LOCUS       NM_001321946           13133 bp    mRNA    linear   PRI 29-JAN-2025
DEFINITION  Homo sapiens fibroblast growth factor 14 (FGF14), transcript
            variant 18, mRNA.
ACCESSION   NM_001321946
VERSION     NM_001321946.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13133)
  AUTHORS   Mohren,L., Erdlenbruch,F., Leitao,E., Kilpert,F., Hones,G.S.,
            Kaya,S., Schroder,C., Thieme,A., Sturm,M., Park,J., Schluter,A.,
            Ruiz,M., Morales de la Prida,M., Casasnovas,C., Becker,K.,
            Roggenbuck,U., Pechlivanis,S., Kaiser,F.J., Synofzik,M., Wirth,T.,
            Anheim,M., Haack,T.B., Lockhart,P.J., Jockel,K.H., Pujol,A.,
            Klebe,S., Timmann,D. and Depienne,C.
  TITLE     Identification and characterisation of pathogenic and
            non-pathogenic FGF14 repeat expansions
  JOURNAL   Nat Commun 15 (1), 7665 (2024)
   PUBMED   39227614
  REMARK    GeneRIF: Identification and characterisation of pathogenic and
            non-pathogenic FGF14 repeat expansions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13133)
  AUTHORS   Zheng,Z.H., Cao,C.Y., Cheng,B., Yuan,R.Y., Zeng,Y.H., Guo,Z.B.,
            Qiu,Y.S., Lv,W.Q., Liang,H., Li,J.L., Zhang,W.X., Fang,M.K.,
            Sun,Y.H., Lin,W., Hong,J.M., Gan,S.R., Wang,N., Chen,W.J., Du,G.Q.
            and Fang,L.
  TITLE     Characteristics of tandem repeat inheritance and sympathetic nerve
            involvement in GAA-FGF14 ataxia
  JOURNAL   J Hum Genet 69 (9), 433-440 (2024)
   PUBMED   38866925
  REMARK    GeneRIF: Characteristics of tandem repeat inheritance and
            sympathetic nerve involvement in GAA-FGF14 ataxia.
REFERENCE   3  (bases 1 to 13133)
  AUTHORS   Pellerin,D., Del Gobbo,G.F., Couse,M., Dolzhenko,E.,
            Nageshwaran,S.K., Cheung,W.A., Xu,I.R.L., Dicaire,M.J.,
            Spurdens,G., Matos-Rodrigues,G., Stevanovski,I., Scriba,C.K.,
            Rebelo,A., Roth,V., Wandzel,M., Bonnet,C., Ashton,C., Agarwal,A.,
            Peter,C., Hasson,D., Tsankova,N.M., Dewar,K., Lamont,P.J.,
            Laing,N.G., Renaud,M., Houlden,H., Synofzik,M., Usdin,K.,
            Nussenzweig,A., Napierala,M., Chen,Z., Jiang,H., Deveson,I.W.,
            Ravenscroft,G., Akbarian,S., Eberle,M.A., Boycott,K.M.,
            Pastinen,T., Brais,B., Zuchner,S. and Danzi,M.C.
  CONSRTM   All of Us Research Program Long Read Working Group
  TITLE     A common flanking variant is associated with enhanced stability of
            the FGF14-SCA27B repeat locus
  JOURNAL   Nat Genet 56 (7), 1366-1370 (2024)
   PUBMED   38937606
  REMARK    GeneRIF: A common flanking variant is associated with enhanced
            stability of the FGF14-SCA27B repeat locus.
REFERENCE   4  (bases 1 to 13133)
  AUTHORS   Ouyang,R., Wan,L., Pellerin,D., Long,Z., Hu,J., Jiang,Q., Wang,C.,
            Peng,L., Peng,H., He,L., Qiu,R., Wang,J., Guo,J., Shen,L.,
            Brais,B., Danzi,M.C., Zuchner,S., Tang,B., Chen,Z. and Jiang,H.
  TITLE     The genetic landscape and phenotypic spectrum of GAA-FGF14 ataxia
            in China: a large cohort study
  JOURNAL   EBioMedicine 102, 105077 (2024)
   PUBMED   38513302
  REMARK    GeneRIF: The genetic landscape and phenotypic spectrum of GAA-FGF14
            ataxia in China: a large cohort study.
