LOCUS       NM_005117               1821 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens fibroblast growth factor 19 (FGF19), mRNA.
ACCESSION   NM_005117
VERSION     NM_005117.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Kim,E., Moore,A.E., Dulnoan,D. and Hampson,G.
  TITLE     Effect of Fibroblast Growth Factor (FGF) 19 and 21 on Hip Geometry
            and Strength in Post-menopausal Osteoporosis (PMO)
  JOURNAL   Calcif Tissue Int 115 (5), 562-569 (2024)
   PUBMED   39341924
  REMARK    GeneRIF: Effect of Fibroblast Growth Factor (FGF) 19 and 21 on Hip
            Geometry and Strength in Post-menopausal Osteoporosis (PMO).
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Xue,T., Wang,X., Pan,X., Liu,M. and Xu,F.
  TITLE     PTX promotes breast cancer migration and invasion by recruiting
            ATF4 to upregulate FGF19
  JOURNAL   Cell Signal 122, 111309 (2024)
   PUBMED   39053672
  REMARK    GeneRIF: PTX promotes breast cancer migration and invasion by
            recruiting ATF4 to upregulate FGF19.
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Chow,M.D., Otersen,K., Wassef,A., Kong,B., Yamarthy,S., Rizzolo,D.,
            Yang,I., Buckley,B., Lu,A., Crook,N., Lee,M., Gao,J., Naganand,S.,
            Stofan,M.F., Armstrong,L., Schumacher,J., Taylor,R., Henry,Z.,
            Basaly,V., Yang,Z., Zhang,M., Huang,M., Kagan,L., Brunetti,L.,
            Sadek,R., Lee,Y.H. and Guo,G.L.
  TITLE     Effects of intestine-specific deletion of FGF15 on the development
            of fatty liver disease with vertical sleeve gastrectomy
  JOURNAL   Hepatol Commun 8 (6), e0444 (2024)
   PUBMED   38780301
  REMARK    GeneRIF: Effects of intestine-specific deletion of FGF15 on the
            development of fatty liver disease with vertical sleeve
            gastrectomy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Shi,S., Zhang,Q., Zhang,K., Chen,W., Xie,H., Pan,S., Xue,Z.,
            You,B., Zhao,J. and You,Y.
  TITLE     FGF19 promotes nasopharyngeal carcinoma progression by inducing
            angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination
  JOURNAL   Cell Oncol (Dordr) 47 (1), 283-301 (2024)
   PUBMED   37782406
  REMARK    GeneRIF: FGF19 promotes nasopharyngeal carcinoma progression by
            inducing angiogenesis via inhibiting TRIM21-mediated ANXA2
            ubiquitination.
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Zuo,K., Fang,C., Gao,Y., Fu,Y., Wang,H., Li,J., Zhong,J., Yang,X.
            and Xu,L.
  TITLE     Suppression of the gut microbiota-bile acid-FGF19 axis in patients
            with atrial fibrillation
  JOURNAL   Cell Prolif 56 (11), e13488 (2023)
   PUBMED   37186335
  REMARK    GeneRIF: Suppression of the gut microbiota-bile acid-FGF19 axis in
            patients with atrial fibrillation.
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Ladher,R.K., Anakwe,K.U., Gurney,A.L., Schoenwolf,G.C. and
            Francis-West,P.H.
  TITLE     Identification of synergistic signals initiating inner ear
            development
  JOURNAL   Science 290 (5498), 1965-1967 (2000)
   PUBMED   11110663
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Cross,M.J., Hodgkin,M.N., Roberts,S., Landgren,E., Wakelam,M.J. and
            Claesson-Welsh,L.
  TITLE     Tyrosine 766 in the fibroblast growth factor receptor-1 is required
            for FGF-stimulation of phospholipase C, phospholipase D,
            phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal
            reorganisation in porcine aortic endothelial cells
  JOURNAL   J Cell Sci 113 (Pt 4), 643-651 (2000)
   PUBMED   10652257
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   Carpenter,G. and Ji,Qs.
  TITLE     Phospholipase C-gamma as a signal-transducing element
  JOURNAL   Exp Cell Res 253 (1), 15-24 (1999)
   PUBMED   10579907
  REMARK    Review article
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Xie,M.H., Holcomb,I., Deuel,B., Dowd,P., Huang,A., Vagts,A.,
            Foster,J., Liang,J., Brush,J., Gu,Q., Hillan,K., Goddard,A. and
            Gurney,A.L.
  TITLE     FGF-19, a novel fibroblast growth factor with unique specificity
            for FGFR4
  JOURNAL   Cytokine 11 (10), 729-735 (1999)
   PUBMED   10525310
REFERENCE   10 (bases 1 to 1821)
  AUTHORS   Nishimura,T., Utsunomiya,Y., Hoshikawa,M., Ohuchi,H. and Itoh,N.
