LOCUS       NM_001361665            6652 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens fibroblast growth factor 2 (FGF2), transcript variant
            1b, mRNA.
ACCESSION   NM_001361665
VERSION     NM_001361665.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6652)
  AUTHORS   Zhang,C., Yuan,L., Wen,W., Shao,C., Liao,Y., Jia,Y., Zhao,X.,
            Liao,Y., Xu,D., Chen,L., Yang,G., Jiang,H., Wang,W. and Yao,S.
  TITLE     LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic
            Metastasis via Epigenetic Regulation of FGF2-Induced
            Lymphangiogenesis
  JOURNAL   Adv Sci (Weinh) 11 (38), e2404645 (2024)
   PUBMED   39119899
  REMARK    GeneRIF: LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic
            Metastasis via Epigenetic Regulation of FGF2-Induced
            Lymphangiogenesis.
REFERENCE   2  (bases 1 to 6652)
  AUTHORS   Li,Z., Liu,Y., Li,X., Yang,S., Feng,S., Li,G., Jin,F. and Nie,S.
  TITLE     Knockdown the moyamoya disease susceptibility gene, RNF213,
            upregulates the expression of basic fibroblast growth factor and
            matrix metalloproteinase-9 in bone marrow derived mesenchymal stem
            cells
  JOURNAL   Neurosurg Rev 47 (1), 246 (2024)
   PUBMED   38811382
  REMARK    GeneRIF: Knockdown the moyamoya disease susceptibility gene,
            RNF213, upregulates the expression of basic fibroblast growth
            factor and matrix metalloproteinase-9 in bone marrow derived
            mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6652)
  AUTHORS   Li,D., Huang,P., Xia,L., Leng,W. and Qin,S.
  TITLE     Cancer-associated fibroblasts promote gastric cancer cell
            proliferation by paracrine FGF2-driven ribosome biogenesis
  JOURNAL   Int Immunopharmacol 131, 111836 (2024)
   PUBMED   38479160
  REMARK    GeneRIF: Cancer-associated fibroblasts promote gastric cancer cell
            proliferation by paracrine FGF2-driven ribosome biogenesis.
REFERENCE   4  (bases 1 to 6652)
  AUTHORS   Ream,M.W., Randolph,L.N., Jiang,Y., Chang,Y., Bao,X. and Lian,X.L.
  TITLE     Direct programming of human pluripotent stem cells into endothelial
            progenitors with SOX17 and FGF2
  JOURNAL   Stem Cell Reports 19 (4), 579-595 (2024)
   PUBMED   38518781
  REMARK    GeneRIF: Direct programming of human pluripotent stem cells into
            endothelial progenitors with SOX17 and FGF2.
REFERENCE   5  (bases 1 to 6652)
  AUTHORS   Yu,P.J., Ferrari,G., Galloway,A.C., Mignatti,P. and Pintucci,G.
  TITLE     Basic fibroblast growth factor (FGF-2): the high molecular weight
            forms come of age
  JOURNAL   J Cell Biochem 100 (5), 1100-1108 (2007)
   PUBMED   17131363
  REMARK    Review article
REFERENCE   6  (bases 1 to 6652)
  AUTHORS   Arnaud,E., Touriol,C., Boutonnet,C., Gensac,M.C., Vagner,S.,
            Prats,H. and Prats,A.C.
  TITLE     A new 34-kilodalton isoform of human fibroblast growth factor 2 is
            cap dependently synthesized by using a non-AUG start codon and
            behaves as a survival factor
  JOURNAL   Mol Cell Biol 19 (1), 505-514 (1999)
   PUBMED   9858574
  REMARK    GeneRIF: A new FGF2 isoform results from the use of a non-AUG (CUG)
            translation initiation codon.
REFERENCE   7  (bases 1 to 6652)
  AUTHORS   Watson,R., Anthony,F., Pickett,M., Lambden,P., Masson,G.M. and
            Thomas,E.J.
