LOCUS       NM_001379342           13014 bp    mRNA    linear   PRI 29-JAN-2025
DEFINITION  Homo sapiens fibroblast growth factor 14 (FGF14), transcript
            variant 22, mRNA.
ACCESSION   NM_001379342
VERSION     NM_001379342.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13014)
  AUTHORS   Mohren,L., Erdlenbruch,F., Leitao,E., Kilpert,F., Hones,G.S.,
            Kaya,S., Schroder,C., Thieme,A., Sturm,M., Park,J., Schluter,A.,
            Ruiz,M., Morales de la Prida,M., Casasnovas,C., Becker,K.,
            Roggenbuck,U., Pechlivanis,S., Kaiser,F.J., Synofzik,M., Wirth,T.,
            Anheim,M., Haack,T.B., Lockhart,P.J., Jockel,K.H., Pujol,A.,
            Klebe,S., Timmann,D. and Depienne,C.
  TITLE     Identification and characterisation of pathogenic and
            non-pathogenic FGF14 repeat expansions
  JOURNAL   Nat Commun 15 (1), 7665 (2024)
   PUBMED   39227614
  REMARK    GeneRIF: Identification and characterisation of pathogenic and
            non-pathogenic FGF14 repeat expansions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13014)
  AUTHORS   Zheng,Z.H., Cao,C.Y., Cheng,B., Yuan,R.Y., Zeng,Y.H., Guo,Z.B.,
            Qiu,Y.S., Lv,W.Q., Liang,H., Li,J.L., Zhang,W.X., Fang,M.K.,
            Sun,Y.H., Lin,W., Hong,J.M., Gan,S.R., Wang,N., Chen,W.J., Du,G.Q.
            and Fang,L.
  TITLE     Characteristics of tandem repeat inheritance and sympathetic nerve
            involvement in GAA-FGF14 ataxia
  JOURNAL   J Hum Genet 69 (9), 433-440 (2024)
   PUBMED   38866925
  REMARK    GeneRIF: Characteristics of tandem repeat inheritance and
            sympathetic nerve involvement in GAA-FGF14 ataxia.
REFERENCE   3  (bases 1 to 13014)
  AUTHORS   Pellerin,D., Del Gobbo,G.F., Couse,M., Dolzhenko,E.,
            Nageshwaran,S.K., Cheung,W.A., Xu,I.R.L., Dicaire,M.J.,
            Spurdens,G., Matos-Rodrigues,G., Stevanovski,I., Scriba,C.K.,
            Rebelo,A., Roth,V., Wandzel,M., Bonnet,C., Ashton,C., Agarwal,A.,
            Peter,C., Hasson,D., Tsankova,N.M., Dewar,K., Lamont,P.J.,
            Laing,N.G., Renaud,M., Houlden,H., Synofzik,M., Usdin,K.,
            Nussenzweig,A., Napierala,M., Chen,Z., Jiang,H., Deveson,I.W.,
            Ravenscroft,G., Akbarian,S., Eberle,M.A., Boycott,K.M.,
            Pastinen,T., Brais,B., Zuchner,S. and Danzi,M.C.
  CONSRTM   All of Us Research Program Long Read Working Group
  TITLE     A common flanking variant is associated with enhanced stability of
            the FGF14-SCA27B repeat locus
  JOURNAL   Nat Genet 56 (7), 1366-1370 (2024)
   PUBMED   38937606
  REMARK    GeneRIF: A common flanking variant is associated with enhanced
            stability of the FGF14-SCA27B repeat locus.
REFERENCE   4  (bases 1 to 13014)
  AUTHORS   Ouyang,R., Wan,L., Pellerin,D., Long,Z., Hu,J., Jiang,Q., Wang,C.,
            Peng,L., Peng,H., He,L., Qiu,R., Wang,J., Guo,J., Shen,L.,
            Brais,B., Danzi,M.C., Zuchner,S., Tang,B., Chen,Z. and Jiang,H.
  TITLE     The genetic landscape and phenotypic spectrum of GAA-FGF14 ataxia
            in China: a large cohort study
  JOURNAL   EBioMedicine 102, 105077 (2024)
   PUBMED   38513302
  REMARK    GeneRIF: The genetic landscape and phenotypic spectrum of GAA-FGF14
            ataxia in China: a large cohort study.
