LOCUS       NM_033642              18786 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens fibroblast growth factor 13 (FGF13), transcript
            variant 6, mRNA.
ACCESSION   NM_033642
VERSION     NM_033642.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18786)
  AUTHORS   Dong,Z.S., Zhang,X.R., Xue,D.Z., Liu,J.H., Yi,F., Zhang,Y.Y.,
            Xian,F.Y., Qiao,R.Y., Liu,B.Y., Zhang,H.L. and Wang,C.
  TITLE     FGF13 enhances the function of TRPV1 by stabilizing microtubules
            and regulates acute and chronic itch
  JOURNAL   FASEB J 38 (10), e23661 (2024)
   PUBMED   38733310
  REMARK    GeneRIF: FGF13 enhances the function of TRPV1 by stabilizing
            microtubules and regulates acute and chronic itch.
REFERENCE   2  (bases 1 to 18786)
  AUTHORS   Yang,H., Zhou,J., Li,D., Zhou,S., Dai,X., Du,X., Mao,H. and Wang,B.
  TITLE     The inhibitory role of microRNA-141-3p in human cutaneous melanoma
            growth and metastasis through the fibroblast growth factor
            13-mediated mitogen-activated protein kinase axis
  JOURNAL   Melanoma Res 33 (6), 492-505 (2023)
   PUBMED   36988403
  REMARK    GeneRIF: The inhibitory role of microRNA-141-3p in human cutaneous
            melanoma growth and metastasis through the fibroblast growth factor
            13-mediated mitogen-activated protein kinase axis.
REFERENCE   3  (bases 1 to 18786)
  AUTHORS   Han,D., Guan,L., Zhang,Y., Yang,H., Si,L., Jia,T., Wu,Y., Lv,K.,
            Song,T. and Yang,G.
  TITLE     FGF13A interacts with NPM1 and UBF and inhibits the invasion of
            bladder cancer cells
  JOURNAL   Biochem Biophys Res Commun 678, 1-10 (2023)
   PUBMED   37603967
  REMARK    GeneRIF: FGF13A interacts with NPM1 and UBF and inhibits the
            invasion of bladder cancer cells.
REFERENCE   4  (bases 1 to 18786)
  AUTHORS   Fan,X., Huang,J., Jin,X. and Yan,N.
  TITLE     Cryo-EM structure of human voltage-gated sodium channel Nav1.6
  JOURNAL   Proc Natl Acad Sci U S A 120 (5), e2220578120 (2023)
   PUBMED   36696443
REFERENCE   5  (bases 1 to 18786)
  AUTHORS   Cheng,H., Miao,P., Wang,Y., Guo,Y., Gao,L., Lou,Y., Yang,F.,
            Liang,M. and Feng,J.
  TITLE     A Heterozygous Variant of FGF13 Caused X-Linked Developmental and
            Epileptic Encephalopathy 90 in a Chinese Family
  JOURNAL   Cytogenet Genome Res 163 (1-2), 36-41 (2023)
   PUBMED   37536293
  REMARK    GeneRIF: A Heterozygous Variant of FGF13 Caused X-Linked
            Developmental and Epileptic Encephalopathy 90 in a Chinese Family.
REFERENCE   6  (bases 1 to 18786)
  AUTHORS   Yao,D.L., Masonic,K., Petullo,D., Li,L.Y., Lincoln,C.,
            Wibberley,L., Alderson,R.F. and Antonaccio,M.
  TITLE     Pretreatment with intravenous FGF-13 reduces infarct volume and
            ameliorates neurological deficits following focal cerebral ischemia
            in rats
  JOURNAL   Brain Res 818 (1), 140-146 (1999)
   PUBMED   9914447
REFERENCE   7  (bases 1 to 18786)
  AUTHORS   Gecz,J., Baker,E., Donnelly,A., Ming,J.E., McDonald-McGinn,D.M.,
            Spinner,N.B., Zackai,E.H., Sutherland,G.R. and Mulley,J.C.
