 34 kDa is encoded by transcript variant 1a;
                     non-AUG (CUG) translation initiation codon; prostatropin;
                     heparin-binding growth factor 2; basic fibroblast growth
                     factor bFGF; fibroblast growth factor 2 (basic)"
                     /codon_start=1
                     /product="fibroblast growth factor 2 isoform 34 kDa"
                     /protein_id="NP_001997.5"
                     /db_xref="CCDS:CCDS34059.1"
                     /db_xref="GeneID:2247"
                     /db_xref="HGNC:HGNC:3676"
                     /db_xref="MIM:134920"
                     /translation="MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPR
                     RRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAP
                     ERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFK
                     DPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAM
                     KEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQ
                     KAILFLPMSAKS"
     exon            672..775
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..6801
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4015..4020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="hexamer: AATATA"
     polyA_site      4031
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
     regulatory      6766..6771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="hexamer: AATAAA"
     polyA_site      6801
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="major polyA site"
ORIGIN      
        1 gtggccgaac cgccgaactc agaggccggc cccagaaaac ccgagcgagt agggggcggc
       61 gcgcaggagg gaggagaact gggggcgcgg gaggctggtg ggtgtggggg gtggagatgt
      121 agaagatgtg acgccgcggc ccggcgggtg ccagattagc ggacgcggtg cccgcggttg
      181 caacgggatc ccgggcgctg cagcttggga ggcggctctc cccaggcggc gtccgcggag
      241 acacccatcc gtgaacccca ggtcccgggc cgccggctcg ccgcgcacca ggggccggcg
      301 gacagaagag cggccgagcg gctcgaggct gggggaccgc gggcgcggcc gcgcgctgcc
      361 gggcgggagg ctggggggcc ggggccgggg ccgtgccccg gagcgggtcg gaggccgggg
      421 ccggggccgg gggacggcgg ctccccgcgc ggctccagcg gctcggggat cccggccggg
      481 ccccgcaggg accatggcag ccgggagcat caccacgctg cccgccttgc ccgaggatgg
      541 cggcagcggc gccttcccgc ccggccactt caaggacccc aagcggctgt actgcaaaaa
      601 cgggggcttc ttcctgcgca tccaccccga cggccgagtt gacggggtcc gggagaagag
      661 cgaccctcac atcaagctac aacttcaagc agaagagaga ggagttgtgt ctatcaaagg
      721 agtgtgtgct aaccgttacc tggctatgaa ggaagatgga agattactgg cttctaaatg
      781 tgttacggat gagtgtttct tttttgaacg attggaatct aataactaca atacttaccg
      841 gtcaaggaaa tacaccagtt ggtatgtggc actgaaacga actgggcagt ataaacttgg
      901 atccaaaaca ggacctgggc agaaagctat actttttctt ccaatgtctg ctaagagctg
      961 attttaatgg ccacatctaa tctcatttca catgaaagaa gaagtatatt ttagaaattt
     1021 gttaatgaga gtaaaagaaa ataaatgtgt atagctcagt ttggataatt ggtcaaacaa
     1081 ttttttatcc agtagtaaaa tatgtaacca ttgtcccagt aaagaaaaat aacaaaagtt
     1141 gtaaaatgta tattctccct tttatattgc atctgctgtt acccagtgaa gcttacctag
     1201 agcaatgatc tttttcacgc atttgcttta ttcgaaaaga ggcttttaaa atgtgcatgt
     1261 ttagaaacaa aatttcttca tggaaatcat atacattaga aaatcacagt cagatgttta
     1321 atcaatccaa aatgtccact atttcttatg tcattcgtta gtctacatgt ttctaaacat
     1381 ataaatgtga atttaatcaa ttcctttcat agttttataa ttctctggca gttccttatg