  TITLE     Reverse transcription with nested polymerase chain reaction shows
            expression of basic fibroblast growth factor transcripts in human
            granulosa and cumulus cells from in vitro fertilisation patients
  JOURNAL   Biochem Biophys Res Commun 187 (3), 1227-1231 (1992)
   PUBMED   1417798
REFERENCE   8  (bases 1 to 6652)
  AUTHORS   Zhu,X., Komiya,H., Chirino,A., Faham,S., Fox,G.M., Arakawa,T.,
            Hsu,B.T. and Rees,D.C.
  TITLE     Three-dimensional structures of acidic and basic fibroblast growth
            factors
  JOURNAL   Science 251 (4989), 90-93 (1991)
   PUBMED   1702556
REFERENCE   9  (bases 1 to 6652)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 6652)
  AUTHORS   Prats,H., Kaghad,M., Prats,A.C., Klagsbrun,M., Lelias,J.M.,
            Liauzun,P., Chalon,P., Tauber,J.P., Amalric,F., Smith,J.A. et al.
  TITLE     High molecular mass forms of basic fibroblast growth factor are
            initiated by alternative CUG codons
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1836-1840 (1989)
   PUBMED   2538817
  REMARK    GeneRIF: Alternate protein isoforms arise through the use of AUG
            and non-AUG (CUG) translation initiation codons.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021205.6, J04513.1, M27968.1,
            BU501243.1, BP292299.1, CN315083.1, AA256481.1 and AI276765.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001361665.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members bind
            heparin and possess broad mitogenic and angiogenic activities. This
            protein has been implicated in diverse biological processes, such
            as limb and nervous system development, wound healing, and tumor
            growth. The mRNA for this gene contains multiple polyadenylation
            sites, and is alternatively translated from non-AUG (CUG) and AUG
            initiation codons, resulting in five different isoforms with
            distinct properties. The CUG-initiated isoforms are localized in
            the nucleus and are responsible for the intracrine effect, whereas,
            the AUG-initiated form is mostly cytosolic and is responsible for
            the paracrine and autocrine effects of this FGF. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1b) may encode multiple distinct
            isoforms through the use of alternative translation start codons
            (PMID: 17131363). This record represents use of the most conserved
            AUG start codon and encodes the shortest (18-kDa) isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04513.1, M27968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644866.2/ ENSP00000494222.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC021205.6         16747-16765
            20-2622             J04513.1           142-2744
            2623-2624           AC021205.6         84123-84124
            2625-3282           J04513.1           2747-3404
            3283-3384           M27968.1           3280-3381
            3385-3385           AC021205.6         84885-84885
            3386-3704           M27968.1           3383-3701
            3705-4482           BU501243.1         28-805
            4483-4483           AC021205.6         85983-85983
            4484-4944           BP292299.1         123-583
            4945-5531           J04513.1           5065-5651
            5532-5532           AC021205.6         87032-87032
            5533-6038           CN315083.1         80-585