REFERENCE   5  (bases 1 to 13014)
  AUTHORS   van Swieten,J.C., Brusse,E., de Graaf,B.M., Krieger,E., van de
            Graaf,R., de Koning,I., Maat-Kievit,A., Leegwater,P., Dooijes,D.,
            Oostra,B.A. and Heutink,P.
  TITLE     A mutation in the fibroblast growth factor 14 gene is associated
            with autosomal dominant cerebellar ataxia [corrected]
  JOURNAL   Am J Hum Genet 72 (1), 191-199 (2003)
   PUBMED   12489043
  REMARK    GeneRIF: A mutation in the fibroblast growth factor 14 gene is
            associated with autosomal dominant cerebral ataxia
            Erratum:[Am J Hum Genet. 2003 Apr;72(4):1078]
REFERENCE   6  (bases 1 to 13014)
  AUTHORS   Chumakov,I., Blumenfeld,M., Guerassimenko,O., Cavarec,L.,
            Palicio,M., Abderrahim,H., Bougueleret,L., Barry,C., Tanaka,H., La
            Rosa,P., Puech,A., Tahri,N., Cohen-Akenine,A., Delabrosse,S.,
            Lissarrague,S., Picard,F.P., Maurice,K., Essioux,L., Millasseau,P.,
            Grel,P., Debailleul,V., Simon,A.M., Caterina,D., Dufaure,I.,
            Malekzadeh,K., Belova,M., Luan,J.J., Bouillot,M., Sambucy,J.L.,
            Primas,G., Saumier,M., Boubkiri,N., Martin-Saumier,S., Nasroune,M.,
            Peixoto,H., Delaye,A., Pinchot,V., Bastucci,M., Guillou,S.,
            Chevillon,M., Sainz-Fuertes,R., Meguenni,S., Aurich-Costa,J.,
            Cherif,D., Gimalac,A., Van Duijn,C., Gauvreau,D., Ouellette,G.,
            Fortier,I., Raelson,J., Sherbatich,T., Riazanskaia,N., Rogaev,E.,
            Raeymaekers,P., Aerssens,J., Konings,F., Luyten,W., Macciardi,F.,
            Sham,P.C., Straub,R.E., Weinberger,D.R., Cohen,N. and Cohen,D.
  TITLE     Genetic and physiological data implicating the new human gene G72
            and the gene for D-amino acid oxidase in schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13675-13680 (2002)
   PUBMED   12364586
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17221.
            Ouelette, G [corrected to Ouellette, G]; Realson, J [corrected to
            Raelson, J]]
REFERENCE   7  (bases 1 to 13014)
  AUTHORS   Wang,Q., Bardgett,M.E., Wong,M., Wozniak,D.F., Lou,J., McNeil,B.D.,
            Chen,C., Nardi,A., Reid,D.C., Yamada,K. and Ornitz,D.M.
  TITLE     Ataxia and paroxysmal dyskinesia in mice lacking axonally
            transported FGF14
  JOURNAL   Neuron 35 (1), 25-38 (2002)
   PUBMED   12123606
REFERENCE   8  (bases 1 to 13014)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
REFERENCE   9  (bases 1 to 13014)
  AUTHORS   Pellerin,D., Danzi,M., Renaud,M., Houlden,H., Synofzik,M.,
            Zuchner,S. and Brais,B.
