LOCUS       NM_003862               1998 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens fibroblast growth factor 18 (FGF18), mRNA.
ACCESSION   NM_003862
VERSION     NM_003862.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1998)
  AUTHORS   Mosleh,B., Schelch,K., Mohr,T., Klikovits,T., Wagner,C.,
            Ratzinger,L., Dong,Y., Sinn,K., Ries,A., Berger,W.,
            Grasl-Kraupp,B., Hoetzenecker,K., Laszlo,V., Dome,B., Hegedus,B.,
            Jakopovic,M., Hoda,M.A. and Grusch,M.
  TITLE     Circulating FGF18 is decreased in pleural mesothelioma but not
            correlated with disease prognosis
  JOURNAL   Thorac Cancer 14 (22), 2177-2186 (2023)
   PUBMED   37340889
  REMARK    GeneRIF: Circulating FGF18 is decreased in pleural mesothelioma but
            not correlated with disease prognosis.
REFERENCE   2  (bases 1 to 1998)
  AUTHORS   Danopoulos,S., Belgacemi,R., Hein,R.F.C., Miller,A.J.,
            Deutsch,G.H., Glass,I., Spence,J.R. and Al Alam,D.
  TITLE     FGF18 promotes human lung branching morphogenesis through
            regulating mesenchymal progenitor cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 324 (4), L433-L444 (2023)
   PUBMED   36791060
  REMARK    GeneRIF: FGF18 promotes human lung branching morphogenesis through
            regulating mesenchymal progenitor cells.
REFERENCE   3  (bases 1 to 1998)
  AUTHORS   Zhang,J., Wong,C.C., Leung,K.T., Wu,F., Zhou,Y., Tong,J.H.M.,
            Chan,R.C.K., Li,H., Wang,Y., Yan,H., Liu,L., Wu,W.K.K.,
            Chan,M.W.Y., Cheng,A.S.L., Yu,J., Wong,N., Lo,K.W., To,K.F. and
            Kang,W.
  TITLE     FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to
            promote carcinogenesis in a subgroup of gastric cancer patients and
            indicates translational potential
  JOURNAL   Oncogene 39 (43), 6647-6663 (2020)
   PUBMED   32934314
  REMARK    GeneRIF: FGF18-FGFR2 signaling triggers the activation of
            c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric
            cancer patients and indicates translational potential.
REFERENCE   4  (bases 1 to 1998)
  AUTHORS   Zhao,T., Zhao,J., Ma,C., Wei,J., Wei,B. and Liu,J.
  TITLE     Evaluation of Relationship Between Common Variants in FGF18 Gene
            and Knee Osteoarthritis Susceptibility
  JOURNAL   Arch Med Res 51 (1), 76-81 (2020)
   PUBMED   32109713
  REMARK    GeneRIF: Identification of a genetic polymorphism in FGF18
            significantly associated with the risk of Knee osteoarthritis based
            on samples with Chinese Han ancestry.
REFERENCE   5  (bases 1 to 1998)
  AUTHORS   Jomrich,G., Hudec,X., Harpain,F., Winkler,D., Timelthaler,G.,
            Mohr,T., Marian,B. and Schoppmann,S.F.
  TITLE     Expression of FGF8, FGF18, and FGFR4 in Gastroesophageal
            Adenocarcinomas
  JOURNAL   Cells 8 (9), 1092 (2019)
   PUBMED   31527546
  REMARK    GeneRIF: The FGF18 is promising candidates for prognostic factors
            in adenocarcinomas of the esophago-gastric junction and new
            potential targets for new anti-cancer therapies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1998)
  AUTHORS   Carpenter,G. and Ji,Qs.
  TITLE     Phospholipase C-gamma as a signal-transducing element
  JOURNAL   Exp Cell Res 253 (1), 15-24 (1999)
   PUBMED   10579907
  REMARK    Review article
REFERENCE   7  (bases 1 to 1998)
  AUTHORS   Hu,M.C., Wang,Y.P. and Qiu,W.R.
  TITLE     Human fibroblast growth factor-18 stimulates fibroblast cell
            proliferation and is mapped to chromosome 14p11
  JOURNAL   Oncogene 18 (16), 2635-2642 (1999)
   PUBMED   10353607
REFERENCE   8  (bases 1 to 1998)
  AUTHORS   Hu,M.C., Qiu,W.R., Wang,Y.P., Hill,D., Ring,B.D., Scully,S.,
            Bolon,B., DeRose,M., Luethy,R., Simonet,W.S., Arakawa,T. and
            Danilenko,D.M.
  TITLE     FGF-18, a novel member of the fibroblast growth factor family,
            stimulates hepatic and intestinal proliferation
  JOURNAL   Mol Cell Biol 18 (10), 6063-6074 (1998)
   PUBMED   9742123
REFERENCE   9  (bases 1 to 1998)
  AUTHORS   Ohbayashi,N., Hoshikawa,M., Kimura,S., Yamasaki,M., Fukui,S. and
            Itoh,N.
