LOCUS       NM_004115              13071 bp    mRNA    linear   PRI 29-JAN-2025
DEFINITION  Homo sapiens fibroblast growth factor 14 (FGF14), transcript
            variant 1, mRNA.
ACCESSION   NM_004115
VERSION     NM_004115.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13071)
  AUTHORS   Mohren,L., Erdlenbruch,F., Leitao,E., Kilpert,F., Hones,G.S.,
            Kaya,S., Schroder,C., Thieme,A., Sturm,M., Park,J., Schluter,A.,
            Ruiz,M., Morales de la Prida,M., Casasnovas,C., Becker,K.,
            Roggenbuck,U., Pechlivanis,S., Kaiser,F.J., Synofzik,M., Wirth,T.,
            Anheim,M., Haack,T.B., Lockhart,P.J., Jockel,K.H., Pujol,A.,
            Klebe,S., Timmann,D. and Depienne,C.
  TITLE     Identification and characterisation of pathogenic and
            non-pathogenic FGF14 repeat expansions
  JOURNAL   Nat Commun 15 (1), 7665 (2024)
   PUBMED   39227614
  REMARK    GeneRIF: Identification and characterisation of pathogenic and
            non-pathogenic FGF14 repeat expansions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13071)
  AUTHORS   Zheng,Z.H., Cao,C.Y., Cheng,B., Yuan,R.Y., Zeng,Y.H., Guo,Z.B.,
            Qiu,Y.S., Lv,W.Q., Liang,H., Li,J.L., Zhang,W.X., Fang,M.K.,
            Sun,Y.H., Lin,W., Hong,J.M., Gan,S.R., Wang,N., Chen,W.J., Du,G.Q.
            and Fang,L.
  TITLE     Characteristics of tandem repeat inheritance and sympathetic nerve
            involvement in GAA-FGF14 ataxia
  JOURNAL   J Hum Genet 69 (9), 433-440 (2024)
   PUBMED   38866925
  REMARK    GeneRIF: Characteristics of tandem repeat inheritance and
            sympathetic nerve involvement in GAA-FGF14 ataxia.
REFERENCE   3  (bases 1 to 13071)
  AUTHORS   Pellerin,D., Del Gobbo,G.F., Couse,M., Dolzhenko,E.,
            Nageshwaran,S.K., Cheung,W.A., Xu,I.R.L., Dicaire,M.J.,
            Spurdens,G., Matos-Rodrigues,G., Stevanovski,I., Scriba,C.K.,
            Rebelo,A., Roth,V., Wandzel,M., Bonnet,C., Ashton,C., Agarwal,A.,
            Peter,C., Hasson,D., Tsankova,N.M., Dewar,K., Lamont,P.J.,
            Laing,N.G., Renaud,M., Houlden,H., Synofzik,M., Usdin,K.,
            Nussenzweig,A., Napierala,M., Chen,Z., Jiang,H., Deveson,I.W.,
            Ravenscroft,G., Akbarian,S., Eberle,M.A., Boycott,K.M.,
            Pastinen,T., Brais,B., Zuchner,S. and Danzi,M.C.
  CONSRTM   All of Us Research Program Long Read Working Group
  TITLE     A common flanking variant is associated with enhanced stability of
            the FGF14-SCA27B repeat locus
  JOURNAL   Nat Genet 56 (7), 1366-1370 (2024)
   PUBMED   38937606
  REMARK    GeneRIF: A common flanking variant is associated with enhanced
            stability of the FGF14-SCA27B repeat locus.
REFERENCE   4  (bases 1 to 13071)
  AUTHORS   Ouyang,R., Wan,L., Pellerin,D., Long,Z., Hu,J., Jiang,Q., Wang,C.,
            Peng,L., Peng,H., He,L., Qiu,R., Wang,J., Guo,J., Shen,L.,
            Brais,B., Danzi,M.C., Zuchner,S., Tang,B., Chen,Z. and Jiang,H.
  TITLE     The genetic landscape and phenotypic spectrum of GAA-FGF14 ataxia
            in China: a large cohort study
  JOURNAL   EBioMedicine 102, 105077 (2024)
   PUBMED   38513302
  REMARK    GeneRIF: The genetic landscape and phenotypic spectrum of GAA-FGF14
            ataxia in China: a large cohort study.