            6039-6637           J04513.1           6159-6757
            6638-6651           AA256481.1         1-14                c
            6652-6652           AI276765.1         24-24               c
FEATURES             Location/Qualifiers
     source          1..6652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..6652
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="fibroblast growth factor 2"
                     /db_xref="GeneID:2247"
                     /db_xref="HGNC:HGNC:3676"
                     /db_xref="MIM:134920"
     exon            1..522
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..812
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="isoform 18 kDa is encoded by transcript variant 1b;
                     prostatropin; heparin-binding growth factor 2; basic
                     fibroblast growth factor bFGF; fibroblast growth factor 2
                     (basic)"
                     /codon_start=1
                     /product="fibroblast growth factor 2 isoform 18 kDa"
                     /protein_id="NP_001348594.1"
                     /db_xref="CCDS:CCDS93618.1"
                     /db_xref="GeneID:2247"
                     /db_xref="HGNC:HGNC:3676"
                     /db_xref="MIM:134920"
                     /translation="MAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIH
                     PDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECF
                     FFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS"
     exon            523..626
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..6652
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3866..3871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="hexamer: AATATA"
     polyA_site      3882
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
     regulatory      6617..6622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="hexamer: AATAAA"
     polyA_site      6652
                     /gene="FGF2"
                     /gene_synonym="BFGF; FGF-2; FGFB; HBGF-2"
                     /note="major polyA site"
ORIGIN      
        1 gccagattag cggacgcggt gcccgcggtt gcaacgggat cccgggcgct gcagcttggg
       61 aggcggctct ccccaggcgg cgtccgcgga gacacccatc cgtgaacccc aggtcccggg
      121 ccgccggctc gccgcgcacc aggggccggc ggacagaaga gcggccgagc ggctcgaggc
      181 tgggggaccg cgggcgcggc cgcgcgctgc cgggcgggag gctggggggc cggggccggg
      241 gccgtgcccc ggagcgggtc ggaggccggg gccggggccg ggggacggcg gctccccgcg
      301 cggctccagc ggctcgggga tcccggccgg gccccgcagg gaccatggca gccgggagca
      361 tcaccacgct gcccgccttg cccgaggatg gcggcagcgg cgccttcccg cccggccact
      421 tcaaggaccc caagcggctg tactgcaaaa acgggggctt cttcctgcgc atccaccccg
      481 acggccgagt tgacggggtc cgggagaaga gcgaccctca catcaagcta caacttcaag
      541 cagaagagag aggagttgtg tctatcaaag gagtgtgtgc taaccgttac ctggctatga
      601 aggaagatgg aagattactg gcttctaaat gtgttacgga tgagtgtttc ttttttgaac
      661 gattggaatc taataactac aatacttacc ggtcaaggaa atacaccagt tggtatgtgg
      721 cactgaaacg aactgggcag tataaacttg gatccaaaac aggacctggg cagaaagcta
      781 tactttttct tccaatgtct gctaagagct gattttaatg gccacatcta atctcatttc
      841 acatgaaaga agaagtatat tttagaaatt tgttaatgag agtaaaagaa aataaatgtg
      901 tatagctcag tttggataat tggtcaaaca attttttatc cagtagtaaa atatgtaacc
      961 attgtcccag taaagaaaaa taacaaaagt tgtaaaatgt atattctccc ttttatattg
     1021 catctgctgt tacccagtga agcttaccta gagcaatgat ctttttcacg catttgcttt