  TITLE     GAA-FGF14-Related Ataxia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38271551
REFERENCE   10 (bases 1 to 13014)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356263.12, AL512629.7,
            AL591909.5 and AL160153.11.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. A mutation in this gene is associated with autosomal
            dominant cerebral ataxia. Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660803.42969.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1968968,
                                    SAMEA2142586 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               AL356263.12        39826-40133         c
            309-436             AL356263.12        39161-39288         c
            437-547             AL512629.7         6849-6959           c
            548-651             AL591909.5         55273-55376         c
            652-850             AL160153.11        58767-58965         c
            851-13014           AL160153.11        42959-55122         c
FEATURES             Location/Qualifiers
     source          1..13014
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.1"
     gene            1..13014
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="fibroblast growth factor 14"
                     /db_xref="GeneID:2259"
                     /db_xref="HGNC:HGNC:3671"
                     /db_xref="MIM:601515"
     exon            1..308
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            309..436
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..987
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="isoform 8 is encoded by transcript variant 22;
                     fibroblast growth factor homologous factor 4; nystagmus 4,
                     congenital autosomal dominant"
                     /codon_start=1
                     /product="fibroblast growth factor 14 isoform 8"
                     /protein_id="NP_001366271.1"
                     /db_xref="GeneID:2259"
                     /db_xref="HGNC:HGNC:3671"
                     /db_xref="MIM:601515"
                     /translation="MWFLWNIFSKGTHMLQCLCGKSLKKNKNPTDPQLKGIVTRLYCR
                     QGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPS
                     ELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAA
                     HFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT"
     exon            437..547
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            548..651
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            652..850
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            851..13014
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2874..2879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: ATTAAA"
     polyA_site      2897
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      4015..4020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AGTAAA"
     polyA_site      4034
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      6949..6954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AATAAA"
     polyA_site      6967
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      12990..12995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AATAAA"
     polyA_site      13014