REFERENCE   5  (bases 1 to 13071)
  AUTHORS   van Swieten,J.C., Brusse,E., de Graaf,B.M., Krieger,E., van de
            Graaf,R., de Koning,I., Maat-Kievit,A., Leegwater,P., Dooijes,D.,
            Oostra,B.A. and Heutink,P.
  TITLE     A mutation in the fibroblast growth factor 14 gene is associated
            with autosomal dominant cerebellar ataxia [corrected]
  JOURNAL   Am J Hum Genet 72 (1), 191-199 (2003)
   PUBMED   12489043
  REMARK    GeneRIF: A mutation in the fibroblast growth factor 14 gene is
            associated with autosomal dominant cerebral ataxia
            Erratum:[Am J Hum Genet. 2003 Apr;72(4):1078]
REFERENCE   6  (bases 1 to 13071)
  AUTHORS   Chumakov,I., Blumenfeld,M., Guerassimenko,O., Cavarec,L.,
            Palicio,M., Abderrahim,H., Bougueleret,L., Barry,C., Tanaka,H., La
            Rosa,P., Puech,A., Tahri,N., Cohen-Akenine,A., Delabrosse,S.,
            Lissarrague,S., Picard,F.P., Maurice,K., Essioux,L., Millasseau,P.,
            Grel,P., Debailleul,V., Simon,A.M., Caterina,D., Dufaure,I.,
            Malekzadeh,K., Belova,M., Luan,J.J., Bouillot,M., Sambucy,J.L.,
            Primas,G., Saumier,M., Boubkiri,N., Martin-Saumier,S., Nasroune,M.,
            Peixoto,H., Delaye,A., Pinchot,V., Bastucci,M., Guillou,S.,
            Chevillon,M., Sainz-Fuertes,R., Meguenni,S., Aurich-Costa,J.,
            Cherif,D., Gimalac,A., Van Duijn,C., Gauvreau,D., Ouellette,G.,
            Fortier,I., Raelson,J., Sherbatich,T., Riazanskaia,N., Rogaev,E.,
            Raeymaekers,P., Aerssens,J., Konings,F., Luyten,W., Macciardi,F.,
            Sham,P.C., Straub,R.E., Weinberger,D.R., Cohen,N. and Cohen,D.
  TITLE     Genetic and physiological data implicating the new human gene G72
            and the gene for D-amino acid oxidase in schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13675-13680 (2002)
   PUBMED   12364586
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17221.
            Ouelette, G [corrected to Ouellette, G]; Realson, J [corrected to
            Raelson, J]]
REFERENCE   7  (bases 1 to 13071)
  AUTHORS   Wang,Q., Bardgett,M.E., Wong,M., Wozniak,D.F., Lou,J., McNeil,B.D.,
            Chen,C., Nardi,A., Reid,D.C., Yamada,K. and Ornitz,D.M.
  TITLE     Ataxia and paroxysmal dyskinesia in mice lacking axonally
            transported FGF14
  JOURNAL   Neuron 35 (1), 25-38 (2002)
   PUBMED   12123606
REFERENCE   8  (bases 1 to 13071)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
REFERENCE   9  (bases 1 to 13071)
  AUTHORS   Pellerin,D., Danzi,M., Renaud,M., Houlden,H., Synofzik,M.,
            Zuchner,S. and Brais,B.
