LOCUS       NM_003867               1320 bp    mRNA    linear   PRI 06-FEB-2022
DEFINITION  Homo sapiens fibroblast growth factor 17 (FGF17), transcript
            variant 1, mRNA.
ACCESSION   NM_003867
VERSION     NM_003867.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Ling Y and Du Q.
  TITLE     FGF10/FGF17 as prognostic and drug response markers in acute
            myeloid leukemia
  JOURNAL   Curr Res Transl Med 70 (1), 103316 (2022)
   PUBMED   34731724
  REMARK    GeneRIF: FGF10/FGF17 as prognostic and drug response markers in
            acute myeloid leukemia.
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B,
            Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M,
            Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov
            P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP,
            Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K and Pitteloud
            N.
  TITLE     Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified
            in individuals with congenital hypogonadotropic hypogonadism
  JOURNAL   Am J Hum Genet 92 (5), 725-743 (2013)
   PUBMED   23643382
  REMARK    GeneRIF: FGF17 and IL17RD prpopsed as the two top candidates in the
            entire proteome on the basis of a statistical test of their
            protein-protein interaction patterns to proteins known to be
            altered in congenital hypogonadotropic hypogonadism.
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Zanni G, Barresi S, Travaglini L, Bernardini L, Rizza T, Digilio
            MC, Mercuri E, Cianfarani S, Valeriani M, Ferraris A, Da Sacco L,
            Novelli A, Valente EM, Dallapiccola B and Bertini ES.
  TITLE     FGF17, a gene involved in cerebellar development, is downregulated
            in a patient with Dandy-Walker malformation carrying a de novo 8p
            deletion
  JOURNAL   Neurogenetics 12 (3), 241-245 (2011)
   PUBMED   21484435
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Greene JM, Li YL, Yourey PA, Gruber J, Carter KC, Shell BK, Dillon
            PA, Florence C, Duan DR, Blunt A, Ornitz DM, Ruben SM and Alderson
            RF.
  TITLE     Identification and characterization of a novel member of the
            fibroblast growth factor family
  JOURNAL   Eur J Neurosci 10 (5), 1911-1925 (1998)
   PUBMED   9751161
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Hoshikawa M, Ohbayashi N, Yonamine A, Konishi M, Ozaki K, Fukui S
            and Itoh N.
  TITLE     Structure and expression of a novel fibroblast growth factor,
            FGF-17, preferentially expressed in the embryonic brain
  JOURNAL   Biochem Biophys Res Commun 244 (1), 187-191 (1998)
   PUBMED   9514906
REFERENCE   7  (bases 1 to 1320)
  AUTHORS   Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR
            and Schlessinger J.
  TITLE     Structures of the tyrosine kinase domain of fibroblast growth
            factor receptor in complex with inhibitors
  JOURNAL   Science 276 (5314), 955-960 (1997)
   PUBMED   9139660
REFERENCE   8  (bases 1 to 1320)
  AUTHORS   Kanai M, Goke M, Tsunekawa S and Podolsky DK.
  TITLE     Signal transduction pathway of human fibroblast growth factor
            receptor 3. Identification of a novel 66-kDa phosphoprotein
  JOURNAL   J Biol Chem 272 (10), 6621-6628 (1997)
   PUBMED   9045692
REFERENCE   9  (bases 1 to 1320)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Gripp
            KW, Mirzaa GM and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301509
REFERENCE   10 (bases 1 to 1320)
  AUTHORS   Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M,
            Burgess WH, Jaye M and Schlessinger J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091171.15, BC105131.1 and
            BM666883.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003867.3.