REFERENCE   5  (bases 1 to 13133)
  AUTHORS   van Swieten,J.C., Brusse,E., de Graaf,B.M., Krieger,E., van de
            Graaf,R., de Koning,I., Maat-Kievit,A., Leegwater,P., Dooijes,D.,
            Oostra,B.A. and Heutink,P.
  TITLE     A mutation in the fibroblast growth factor 14 gene is associated
            with autosomal dominant cerebellar ataxia [corrected]
  JOURNAL   Am J Hum Genet 72 (1), 191-199 (2003)
   PUBMED   12489043
  REMARK    GeneRIF: A mutation in the fibroblast growth factor 14 gene is
            associated with autosomal dominant cerebral ataxia
            Erratum:[Am J Hum Genet. 2003 Apr;72(4):1078]
REFERENCE   6  (bases 1 to 13133)
  AUTHORS   Chumakov,I., Blumenfeld,M., Guerassimenko,O., Cavarec,L.,
            Palicio,M., Abderrahim,H., Bougueleret,L., Barry,C., Tanaka,H., La
            Rosa,P., Puech,A., Tahri,N., Cohen-Akenine,A., Delabrosse,S.,
            Lissarrague,S., Picard,F.P., Maurice,K., Essioux,L., Millasseau,P.,
            Grel,P., Debailleul,V., Simon,A.M., Caterina,D., Dufaure,I.,
            Malekzadeh,K., Belova,M., Luan,J.J., Bouillot,M., Sambucy,J.L.,
            Primas,G., Saumier,M., Boubkiri,N., Martin-Saumier,S., Nasroune,M.,
            Peixoto,H., Delaye,A., Pinchot,V., Bastucci,M., Guillou,S.,
            Chevillon,M., Sainz-Fuertes,R., Meguenni,S., Aurich-Costa,J.,
            Cherif,D., Gimalac,A., Van Duijn,C., Gauvreau,D., Ouellette,G.,
            Fortier,I., Raelson,J., Sherbatich,T., Riazanskaia,N., Rogaev,E.,
            Raeymaekers,P., Aerssens,J., Konings,F., Luyten,W., Macciardi,F.,
            Sham,P.C., Straub,R.E., Weinberger,D.R., Cohen,N. and Cohen,D.
  TITLE     Genetic and physiological data implicating the new human gene G72
            and the gene for D-amino acid oxidase in schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13675-13680 (2002)
   PUBMED   12364586
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17221.
            Ouelette, G [corrected to Ouellette, G]; Realson, J [corrected to
            Raelson, J]]
REFERENCE   7  (bases 1 to 13133)
  AUTHORS   Wang,Q., Bardgett,M.E., Wong,M., Wozniak,D.F., Lou,J., McNeil,B.D.,
            Chen,C., Nardi,A., Reid,D.C., Yamada,K. and Ornitz,D.M.
  TITLE     Ataxia and paroxysmal dyskinesia in mice lacking axonally
            transported FGF14
  JOURNAL   Neuron 35 (1), 25-38 (2002)
   PUBMED   12123606
REFERENCE   8  (bases 1 to 13133)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
REFERENCE   9  (bases 1 to 13133)
  AUTHORS   Pellerin,D., Danzi,M., Renaud,M., Houlden,H., Synofzik,M.,
            Zuchner,S. and Brais,B.
  TITLE     GAA-FGF14-Related Ataxia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38271551
REFERENCE   10 (bases 1 to 13133)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356263.12, AL512629.7,
            AL591909.5 and AL160153.11.