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
ORIGIN      
        1 ctcctccctc taatgcctgt aactcacatc cgaggctggg cgaggaatcc ggaggggaga
       61 ttttcctcat gctcacggtt gttggaaact ggaagagtga gaggaaggag gaaggggatt
      121 tgtggcgctc tctacctact acaagactga caaggggagg gggcacctaa atttgcatct
      181 tttcttcgtg gtgattgaga actgcaggtt caaaccgatc ccactgagca ctggcgattg
      241 attataaaaa aaaatcgaca ctgggagaag ggaggctctg tcttcggctg tcagactcaa
      301 tctcggaggg tgtctaagct gctggattgc ttttcgccca aatcaatgtg gtttctttgg
      361 aacattttca gcaaaggaac gcatatgctg cagtgtcttt gtggcaagag tcttaagaaa
      421 aacaagaacc caactgatcc ccagctcaag ggtatagtga ccaggttata ttgcaggcaa
      481 ggctactact tgcaaatgca ccccgatgga gctctcgatg gaaccaagga tgacagcact
      541 aattctacac tcttcaacct cataccagtg ggactacgtg ttgttgccat ccagggagtg
      601 aaaacagggt tgtatatagc catgaatgga gaaggttacc tctacccatc agaacttttt
      661 acccctgaat gcaagtttaa agaatctgtt tttgaaaatt attatgtaat ctactcatcc
      721 atgttgtaca gacaacagga atctggtaga gcctggtttt tgggattaaa taaggaaggg
      781 caagctatga aagggaacag agtaaagaaa accaaaccag cagctcattt tctacccaag
      841 ccattggaag ttgccatgta ccgagaacca tctttgcatg atgttgggga aacggtcccg
      901 aagcctgggg tgacgccaag taaaagcaca agtgcgtctg caataatgaa tggaggcaaa
      961 ccagtcaaca agagtaagac aacatagcca gatcctcaca ggtgttgtga cttattcgtc
     1021 ctgagcacag ttgagtgatt tatcctcacc agacattcct gctccgtggc tgaagagcag
     1081 caggaagtaa gctaatgctt attctttgct gtctccgaac ttctctgttg caagtggata
     1141 aatctcaacc tgttgcaccc cccacaacaa gaagacacct ggataaccag ctaaactcag
     1201 accatggaat gccctaccag atatggaatg cctttttaat atcttttctg tgactgtgac
     1261 acttcatgtg aatgacatac ttcacaagta cactcgatac cttgcctgct gacagctacc
     1321 cataatcctt tttgagtcct gtttcagcga aatctatgtg tttaagttca attttgtagc
     1381 acacaaataa tattgagtaa tttctagtta gacgctgtaa acctgtgcta ttacggattt
     1441 ctcttcttcc catttttaca gggctgctcg ctccactgtc tgtgaccttt tgcagggatt
     1501 ttgttcctct aaatcttaaa tgttgcagtt ggcttaggtc ggagagcaat cagggaatca
     1561 ggaagccttc taaacctatt attacaaatt gcatctataa agaaagatta agaaagattg
     1621 ttgtctctgg ctcacactat cgattaaaca cacatatacg ctctgtccag tagcagatac
     1681 tgtgctccca aggtcggcat tgcctgggtg ggaaatggct caaacacaat ccagggaagc
     1741 tctctatgat atgtgtttga catccccctc tagtttcttt gtgtgtgtgt gttttataca
     1801 tatcacaagc ttactggtaa tggtaacatt tgccttgccc agcgagcaag acccactggt
     1861 ttttgagaaa gtgggtccaa agatttctgt aggccttgta ggcctgatta aggttcattt
     1921 ttcatctatt aattctcatt atttggaaaa aaaaaaaaag gaaaatcagt aattataacc
     1981 tacaagaatt gcgctaccta aatccatttc agatatactc cgtcctgttt ttaatgaacc
     2041 aaacttaacg ccatccccgt ttctggctgc gttcccctca tactcagcag agcatgggca
     2101 agacggctgt tgtgttcttt cctgcagcag caatgcaaac gttagttata aattaattag
     2161 actttaatat ttttggtgtt taatgacaag tttttaaact ggacatatta ggaaaaatat
     2221 tttttttagc tcagcatgct gagtccggta ctgtgtattt caccagtaca tgcctctagc
     2281 tcagcatctg gggctcatgt tgcccagtgg ctgggttaga ggtgccttgc catgatctca
     2341 gaatacagtc tgttgaatta tcctagatga aaataaaggc aaaccaacac attcatccat
     2401 gaggattttg gtccattcca tttattttct tttattttgc attcttaatt tcctttttag
     2461 tttaacactg tttgtttgag cttagggaag acaactacca agaaaggcca ggaacagttg
     2521 actacacaat gaagattcca tgcaaaatgt tcaatattgg atctaaaggg gttcaaaatg