  TITLE     GAA-FGF14-Related Ataxia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38271551
REFERENCE   10 (bases 1 to 13071)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512629.7, AL591909.5 and
            AL160153.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 30, 2020 this sequence version replaced NM_004115.3.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. A mutation in this gene is associated with autosomal
            dominant cerebral ataxia. Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.4345899.1,
                                           SRR14372079.2132549.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376143.5/ ENSP00000365313.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               AL512629.7         48116-48608         c
            494-604             AL512629.7         6849-6959           c
            605-708             AL591909.5         55273-55376         c
            709-907             AL160153.11        58767-58965         c
            908-13071           AL160153.11        42959-55122         c
FEATURES             Location/Qualifiers
     source          1..13071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.1"
     gene            1..13071
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="fibroblast growth factor 14"
                     /db_xref="GeneID:2259"
                     /db_xref="HGNC:HGNC:3671"
                     /db_xref="MIM:601515"
     exon            1..493
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1044
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="isoform 1A is encoded by transcript variant 1;
                     fibroblast growth factor homologous factor 4; nystagmus 4,
                     congenital autosomal dominant"
                     /codon_start=1
                     /product="fibroblast growth factor 14 isoform 1A"
                     /protein_id="NP_004106.1"
                     /db_xref="CCDS:CCDS9501.1"
                     /db_xref="GeneID:2259"
                     /db_xref="HGNC:HGNC:3671"
                     /db_xref="MIM:601515"
                     /translation="MAAAIASGLIRQKRQAREQHWDRPSASRRRSSPSKNRGLCNGNL
                     VDIFSKVRIFGLKKRRLRRQDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNST
                     LFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSM
                     LYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETV
                     PKPGVTPSKSTSASAIMNGGKPVNKSKTT"
     exon            494..604
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            605..708
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            709..907
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            908..13071
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2931..2936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: ATTAAA"
     polyA_site      2954
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      4072..4077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AGTAAA"
     polyA_site      4091
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      7006..7011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AATAAA"
     polyA_site      7024
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      13047..13052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AATAAA"
