LOCUS       NM_003868               1666 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens fibroblast growth factor 16 (FGF16), mRNA.
ACCESSION   NM_003868
VERSION     NM_003868.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Ye,L., Yu,Y., Zhao,Z.A., Zhao,D., Ni,X., Wang,Y., Fang,X., Yu,M.,
            Wang,Y., Tang,J.M., Chen,Y., Shen,Z., Lei,W. and Hu,S.
  TITLE     Patient-specific iPSC-derived cardiomyocytes reveal abnormal
            regulation of FGF16 in a familial atrial septal defect
  JOURNAL   Cardiovasc Res 118 (3), 859-871 (2022)
   PUBMED   33956078
  REMARK    GeneRIF: Patient-specific iPSC-derived cardiomyocytes reveal
            abnormal regulation of FGF16 in a familial atrial septal defect.
            Erratum:[Cardiovasc Res. 2024 Dec 31;120(17):2320. doi:
            10.1093/cvr/cvae227.. PMID: 39485389]
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Jennbacken,K., Wagberg,F., Karlsson,U., Eriksson,J., Magnusson,L.,
            Chimienti,M., Ricchiuto,P., Bernstrom,J., Ding,M.,
            Ross-Thriepland,D., Xue,Y., Peiris,D., Aastrup,T., Tegel,H.,
            Hober,S., Sivertsson,A., Uhlen,M., Stromstedt,P.E., Davies,R. and
            Holmberg Schiavone,L.
  TITLE     Phenotypic Screen with the Human Secretome Identifies FGF16 as
            Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells
  JOURNAL   Int J Mol Sci 20 (23), 6037 (2019)
   PUBMED   31801200
  REMARK    GeneRIF: FGF16 is capable of inducing proliferation of iPSC-derived
            cardiac progenitor cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1666)
  AUTHORS   Chen,C., Zhao,C., Gu,C., Cui,X. and Wu,J.
  TITLE     MiRNA-144-3p inhibits high glucose induced cell proliferation
            through suppressing FGF16
  JOURNAL   Biosci Rep 39 (7) (2019)
   PUBMED   31292167
  REMARK    GeneRIF: MiRNA-144-3p inhibits high glucose induced cell
            proliferation through suppressing FGF16.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1666)
  AUTHORS   Cheng,J., Fang,Z., Yang,H., Li,Y., Tian,H., Gong,W., Chen,T.,
            Liu,M., Li,X. and Jiang,C.
  TITLE     High-yield of biologically active recombinant human fibroblast
            growth factor-16 in E. coli and its mechanism of proliferation in
            NCL-H460 cells
  JOURNAL   Prep Biochem Biotechnol 47 (7), 720-729 (2017)
   PUBMED   28409700
  REMARK    GeneRIF: Experiments demonstrated FGF16 could promote proliferation
            of NCL-H460 cells by activating Akt, Erk1/2, and p38 MAPK
            signaling, whereas JNK had no significant effect.
REFERENCE   6  (bases 1 to 1666)
  AUTHORS   Kim,H.S.
  TITLE     The human FGF gene family: chromosome location and phylogenetic
            analysis
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 131-132 (2001)
   PUBMED   11474196
REFERENCE   7  (bases 1 to 1666)
  AUTHORS   Ornitz,D.M. and Itoh,N.
  TITLE     Fibroblast growth factors
  JOURNAL   Genome Biol 2 (3), REVIEWS3005 (2001)
   PUBMED   11276432
  REMARK    Review article
REFERENCE   8  (bases 1 to 1666)
  AUTHORS   Granerus,M. and Engstrom,W.
  TITLE     Dual effects of four members of the fibroblast growth factor member
            family on multiplication and motility in human teratocarcinoma
            cells in vitro
  JOURNAL   Anticancer Res 20 (5B), 3527-3531 (2000)
   PUBMED   11131657
REFERENCE   9  (bases 1 to 1666)
  AUTHORS   Konishi,M., Mikami,T., Yamasaki,M., Miyake,A. and Itoh,N.
  TITLE     Fibroblast growth factor-16 is a growth factor for embryonic brown
            adipocytes
  JOURNAL   J Biol Chem 275 (16), 12119-12122 (2000)
   PUBMED   10766846
REFERENCE   10 (bases 1 to 1666)
  AUTHORS   Miyake,A., Konishi,M., Martin,F.H., Hernday,N.A., Ozaki,K.,
            Yamamoto,S., Mikami,T., Arakawa,T. and Itoh,N.
  TITLE     Structure and expression of a novel member, FGF-16, on the
            fibroblast growth factor family
  JOURNAL   Biochem Biophys Res Commun 243 (1), 148-152 (1998)
   PUBMED   9473496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243316.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003868.2.
            
            Summary: This gene encodes a member of a family of proteins that
            are involved in a variety of biological processes, including
            embryonic development, cell growth, morphogenesis, tissue repair,
            tumor growth and invasion. This gene is expressed in cardiac cells
            and is required for proper heart development. Mutation in this gene
            was also observed in individuals with metacarpal 4-5 fusion.