     1441 atagagttta taaaacagtc ctgtgtaaac tgctggaagt tcttccacag tcaggtcaat
     1501 tttgtcaaac ccttctctgt acccatacag cagcagccta gcaactctgc tggtgatggg
     1561 agttgtattt tcagtcttcg ccaggtcatt gagatccatc cactcacatc ttaagcattc
     1621 ttcctggcaa aaatttatgg tgaatgaata tggctttagg cggcagatga tatacatatc
     1681 tgacttccca aaagctccag gatttgtgtg ctgttgccga atactcagga cggacctgaa
     1741 ttctgatttt ataccagtct cttcaaaaac ttctcgaacc gctgtgtctc ctacgtaaaa
     1801 aaagagatgt acaaatcaat aataattaca cttttagaaa ctgtatcatc aaagattttc
     1861 agttaaagta gcattatgta aaggctcaaa acattaccct aacaaagtaa agttttcaat
     1921 acaaattctt tgccttgtgg atatcaagaa atcccaaaat attttcttac cactgtaaat
     1981 tcaagaagct tttgaaatgc tgaatatttc tttggctgct acttggaggc ttatctacct
     2041 gtacattttt ggggtcagct ctttttaact tcttgctgct ctttttccca aaaggtaaaa
     2101 atatagattg aaaagttaaa acattttgca tggctgcagt tcctttgttt cttgagataa
     2161 gattccaaag aacttagatt catttcttca acaccgaaat gctggaggtg tttgatcagt
     2221 tttcaagaaa cttggaatat aaataatttt ataattcaac aaaggttttc acattttata
     2281 aggttgattt ttcaattaaa tgcaaatttg tgtggcagga tttttattgc cattaacata
     2341 tttttgtggc tgctttttct acacatccag atggtccctc taactgggct ttctctaatt
     2401 ttgtgatgtt ctgtcattgt ctcccaaagt atttaggaga agccctttaa aaagctgcct
     2461 tcctctacca ctttgctgga aagcttcaca attgtcacag acaaagattt ttgttccaat
     2521 actcgttttg cctctatttt tcttgtttgt caaatagtaa atgatatttg cccttgcagt
     2581 aattctactg gtgaaaaaca tgcaaagaag aggaagtcac agaaacatgt ctcaattccc
     2641 atgtgctgtg actgtagact gtcttaccat agactgtctt acccatcccc tggatatgct
     2701 cttgtttttt ccctctaata gctatggaaa gatgcataga aagagtataa tgttttaaaa
     2761 cataaggcat ttgtctgcca tttttcaatt acatgctgac ttcccttaca attgagattt
     2821 gcccataggt taaacatggt tagaaacaac tgaaagcata aaagaaaaat ctaggccggg
     2881 tgcagtggct catgcctata ttccctgcac tttgggaggc caaagcagga ggatcgcttg
     2941 agcccaggag ttcaagacca acctggtgaa accccgtctc tacaaaaaaa cacaaaaaat
     3001 agccaggcat ggtggcgtgt acatgtggtc tcagatactt gggaggctga ggtgggaggg
     3061 ttgatcactt gaggctgaga ggtcaaggtt gcagtgagcc ataatcgtgc cactgcagtc
     3121 cagcctaggc aacagagtga gactttgtct caaaaaaaga gaaattttcc ttaataagaa
     3181 aagtaatttt tactctgatg tgcaatacat ttgttattaa atttattatt taagatggta
     3241 gcactagtct taaattgtat aaaatatccc ctaacatgtt taaatgtcca tttttattca
     3301 ttatgctttg aaaaataatt atggggaaat acatgtttgt tattaaattt attattaaag
     3361 atagtagcac tagtcttaaa tttgatataa catctcctaa cttgtttaaa tgtccatttt
     3421 tattctttat gtttgaaaat aaattatggg gatcctattt agctcttagt accactaatc
     3481 aaaagttcgg catgtagctc atgatctatg ctgtttctat gtcgtggaag cactggatgg
     3541 gggtagtgag caaatctgcc ctgctcagca gtcaccatag cagctgactg aaaatcagca
     3601 ctgcctgagt agttttgatc agtttaactt gaatcactaa ctgactgaaa attgaatggg
     3661 caaataagtg cttttgtctc cagagtatgc gggagaccct tccacctcaa gatggatatt
     3721 tcttccccaa ggatttcaag atgaattgaa atttttaatc aagatagtgt gctttattct
     3781 gttgtatttt ttattatttt aatatactgt aagccaaact gaaataacat ttgctgtttt
     3841 ataggtttga agaacatagg aaaaactaag aggttttgtt tttatttttg ctgatgaaga
     3901 gatatgttta aatatgttgt attgttttgt ttagttacag gacaataatg aaatggagtt
     3961 tatatttgtt atttctattt tgttatattt aataatagaa ttagattgaa ataaaatata
     4021 atgggaaata atctgcagaa tgtgggtttt cctggtgttt ccctctgact ctagtgcact
     4081 gatgatctct gataaggctc agctgcttta tagttctctg gctaatgcag cagatactct