     polyA_site      13071
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
ORIGIN      
        1 gcagccgcgg tcccgctctc cactcggacg tggccaagcg gcggcggcca cgacgtccgg
       61 cttcccggga tcgtccggct gcgccctggg cgcatctgcg cgcctggccc cgcgccccgc
      121 ggagagggcg atgggtcccg gtcaggactg agcccccctt cccctctccc cagtcccgcc
      181 tggcaccccc tcctctgccc cgagggcgag ccacggtctg cgccgccgcc ttcccctccg
      241 gtgcccccgg ctcgccgtcc tcccgcgccc tccctccccg gacccgttcc cggggccacc
      301 atggccgcgg ccatcgctag cggcttgatc cgccagaagc ggcaggcgcg ggagcagcac
      361 tgggaccggc cgtctgccag caggaggcgg agcagcccca gcaagaaccg cgggctctgc
      421 aacggcaacc tggtggatat cttctccaaa gtgcgcatct tcggcctcaa gaagcgcagg
      481 ttgcggcgcc aagatcccca gctcaagggt atagtgacca ggttatattg caggcaaggc
      541 tactacttgc aaatgcaccc cgatggagct ctcgatggaa ccaaggatga cagcactaat
      601 tctacactct tcaacctcat accagtggga ctacgtgttg ttgccatcca gggagtgaaa
      661 acagggttgt atatagccat gaatggagaa ggttacctct acccatcaga actttttacc
      721 cctgaatgca agtttaaaga atctgttttt gaaaattatt atgtaatcta ctcatccatg
      781 ttgtacagac aacaggaatc tggtagagcc tggtttttgg gattaaataa ggaagggcaa
      841 gctatgaaag ggaacagagt aaagaaaacc aaaccagcag ctcattttct acccaagcca
      901 ttggaagttg ccatgtaccg agaaccatct ttgcatgatg ttggggaaac ggtcccgaag
      961 cctggggtga cgccaagtaa aagcacaagt gcgtctgcaa taatgaatgg aggcaaacca
     1021 gtcaacaaga gtaagacaac atagccagat cctcacaggt gttgtgactt attcgtcctg
     1081 agcacagttg agtgatttat cctcaccaga cattcctgct ccgtggctga agagcagcag
     1141 gaagtaagct aatgcttatt ctttgctgtc tccgaacttc tctgttgcaa gtggataaat
     1201 ctcaacctgt tgcacccccc acaacaagaa gacacctgga taaccagcta aactcagacc
     1261 atggaatgcc ctaccagata tggaatgcct ttttaatatc ttttctgtga ctgtgacact
     1321 tcatgtgaat gacatacttc acaagtacac tcgatacctt gcctgctgac agctacccat
     1381 aatccttttt gagtcctgtt tcagcgaaat ctatgtgttt aagttcaatt ttgtagcaca
     1441 caaataatat tgagtaattt ctagttagac gctgtaaacc tgtgctatta cggatttctc
     1501 ttcttcccat ttttacaggg ctgctcgctc cactgtctgt gaccttttgc agggattttg
     1561 ttcctctaaa tcttaaatgt tgcagttggc ttaggtcgga gagcaatcag ggaatcagga
     1621 agccttctaa acctattatt acaaattgca tctataaaga aagattaaga aagattgttg
     1681 tctctggctc acactatcga ttaaacacac atatacgctc tgtccagtag cagatactgt
     1741 gctcccaagg tcggcattgc ctgggtggga aatggctcaa acacaatcca gggaagctct
     1801 ctatgatatg tgtttgacat ccccctctag tttctttgtg tgtgtgtgtt ttatacatat
     1861 cacaagctta ctggtaatgg taacatttgc cttgcccagc gagcaagacc cactggtttt
     1921 tgagaaagtg ggtccaaaga tttctgtagg ccttgtaggc ctgattaagg ttcatttttc
     1981 atctattaat tctcattatt tggaaaaaaa aaaaaaggaa aatcagtaat tataacctac
     2041 aagaattgcg ctacctaaat ccatttcaga tatactccgt cctgttttta atgaaccaaa
     2101 cttaacgcca tccccgtttc tggctgcgtt cccctcatac tcagcagagc atgggcaaga
     2161 cggctgttgt gttctttcct gcagcagcaa tgcaaacgtt agttataaat taattagact
     2221 ttaatatttt tggtgtttaa tgacaagttt ttaaactgga catattagga aaaatatttt
     2281 ttttagctca gcatgctgag tccggtactg tgtatttcac cagtacatgc ctctagctca
     2341 gcatctgggg ctcatgttgc ccagtggctg ggttagaggt gccttgccat gatctcagaa
     2401 tacagtctgt tgaattatcc tagatgaaaa taaaggcaaa ccaacacatt catccatgag
     2461 gattttggtc cattccattt attttctttt attttgcatt cttaatttcc tttttagttt