  TITLE     Fibroblast growth factor homologous factor 2 (FHF2): gene
            structure, expression and mapping to the Borjeson-Forssman-Lehmann
            syndrome region in Xq26 delineated by a duplication breakpoint in a
            BFLS-like patient
  JOURNAL   Hum Genet 104 (1), 56-63 (1999)
   PUBMED   10071193
REFERENCE   8  (bases 1 to 18786)
  AUTHORS   Munoz-Sanjuan,I., Simandl,B.K., Fallon,J.F. and Nathans,J.
  TITLE     Expression of chicken fibroblast growth factor homologous factor
            (FHF)-1 and of differentially spliced isoforms of FHF-2 during
            development and involvement of FHF-2 in chicken limb development
  JOURNAL   Development 126 (2), 409-421 (1999)
   PUBMED   9847253
REFERENCE   9  (bases 1 to 18786)
  AUTHORS   Greene,J.M., Li,Y.L., Yourey,P.A., Gruber,J., Carter,K.C.,
            Shell,B.K., Dillon,P.A., Florence,C., Duan,D.R., Blunt,A.,
            Ornitz,D.M., Ruben,S.M. and Alderson,R.F.
  TITLE     Identification and characterization of a novel member of the
            fibroblast growth factor family
  JOURNAL   Eur J Neurosci 10 (5), 1911-1925 (1998)
   PUBMED   9751161
REFERENCE   10 (bases 1 to 18786)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z82193.1, AL031386.1 and
            AL357123.11.
            
            On Jul 10, 2019 this sequence version replaced NM_033642.2.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth, and
            invasion. This gene is located in a region on chromosome X, which
            is associated with Borjeson-Forssman-Lehmann syndrome (BFLS),
            making it a possible candidate gene for familial cases of the BFLS,
            and for other syndromal and nonspecific forms of X-linked cognitive
            disability mapping to this region. Alternative splicing of this
            gene at the 5' end results in several transcript variants encoding
            different isoforms with different N-termini. [provided by RefSeq,
            Nov 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF100144.1, SRR14372079.1068928.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               Z82193.1           80133-80244         c
            113-223             Z82193.1           49709-49819         c
            224-327             Z82193.1           43875-43978         c
            328-526             AL031386.1         14494-14692         c
            527-12449           AL031386.1         101-12023           c
            12450-18786         AL357123.11        66018-72354         c
FEATURES             Location/Qualifiers
     source          1..18786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3-q27.1"
     gene            1..18786
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="fibroblast growth factor 13"
                     /db_xref="GeneID:2258"
                     /db_xref="HGNC:HGNC:3670"
                     /db_xref="MIM:300070"
     exon            1..112
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..663
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="isoform 5 is encoded by transcript variant 6;