     2581 tttcatacta aactgtttgg gaatttattt gttaactctg tgtacaccta ataaaattca
     2641 atgttttctt ctcagaagag ttcattgaga ccaaactgaa cctcatttat tgaaaattat
     2701 atgtgggatc aatgtactgg cctcttgtta ttctttctat gtgggaggat gacccagtca
     2761 tcattttccc catctgcact gtatttattg ggaaattatt ttgtcactgc tttcataaat
     2821 cttcttcatg acagcccttg cccagcatta aaaaattctg gcctgcttag ctgattaaag
     2881 gtttagtaga aatttaactg tttgtttatg cttatttcat tttcatattg gattctactt
     2941 gaataaataa aaagttagca gaacgtttga gtagatttat tgccaatgat gctaaattac
     3001 aaatctaaca aacaaaatga ttcctttggt catttttgat ttggtgttat gtcatcttga
     3061 agcctattgt ttttaacagg aacagttaaa atatattaga taacttccat taaccaatta
     3121 ttttcagaaa acatagatcc cataatatgt ggccaactat atgagtaatt aactaacttg
     3181 taatacagtc aaatgggctt atggacacta cttacagcag caacacttca cttcacacaa
     3241 acacacacat atacacacac acacacacac acacacacac acacacagag caaacacccc
     3301 catctatttg ttactgataa ttagccctac ttgctggttt ctttttcccc tgcaagtctg
     3361 tttattggtt taaattaaga caagatttat ttttgtaaat gactgagatt tatgtaaatg
     3421 tgtatctctg ttgtgtttta tatatggggt gtctataagg gcatttatcc ctatgaagga
     3481 tgtcaaatac tttcttctaa tatatgttta gacatattgc agaggggtcc ttgttatttg
     3541 taattgagtt aggtcattta ctttgtgtct ggtctcacct gtagcatggg aagaggacag
     3601 caatgatgag ctgcatgtag taggtacctg tgtatcaaga actgttggta tgtattgcta
     3661 atttgcatac aaagagtttg tctgtctgca ttgtagtttg tgtttaatat catttgttaa
     3721 attcacaaat acaacatatt gaataaaata tttatatgaa ggcatattaa aaaacatcaa
     3781 acaactttat gtaacaaaat ggcattgcat tactcaccaa tatagagaaa tgtcatgtaa
     3841 ataagttggt aaactcaatt tcccccttta ccatgccaaa gaaaatttta gctctttgat
     3901 gatacctctc ttgctatttg tttgggataa gacttcgcca tttttttccc ctcagaaatt
     3961 aagtttgctg ttattaagta agaagtgcaa tctgtcacta ctgatgttcc gtatagtaaa
     4021 tctgatggaa ttcatttgta tttagactgt gtgttttgta cctccatgtg catatgtcca
     4081 ttgtatcaag tctctataat actccattcc ttctgcatgc atatctggtg tgggagggtt
     4141 atttctactg atttgttata gtagctgatt gctttgccag tccctcaaca acgctcagaa
     4201 atgttgtttt ggtatttcaa gtgacaacat ttttgttttc taatataaga ttgcttttta
     4261 aaacattttg ctaccacttt acttggaaaa attagagaag acatgacaat tctccaccct
     4321 atgtaaagag caaaatggaa ctgaacatca tttcattaca aatcctgaag aatttggaga
     4381 ttcttgctct aaatgtttgc ttgtcctgaa tgtttttggg tagcagtggc ttaaagagat
     4441 ccacgatggg tccaaaggac tcccgctcca gttcttctaa tagtttgcct cttggggagc
     4501 aagcagaagt tctttatcat acctagccac ttgcttaatt aatgctttaa gcactaaaag
     4561 ttgttatttt tatcaggatg aacaatatca gatttggttg tctttaaaag caaaaaccaa
     4621 aaacttattc tttaagtaag ttagacacgt atcacttcat ttaaaattat ctccctaata
     4681 ttatggatca ttaatatttg atacatattc aaaaagagac cacattgact aacatccagt
     4741 tgagaacaag atgaaaataa ttgaaatatt ttttccattt taattcagaa caaggctata
     4801 tcaagggaaa gcgactgggc taaatcctca attttttttt ccaaaatgca ggcatatcaa
     4861 aatccaggat gtacatggtc ttactttgag tgaaatagta gtcatagctg aggtttctta
     4921 gcctacaatg tgacataggg cctgttgact ctcttgaata tggagtaggg tttcaaagtg
     4981 ttgacagttg agtctgcaaa ctaaggctga gttatatttt agtttttttt ttttttcctg
     5041 gttttcacta agtctaattc caatgtctac tggcagagat tgtgtttgca tttgaggtag
     5101 tggagggcgg tactttccaa gtgctgttgg aatccagata aactcaagga gcccagaaag