     2521 aacactgttt gtttgagctt agggaagaca actaccaaga aaggccagga acagttgact
     2581 acacaatgaa gattccatgc aaaatgttca atattggatc taaaggggtt caaaatgttt
     2641 catactaaac tgtttgggaa tttatttgtt aactctgtgt acacctaata aaattcaatg
     2701 ttttcttctc agaagagttc attgagacca aactgaacct catttattga aaattatatg
     2761 tgggatcaat gtactggcct cttgttattc tttctatgtg ggaggatgac ccagtcatca
     2821 ttttccccat ctgcactgta tttattggga aattattttg tcactgcttt cataaatctt
     2881 cttcatgaca gcccttgccc agcattaaaa aattctggcc tgcttagctg attaaaggtt
     2941 tagtagaaat ttaactgttt gtttatgctt atttcatttt catattggat tctacttgaa
     3001 taaataaaaa gttagcagaa cgtttgagta gatttattgc caatgatgct aaattacaaa
     3061 tctaacaaac aaaatgattc ctttggtcat ttttgatttg gtgttatgtc atcttgaagc
     3121 ctattgtttt taacaggaac agttaaaata tattagataa cttccattaa ccaattattt
     3181 tcagaaaaca tagatcccat aatatgtggc caactatatg agtaattaac taacttgtaa
     3241 tacagtcaaa tgggcttatg gacactactt acagcagcaa cacttcactt cacacaaaca
     3301 cacacatata cacacacaca cacacacaca cacacacaca cacagagcaa acacccccat
     3361 ctatttgtta ctgataatta gccctacttg ctggtttctt tttcccctgc aagtctgttt
     3421 attggtttaa attaagacaa gatttatttt tgtaaatgac tgagatttat gtaaatgtgt
     3481 atctctgttg tgttttatat atggggtgtc tataagggca tttatcccta tgaaggatgt
     3541 caaatacttt cttctaatat atgtttagac atattgcaga ggggtccttg ttatttgtaa
     3601 ttgagttagg tcatttactt tgtgtctggt ctcacctgta gcatgggaag aggacagcaa
     3661 tgatgagctg catgtagtag gtacctgtgt atcaagaact gttggtatgt attgctaatt
     3721 tgcatacaaa gagtttgtct gtctgcattg tagtttgtgt ttaatatcat ttgttaaatt
     3781 cacaaataca acatattgaa taaaatattt atatgaaggc atattaaaaa acatcaaaca
     3841 actttatgta acaaaatggc attgcattac tcaccaatat agagaaatgt catgtaaata
     3901 agttggtaaa ctcaatttcc ccctttacca tgccaaagaa aattttagct ctttgatgat
     3961 acctctcttg ctatttgttt gggataagac ttcgccattt ttttcccctc agaaattaag
     4021 tttgctgtta ttaagtaaga agtgcaatct gtcactactg atgttccgta tagtaaatct
     4081 gatggaattc atttgtattt agactgtgtg ttttgtacct ccatgtgcat atgtccattg
     4141 tatcaagtct ctataatact ccattccttc tgcatgcata tctggtgtgg gagggttatt
     4201 tctactgatt tgttatagta gctgattgct ttgccagtcc ctcaacaacg ctcagaaatg
     4261 ttgttttggt atttcaagtg acaacatttt tgttttctaa tataagattg ctttttaaaa
     4321 cattttgcta ccactttact tggaaaaatt agagaagaca tgacaattct ccaccctatg
     4381 taaagagcaa aatggaactg aacatcattt cattacaaat cctgaagaat ttggagattc
     4441 ttgctctaaa tgtttgcttg tcctgaatgt ttttgggtag cagtggctta aagagatcca
     4501 cgatgggtcc aaaggactcc cgctccagtt cttctaatag tttgcctctt ggggagcaag
     4561 cagaagttct ttatcatacc tagccacttg cttaattaat gctttaagca ctaaaagttg
     4621 ttatttttat caggatgaac aatatcagat ttggttgtct ttaaaagcaa aaaccaaaaa
     4681 cttattcttt aagtaagtta gacacgtatc acttcattta aaattatctc cctaatatta
     4741 tggatcatta atatttgata catattcaaa aagagaccac attgactaac atccagttga
     4801 gaacaagatg aaaataattg aaatattttt tccattttaa ttcagaacaa ggctatatca
     4861 agggaaagcg actgggctaa atcctcaatt tttttttcca aaatgcaggc atatcaaaat
     4921 ccaggatgta catggtctta ctttgagtga aatagtagtc atagctgagg tttcttagcc
     4981 tacaatgtga catagggcct gttgactctc ttgaatatgg agtagggttt caaagtgttg
     5041 acagttgagt ctgcaaacta aggctgagtt atattttagt tttttttttt tttcctggtt
     5101 ttcactaagt ctaattccaa tgtctactgg cagagattgt gtttgcattt gaggtagtgg
