LOCUS       NM_001304478            1369 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens fibroblast growth factor 17 (FGF17), transcript
            variant 2, mRNA.
ACCESSION   NM_001304478 XM_005273676
VERSION     NM_001304478.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1369)
  AUTHORS   Ling,Y. and Du,Q.
  TITLE     FGF10/FGF17 as prognostic and drug response markers in acute
            myeloid leukemia
  JOURNAL   Curr Res Transl Med 70 (1), 103316 (2022)
   PUBMED   34731724
  REMARK    GeneRIF: FGF10/FGF17 as prognostic and drug response markers in
            acute myeloid leukemia.
REFERENCE   2  (bases 1 to 1369)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1369)
  AUTHORS   Miraoui,H., Dwyer,A.A., Sykiotis,G.P., Plummer,L., Chung,W.,
            Feng,B., Beenken,A., Clarke,J., Pers,T.H., Dworzynski,P., Keefe,K.,
            Niedziela,M., Raivio,T., Crowley,W.F. Jr., Seminara,S.B.,
            Quinton,R., Hughes,V.A., Kumanov,P., Young,J., Yialamas,M.A.,
            Hall,J.E., Van Vliet,G., Chanoine,J.P., Rubenstein,J.,
            Mohammadi,M., Tsai,P.S., Sidis,Y., Lage,K. and Pitteloud,N.
  TITLE     Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified
            in individuals with congenital hypogonadotropic hypogonadism
  JOURNAL   Am J Hum Genet 92 (5), 725-743 (2013)
   PUBMED   23643382
  REMARK    GeneRIF: FGF17 and IL17RD prpopsed as the two top candidates in the
            entire proteome on the basis of a statistical test of their
            protein-protein interaction patterns to proteins known to be
            altered in congenital hypogonadotropic hypogonadism.
REFERENCE   4  (bases 1 to 1369)
  AUTHORS   Zanni,G., Barresi,S., Travaglini,L., Bernardini,L., Rizza,T.,
            Digilio,M.C., Mercuri,E., Cianfarani,S., Valeriani,M., Ferraris,A.,
            Da Sacco,L., Novelli,A., Valente,E.M., Dallapiccola,B. and
            Bertini,E.S.
  TITLE     FGF17, a gene involved in cerebellar development, is downregulated
            in a patient with Dandy-Walker malformation carrying a de novo 8p
            deletion
  JOURNAL   Neurogenetics 12 (3), 241-245 (2011)
   PUBMED   21484435
REFERENCE   5  (bases 1 to 1369)
  AUTHORS   Greene,J.M., Li,Y.L., Yourey,P.A., Gruber,J., Carter,K.C.,
            Shell,B.K., Dillon,P.A., Florence,C., Duan,D.R., Blunt,A.,
            Ornitz,D.M., Ruben,S.M. and Alderson,R.F.
  TITLE     Identification and characterization of a novel member of the
            fibroblast growth factor family
  JOURNAL   Eur J Neurosci 10 (5), 1911-1925 (1998)
   PUBMED   9751161
REFERENCE   6  (bases 1 to 1369)
  AUTHORS   Hoshikawa,M., Ohbayashi,N., Yonamine,A., Konishi,M., Ozaki,K.,
            Fukui,S. and Itoh,N.
  TITLE     Structure and expression of a novel fibroblast growth factor,
            FGF-17, preferentially expressed in the embryonic brain
  JOURNAL   Biochem Biophys Res Commun 244 (1), 187-191 (1998)
   PUBMED   9514906
REFERENCE   7  (bases 1 to 1369)
  AUTHORS   Mohammadi,M., McMahon,G., Sun,L., Tang,C., Hirth,P., Yeh,B.K.,
            Hubbard,S.R. and Schlessinger,J.
  TITLE     Structures of the tyrosine kinase domain of fibroblast growth
            factor receptor in complex with inhibitors
  JOURNAL   Science 276 (5314), 955-960 (1997)
   PUBMED   9139660
REFERENCE   8  (bases 1 to 1369)
  AUTHORS   Kanai,M., Goke,M., Tsunekawa,S. and Podolsky,D.K.
  TITLE     Signal transduction pathway of human fibroblast growth factor
            receptor 3. Identification of a novel 66-kDa phosphoprotein
  JOURNAL   J Biol Chem 272 (10), 6621-6628 (1997)
   PUBMED   9045692
REFERENCE   9  (bases 1 to 1369)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
REFERENCE   10 (bases 1 to 1369)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091171.15, DR159037.1 and
            BM666883.1.
            
            On Jan 28, 2015 this sequence version replaced XM_005273676.1.