            [provided by RefSeq, Mar 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.449379.1,
                                           SRR18074969.3281041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439435.3/ ENSP00000399324.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               AC243316.3         33856-34415         c
            561-664             AC243316.3         27544-27647         c
            665-1666            AC243316.3         24526-25527         c
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..1666
                     /gene="FGF16"
                     /gene_synonym="FGF-16; MF4"
                     /note="fibroblast growth factor 16"
                     /db_xref="GeneID:8823"
                     /db_xref="HGNC:HGNC:3672"
                     /db_xref="MIM:300827"
     exon            1..560
                     /gene="FGF16"
                     /gene_synonym="FGF-16; MF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..910
                     /gene="FGF16"
                     /gene_synonym="FGF-16; MF4"
                     /note="metacarpal 4-5 fusion"
                     /codon_start=1
                     /product="fibroblast growth factor 16"
                     /protein_id="NP_003859.1"
                     /db_xref="CCDS:CCDS75996.1"
                     /db_xref="GeneID:8823"
                     /db_xref="HGNC:HGNC:3672"
                     /db_xref="MIM:300827"
                     /translation="MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGK
                     LQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVG
                     LISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQ
                     YYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR"
     exon            561..664
                     /gene="FGF16"
                     /gene_synonym="FGF-16; MF4"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1666
                     /gene="FGF16"
                     /gene_synonym="FGF-16; MF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1642..1647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF16"
                     /gene_synonym="FGF-16; MF4"
                     /note="hexamer: AATAAA"
     polyA_site      1666
                     /gene="FGF16"
                     /gene_synonym="FGF-16; MF4"
                     /note="major polyA site"
ORIGIN      
        1 ggacgaagcc agctatgaga ggccggggga gatggatgcg gaggggaaga ggcactttga
       61 ctgagagcaa ggtcaggagc acgctgcccc gcgctccccg ccactgagaa gttccttgga
      121 cgcgaacaga cgtcgactgc agctcggcag agcgcggagc aagcgagcta gcgagggagc
      181 gccgccgaac cgcccgcgcc cgctgcgggg agaggcagtt cgcgccccgt ggccccggct
      241 cggcccgcgc gcgcccagca caaccagcgc cgcaatcggc ccagccatgg cagaggtggg
      301 gggcgtcttc gcctccttgg actgggatct acacggcttc tcctcgtctc tggggaacgt
      361 gcccttagct gactccccag gtttcctgaa cgagcgcctg ggccaaatcg aggggaagct
      421 gcagcgtggc tcacccacag acttcgccca cctaaagggg atcctgcggc gccgccagct
      481 ctactgccgc accggcttcc acctggagat cttccccaac ggcacggtgc acgggacccg
      541 ccacgaccac agccgcttcg gaatcctgga gtttatcagc ctggctgtgg ggctgatcag
      601 catccgggga gtggactctg gcctgtacct aggaatgaat gagcgaggag aactctatgg
      661 gtcgaagaaa ctcacacgtg aatgtgtttt ccgggaacag tttgaagaaa actggtacaa
      721 cacctatgcc tcaaccttgt acaaacattc ggactcagag agacagtatt acgtggccct
      781 gaacaaagat ggctcacccc gggagggata caggactaaa cgacaccaga aattcactca
      841 ctttttaccc aggcctgtag atccttctaa gttgccctcc atgtccagag acctctttca
      901 ctataggtaa tgaacctctg gtgtgccctc tgtgacccat gtaccctggg gccacggttg
      961 tctctgcaag cactatattc atagcttttc aatccttcct tcctatcatt ttagataaca
     1021 gaaaagcact tactgttgaa ctcaacccag ctgttccctt gttgttcaaa gtgtatatca
     1081 aggttgggtt attttgggga gggatggggg gctgggctcg agggaatctt gtatatactt
     1141 ttttctttac tcatgttcct tcccctgagg tagcataaca aagaatggga gcccctgcta
     1201 agggccaggg gtgtcttacc ccacaattta ctcaaatacc ttgacaatgg gtataaatga
     1261 aaggccaagg aatctgccac agatgctacc tacagagctt tggaaaagtc tcattaagaa
     1321 aatccttggg gctacagcct tgctgcaagc cttccctgca ttggctctgc agatttctca
     1381 tctgtcctga catgcagttt tcctgtcatt ggaagtggga gatggggtag gttgtaagaa
     1441 aatgatatta aaatgtaagc atggatactg tgcataagga caaactattt ataaaatgta
     1501 tatgctattt attttatata tttatttatt tcaaaataat aattttattt ttaatgagag
     1561 atgcgatggc tggattttca tcagaaagaa taaggtccta ctgaaacagg ataaaatgag
     1621 ttattaaagg cttttactga caataaaatt tgtctttata ttgtaa
//