     5161 agggcggtac tttccaagtg ctgttggaat ccagataaac tcaaggagcc cagaaagaca
     5221 acgggtataa tggctctcct cttatgactt agcactttag ttgacttttt tgaaaaagtc
     5281 tctgggtgga atacctcagt gatgatgatt tgccaaacaa gcagcgttag tgccaacacc
     5341 ttctctaaac ttgctgcatc ccttccaatt gacattaatc ccactgcaac ttcctaaaaa
     5401 caggaatgag ccaatgagat ttgcttattt tctctcaccc attacaagta agtttgttct
     5461 tgccctgctt gttttttaga gggagtttct atcatagagt tgaaaatcac atttaagaag
     5521 gaaagagttt atgtctttac atgtaactat tttatttttt ccaatctaaa ttcaatcact
     5581 tcttaataga tatattggtg tttgcattgc tggcatcaaa accacacata cacacacaaa
     5641 cacacacata cacacaaaca tagtggacag aaataagtaa aaatatttct gttttcaaag
     5701 aaaaagcatt ccttagagtt taggtaccat taacttctac tataatacag ttccggtact
     5761 atggtttcta actaaatgaa cactagaaca gagctgacta tattttcatc tttgtccaaa
     5821 attttagatg aatcacattt tgaacttttt atggtatgat aatttctcca atatctaaat
     5881 tctttttctg agaaaacaaa tgccgaggac atttttgaca ctcttcttac atgagactat
     5941 gaaaaagagc agcacttttg ttgtagttgt tgttgttaat aaaaaggata ataacataca
     6001 gaggattata agaaaaataa gacatacctg aggttttgtg atgagctata gagaatcaag
     6061 ggcagttcca gtggagctga ggctgacaaa gtactgccca gctgccagcc aaatccaccc
     6121 ttaagttgct tttgtatggc ctgggagctc agaaggaatt ttttaaattt tttttacagc
     6181 tttaaagtat taaacagaaa ccaacaaaga agaatatgag acagggacgt acgtggtccg
     6241 taaagtttaa ctttctgatc cttaatagga ggataagcgc cgtgatagag aaatccaaag
     6301 gtcatttgta ttacgatggc tagataatgt aatgaattcc aatgtctgtg catcagcgaa
     6361 tacgtcatca aaattgctac aaaacaataa taataggttg ttcacagctt aaaatgttta
     6421 ggtagtgaag aggaaagaat ataacctaca ttatttattg actacttata tttccctcat
     6481 tttacggaag agatctatca atttacgtac tcaataatag aactacaaca tggttgcact
     6541 ccttaatctc aggatagaga taacaatttt tataaatcta ttacattatg agaacattgt
     6601 tagtactata aaaatcagga tcagttaaat gttctcttaa aataattttc aatattaaat
     6661 ttttaagtaa ctcagtggat gcatattttc cttatttttg gaaatttgac ttataaagtt
     6721 taagccatga ctagaatatt tacatcatta aaataaaatt tccaagtaaa aattttcatc
     6781 ttaaagtaat acggaaatga ttttgctaca ttattctagg attttacaaa gtaattcacc
     6841 tttagaaaaa aagtggtttt ttttttagct ctaaataatt aaaggttgcc taaactaatg
     6901 tgtataagta gatttacctg taaatatgta agggaagtcc caattattgt acactttcat
     6961 aattcaatgt gaatttcata caaagcaaag tttcaccatt aagaaaataa acattttgtt
     7021 cctatcactg agtgaatatt tgtaatttct atttaagcca tttctagatt tttttttttt
     7081 tttggtcttt tgtgagcttc tgagattggt gccattttat cacagtattt ctcgtcttga
     7141 cttctttgca tgaccccagg tttccagtaa gtaaggtatc cttagaaaaa aaagtatttt
     7201 aagggaaatg gatgcatact tcaggcccat tttatatgta actcaatatt gtctttttaa
     7261 aaggccacac taccatggaa taaattaaaa taaaaaatca gatttcttgt acgcataacc
     7321 cctgcccagt tttaaaaatg tgatccctta tttctagaaa cctaaaatag atatccctga
     7381 ataacaattc atttttaatt atcagtagat atatatactg acacagagta taaacaactt
     7441 ctgtcactat ttatttaaaa tgttaaattg tacatttttc ataatttctt taagagaatc
     7501 ttctttggtg agtttaaagt gagagtagac aaataactta gtggctaaat gatttaatgt
     7561 cagatgactt aatgaccagt ttttgccctt gatccagccc cactctgata ttctacctcc
     7621 tgtgtgcttg tcttcattgt ccccatatta aaatggtgac tgatacggaa ttctggaaaa
     7681 atctgatcga ttaattaatg tgaatatgca tgttttcctt agattctaat atggtctttc
     7741 ttgtgtaaga atgtggattt ctaatagcca tataactcaa tgtttctcag tttgagccct