                     fibroblast growth factor homologous factor 2"
                     /codon_start=1
                     /product="fibroblast growth factor 13 isoform 5"
                     /protein_id="NP_378668.1"
                     /db_xref="CCDS:CCDS14664.1"
                     /db_xref="GeneID:2258"
                     /db_xref="HGNC:HGNC:3670"
                     /db_xref="MIM:300070"
                     /translation="MALLRKSYSEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDS
                     TYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTY
                     SSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLT
                     EFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST"
     exon            113..223
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            224..327
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            328..526
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            527..18786
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="hexamer: AATAAA"
     polyA_site      1937
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="major polyA site"
     regulatory      18757..18762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="hexamer: AATAAA"
     polyA_site      18786
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
ORIGIN      
        1 aaactttctc tgatctcctc tctctctgtg tctgctccaa atgtagacag caattgtctg
       61 ggtaggacca gcttataaag aagcatggct ttgttaagga agtcgtattc agagcctcag
      121 cttaagggta tagttaccaa gctatacagc cgacaaggct accacttgca gctgcaggcg
      181 gatggaacca ttgatggcac caaagatgag gacagcactt acactctgtt taacctcatc
      241 cctgtgggtc tgcgagtggt ggctatccaa ggagttcaaa ccaagctgta cttggcaatg
      301 aacagtgagg gatacttgta cacctcggaa cttttcacac ctgagtgcaa attcaaagaa
      361 tcagtgtttg aaaattatta tgtgacatat tcatcaatga tataccgtca gcagcagtca
      421 ggccgagggt ggtatctggg tctgaacaaa gaaggagaga tcatgaaagg caaccatgtg
      481 aagaagaaca agcctgcagc tcattttctg cctaaaccac tgaaagtggc catgtacaag
      541 gagccatcac tgcacgatct cacggagttc tcccgatctg gaagcgggac cccaaccaag
      601 agcagaagtg tctctggcgt gctgaacgga ggcaaatcca tgagccacaa tgaatcaacg
      661 tagccagtga gggcaaaaga agggctctgt aacagaacct tacctccagg tgctgttgaa
      721 ttcttctagc agtccttcac ccaaaagttc aaatttgtca gtgacattta ccaaacaaac
      781 aggcagagtt cactattcta tctgccatta gaccttctta tcatccatac taaagcccca
      841 ttatttagat tgagcttgtg cataagaatg ccaagcattt tagtgaacta aatctgagag
      901 aaggactgcc aaattttctc atgatctcac ctatactttg gggatgataa tccaaaagta
      961 tttcacagca ctaatgctga tcaaaatttg ctctcccacc aagaaaatgt aaaagaccac
     1021 aattgttctt caaaaacaaa caaaacaaaa caaaacaaaa ttaactgctt aaatgttttg
     1081 tcggggcaaa caaaattatg tgaattgtgt tgttttcttg gcttgatgtt ttctatctac
     1141 gcttgattca catgtactct tttctttggc atagtgcaac tttatgattt ctgaaattca
     1201 atggttctat tgactttttg cgtcacttaa tccaaatcaa ccaaattcag ggttgaatct
     1261 gaattggctt ctcaggctca aggtaacagt gttcttgtgg tttgaccaat tgtttttctt