     5161 acaacgggta taatggctct cctcttatga cttagcactt tagttgactt ttttgaaaaa
     5221 gtctctgggt ggaatacctc agtgatgatg atttgccaaa caagcagcgt tagtgccaac
     5281 accttctcta aacttgctgc atcccttcca attgacatta atcccactgc aacttcctaa
     5341 aaacaggaat gagccaatga gatttgctta ttttctctca cccattacaa gtaagtttgt
     5401 tcttgccctg cttgtttttt agagggagtt tctatcatag agttgaaaat cacatttaag
     5461 aaggaaagag tttatgtctt tacatgtaac tattttattt tttccaatct aaattcaatc
     5521 acttcttaat agatatattg gtgtttgcat tgctggcatc aaaaccacac atacacacac
     5581 aaacacacac atacacacaa acatagtgga cagaaataag taaaaatatt tctgttttca
     5641 aagaaaaagc attccttaga gtttaggtac cattaacttc tactataata cagttccggt
     5701 actatggttt ctaactaaat gaacactaga acagagctga ctatattttc atctttgtcc
     5761 aaaattttag atgaatcaca ttttgaactt tttatggtat gataatttct ccaatatcta
     5821 aattcttttt ctgagaaaac aaatgccgag gacatttttg acactcttct tacatgagac
     5881 tatgaaaaag agcagcactt ttgttgtagt tgttgttgtt aataaaaagg ataataacat
     5941 acagaggatt ataagaaaaa taagacatac ctgaggtttt gtgatgagct atagagaatc
     6001 aagggcagtt ccagtggagc tgaggctgac aaagtactgc ccagctgcca gccaaatcca
     6061 cccttaagtt gcttttgtat ggcctgggag ctcagaagga attttttaaa ttttttttac
     6121 agctttaaag tattaaacag aaaccaacaa agaagaatat gagacaggga cgtacgtggt
     6181 ccgtaaagtt taactttctg atccttaata ggaggataag cgccgtgata gagaaatcca
     6241 aaggtcattt gtattacgat ggctagataa tgtaatgaat tccaatgtct gtgcatcagc
     6301 gaatacgtca tcaaaattgc tacaaaacaa taataatagg ttgttcacag cttaaaatgt
     6361 ttaggtagtg aagaggaaag aatataacct acattattta ttgactactt atatttccct
     6421 cattttacgg aagagatcta tcaatttacg tactcaataa tagaactaca acatggttgc
     6481 actccttaat ctcaggatag agataacaat ttttataaat ctattacatt atgagaacat
     6541 tgttagtact ataaaaatca ggatcagtta aatgttctct taaaataatt ttcaatatta
     6601 aatttttaag taactcagtg gatgcatatt ttccttattt ttggaaattt gacttataaa
     6661 gtttaagcca tgactagaat atttacatca ttaaaataaa atttccaagt aaaaattttc
     6721 atcttaaagt aatacggaaa tgattttgct acattattct aggattttac aaagtaattc
     6781 acctttagaa aaaaagtggt ttttttttta gctctaaata attaaaggtt gcctaaacta
     6841 atgtgtataa gtagatttac ctgtaaatat gtaagggaag tcccaattat tgtacacttt
     6901 cataattcaa tgtgaatttc atacaaagca aagtttcacc attaagaaaa taaacatttt
     6961 gttcctatca ctgagtgaat atttgtaatt tctatttaag ccatttctag attttttttt
     7021 ttttttggtc ttttgtgagc ttctgagatt ggtgccattt tatcacagta tttctcgtct
     7081 tgacttcttt gcatgacccc aggtttccag taagtaaggt atccttagaa aaaaaagtat
     7141 tttaagggaa atggatgcat acttcaggcc cattttatat gtaactcaat attgtctttt
     7201 taaaaggcca cactaccatg gaataaatta aaataaaaaa tcagatttct tgtacgcata
     7261 acccctgccc agttttaaaa atgtgatccc ttatttctag aaacctaaaa tagatatccc
     7321 tgaataacaa ttcattttta attatcagta gatatatata ctgacacaga gtataaacaa
     7381 cttctgtcac tatttattta aaatgttaaa ttgtacattt ttcataattt ctttaagaga
     7441 atcttctttg gtgagtttaa agtgagagta gacaaataac ttagtggcta aatgatttaa
     7501 tgtcagatga cttaatgacc agtttttgcc cttgatccag ccccactctg atattctacc
     7561 tcctgtgtgc ttgtcttcat tgtccccata ttaaaatggt gactgatacg gaattctgga
     7621 aaaatctgat cgattaatta atgtgaatat gcatgttttc cttagattct aatatggtct
     7681 ttcttgtgta agaatgtgga tttctaatag ccatataact caatgtttct cagtttgagc
     7741 cctattggca tttggggctg gataattcct tgtttggggg ctgtcctgta cactgcggga