     1081 attcgaaaag aggcttttaa aatgtgcatg tttagaaaca aaatttcttc atggaaatca
     1141 tatacattag aaaatcacag tcagatgttt aatcaatcca aaatgtccac tatttcttat
     1201 gtcattcgtt agtctacatg tttctaaaca tataaatgtg aatttaatca attcctttca
     1261 tagttttata attctctggc agttccttat gatagagttt ataaaacagt cctgtgtaaa
     1321 ctgctggaag ttcttccaca gtcaggtcaa ttttgtcaaa cccttctctg tacccataca
     1381 gcagcagcct agcaactctg ctggtgatgg gagttgtatt ttcagtcttc gccaggtcat
     1441 tgagatccat ccactcacat cttaagcatt cttcctggca aaaatttatg gtgaatgaat
     1501 atggctttag gcggcagatg atatacatat ctgacttccc aaaagctcca ggatttgtgt
     1561 gctgttgccg aatactcagg acggacctga attctgattt tataccagtc tcttcaaaaa
     1621 cttctcgaac cgctgtgtct cctacgtaaa aaaagagatg tacaaatcaa taataattac
     1681 acttttagaa actgtatcat caaagatttt cagttaaagt agcattatgt aaaggctcaa
     1741 aacattaccc taacaaagta aagttttcaa tacaaattct ttgccttgtg gatatcaaga
     1801 aatcccaaaa tattttctta ccactgtaaa ttcaagaagc ttttgaaatg ctgaatattt
     1861 ctttggctgc tacttggagg cttatctacc tgtacatttt tggggtcagc tctttttaac
     1921 ttcttgctgc tctttttccc aaaaggtaaa aatatagatt gaaaagttaa aacattttgc
     1981 atggctgcag ttcctttgtt tcttgagata agattccaaa gaacttagat tcatttcttc
     2041 aacaccgaaa tgctggaggt gtttgatcag ttttcaagaa acttggaata taaataattt
     2101 tataattcaa caaaggtttt cacattttat aaggttgatt tttcaattaa atgcaaattt
     2161 gtgtggcagg atttttattg ccattaacat atttttgtgg ctgctttttc tacacatcca
     2221 gatggtccct ctaactgggc tttctctaat tttgtgatgt tctgtcattg tctcccaaag
     2281 tatttaggag aagcccttta aaaagctgcc ttcctctacc actttgctgg aaagcttcac
     2341 aattgtcaca gacaaagatt tttgttccaa tactcgtttt gcctctattt ttcttgtttg
     2401 tcaaatagta aatgatattt gcccttgcag taattctact ggtgaaaaac atgcaaagaa
     2461 gaggaagtca cagaaacatg tctcaattcc catgtgctgt gactgtagac tgtcttacca
     2521 tagactgtct tacccatccc ctggatatgc tcttgttttt tccctctaat agctatggaa
     2581 agatgcatag aaagagtata atgttttaaa acataaggca tttgtctgcc atttttcaat
     2641 tacatgctga cttcccttac aattgagatt tgcccatagg ttaaacatgg ttagaaacaa
     2701 ctgaaagcat aaaagaaaaa tctaggccgg gtgcagtggc tcatgcctat attccctgca
     2761 ctttgggagg ccaaagcagg aggatcgctt gagcccagga gttcaagacc aacctggtga
     2821 aaccccgtct ctacaaaaaa acacaaaaaa tagccaggca tggtggcgtg tacatgtggt
     2881 ctcagatact tgggaggctg aggtgggagg gttgatcact tgaggctgag aggtcaaggt
     2941 tgcagtgagc cataatcgtg ccactgcagt ccagcctagg caacagagtg agactttgtc
     3001 tcaaaaaaag agaaattttc cttaataaga aaagtaattt ttactctgat gtgcaataca
     3061 tttgttatta aatttattat ttaagatggt agcactagtc ttaaattgta taaaatatcc
     3121 cctaacatgt ttaaatgtcc atttttattc attatgcttt gaaaaataat tatggggaaa
     3181 tacatgtttg ttattaaatt tattattaaa gatagtagca ctagtcttaa atttgatata
     3241 acatctccta acttgtttaa atgtccattt ttattcttta tgtttgaaaa taaattatgg
     3301 ggatcctatt tagctcttag taccactaat caaaagttcg gcatgtagct catgatctat
     3361 gctgtttcta tgtcgtggaa gcactggatg ggggtagtga gcaaatctgc cctgctcagc
     3421 agtcaccata gcagctgact gaaaatcagc actgcctgag tagttttgat cagtttaact
     3481 tgaatcacta actgactgaa aattgaatgg gcaaataagt gcttttgtct ccagagtatg
     3541 cgggagaccc ttccacctca agatggatat ttcttcccca aggatttcaa gatgaattga
     3601 aatttttaat caagatagtg tgctttattc tgttgtattt tttattattt taatatactg
     3661 taagccaaac tgaaataaca tttgctgttt tataggtttg aagaacatag gaaaaactaa
     3721 gaggttttgt ttttattttt gctgatgaag agatatgttt aaatatgttg tattgttttg
     3781 tttagttaca ggacaataat gaaatggagt ttatatttgt tatttctatt ttgttatatt
     3841 taataataga attagattga aataaaatat aatgggaaat aatctgcaga atgtgggttt