            
            On Jun 2, 2019 this sequence version replaced NM_001321946.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. A mutation in this gene is associated with autosomal
            dominant cerebral ataxia. Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.113433.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142586 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AL356263.12        39813-40133         c
            322-386             AL356263.12        39161-39225         c
            387-555             AL356263.12        4135-4303           c
            556-666             AL512629.7         6849-6959           c
            667-770             AL591909.5         55273-55376         c
            771-969             AL160153.11        58767-58965         c
            970-13133           AL160153.11        42959-55122         c
FEATURES             Location/Qualifiers
     source          1..13133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.1"
     gene            1..13133
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="fibroblast growth factor 14"
                     /db_xref="GeneID:2259"
                     /db_xref="HGNC:HGNC:3671"
                     /db_xref="MIM:601515"
     exon            1..321
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            322..386
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            387..555
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            556..666
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     CDS             615..1106
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="isoform 2 is encoded by transcript variant 18;
                     fibroblast growth factor homologous factor 4; nystagmus 4,
                     congenital autosomal dominant"
                     /codon_start=1
                     /product="fibroblast growth factor 14 isoform 2"
                     /protein_id="NP_001308875.1"
                     /db_xref="GeneID:2259"
                     /db_xref="HGNC:HGNC:3671"
                     /db_xref="MIM:601515"
                     /translation="MHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMN
                     GEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNR
                     VKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKS
                     KTT"
     exon            667..770
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            771..969
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     exon            970..13133
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2993..2998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: ATTAAA"
     polyA_site      3016
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      4134..4139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AGTAAA"
     polyA_site      4153
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      7068..7073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AATAAA"
     polyA_site      7086
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="major polyA site"
     regulatory      13109..13114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
                     /note="hexamer: AATAAA"
     polyA_site      13133
                     /gene="FGF14"