            
            Summary: This gene encodes a member of the fibroblast growth factor
            (FGF) family. Member of the FGF family possess broad mitogenic and
            cell survival activities, and are involved in a variety of
            biological processes including embryonic development cell growth,
            morphogenesis, tissue repair, tumor growth and invasion. This
            protein is expressed during embryogenesis and in the adult
            cerebellum and cortex and may be essential for vascular growth and
            normal brain development. Mutations in this gene are the cause of
            hypogonadotropic hypogonadism 20 with or without anosmia. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105131.1, DR156510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359441.4/ ENSP00000352414.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC091171.15        93294-93352
            60-813              BC105131.1         1-754
            814-1320            BM666883.1         16-522              c
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..1320
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /note="fibroblast growth factor 17"
                     /db_xref="GeneID:8822"
                     /db_xref="HGNC:HGNC:3673"
                     /db_xref="MIM:603725"
     exon            1..144
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..760
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="fibroblast growth factor 17 isoform 1 precursor"
                     /protein_id="NP_003858.1"
                     /db_xref="CCDS:CCDS6019.1"
                     /db_xref="GeneID:8822"
                     /db_xref="HGNC:HGNC:3673"
                     /db_xref="MIM:603725"
                     /translation="MGAARLLPNLTLCLQLLILCCQTQGENHPSPNFNQYVRDQGAMT
                     DQLSRRQIREYQLYSRTSGKHVQVTGRRISATAEDGNKFAKLIVETDTFGSRVRIKGA
                     ESEKYICMNKRGKLIGKPSGKSKDCVFTEIVLENNYTAFQNARHEGWFMAFTRQGRPR
                     QASRSRQNQREAHFIKRLYQGQLPFPNHAEKQKQFEFVGSAPTRRTKRTRRPQPLT"
     exon            145..181
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     exon            182..359
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     exon            360..466
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1320
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1299..1304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /note="major polyA site"
ORIGIN      
        1 gtggctcgga gagaccttgg cttctctggg actctacccc tggggacttc ccacatctgc
       61 tcctgagctt gggggcaggg gggcaaccgc ctgaggaacc tctccagcga tgggagccgc
      121 ccgcctgctg cccaacctca ctctgtgctt acagctgctg attctctgct gtcaaactca
      181 gggggagaat cacccgtctc ctaattttaa ccagtacgtg agggaccagg gcgccatgac
      241 cgaccagctg agcaggcggc agatccgcga gtaccaactc tacagcagga ccagtggcaa
      301 gcacgtgcag gtcaccgggc gtcgcatctc cgccaccgcc gaggacggca acaagtttgc
      361 caagctcata gtggagacgg acacgtttgg cagccgggtt cgcatcaaag gggctgagag
      421 tgagaagtac atctgtatga acaagagggg caagctcatc gggaagccca gcgggaagag
      481 caaagactgc gtgttcacgg agatcgtgct ggagaacaac tatacggcct tccagaacgc
      541 ccggcacgag ggctggttca tggccttcac gcggcagggg cggccccgcc aggcttcccg
      601 cagccgccag aaccagcgcg aggcccactt catcaagcgc ctctaccaag gccagctgcc
      661 cttccccaac cacgccgaga agcagaagca gttcgagttt gtgggctccg cccccacccg
      721 ccggaccaag cgcacacggc ggccccagcc cctcacgtag tctgggaggc agggggcagc
      781 agcccctggg ccgcctcccc acccctttcc cttcttaatc caaggactgg gctggggtgg
      841 cgggagggga gccagatccc cgagggagga ccctgagggc cgcgaagcat ccgagccccc
      901 agctgggaag gggcaggccg gtgccccagg ggcggctggc acagtgcccc cttcccggac
      961 gggtggcagg ccctggagag gaactgagtg tcaccctgat ctcaggccac cagcctctgc
     1021 cggcctccca gccgggctcc tgaagcccgc tgaaaggtca gcgactgaag gccttgcaga
     1081 caaccgtctg gaggtggctg tcctcaaaat ctgcttctcg gatctccctc agtctgcccc
     1141 cagcccccaa actcctcctg gctagactgt aggaagggac ttttgtttgt ttgtttgttt
     1201 caggaaaaaa gaaagggaga gagaggaaaa tagagggttg tccactcctc acattccacg
     1261 acccaggcct gcaccccacc cccaactccc agccccggaa taaaaccatt ttcctgcaaa
//