     1321 tctttttttt tttttttaga tttgtggtat tctggtcaag ttattgtgct gtactttgtg
     1381 cgtagaaatt gagttgtatt gtcaacccca gtcagtaaag agaacttcaa aaaattatcc
     1441 tcaagtgtag atttctctta attccatttg tgtatcatgt taaactattg ttgtggcttc
     1501 ttgtgtaaag acaggaactg tggaactgtg atgttgtctt ttgtgttgtt aaaataagaa
     1561 atgtcttatc tgtatatgta tgagtcttcc tgtcattgta tttggcacat gaatattgtg
     1621 tacaaggaat tgttaagact ggttttccct caacaacata tattatactt gctactggaa
     1681 aagtgtttaa gacttagcta ggtttccatt tagatcttca tatctgttgc atggaagaaa
     1741 gttgggttct tggcatagag ttgcatgata tgtaagattt tgtgcattca taattgttaa
     1801 aaatctgtgt tccaaaagtg gacatagcat gtacaggcag ttttctgtcc tgtgcacaaa
     1861 aagtttaaaa aagttgttta atatttgttg ttgtataccc aaatacgcac cgaataaact
     1921 ctttatattc attcaaagaa taatcttcca acatgtattt attgagcgtc cattatgtgc
     1981 cagtaactga agtagcaact ggaagtaaac attgtataat gcagataagg tcactgtcct
     2041 cagatagtct acagtctaga gagtcatatt aacatgaaca ctttaaagtg tgtttatttt
     2101 actagttact gtacttgcac ttcagattgg tacaaaggaa ttcacattcc cgttcagtag
     2161 tcaaattata caaatgaggc gtttgtgcta gtattttctc tgccactcac agtgtcattt
     2221 cccctctctg ttgcttattt ctctcctctc tagagggaat acacaggact aaatagtgtc
     2281 ctttctacct ttgagaactg aaggaaaatg taaatttttt taaatgttga tgacttttct
     2341 ctagctcccc aaagctgcat tgtctggcaa tgaacacttt gagaacagtc aatacagatg
     2401 gtctctgact tacagtagtt caacttacat tttttcgggg gctttacagt ggtacagaag
     2461 caataggcat ttagtagaac tcatacttta ccatacaacc attttgcttt ttatttccag
     2521 tacactattc aataaatgac atgagctatt caacactttt taattacaaa atttgctttg
     2581 tagtacatga ttttgtccaa ctgtaagcta atataagcgt tctaagcaca tttaaagtag
     2641 gctaggctaa gctatgatgt ttgctaggtt aggtgtatta aatgcatttt caacttaaga
     2701 tgggtttatt ggtatgtgac ccccatcgta agtgaaggat catctgtata tggagggaag
     2761 aattgtgaaa tacataaaac gtagttgact agtgcttttc agagcatctg caaataaaat
     2821 tactggggcc ccaaacagcc tgcttttgca aggaggggag actcctcatt tctaagatgt
     2881 ttggaccaga ttcagcatga gctcctatcc ctgcccaccc cagcccagtc taagtcacct
     2941 tgtaatttca tgagataagt cctcctcatc ctgcttcatc ctgcctgagc tctaaacaca
     3001 cctacatgag gtacgctcac ctgcctagct atcttggatg caggatcctt tgtaccatgt
     3061 tttaaaaatc aggagatgct cactcaacca cctctcccta ttaactctta ctaattttca
     3121 atcagtaggg aaaagtagtg cattgtctcc ctctttctct aagaacttta aagtttggtc
     3181 actgactact tcagttgctg gtcttgcttt ttctgttgtt cagaaatagt gtaggtctgc
     3241 tggtagtaag caaattagca ctatgtgggt ctcagggatg cctgcgttaa taggatggag
     3301 tcaaaatgcc caggaagaat cctttacccc cagcattctt tttgagctgc cttaaagttg
     3361 ctttaaacag acagtggtgt taaaataaat taataagtaa ataaatagtc ctcaaacctt
     3421 cctacaagtg atgatatcaa tactttcaca catcttcatt acacacacac atacacacac
     3481 accctttccc accccatccc ctcatgcaca tcctttagta gcattcctcc tggcagaaaa
     3541 tactagtcct gccacataac tgatgaaaga aaaaaagact ctagtcaaat agttgtggga
     3601 aacacttcaa atactattgg gtctcagata ttagctcaca tcagaatcac ctggaaggct
     3661 tgtaagactc agatcactgg acttcacctt cagagtttct gattgagtga gtcttgtgtg
     3721 ggcccaaaac ttggcatttc taacaagttt ccaggtgatg ctgaggctgt tgatcctcgg