                     /gene_synonym="FGF-14; FHF-4; FHF4; NYS4; SCA27; SCA27A;
                     SCA27B"
ORIGIN      
        1 ctcctccctc taatgcctgt aactcacatc cgaggctggg cgaggaatcc ggaggggaga
       61 ttttcctcat gctcacggtt gttggaaact ggaagagtga gaggaaggag gaaggggatt
      121 tgtggcgctc tctacctact acaagactga caaggggagg gggcacctaa atttgcatct
      181 tttcttcgtg gtgattgaga actgcaggtt caaaccgatc ccactgagca ctggcgattg
      241 attataaaaa aaaatcgaca ctgggagaag ggaggctctg tcttcggctg tcagactcaa
      301 tctcggaggt ggtattggtg tcaaaggaac gcatatgctg cagtgtcttt gtggcaagag
      361 tcttaagaaa aacaagaacc caactggaga atgtggtcag tgtttcagcc agtgcttgct
      421 gctgaggcag gagagaataa ttgtgtaaag agggggctcc cgcagtgcag gacaggaagc
      481 caccatgtga gcaccacatc cacgtgcagg tcgcaggctt catcatgtcc tgaataccat
      541 gccttagcat tttatatccc cagctcaagg gtatagtgac caggttatat tgcaggcaag
      601 gctactactt gcaaatgcac cccgatggag ctctcgatgg aaccaaggat gacagcacta
      661 attctacact cttcaacctc ataccagtgg gactacgtgt tgttgccatc cagggagtga
      721 aaacagggtt gtatatagcc atgaatggag aaggttacct ctacccatca gaacttttta
      781 cccctgaatg caagtttaaa gaatctgttt ttgaaaatta ttatgtaatc tactcatcca
      841 tgttgtacag acaacaggaa tctggtagag cctggttttt gggattaaat aaggaagggc
      901 aagctatgaa agggaacaga gtaaagaaaa ccaaaccagc agctcatttt ctacccaagc
      961 cattggaagt tgccatgtac cgagaaccat ctttgcatga tgttggggaa acggtcccga
     1021 agcctggggt gacgccaagt aaaagcacaa gtgcgtctgc aataatgaat ggaggcaaac
     1081 cagtcaacaa gagtaagaca acatagccag atcctcacag gtgttgtgac ttattcgtcc
     1141 tgagcacagt tgagtgattt atcctcacca gacattcctg ctccgtggct gaagagcagc
     1201 aggaagtaag ctaatgctta ttctttgctg tctccgaact tctctgttgc aagtggataa
     1261 atctcaacct gttgcacccc ccacaacaag aagacacctg gataaccagc taaactcaga
     1321 ccatggaatg ccctaccaga tatggaatgc ctttttaata tcttttctgt gactgtgaca
     1381 cttcatgtga atgacatact tcacaagtac actcgatacc ttgcctgctg acagctaccc
     1441 ataatccttt ttgagtcctg tttcagcgaa atctatgtgt ttaagttcaa ttttgtagca
     1501 cacaaataat attgagtaat ttctagttag acgctgtaaa cctgtgctat tacggatttc
     1561 tcttcttccc atttttacag ggctgctcgc tccactgtct gtgacctttt gcagggattt
     1621 tgttcctcta aatcttaaat gttgcagttg gcttaggtcg gagagcaatc agggaatcag
     1681 gaagccttct aaacctatta ttacaaattg catctataaa gaaagattaa gaaagattgt
     1741 tgtctctggc tcacactatc gattaaacac acatatacgc tctgtccagt agcagatact
     1801 gtgctcccaa ggtcggcatt gcctgggtgg gaaatggctc aaacacaatc cagggaagct
     1861 ctctatgata tgtgtttgac atccccctct agtttctttg tgtgtgtgtg ttttatacat
     1921 atcacaagct tactggtaat ggtaacattt gccttgccca gcgagcaaga cccactggtt
     1981 tttgagaaag tgggtccaaa gatttctgta ggccttgtag gcctgattaa ggttcatttt
     2041 tcatctatta attctcatta tttggaaaaa aaaaaaaagg aaaatcagta attataacct
     2101 acaagaattg cgctacctaa atccatttca gatatactcc gtcctgtttt taatgaacca
     2161 aacttaacgc catccccgtt tctggctgcg ttcccctcat actcagcaga gcatgggcaa
     2221 gacggctgtt gtgttctttc ctgcagcagc aatgcaaacg ttagttataa attaattaga
     2281 ctttaatatt tttggtgttt aatgacaagt ttttaaactg gacatattag gaaaaatatt
     2341 ttttttagct cagcatgctg agtccggtac tgtgtatttc accagtacat gcctctagct
     2401 cagcatctgg ggctcatgtt gcccagtggc tgggttagag gtgccttgcc atgatctcag
     2461 aatacagtct gttgaattat cctagatgaa aataaaggca aaccaacaca ttcatccatg
     2521 aggattttgg tccattccat ttattttctt ttattttgca ttcttaattt cctttttagt