  TITLE     Structure and expression of a novel human FGF, FGF-19, expressed in
            the fetal brain
  JOURNAL   Biochim Biophys Acta 1444 (1), 148-151 (1999)
   PUBMED   9931477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF110400.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005117.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes including embryonic development
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This growth factor is a high affinity, heparin dependent
            ligand for FGFR4. Expression of this gene was detected only in
            fetal but not adult brain tissue. Synergistic interaction of the
            chick homolog and Wnt-8c has been shown to be required for
            initiation of inner ear development. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110400.1, AY358302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294312.4/ ENSP00000294312.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1821              AF110400.1         318-2138
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..1821
                     /gene="FGF19"
                     /note="fibroblast growth factor 19"
                     /db_xref="GeneID:9965"
                     /db_xref="HGNC:HGNC:3675"
                     /db_xref="MIM:603891"
     exon            1..378
                     /gene="FGF19"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..797
                     /gene="FGF19"
                     /note="FGF-19"
                     /codon_start=1
                     /product="fibroblast growth factor 19 precursor"
                     /protein_id="NP_005108.1"
                     /db_xref="CCDS:CCDS8193.1"
                     /db_xref="GeneID:9965"
                     /db_xref="HGNC:HGNC:3675"
                     /db_xref="MIM:603891"
                     /translation="MRSGCVVVHVWILAGLWLAVAGRPLAFSDAGPHVHYGWGDPIRL
                     RHLYTSGPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLC
                     MGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFL
                     PLSHFLPMLPMVPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK"
     exon            379..482
                     /gene="FGF19"
                     /inference="alignment:Splign:2.1.0"
     exon            483..1821
                     /gene="FGF19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF19"
                     /note="hexamer: ATTAAA"
     polyA_site      1821
                     /gene="FGF19"
                     /note="major polyA site"
ORIGIN      
        1 gccgtcagag caggagcgct gcgtccagga tctagggcca cgaccatccc aacccggcac
       61 tcacagcccc gcagcgcatc ccggtcgccg cccagcctcc cgcaccccca tcgccggagc
      121 tgcgccgaga gccccaggga ggtgccatgc ggagcgggtg tgtggtggtc cacgtatgga
      181 tcctggccgg cctctggctg gccgtggccg ggcgccccct cgccttctcg gacgcggggc
      241 cccacgtgca ctacggctgg ggcgacccca tccgcctgcg gcacctgtac acctccggcc
      301 cccacgggct ctccagctgc ttcctgcgca tccgtgccga cggcgtcgtg gactgcgcgc
      361 ggggccagag cgcgcacagt ttgctggaga tcaaggcagt cgctctgcgg accgtggcca
      421 tcaagggcgt gcacagcgtg cggtacctct gcatgggcgc cgacggcaag atgcaggggc
      481 tgcttcagta ctcggaggaa gactgtgctt tcgaggagga gatccgccca gatggctaca
      541 atgtgtaccg atccgagaag caccgcctcc cggtctccct gagcagtgcc aaacagcggc
      601 agctgtacaa gaacagaggc tttcttccac tctctcattt cctgcccatg ctgcccatgg
      661 tcccagagga gcctgaggac ctcaggggcc acttggaatc tgacatgttc tcttcgcccc
      721 tggagaccga cagcatggac ccatttgggc ttgtcaccgg actggaggcc gtgaggagtc
      781 ccagctttga gaagtaactg agaccatgcc cgggcctctt cactgctgcc aggggctgtg
      841 gtacctgcag cgtgggggac gtgcttctac aagaacagtc ctgagtccac gttctgttta
      901 gctttaggaa gaaacatcta gaagttgtac atattcagag ttttccattg gcagtgccag
      961 tttctagcca atagacttgt ctgatcataa cattgtaagc ctgtagcttg cccagctgct
     1021 gcctgggccc ccattctgct ccctcgaggt tgctggacaa gctgctgcac tgtctcagtt
     1081 ctgcttgaat acctccatcg atggggaact cacttccttt ggaaaaattc ttatgtcaag
     1141 ctgaaattct ctaatttttt ctcatcactt ccccaggagc agccagaaga caggcagtag
     1201 ttttaatttc aggaacaggt gatccactct gtaaaacagc aggtaaattt cactcaaccc
     1261 catgtgggaa ttgatctata tctctacttc cagggaccat ttgcccttcc caaatccctc
     1321 caggccagaa ctgactggag caggcatggc ccaccaggct tcaggagtag gggaagcctg
     1381 gagccccact ccagccctgg gacaacttga gaattccccc tgaggccagt tctgtcatgg
     1441 atgctgtcct gagaataact tgctgtcccg gtgtcacctg cttccatctc ccagcccacc
     1501 agccctctgc ccacctcaca tgcctcccca tggattgggg cctcccaggc cccccacctt
     1561 atgtcaacct gcacttcttg ttcaaaaatc aggaaaagaa aagatttgaa gaccccaagt
     1621 cttgtcaata acttgctgtg tggaagcagc gggggaagac ctagaaccct ttccccagca
     1681 cttggttttc caacatgata tttatgagta atttattttg atatgtacat ctcttatttt
     1741 cttacattat ttatgccccc aaattatatt tatgtatgta agtgaggttt gttttgtata
     1801 ttaaaatgga gtttgtttgt a
//