     4141 tcctgccagt ggtaatacga ttttttaaga aggcagtttg tcaattttaa tcttgtggat
     4201 acctttatac tcttagggta ttattttata caaaagcctt gaggattgca ttctattttc
     4261 tatatgaccc tcttgatatt taaaaaacac tatggataac aattcttcat ttacctagta
     4321 ttatgaaaga atgaaggagt tcaaacaaat gtgtttccca gttaactagg gtttactgtt
     4381 tgagccaata taaatgttta actgtttgtg atggcagtat tcctaaagta cattgcatgt
     4441 tttcctaaat acagagttta aataatttca gtaattctta gatgattcag cttcatcatt
     4501 aagaatatct tttgttttat gttgagttag aaatgccttc atatagacat agtctttcag
     4561 acctctactg tcagttttca tttctagctg ctttcagggt tttatgaatt ttcaggcaaa
     4621 gctttaattt acactaagct taggaagtat ggctaatgcc aacggcagtt tttttcttct
     4681 taattccaca tgactgaggc atatatgatc tctgggtagg tgagttgttg tgacaaccac
     4741 aagcactttt ttttttttta aagaaaaaaa ggtagtgaat ttttaatcat ctggacttta
     4801 agaaggattc tggagtatac ttaggcctga aattatatat atttggcttg gaaatgtgtt
     4861 tttcttcaat tacatctaca agtaagtaca gctgaaattc agaggaccca taagagttca
     4921 catgaaaaaa atcaatttat ttgaaaaggc aagatgcagg agagaggaag ccttgcaaac
     4981 ctgcagactg ctttttgccc aatatagatt gggtaaggct gcaaaacata agcttaatta
     5041 gctcacatgc tctgctctca cgtggcacca gtggatagtg tgagagaatt aggctgtaga
     5101 acaaatggcc ttctctttca gcattcacac cactacaaaa tcatctttta tatcaacaga
     5161 agaataagca taaactaagc aaaaggtcaa taagtacctg aaaccaagat tggctagaga
     5221 tatatcttaa tgcaatccat tttctgatgg attgttacga gttggctata taatgtatgt
     5281 atggtatttt gatttgtgta aaagttttaa aaatcaagct ttaagtacat ggacattttt
     5341 aaataaaata tttaaagaca atttagaaaa ttgccttaat atcattgttg gctaaataga
     5401 ataggggaca tgcatattaa ggaaaaggtc atggagaaat aatattggta tcaaacaaat
     5461 acattgattt gtcatgatac acattgaatt tgatccaata gtttaaggaa taggtaggaa
     5521 aatttggttt ctatttttcg atttcctgta aatcagtgac ataaataatt cttagcttat
     5581 tttatatttc cttgtcttaa atactgagct cagtaagttg tgttagggga ttatttctca
     5641 gttgagactt tcttatatga cattttacta tgttttgact acctgactat taaaaataaa
     5701 tagtagatac aattttcata aagtgaagaa ttatataatc actgctttat aactgacttt
     5761 attatattta tttcaaagtt catttaaagg ctactattca tcctctgtga tggaatggtc
     5821 aggaatttgt tttctcatag tttaattcca acaacaatat tagtcgtatc caaaataacc
     5881 tttaatgcta aactttactg atgtatatcc aaagcttctc attttcagac agattaatcc
     5941 agaagcagtc ataaacagaa gaataggtgg tatgttccta atgatattat ttctactaat
     6001 ggaataaact gtaatattag aaattatgct gctaattata tcagctctga ggtaatttct
     6061 gaaatgttca gactcagtcg gaacaaattg gaaaatttaa atttttattc ttagctataa
     6121 agcaagaaag taaacacatt aatttcctca acatttttaa gccaattaaa aatataaaag
     6181 atacacacca atatcttctt caggctctga caggcctcct ggaaacttcc acatattttt
     6241 caactgcagt ataaagtcag aaaataaagt taacataact ttcactaaca cacacatatg
     6301 tagatttcac aaaatccacc tataattggt caaagtggtt gagaatatat tttttagtaa
     6361 ttgcatgcaa aatttttcta gcttccatcc tttctccctc gtttcttctt tttttggggg
     6421 agctggtaac tgatgaaatc ttttcccacc ttttctcttc aggaaatata agtggttttg
     6481 tttggttaac gtgatacatt ctgtatgaat gaaacattgg agggaaacat ctactgaatt
     6541 tctgtaattt aaaatatttt gctgctagtt aactatgaac agatagaaga atcttacaga
     6601 tgctgctata aataagtaga aaatataaat ttcatcacta aaatatgcta ttttaaaatc
     6661 tatttcctat attgtatttc taatcagatg tattactctt attatttcta ttgtatgtgt
     6721 taatgatttt atgtaaaaat gtaattgctt ttcatgagta gtatgaataa aattgattag
     6781 tttgtgtttt cttgtctccc a
//