     3781 gactttgaga accactggta ttagttcatt ctcacgctgc tataaagata ctacctgaga
     3841 ctgggtaatt tataaaggaa agaggtttaa ttgactcaca gttctgcatg gctggggagg
     3901 cctcaggaaa cttaccatca tggcagaaga tgaaggggaa gcaaggacct tttccacgtg
     3961 gcagcaggag agagaatggg aaagcgccac ttatcaaaca gatttagtga gaacttcctc
     4021 actatatgag acagcatggg gaaaccgccc cgaggatcca atcacctccc accaggtccc
     4081 tccctcaaca cattgggatt acaactctaa atgagattta ggtggggaca cagagccaaa
     4141 ccatatcaca ctggcataca ctattccttt cttcaggatt agcgtgcatt agcaaattaa
     4201 tttctgaaaa gtcttgtgtt aaagaaatct gtttaacttt tacaaatgct gagacaaact
     4261 tattgggcca caaagccaca ttttcatgga gcgtctatta acattgcagt agagtggtag
     4321 tcctcaagct ttttatgtgt acctgaatca cctgtggtgt tttatatgct tcttttgttt
     4381 taagcttggc ctgggaatct cctgaatctg atacctactg ttctatgcca cagcacttaa
     4441 tgtcagtgtt ctatggcatg gcacttaatg tcagttttcc accccatctg tgaacgtgta
     4501 ttcaatcatt atactgtatt tagcctgaga atgaatatgg aaaagaaaac aacactttct
     4561 tcaggctttt tgcaactttt taaaagcaaa acaggctcca attccccctc ccaggagttt
     4621 tgtttgtatc caaagagagg acatgctcat tgccatggaa tccttaaagg actgagaggg
     4681 aagtgatctg tggcactcct cccctcccta accagtacat ttgttccagt tttaagccag
     4741 tcaagctcac cgaagagttt ttcaaagacc ttagctacat ggatttaact ttaccaagca
     4801 tccattgtcc aaatgaacat atgagggaaa atgaatatct cttcatctac atcagctgac
     4861 cataactatg ctgtggataa ggggtggtgg gatcagaact gataaccatt ttcaacaaat
     4921 ttcatacgaa tgtgtcttag aagcctcatt tagatgcgat gtcattcatg ggtaaaattg
     4981 aaatgtgcct tcactggcag agtctttaac aatctctgca agacaatcta cgcttttttc
     5041 tattgtttct gaaaatcctt tcaacctcta ttcaaagcca ttttctcact ttagaaattg
     5101 attacagcag ggctgtgatt gtcagtacaa aaatctgtac agggatatgg cagtggtata
     5161 atagatgacc atttccaatt ataaaacaat tagcaaagta tagctaggtc aggccactag
     5221 tacccttcaa attcttaacc atatttacaa agacagcttt tcataacttt tattgctctg
     5281 tccacaaaga tgtggtctca tggtttcaca cgattgagaa tgctacaagt aatagtatac
     5341 tgaaaagaac atgtctctaa ttctggactg ctctttatct ccaagaaaca gagagagaga
     5401 gaatgaaaaa aaatcccagc ttagaggaat tttggaagtt actctttcat gaaccatcac
     5461 attttctggg cctttgtaat ctttaaacac tgttactctt tagaggttgg tttgaatttg
     5521 ttgcacagag aacaataatc tatgacaaat taatgaaccc ttttgctaat atcacatgag
     5581 tacaagtatc ttgtatttct catcacattt accgtaataa agaatgcaga caagtataat
     5641 acatggcatc attttgggga ttttccaatt tctatgtggg catactggaa gaagtttgta
     5701 acagttgcaa ttctgtcaca atgcaggaag tctttctaga acacacaatg tggatgattt
     5761 tcagttttag aattgtaaac taaccaaatg tcaattcagt ttctcatttt atattagttt
     5821 ttgttacaaa cactgcctat ttctcttttg tacaaacact tcacacacac acacacacac
     5881 acgcgcacac acacacacac acacacacac acacaggcac acacacacta gatgggcctc
     5941 caaaagaact cagagctgct gtcttcctct gggaggttga tcatatgtct attcagttgg
     6001 gagaatggag cagtcaagtt caaaatccat gtggctctct ggcttcagaa gctatccttt
     6061 cagctatgac acacacacta aatagtattg cccaggtttg ccctacaaca tgttagcata
     6121 tctacatatt ttgtactgta ataatgtgta cgctcttaat aatttgtttt taatgctgtg