     7801 tgctcagcag catccctggc ctctacccac caaatgtctg cagcatacct tcctacccga
     7861 cccagtgtga caatcaaaat tgtctgtaga tgttgccaaa tgacttttgg gtggaaaaat
     7921 tgctctcgtt aggaaccact tatgttaatt atggaagaat cttttttttc taatgttatt
     7981 tgcatctaaa tttgcataac tcatttctaa taggtactcg gatttcattc gtaattcaga
     8041 aatagaaaaa catacaatgg tctttttaac ctgtcctagt ggtgaatata catggtttcc
     8101 ttcgcattta tctgttctaa tggcccagaa aaaataagaa tccagacctc tctcatgtaa
     8161 ttgttaagga tattctgagc caagccagat ttcacatgca tttccattcc atccatccca
     8221 gcattcacag tttccacagc tacatattcc attccctgca ataaaataca tataggtatc
     8281 atgattatga tcaaaatgtg ccaaatttaa acatgctatt ataaatcaca agtgtccaca
     8341 atgaaatcat ttcattcatc cttggtagat tttcttattg tgcaatgatg ttattattac
     8401 atcttattaa gcagctgcga gacatctaat ctttcaaaca attagtggca tttatttggt
     8461 gccacccttt accgatcaga tagtcaccat cctgtatcac tccagctagg cttttaggtg
     8521 acaattttgt tttcccttaa agagcaagtt atatctgact tatgaataaa tacagaaaaa
     8581 cataaggctc tttgacataa catgaggcag gccaagtaat ccgtgaagag agtcttacgt
     8641 agtaaggatg ggcagaaagc aaaggtctaa cttaatgaca cacaaagagt catcttttac
     8701 cttcagctag agctgaggag aagtatacat gtctctgttt cctcgtaact tggctaaaca
     8761 aatgaattta taaccaatta tgaggactca ataaattagg atagcagtgg ctatgacacg
     8821 gctgagccct ctttatacct ctcccccata cacacatcca gttccctaaa agcaaccaac
     8881 acatcaacta gtggtaccca gattctgttt aaaagaatat ttcattccct ataccatgtt
     8941 caaagtaaaa tggttgccaa caaaattctt ttctgtgttc aatatacaac tgcatacatg
     9001 tgagtttgag ggtggggagg ttactttgtg gaaggatccc aaataatcac aaaatttagc
     9061 ttcattctct tgtattcttc tatgcctagg aataatgtga ggcttttgtg agggcttttt
     9121 cccaaatgcc cacttcgcct ttggtagata tttcatattc acggttggcc ctgttggtcc
     9181 agccacctaa agcattgcat gacgagtgtc tcttggctct ataacaaact gtggcataga
     9241 gcaattagaa aaggttaata ctgcacctgt acaaatgaga ccatcatgtt tgtcgcagtc
     9301 tctgtcatca cagtcacaga actccccaga aatataccac tcttcagcag aacaaatgca
     9361 cttcccacaa tgacaagaac ctgaaattac aaaggctatt actcaccatc accttataac
     9421 taaaggtttc catctcgaat agaatatcgt tgacacactg acaacaggct tctaataacc
     9481 catcatccaa aggtaaaagt gtattgaatg gctggtttct cagaggggag ctttacttac
     9541 tgtaattcat aaaggtcacc caggaaagcc ttcattatgg atctagacag ttgcaattag
     9601 ccttgaacaa atgtcccatg gcccagtctg gttgaaatgt caatgagagc aggatggggt
     9661 tgattcttat agatggtctt ccaaaaaagt attcaaaaat agattttttc ctcctaaatt
     9721 gaatcatgtt tttaaagtgc ctgctcttta aaggaaatga atagggaatt gtattaaatt
     9781 aggttgcatt tctaattaaa acaactacta aattattgtg cttataattt tggattttcg
     9841 tttacatgat tttcttggag taggagcaca cctgcatatt gggtggctaa ttaaagtgct
     9901 aaaaatgcat acagtcactc agtatatttg ccttgtgaga ctcatcctca ggaccctctg
     9961 tcataaactg ggatagctca aattactccc aaagttcata ttttatgagg ctctggattc
    10021 aactcttttt ccctccactt cacccatttc tcctacctaa ctaaaaaact tcctctttgg
    10081 ttatttaaaa tatctttact tactgagtaa aaattttatt aatgatatat ttaaaataaa
    10141 agaaaataaa tgagatgatg aatggtatcc aagacagaag ttctctcagt ctaaacagct
    10201 ttccatgaca gactaaaaac ccttacatgg aaaaactgcc tcaacgacag caggaaagac
    10261 tttacaatga aaaagaaaca aataaaaagg actttctttt ccttctgttt ccttgggttg
    10321 gttgttcttt ccaaacatga cttccattta ctaaaagatg gctgtattct ttttgagtca