     2581 ttaacactgt ttgtttgagc ttagggaaga caactaccaa gaaaggccag gaacagttga
     2641 ctacacaatg aagattccat gcaaaatgtt caatattgga tctaaagggg ttcaaaatgt
     2701 ttcatactaa actgtttggg aatttatttg ttaactctgt gtacacctaa taaaattcaa
     2761 tgttttcttc tcagaagagt tcattgagac caaactgaac ctcatttatt gaaaattata
     2821 tgtgggatca atgtactggc ctcttgttat tctttctatg tgggaggatg acccagtcat
     2881 cattttcccc atctgcactg tatttattgg gaaattattt tgtcactgct ttcataaatc
     2941 ttcttcatga cagcccttgc ccagcattaa aaaattctgg cctgcttagc tgattaaagg
     3001 tttagtagaa atttaactgt ttgtttatgc ttatttcatt ttcatattgg attctacttg
     3061 aataaataaa aagttagcag aacgtttgag tagatttatt gccaatgatg ctaaattaca
     3121 aatctaacaa acaaaatgat tcctttggtc atttttgatt tggtgttatg tcatcttgaa
     3181 gcctattgtt tttaacagga acagttaaaa tatattagat aacttccatt aaccaattat
     3241 tttcagaaaa catagatccc ataatatgtg gccaactata tgagtaatta actaacttgt
     3301 aatacagtca aatgggctta tggacactac ttacagcagc aacacttcac ttcacacaaa
     3361 cacacacata tacacacaca cacacacaca cacacacaca cacacagagc aaacaccccc
     3421 atctatttgt tactgataat tagccctact tgctggtttc tttttcccct gcaagtctgt
     3481 ttattggttt aaattaagac aagatttatt tttgtaaatg actgagattt atgtaaatgt
     3541 gtatctctgt tgtgttttat atatggggtg tctataaggg catttatccc tatgaaggat
     3601 gtcaaatact ttcttctaat atatgtttag acatattgca gaggggtcct tgttatttgt
     3661 aattgagtta ggtcatttac tttgtgtctg gtctcacctg tagcatggga agaggacagc
     3721 aatgatgagc tgcatgtagt aggtacctgt gtatcaagaa ctgttggtat gtattgctaa
     3781 tttgcataca aagagtttgt ctgtctgcat tgtagtttgt gtttaatatc atttgttaaa
     3841 ttcacaaata caacatattg aataaaatat ttatatgaag gcatattaaa aaacatcaaa
     3901 caactttatg taacaaaatg gcattgcatt actcaccaat atagagaaat gtcatgtaaa
     3961 taagttggta aactcaattt ccccctttac catgccaaag aaaattttag ctctttgatg
     4021 atacctctct tgctatttgt ttgggataag acttcgccat ttttttcccc tcagaaatta
     4081 agtttgctgt tattaagtaa gaagtgcaat ctgtcactac tgatgttccg tatagtaaat
     4141 ctgatggaat tcatttgtat ttagactgtg tgttttgtac ctccatgtgc atatgtccat
     4201 tgtatcaagt ctctataata ctccattcct tctgcatgca tatctggtgt gggagggtta
     4261 tttctactga tttgttatag tagctgattg ctttgccagt ccctcaacaa cgctcagaaa
     4321 tgttgttttg gtatttcaag tgacaacatt tttgttttct aatataagat tgctttttaa
     4381 aacattttgc taccacttta cttggaaaaa ttagagaaga catgacaatt ctccacccta
     4441 tgtaaagagc aaaatggaac tgaacatcat ttcattacaa atcctgaaga atttggagat
     4501 tcttgctcta aatgtttgct tgtcctgaat gtttttgggt agcagtggct taaagagatc
     4561 cacgatgggt ccaaaggact cccgctccag ttcttctaat agtttgcctc ttggggagca
     4621 agcagaagtt ctttatcata cctagccact tgcttaatta atgctttaag cactaaaagt
     4681 tgttattttt atcaggatga acaatatcag atttggttgt ctttaaaagc aaaaaccaaa
     4741 aacttattct ttaagtaagt tagacacgta tcacttcatt taaaattatc tccctaatat
     4801 tatggatcat taatatttga tacatattca aaaagagacc acattgacta acatccagtt
     4861 gagaacaaga tgaaaataat tgaaatattt tttccatttt aattcagaac aaggctatat
     4921 caagggaaag cgactgggct aaatcctcaa tttttttttc caaaatgcag gcatatcaaa
     4981 atccaggatg tacatggtct tactttgagt gaaatagtag tcatagctga ggtttcttag
     5041 cctacaatgt gacatagggc ctgttgactc tcttgaatat ggagtagggt ttcaaagtgt
     5101 tgacagttga gtctgcaaac taaggctgag ttatatttta gttttttttt tttttcctgg
     5161 ttttcactaa gtctaattcc aatgtctact ggcagagatt gtgtttgcat ttgaggtagt