     7801 attggcattt ggggctggat aattccttgt ttgggggctg tcctgtacac tgcgggatgc
     7861 tcagcagcat ccctggcctc tacccaccaa atgtctgcag cataccttcc tacccgaccc
     7921 agtgtgacaa tcaaaattgt ctgtagatgt tgccaaatga cttttgggtg gaaaaattgc
     7981 tctcgttagg aaccacttat gttaattatg gaagaatctt ttttttctaa tgttatttgc
     8041 atctaaattt gcataactca tttctaatag gtactcggat ttcattcgta attcagaaat
     8101 agaaaaacat acaatggtct ttttaacctg tcctagtggt gaatatacat ggtttccttc
     8161 gcatttatct gttctaatgg cccagaaaaa ataagaatcc agacctctct catgtaattg
     8221 ttaaggatat tctgagccaa gccagatttc acatgcattt ccattccatc catcccagca
     8281 ttcacagttt ccacagctac atattccatt ccctgcaata aaatacatat aggtatcatg
     8341 attatgatca aaatgtgcca aatttaaaca tgctattata aatcacaagt gtccacaatg
     8401 aaatcatttc attcatcctt ggtagatttt cttattgtgc aatgatgtta ttattacatc
     8461 ttattaagca gctgcgagac atctaatctt tcaaacaatt agtggcattt atttggtgcc
     8521 accctttacc gatcagatag tcaccatcct gtatcactcc agctaggctt ttaggtgaca
     8581 attttgtttt cccttaaaga gcaagttata tctgacttat gaataaatac agaaaaacat
     8641 aaggctcttt gacataacat gaggcaggcc aagtaatccg tgaagagagt cttacgtagt
     8701 aaggatgggc agaaagcaaa ggtctaactt aatgacacac aaagagtcat cttttacctt
     8761 cagctagagc tgaggagaag tatacatgtc tctgtttcct cgtaacttgg ctaaacaaat
     8821 gaatttataa ccaattatga ggactcaata aattaggata gcagtggcta tgacacggct
     8881 gagccctctt tatacctctc ccccatacac acatccagtt ccctaaaagc aaccaacaca
     8941 tcaactagtg gtacccagat tctgtttaaa agaatatttc attccctata ccatgttcaa
     9001 agtaaaatgg ttgccaacaa aattcttttc tgtgttcaat atacaactgc atacatgtga
     9061 gtttgagggt ggggaggtta ctttgtggaa ggatcccaaa taatcacaaa atttagcttc
     9121 attctcttgt attcttctat gcctaggaat aatgtgaggc ttttgtgagg gctttttccc
     9181 aaatgcccac ttcgcctttg gtagatattt catattcacg gttggccctg ttggtccagc
     9241 cacctaaagc attgcatgac gagtgtctct tggctctata acaaactgtg gcatagagca
     9301 attagaaaag gttaatactg cacctgtaca aatgagacca tcatgtttgt cgcagtctct
     9361 gtcatcacag tcacagaact ccccagaaat ataccactct tcagcagaac aaatgcactt
     9421 cccacaatga caagaacctg aaattacaaa ggctattact caccatcacc ttataactaa
     9481 aggtttccat ctcgaataga atatcgttga cacactgaca acaggcttct aataacccat
     9541 catccaaagg taaaagtgta ttgaatggct ggtttctcag aggggagctt tacttactgt
     9601 aattcataaa ggtcacccag gaaagccttc attatggatc tagacagttg caattagcct
     9661 tgaacaaatg tcccatggcc cagtctggtt gaaatgtcaa tgagagcagg atggggttga
     9721 ttcttataga tggtcttcca aaaaagtatt caaaaataga ttttttcctc ctaaattgaa
     9781 tcatgttttt aaagtgcctg ctctttaaag gaaatgaata gggaattgta ttaaattagg
     9841 ttgcatttct aattaaaaca actactaaat tattgtgctt ataattttgg attttcgttt
     9901 acatgatttt cttggagtag gagcacacct gcatattggg tggctaatta aagtgctaaa
     9961 aatgcataca gtcactcagt atatttgcct tgtgagactc atcctcagga ccctctgtca
    10021 taaactggga tagctcaaat tactcccaaa gttcatattt tatgaggctc tggattcaac
    10081 tctttttccc tccacttcac ccatttctcc tacctaacta aaaaacttcc tctttggtta
    10141 tttaaaatat ctttacttac tgagtaaaaa ttttattaat gatatattta aaataaaaga
    10201 aaataaatga gatgatgaat ggtatccaag acagaagttc tctcagtcta aacagctttc
    10261 catgacagac taaaaaccct tacatggaaa aactgcctca acgacagcag gaaagacttt
    10321 acaatgaaaa agaaacaaat aaaaaggact ttcttttcct tctgtttcct tgggttggtt
    10381 gttctttcca aacatgactt ccatttacta aaagatggct gtattctttt tgagtcaaaa