  TITLE     Structure and expression of the mRNA encoding a novel fibroblast
            growth factor, FGF-18
  JOURNAL   J Biol Chem 273 (29), 18161-18164 (1998)
   PUBMED   9660775
REFERENCE   10 (bases 1 to 1998)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093246.3, AF075292.1 and
            BQ018759.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003862.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth, and
            invasion. It has been shown in vitro that this protein is able to
            induce neurite outgrowth in PC12 cells. Studies of the similar
            proteins in mouse and chick suggested that this protein is a
            pleiotropic growth factor that stimulates proliferation in a number
            of tissues, most notably the liver and small intestine. Knockout
            studies of the similar gene in mice implied the role of this
            protein in regulating proliferation and differentiation of midline
            cerebellar structures. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF075292.1, BC006245.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274625.6/ ENSP00000274625.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC093246.3         75410-75425         c
            17-1544             AF075292.1         1-1528
            1545-1998           BQ018759.1         18-471              c
FEATURES             Location/Qualifiers
     source          1..1998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..1998
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /note="fibroblast growth factor 18"
                     /db_xref="GeneID:8817"
                     /db_xref="HGNC:HGNC:3674"
                     /db_xref="MIM:603726"
     exon            1..585
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             554..1177
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /codon_start=1
                     /product="fibroblast growth factor 18 precursor"
                     /protein_id="NP_003853.1"
                     /db_xref="CCDS:CCDS4378.1"
                     /db_xref="GeneID:8817"
                     /db_xref="HGNC:HGNC:3674"
                     /db_xref="MIM:603726"
                     /translation="MYSAPSACTCLCLHFLLLCFQVQVLVAEENVDFRIHVENQTRAR
                     DDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGK
                     ETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPR
                     KGPKTRENQQDVHFMKRYPKGQPELQKPFKYTTVTKRSRRIRPTHPA"
     exon            586..622
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /inference="alignment:Splign:2.1.0"
     exon            623..803
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /inference="alignment:Splign:2.1.0"
     exon            804..910
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1998
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1965..1970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /note="hexamer: ATTAAA"
     polyA_site      1998
                     /gene="FGF18"
                     /gene_synonym="FGF-18; ZFGF5"
                     /note="major polyA site"
ORIGIN      
        1 gggaggcggc gatgcgcacg gccggagaga cgcggaggag gagacatgag ccggcgggcg
       61 cccagacgga gcggccgtga cgctttcgcg ctgcagccgc gcgccccgac cccggagcgc
      121 tgacccctgg ccccacgcag ctccgcgccc gggccggaga gcgcaactcg gcttccagac
      181 ccgccgcgca tgctgtcccc ggactgagcc gggcagccag cctcccacgg acgcccggac
      241 ggccggccgg ccagcagtga gcgagcttcc ccgcaccggc caggcgcctc ctgcacagcg
      301 gctgccgccc cgcagcccct gcgccagccc ggagggcgca gcgctcggga ggagccgcgc
      361 ggggcgctga tgccgcaggg cgcgccgcgg agcgccccgg agcagcagag tctgcagcag
      421 cagcagccgg cgaggaggga gcagcagcag cggcggcggc ggcggcggcg gcggcggagg
      481 cgcccggtcc cggccgcgcg gagcggacat gtgcaggctg ggctaggagc cgccgcctcc
      541 ctcccgccca gcgatgtatt cagcgccctc cgcctgcact tgcctgtgtt tacacttcct
      601 gctgctgtgc ttccaggtac aggtgctggt tgccgaggag aacgtggact tccgcatcca
      661 cgtggagaac cagacgcggg ctcgggacga tgtgagccgt aagcagctgc ggctgtacca
      721 gctctacagc cggaccagtg ggaaacacat ccaggtcctg ggccgcagga tcagtgcccg
      781 cggcgaggat ggggacaagt atgcccagct cctagtggag acagacacct tcggtagtca
      841 agtccggatc aagggcaagg agacggaatt ctacctgtgc atgaaccgca aaggcaagct
      901 cgtggggaag cccgatggca ccagcaagga gtgtgtgttc atcgagaagg ttctggagaa
      961 caactacacg gccctgatgt cggctaagta ctccggctgg tacgtgggct tcaccaagaa
     1021 ggggcggccg cggaagggcc ccaagacccg ggagaaccag caggacgtgc atttcatgaa
     1081 gcgctacccc aaggggcagc cggagcttca gaagcccttc aagtacacga cggtgaccaa
     1141 gaggtcccgt cggatccggc ccacacaccc tgcctaggcc accccgccgc ggcccctcag
     1201 gtcgccctgg ccacactcac actcccagaa aactgcatca gaggaatatt tttacatgaa
     1261 aaataaggaa gaagctctat ttttgtacat tgtgtttaaa agaagacaaa aactgaacca
     1321 aaactcttgg ggggaggggt gataaggatt ttattgttga cttgaaaccc ccgatgacaa
     1381 aagactcacg caaagggact gtagtcaacc cacaggtgct tgtctctctc taggaacaga
     1441 caactctaaa ctcgtcccca gaggaggact tgaatgagga aaccaacact ttgagaaacc
     1501 aaagtccttt ttcccaaagg ttctgaaagg aaaaaaaaaa aaaacaaaaa aaaagaaaaa
     1561 caaagagaaa gtagtactcc gcccaccaac aaactccccc taactttccc aatcctctgt
     1621 tcctgcccca aactccaaca aaaatcgctc tctggtttgc agtcatttat ttattgtccg
     1681 ctgcaagctg ccccgagaca ccgcgcaggg aaggcgtgcc cctgggaatt ctccgcgcct
     1741 cgacctcccg acgacagacg cctcgtccaa tcatggtgac cctgccttgc tcgcagttct
     1801 ggaggatgct gctatcgacc ttccgtgact cacgtgacct agtacaccaa tgataaggga
     1861 atattttaaa accagctata ttatatatat tatatatata taagctattt atttcacctc
     1921 tctgtatatt gcagtttcat gaaccaagta ttactgcctc aacaattaaa aacaacagac
     1981 aaattattta aaaaacca
//