     5221 ggagggcggt actttccaag tgctgttgga atccagataa actcaaggag cccagaaaga
     5281 caacgggtat aatggctctc ctcttatgac ttagcacttt agttgacttt tttgaaaaag
     5341 tctctgggtg gaatacctca gtgatgatga tttgccaaac aagcagcgtt agtgccaaca
     5401 ccttctctaa acttgctgca tcccttccaa ttgacattaa tcccactgca acttcctaaa
     5461 aacaggaatg agccaatgag atttgcttat tttctctcac ccattacaag taagtttgtt
     5521 cttgccctgc ttgtttttta gagggagttt ctatcataga gttgaaaatc acatttaaga
     5581 aggaaagagt ttatgtcttt acatgtaact attttatttt ttccaatcta aattcaatca
     5641 cttcttaata gatatattgg tgtttgcatt gctggcatca aaaccacaca tacacacaca
     5701 aacacacaca tacacacaaa catagtggac agaaataagt aaaaatattt ctgttttcaa
     5761 agaaaaagca ttccttagag tttaggtacc attaacttct actataatac agttccggta
     5821 ctatggtttc taactaaatg aacactagaa cagagctgac tatattttca tctttgtcca
     5881 aaattttaga tgaatcacat tttgaacttt ttatggtatg ataatttctc caatatctaa
     5941 attctttttc tgagaaaaca aatgccgagg acatttttga cactcttctt acatgagact
     6001 atgaaaaaga gcagcacttt tgttgtagtt gttgttgtta ataaaaagga taataacata
     6061 cagaggatta taagaaaaat aagacatacc tgaggttttg tgatgagcta tagagaatca
     6121 agggcagttc cagtggagct gaggctgaca aagtactgcc cagctgccag ccaaatccac
     6181 ccttaagttg cttttgtatg gcctgggagc tcagaaggaa ttttttaaat tttttttaca
     6241 gctttaaagt attaaacaga aaccaacaaa gaagaatatg agacagggac gtacgtggtc
     6301 cgtaaagttt aactttctga tccttaatag gaggataagc gccgtgatag agaaatccaa
     6361 aggtcatttg tattacgatg gctagataat gtaatgaatt ccaatgtctg tgcatcagcg
     6421 aatacgtcat caaaattgct acaaaacaat aataataggt tgttcacagc ttaaaatgtt
     6481 taggtagtga agaggaaaga atataaccta cattatttat tgactactta tatttccctc
     6541 attttacgga agagatctat caatttacgt actcaataat agaactacaa catggttgca
     6601 ctccttaatc tcaggataga gataacaatt tttataaatc tattacatta tgagaacatt
     6661 gttagtacta taaaaatcag gatcagttaa atgttctctt aaaataattt tcaatattaa
     6721 atttttaagt aactcagtgg atgcatattt tccttatttt tggaaatttg acttataaag
     6781 tttaagccat gactagaata tttacatcat taaaataaaa tttccaagta aaaattttca
     6841 tcttaaagta atacggaaat gattttgcta cattattcta ggattttaca aagtaattca
     6901 cctttagaaa aaaagtggtt ttttttttag ctctaaataa ttaaaggttg cctaaactaa
     6961 tgtgtataag tagatttacc tgtaaatatg taagggaagt cccaattatt gtacactttc
     7021 ataattcaat gtgaatttca tacaaagcaa agtttcacca ttaagaaaat aaacattttg
     7081 ttcctatcac tgagtgaata tttgtaattt ctatttaagc catttctaga tttttttttt
     7141 tttttggtct tttgtgagct tctgagattg gtgccatttt atcacagtat ttctcgtctt
     7201 gacttctttg catgacccca ggtttccagt aagtaaggta tccttagaaa aaaaagtatt
     7261 ttaagggaaa tggatgcata cttcaggccc attttatatg taactcaata ttgtcttttt
     7321 aaaaggccac actaccatgg aataaattaa aataaaaaat cagatttctt gtacgcataa
     7381 cccctgccca gttttaaaaa tgtgatccct tatttctaga aacctaaaat agatatccct
     7441 gaataacaat tcatttttaa ttatcagtag atatatatac tgacacagag tataaacaac
     7501 ttctgtcact atttatttaa aatgttaaat tgtacatttt tcataatttc tttaagagaa
     7561 tcttctttgg tgagtttaaa gtgagagtag acaaataact tagtggctaa atgatttaat
     7621 gtcagatgac ttaatgacca gtttttgccc ttgatccagc cccactctga tattctacct
     7681 cctgtgtgct tgtcttcatt gtccccatat taaaatggtg actgatacgg aattctggaa
     7741 aaatctgatc gattaattaa tgtgaatatg catgttttcc ttagattcta atatggtctt
     7801 tcttgtgtaa gaatgtggat ttctaatagc catataactc aatgtttctc agtttgagcc