    10381 aaatcacgtt gaaaaaatgt gcagttgaaa agagtatttt gacatattta acaaaactgc
    10441 agaattggta agttcaaaat atattgaaaa ggggcaagaa tcaatcatta gtgcttcttt
    10501 taaaacacag tgattaaaaa tgagttaaca gcctgggtga ttaaagtgat caggaaaaag
    10561 gagttgtggt catcacagat atcatgaaag gattcaggtt catgtgtctc aactatgtga
    10621 tatttcatat cagggaaact ggtatatgca tttcagctgc aaaaatcccc aaagtccaaa
    10681 ttaaatgttt gccatttctt gacacacttc tcaaagtaag agtgcagtca gaattattta
    10741 gattgtgaca attgtgtttt ttaacttctt gcgtagctat ggcataattg tatttagtct
    10801 tgacttgttt tcctgagggt ccaggttgat ttgcatgctc ttgaggaaat atacacgtct
    10861 tctcagtttt aataattgac tgacagccct gtggtttctc aggacccagt gagctgctgc
    10921 tcccaggtca gtctgcaaag gatgctggtt cccttgtggt ctcatcaagg tgaggaattt
    10981 cctgatttta gagatttctt tatcctaatt ttgaagactt tctttcacat ttctaggcat
    11041 aaaaaaatgt acagcactct actgcttgtt taacaaatgg atagtgatat atctgccaac
    11101 aaagaccaca tggagtattt cattgactat cagagaagtt tcctcgaaag gcaccatact
    11161 tagtgtttta tttccatgag tgaaggaaaa ttagttattt gaagtatttg gctgtcttta
    11221 gttgtttcta aagtagtgct gattttatat gcccataata ttcatatata cacccaggat
    11281 atcattttat atatgtcaca attcatgaaa tatcttatat ttcatcttca aacttatcct
    11341 ctggccctgg aactattcta atcactgctc ttgcttctgg aatgcttagc ttcatgccat
    11401 agtagagcat tttcagaaaa ctggtaagct cagctaaagc taatatggca tatatggata
    11461 gaacatttga tgagtaaatt ccagttctga aagtctacta gtcgctgaaa tacttagaat
    11521 aaaaaatgag gattgatttt gtatgtgtca tgaaacagta gcatttctag gtcagcattt
    11581 tcccagctgt gttattcttt cctgtttgtc aatgctcagt gcatcttaga ggtaggaaat
    11641 tattctactg cttgtgaaac tagaactaga tagcacatag taataacaca gtgtgaatag
    11701 ttattaggac ctattatagc acttttcctg tagaacgctc tagctgtttt cttccataac
    11761 atgggtcaaa ttgtgcctct cttaaatggg aagcacacag ggagagggtt ccatcagaca
    11821 gatgtaggct gcatgactat caagaggtga gaaatggttc aactcagctg gccaagaccc
    11881 actcacaccc ctgagaccca gcctagccag agaacagctg gctgatcttg gcaggagttt
    11941 tagggcagat agttcatcac cacagcacca ctaatccatt cattttcttt ctcaatataa
    12001 ggacccttga gaatgttccc atctcccttc tgtgcatttt tgctggcttc catccctggg
    12061 gaatcagcca cattttctca tgtgtcttca gggcatctta ggacatagga aggggaaaga
    12121 aatgaaattt taccttcaaa gatgagaatg gaagagagaa taaaggaaac tgtcctggac
    12181 ctcacaggca ataaacaaac agttaactga agacttcact ctgattcaat ccactcttct
    12241 ttttagtgat ctgcctatct gtgatgtatc tccaggcaaa aactttcata tacagtagtt
    12301 taaaaatgag ctgtttcttc ctgcaggtct gactgcacag gcatattgag cgaggcaact
    12361 tgaacaccag gctgaggccg attttgtgaa gcatctttca ctctttctct tttctgggga
    12421 tgtgggacag gttgtgggtg ggtgagtgtg tgtgtatgct ggacttcttt ggaagatgtg
    12481 ggacccaaga agtatcactg tgagagttta aggagacagt taatgacatg tgtttacagc
    12541 cattgtcaca caacagcatc tgtaagaaga ttggacgtga ttatctggat ctagcttgaa
    12601 gtagtcaagg caaagatata attgtgtagt cttgaagcca aataaatccc caaatgaaca
    12661 aaacaaccca caatgaatta tatcatgtac tttgcaaagg tagctaagct tagggaagac
    12721 ccggcactgc actaacctca tctctcttgg ttattcacaa aaacaatttg agtctaaggg
    12781 caaggcacct ttgtcagttg cccattccat tactaatgtt ggactttctt tttcattcaa
    12841 gcctgacaaa atgctgcaac ctgacatccc agcaggcagt tttcactatt gtactaacta
    12901 ctccatctgt tatgaaggtc acaagaatgt atcttgtttt aaatttttct atggagtgat
    12961 ttattgtctt ggctataaat ttgtaaagaa ataaaacgct atttcttcat cgtc
//