     3901 tcctggtgtt tccctctgac tctagtgcac tgatgatctc tgataaggct cagctgcttt
     3961 atagttctct ggctaatgca gcagatactc ttcctgccag tggtaatacg attttttaag
     4021 aaggcagttt gtcaatttta atcttgtgga tacctttata ctcttagggt attattttat
     4081 acaaaagcct tgaggattgc attctatttt ctatatgacc ctcttgatat ttaaaaaaca
     4141 ctatggataa caattcttca tttacctagt attatgaaag aatgaaggag ttcaaacaaa
     4201 tgtgtttccc agttaactag ggtttactgt ttgagccaat ataaatgttt aactgtttgt
     4261 gatggcagta ttcctaaagt acattgcatg ttttcctaaa tacagagttt aaataatttc
     4321 agtaattctt agatgattca gcttcatcat taagaatatc ttttgtttta tgttgagtta
     4381 gaaatgcctt catatagaca tagtctttca gacctctact gtcagttttc atttctagct
     4441 gctttcaggg ttttatgaat tttcaggcaa agctttaatt tacactaagc ttaggaagta
     4501 tggctaatgc caacggcagt ttttttcttc ttaattccac atgactgagg catatatgat
     4561 ctctgggtag gtgagttgtt gtgacaacca caagcacttt tttttttttt aaagaaaaaa
     4621 aggtagtgaa tttttaatca tctggacttt aagaaggatt ctggagtata cttaggcctg
     4681 aaattatata tatttggctt ggaaatgtgt ttttcttcaa ttacatctac aagtaagtac
     4741 agctgaaatt cagaggaccc ataagagttc acatgaaaaa aatcaattta tttgaaaagg
     4801 caagatgcag gagagaggaa gccttgcaaa cctgcagact gctttttgcc caatatagat
     4861 tgggtaaggc tgcaaaacat aagcttaatt agctcacatg ctctgctctc acgtggcacc
     4921 agtggatagt gtgagagaat taggctgtag aacaaatggc cttctctttc agcattcaca
     4981 ccactacaaa atcatctttt atatcaacag aagaataagc ataaactaag caaaaggtca
     5041 ataagtacct gaaaccaaga ttggctagag atatatctta atgcaatcca ttttctgatg
     5101 gattgttacg agttggctat ataatgtatg tatggtattt tgatttgtgt aaaagtttta
     5161 aaaatcaagc tttaagtaca tggacatttt taaataaaat atttaaagac aatttagaaa
     5221 attgccttaa tatcattgtt ggctaaatag aataggggac atgcatatta aggaaaaggt
     5281 catggagaaa taatattggt atcaaacaaa tacattgatt tgtcatgata cacattgaat
     5341 ttgatccaat agtttaagga ataggtagga aaatttggtt tctatttttc gatttcctgt
     5401 aaatcagtga cataaataat tcttagctta ttttatattt ccttgtctta aatactgagc
     5461 tcagtaagtt gtgttagggg attatttctc agttgagact ttcttatatg acattttact
     5521 atgttttgac tacctgacta ttaaaaataa atagtagata caattttcat aaagtgaaga
     5581 attatataat cactgcttta taactgactt tattatattt atttcaaagt tcatttaaag
     5641 gctactattc atcctctgtg atggaatggt caggaatttg ttttctcata gtttaattcc
     5701 aacaacaata ttagtcgtat ccaaaataac ctttaatgct aaactttact gatgtatatc
     5761 caaagcttct cattttcaga cagattaatc cagaagcagt cataaacaga agaataggtg
     5821 gtatgttcct aatgatatta tttctactaa tggaataaac tgtaatatta gaaattatgc
     5881 tgctaattat atcagctctg aggtaatttc tgaaatgttc agactcagtc ggaacaaatt
     5941 ggaaaattta aatttttatt cttagctata aagcaagaaa gtaaacacat taatttcctc
     6001 aacattttta agccaattaa aaatataaaa gatacacacc aatatcttct tcaggctctg
     6061 acaggcctcc tggaaacttc cacatatttt tcaactgcag tataaagtca gaaaataaag
     6121 ttaacataac tttcactaac acacacatat gtagatttca caaaatccac ctataattgg
     6181 tcaaagtggt tgagaatata ttttttagta attgcatgca aaatttttct agcttccatc
     6241 ctttctccct cgtttcttct ttttttgggg gagctggtaa ctgatgaaat cttttcccac
     6301 cttttctctt caggaaatat aagtggtttt gtttggttaa cgtgatacat tctgtatgaa
     6361 tgaaacattg gagggaaaca tctactgaat ttctgtaatt taaaatattt tgctgctagt
     6421 taactatgaa cagatagaag aatcttacag atgctgctat aaataagtag aaaatataaa
     6481 tttcatcact aaaatatgct attttaaaat ctatttccta tattgtattt ctaatcagat
     6541 gtattactct tattatttct attgtatgtg ttaatgattt tatgtaaaaa tgtaattgct
     6601 tttcatgagt agtatgaata aaattgatta gtttgtgttt tcttgtctcc ca
//