     7861 ctattggcat ttggggctgg ataattcctt gtttgggggc tgtcctgtac actgcgggat
     7921 gctcagcagc atccctggcc tctacccacc aaatgtctgc agcatacctt cctacccgac
     7981 ccagtgtgac aatcaaaatt gtctgtagat gttgccaaat gacttttggg tggaaaaatt
     8041 gctctcgtta ggaaccactt atgttaatta tggaagaatc ttttttttct aatgttattt
     8101 gcatctaaat ttgcataact catttctaat aggtactcgg atttcattcg taattcagaa
     8161 atagaaaaac atacaatggt ctttttaacc tgtcctagtg gtgaatatac atggtttcct
     8221 tcgcatttat ctgttctaat ggcccagaaa aaataagaat ccagacctct ctcatgtaat
     8281 tgttaaggat attctgagcc aagccagatt tcacatgcat ttccattcca tccatcccag
     8341 cattcacagt ttccacagct acatattcca ttccctgcaa taaaatacat ataggtatca
     8401 tgattatgat caaaatgtgc caaatttaaa catgctatta taaatcacaa gtgtccacaa
     8461 tgaaatcatt tcattcatcc ttggtagatt ttcttattgt gcaatgatgt tattattaca
     8521 tcttattaag cagctgcgag acatctaatc tttcaaacaa ttagtggcat ttatttggtg
     8581 ccacccttta ccgatcagat agtcaccatc ctgtatcact ccagctaggc ttttaggtga
     8641 caattttgtt ttcccttaaa gagcaagtta tatctgactt atgaataaat acagaaaaac
     8701 ataaggctct ttgacataac atgaggcagg ccaagtaatc cgtgaagaga gtcttacgta
     8761 gtaaggatgg gcagaaagca aaggtctaac ttaatgacac acaaagagtc atcttttacc
     8821 ttcagctaga gctgaggaga agtatacatg tctctgtttc ctcgtaactt ggctaaacaa
     8881 atgaatttat aaccaattat gaggactcaa taaattagga tagcagtggc tatgacacgg
     8941 ctgagccctc tttatacctc tcccccatac acacatccag ttccctaaaa gcaaccaaca
     9001 catcaactag tggtacccag attctgttta aaagaatatt tcattcccta taccatgttc
     9061 aaagtaaaat ggttgccaac aaaattcttt tctgtgttca atatacaact gcatacatgt
     9121 gagtttgagg gtggggaggt tactttgtgg aaggatccca aataatcaca aaatttagct
     9181 tcattctctt gtattcttct atgcctagga ataatgtgag gcttttgtga gggctttttc
     9241 ccaaatgccc acttcgcctt tggtagatat ttcatattca cggttggccc tgttggtcca
     9301 gccacctaaa gcattgcatg acgagtgtct cttggctcta taacaaactg tggcatagag
     9361 caattagaaa aggttaatac tgcacctgta caaatgagac catcatgttt gtcgcagtct
     9421 ctgtcatcac agtcacagaa ctccccagaa atataccact cttcagcaga acaaatgcac
     9481 ttcccacaat gacaagaacc tgaaattaca aaggctatta ctcaccatca ccttataact
     9541 aaaggtttcc atctcgaata gaatatcgtt gacacactga caacaggctt ctaataaccc
     9601 atcatccaaa ggtaaaagtg tattgaatgg ctggtttctc agaggggagc tttacttact
     9661 gtaattcata aaggtcaccc aggaaagcct tcattatgga tctagacagt tgcaattagc
     9721 cttgaacaaa tgtcccatgg cccagtctgg ttgaaatgtc aatgagagca ggatggggtt
     9781 gattcttata gatggtcttc caaaaaagta ttcaaaaata gattttttcc tcctaaattg
     9841 aatcatgttt ttaaagtgcc tgctctttaa aggaaatgaa tagggaattg tattaaatta
     9901 ggttgcattt ctaattaaaa caactactaa attattgtgc ttataatttt ggattttcgt
     9961 ttacatgatt ttcttggagt aggagcacac ctgcatattg ggtggctaat taaagtgcta
    10021 aaaatgcata cagtcactca gtatatttgc cttgtgagac tcatcctcag gaccctctgt
    10081 cataaactgg gatagctcaa attactccca aagttcatat tttatgaggc tctggattca
    10141 actctttttc cctccacttc acccatttct cctacctaac taaaaaactt cctctttggt
    10201 tatttaaaat atctttactt actgagtaaa aattttatta atgatatatt taaaataaaa
    10261 gaaaataaat gagatgatga atggtatcca agacagaagt tctctcagtc taaacagctt
    10321 tccatgacag actaaaaacc cttacatgga aaaactgcct caacgacagc aggaaagact
    10381 ttacaatgaa aaagaaacaa ataaaaagga ctttcttttc cttctgtttc cttgggttgg
    10441 ttgttctttc caaacatgac ttccatttac taaaagatgg ctgtattctt tttgagtcaa