            
            Summary: This gene encodes a member of the fibroblast growth factor
            (FGF) family. Member of the FGF family possess broad mitogenic and
            cell survival activities, and are involved in a variety of
            biological processes including embryonic development cell growth,
            morphogenesis, tissue repair, tumor growth and invasion. This
            protein is expressed during embryogenesis and in the adult
            cerebellum and cortex and may be essential for vascular growth and
            normal brain development. Mutations in this gene are the cause of
            hypogonadotropic hypogonadism 20 with or without anosmia. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358869.1, DR159037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC091171.15        93227-93251
            26-791              DR159037.1         29-794
            792-847             AC091171.15        98721-98776
            848-1369            BM666883.1         1-522               c
FEATURES             Location/Qualifiers
     source          1..1369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..1369
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /note="fibroblast growth factor 17"
                     /db_xref="GeneID:8822"
                     /db_xref="HGNC:HGNC:3673"
                     /db_xref="MIM:603725"
     exon            1..211
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..794
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="fibroblast growth factor 17 isoform 2 precursor"
                     /protein_id="NP_001291407.1"
                     /db_xref="CCDS:CCDS78310.1"
                     /db_xref="GeneID:8822"
                     /db_xref="HGNC:HGNC:3673"
                     /db_xref="MIM:603725"
                     /translation="MGAARLLPNLTLCLQLLILCCQTQYVRDQGAMTDQLSRRQIREY
                     QLYSRTSGKHVQVTGRRISATAEDGNKFAKLIVETDTFGSRVRIKGAESEKYICMNKR
                     GKLIGKPSGKSKDCVFTEIVLENNYTAFQNARHEGWFMAFTRQGRPRQASRSRQNQRE
                     AHFIKRLYQGQLPFPNHAEKQKQFEFVGSAPTRRTKRTRRPQPLT"
     exon            212..248
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     exon            249..393
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     exon            394..500
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     exon            501..1354
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /note="hexamer: AATAAA"
     polyA_site      1354
                     /gene="FGF17"
                     /gene_synonym="FGF-13; FGF-17; HH20"
                     /note="major polyA site"
ORIGIN      
        1 cccctcctcc tccctctttt ctctcctcct cctccccttt ctctcctcct cgcccccctg
       61 aaaacctgtg gctcggagag accttggctt ctctgggact ctacccctgg ggacttccca
      121 catctgctcc tgagcttggg ggcagggggg caaccgcctg aggaacctct ccagcgatgg
      181 gagccgcccg cctgctgccc aacctcactc tgtgcttaca gctgctgatt ctctgctgtc
      241 aaactcagta cgtgagggac cagggcgcca tgaccgacca gctgagcagg cggcagatcc
      301 gcgagtacca actctacagc aggaccagtg gcaagcacgt gcaggtcacc gggcgtcgca
      361 tctccgccac cgccgaggac ggcaacaagt ttgccaagct catagtggag acggacacgt
      421 ttggcagccg ggttcgcatc aaaggggctg agagtgagaa gtacatctgt atgaacaaga
      481 ggggcaagct catcgggaag cccagcggga agagcaaaga ctgcgtgttc acggagatcg
      541 tgctggagaa caactatacg gccttccaga acgcccggca cgagggctgg ttcatggcct
      601 tcacgcggca ggggcggccc cgccaggctt cccgcagccg ccagaaccag cgcgaggccc
      661 acttcatcaa gcgcctctac caaggccagc tgcccttccc caaccacgcc gagaagcaga
      721 agcagttcga gtttgtgggc tccgccccca cccgccggac caagcgcaca cggcggcccc
      781 agcccctcac gtagtctggg aggcaggggg cagcagcccc tgggccgcct ccccacccct
      841 ttcccttctt aatccaagga ctgggctggg gtggcgggag gggagccaga tccccgaggg
      901 aggaccctga gggccgcgaa gcatccgagc ccccagctgg gaaggggcag gccggtgccc
      961 caggggcggc tggcacagtg cccccttccc ggacgggtgg caggccctgg agaggaactg
     1021 agtgtcaccc tgatctcagg ccaccagcct ctgccggcct cccagccggg ctcctgaagc
     1081 ccgctgaaag gtcagcgact gaaggccttg cagacaaccg tctggaggtg gctgtcctca
     1141 aaatctgctt ctcggatctc cctcagtctg cccccagccc ccaaactcct cctggctaga
     1201 ctgtaggaag ggacttttgt ttgtttgttt gtttcaggaa aaaagaaagg gagagagagg
     1261 aaaatagagg gttgtccact cctcacattc cacgacccag gcctgcaccc cacccccaac
     1321 tcccagcccc ggaataaaac cattttcctg caaaaaaaaa aaaaaaaaa
//