    10441 tcacgttgaa aaaatgtgca gttgaaaaga gtattttgac atatttaaca aaactgcaga
    10501 attggtaagt tcaaaatata ttgaaaaggg gcaagaatca atcattagtg cttcttttaa
    10561 aacacagtga ttaaaaatga gttaacagcc tgggtgatta aagtgatcag gaaaaaggag
    10621 ttgtggtcat cacagatatc atgaaaggat tcaggttcat gtgtctcaac tatgtgatat
    10681 ttcatatcag ggaaactggt atatgcattt cagctgcaaa aatccccaaa gtccaaatta
    10741 aatgtttgcc atttcttgac acacttctca aagtaagagt gcagtcagaa ttatttagat
    10801 tgtgacaatt gtgtttttta acttcttgcg tagctatggc ataattgtat ttagtcttga
    10861 cttgttttcc tgagggtcca ggttgatttg catgctcttg aggaaatata cacgtcttct
    10921 cagttttaat aattgactga cagccctgtg gtttctcagg acccagtgag ctgctgctcc
    10981 caggtcagtc tgcaaaggat gctggttccc ttgtggtctc atcaaggtga ggaatttcct
    11041 gattttagag atttctttat cctaattttg aagactttct ttcacatttc taggcataaa
    11101 aaaatgtaca gcactctact gcttgtttaa caaatggata gtgatatatc tgccaacaaa
    11161 gaccacatgg agtatttcat tgactatcag agaagtttcc tcgaaaggca ccatacttag
    11221 tgttttattt ccatgagtga aggaaaatta gttatttgaa gtatttggct gtctttagtt
    11281 gtttctaaag tagtgctgat tttatatgcc cataatattc atatatacac ccaggatatc
    11341 attttatata tgtcacaatt catgaaatat cttatatttc atcttcaaac ttatcctctg
    11401 gccctggaac tattctaatc actgctcttg cttctggaat gcttagcttc atgccatagt
    11461 agagcatttt cagaaaactg gtaagctcag ctaaagctaa tatggcatat atggatagaa
    11521 catttgatga gtaaattcca gttctgaaag tctactagtc gctgaaatac ttagaataaa
    11581 aaatgaggat tgattttgta tgtgtcatga aacagtagca tttctaggtc agcattttcc
    11641 cagctgtgtt attctttcct gtttgtcaat gctcagtgca tcttagaggt aggaaattat
    11701 tctactgctt gtgaaactag aactagatag cacatagtaa taacacagtg tgaatagtta
    11761 ttaggaccta ttatagcact tttcctgtag aacgctctag ctgttttctt ccataacatg
    11821 ggtcaaattg tgcctctctt aaatgggaag cacacaggga gagggttcca tcagacagat
    11881 gtaggctgca tgactatcaa gaggtgagaa atggttcaac tcagctggcc aagacccact
    11941 cacacccctg agacccagcc tagccagaga acagctggct gatcttggca ggagttttag
    12001 ggcagatagt tcatcaccac agcaccacta atccattcat tttctttctc aatataagga
    12061 cccttgagaa tgttcccatc tcccttctgt gcatttttgc tggcttccat ccctggggaa
    12121 tcagccacat tttctcatgt gtcttcaggg catcttagga cataggaagg ggaaagaaat
    12181 gaaattttac cttcaaagat gagaatggaa gagagaataa aggaaactgt cctggacctc
    12241 acaggcaata aacaaacagt taactgaaga cttcactctg attcaatcca ctcttctttt
    12301 tagtgatctg cctatctgtg atgtatctcc aggcaaaaac tttcatatac agtagtttaa
    12361 aaatgagctg tttcttcctg caggtctgac tgcacaggca tattgagcga ggcaacttga
    12421 acaccaggct gaggccgatt ttgtgaagca tctttcactc tttctctttt ctggggatgt
    12481 gggacaggtt gtgggtgggt gagtgtgtgt gtatgctgga cttctttgga agatgtggga
    12541 cccaagaagt atcactgtga gagtttaagg agacagttaa tgacatgtgt ttacagccat
    12601 tgtcacacaa cagcatctgt aagaagattg gacgtgatta tctggatcta gcttgaagta
    12661 gtcaaggcaa agatataatt gtgtagtctt gaagccaaat aaatccccaa atgaacaaaa
    12721 caacccacaa tgaattatat catgtacttt gcaaaggtag ctaagcttag ggaagacccg
    12781 gcactgcact aacctcatct ctcttggtta ttcacaaaaa caatttgagt ctaagggcaa
    12841 ggcacctttg tcagttgccc attccattac taatgttgga ctttcttttt cattcaagcc
    12901 tgacaaaatg ctgcaacctg acatcccagc aggcagtttt cactattgta ctaactactc
    12961 catctgttat gaaggtcaca agaatgtatc ttgttttaaa tttttctatg gagtgattta
    13021 ttgtcttggc tataaatttg taaagaaata aaacgctatt tcttcatcgt c
//