    10501 aatcacgttg aaaaaatgtg cagttgaaaa gagtattttg acatatttaa caaaactgca
    10561 gaattggtaa gttcaaaata tattgaaaag gggcaagaat caatcattag tgcttctttt
    10621 aaaacacagt gattaaaaat gagttaacag cctgggtgat taaagtgatc aggaaaaagg
    10681 agttgtggtc atcacagata tcatgaaagg attcaggttc atgtgtctca actatgtgat
    10741 atttcatatc agggaaactg gtatatgcat ttcagctgca aaaatcccca aagtccaaat
    10801 taaatgtttg ccatttcttg acacacttct caaagtaaga gtgcagtcag aattatttag
    10861 attgtgacaa ttgtgttttt taacttcttg cgtagctatg gcataattgt atttagtctt
    10921 gacttgtttt cctgagggtc caggttgatt tgcatgctct tgaggaaata tacacgtctt
    10981 ctcagtttta ataattgact gacagccctg tggtttctca ggacccagtg agctgctgct
    11041 cccaggtcag tctgcaaagg atgctggttc ccttgtggtc tcatcaaggt gaggaatttc
    11101 ctgattttag agatttcttt atcctaattt tgaagacttt ctttcacatt tctaggcata
    11161 aaaaaatgta cagcactcta ctgcttgttt aacaaatgga tagtgatata tctgccaaca
    11221 aagaccacat ggagtatttc attgactatc agagaagttt cctcgaaagg caccatactt
    11281 agtgttttat ttccatgagt gaaggaaaat tagttatttg aagtatttgg ctgtctttag
    11341 ttgtttctaa agtagtgctg attttatatg cccataatat tcatatatac acccaggata
    11401 tcattttata tatgtcacaa ttcatgaaat atcttatatt tcatcttcaa acttatcctc
    11461 tggccctgga actattctaa tcactgctct tgcttctgga atgcttagct tcatgccata
    11521 gtagagcatt ttcagaaaac tggtaagctc agctaaagct aatatggcat atatggatag
    11581 aacatttgat gagtaaattc cagttctgaa agtctactag tcgctgaaat acttagaata
    11641 aaaaatgagg attgattttg tatgtgtcat gaaacagtag catttctagg tcagcatttt
    11701 cccagctgtg ttattctttc ctgtttgtca atgctcagtg catcttagag gtaggaaatt
    11761 attctactgc ttgtgaaact agaactagat agcacatagt aataacacag tgtgaatagt
    11821 tattaggacc tattatagca cttttcctgt agaacgctct agctgttttc ttccataaca
    11881 tgggtcaaat tgtgcctctc ttaaatggga agcacacagg gagagggttc catcagacag
    11941 atgtaggctg catgactatc aagaggtgag aaatggttca actcagctgg ccaagaccca
    12001 ctcacacccc tgagacccag cctagccaga gaacagctgg ctgatcttgg caggagtttt
    12061 agggcagata gttcatcacc acagcaccac taatccattc attttctttc tcaatataag
    12121 gacccttgag aatgttccca tctcccttct gtgcattttt gctggcttcc atccctgggg
    12181 aatcagccac attttctcat gtgtcttcag ggcatcttag gacataggaa ggggaaagaa
    12241 atgaaatttt accttcaaag atgagaatgg aagagagaat aaaggaaact gtcctggacc
    12301 tcacaggcaa taaacaaaca gttaactgaa gacttcactc tgattcaatc cactcttctt
    12361 tttagtgatc tgcctatctg tgatgtatct ccaggcaaaa actttcatat acagtagttt
    12421 aaaaatgagc tgtttcttcc tgcaggtctg actgcacagg catattgagc gaggcaactt
    12481 gaacaccagg ctgaggccga ttttgtgaag catctttcac tctttctctt ttctggggat
    12541 gtgggacagg ttgtgggtgg gtgagtgtgt gtgtatgctg gacttctttg gaagatgtgg
    12601 gacccaagaa gtatcactgt gagagtttaa ggagacagtt aatgacatgt gtttacagcc
    12661 attgtcacac aacagcatct gtaagaagat tggacgtgat tatctggatc tagcttgaag
    12721 tagtcaaggc aaagatataa ttgtgtagtc ttgaagccaa ataaatcccc aaatgaacaa
    12781 aacaacccac aatgaattat atcatgtact ttgcaaaggt agctaagctt agggaagacc
    12841 cggcactgca ctaacctcat ctctcttggt tattcacaaa aacaatttga gtctaagggc
    12901 aaggcacctt tgtcagttgc ccattccatt actaatgttg gactttcttt ttcattcaag
    12961 cctgacaaaa tgctgcaacc tgacatccca gcaggcagtt ttcactattg tactaactac
    13021 tccatctgtt atgaaggtca caagaatgta tcttgtttta aatttttcta tggagtgatt
    13081 tattgtcttg gctataaatt tgtaaagaaa taaaacgcta tttcttcatc gtc
//