     6181 taaagttagc aattagagta agagaaacgt atgggataat gattgagtaa aatctcagct
     6241 ccttttgagt caatcactca gcttgttggc acagtagata tttatgacct taaatactgt
     6301 cagcgcttca cagcacatta ctgaggcctg gataaagcat tcacacaaag ataaatggat
     6361 tgaaactgtg tcaattttgt agaaaaagat attctggggt ttagtaacag agaatttttc
     6421 tttccttact gcgattaata aagtggaact ccaattgcaa gtaactattc agttttatgt
     6481 tcttcacata tggaaacctc tctgtcacta ataccctggg acaaactgga tgattaccat
     6541 ccaagtgtta ttttcttcct cgaaaatttc aaaaccagaa tgaattagtt ctccaagtct
     6601 ggctatacta tagttttctt cttaatgtaa aacagctgaa taaaacagct tgaacaatat
     6661 ttgactttca tgggtcttaa gaacgtttca aaatacacca ccaatatatt taccaacata
     6721 tttagtgcca gatatacaca gaacaaacac taccctattg tttctgtgtg cgtgtgtgtg
     6781 tgtctgtgtc tgtgtgtgtg tgtagcagga cactaaataa acaagtcatg ttgctgttct
     6841 tagggaagtt ttggtaaaga gagcttcaaa gttccttgga gtcacctgca aggctaactg
     6901 tactaaaagc ggaatttgca tgatctttct acaaactctc agtgtaaagt ggtagataga
     6961 catgcaagca tcacacttag attgcaataa atgctgtgat gtaaaaaata caatggagga
     7021 aaaatttttg attagggaaa tttaaacatt ttcaaagaag agttaatgtt tcagtggagt
     7081 cttaaaagat gagtaggaat tcaacagcca gaagggaagt gtagacgctc tgtgtcacat
     7141 aaaacaaaac agaacagaat agtataagtg aaggcataga gcttcacatg aaaggcacat
     7201 gaaatagcac tgggtatctc taaaatatta attagcctag tgtagctgga caatgagggg
     7261 cagagcccct ggtatgcaag tgatgtctgg gaaaggagca atctttctac agtgcctcat
     7321 tccatcatac ctcattacca gaaaaacatt atgagccact taggcctgta ttatttgagc
     7381 atctctgaaa tggagttgct ctacatgttt tgtagaaacc taatgagtaa tttattctca
     7441 tcagtagaca aaatgaaaga aagaaaatag actctgagca aagtatgatt cacaaccttg
     7501 cctattaggc tatagaagat tgccctacta attcctcctt ttcgtctgtt gaacaatctg
     7561 tattttgcct gctcaaaaag gaattcctca agttataggg gcagtttgac cagtacaatc
     7621 atatcagaaa aaaatcagca aaattatgtt ctaacaacat cttcccatct aaagtgcaca
     7681 ttttattttt ttaaggtaac ataattacta cgaacaaccg aaatggtata taaaggtgaa
     7741 aaattaaaat aatttttttt acagctccac gttacctcac cccctagacc ctggtaacca
     7801 ccattcaact ctctgtttcc attagttcaa ctttttaaga ttctttttat acaaaggatg
     7861 tcatgtagca tttttttctt ttttcatctg gcttatttca cttagtttgc ttatttcaac
     7921 gtgctctgaa gtttcatcca tgtttatgta aatggaagga gctccctctt tatatggcta
     7981 agatatatat atatattata ttatatatat atatgtatat atatatatta tatatatata
     8041 tgtatatata tataattttc tttcttcatt catctgtccg tgggcactta ggttgttcca
     8101 taacttatct attgtgaata atggtgcaat gggaatgaat gggagtgcag atgtctgttt
     8161 ggcatactga tttaatttcc tttggatata taaccagaag tgggaatgct ggatcataca
     8221 gtagttctat ttttactttt atgaggatct ccatactgtt ttacataatg gcttactaat
     8281 ttacattccc ataaacagtg tacaagaata cctccttgcc aacacattat cttttaagtt
     8341 ttggataata ttattcctat taataacatg tgtgatatta cattgtggtt ttgatttgca
     8401 tttcccttat gattaatgat gttaagtacc ttttcagata tatgttggcc atttgtatgt
     8461 cttccttgga gagatgtcta ttcagctcct tggtccattt ttcaaaatac agtttacttg
     8521 tatttttgct attgacttgt atgagttcct tatatatttt ggatattaac cccttatgag
     8581 aaatatggtt tgcaaatatt ttctcctatt ctgcaggttg ccttttcgtt ttgtcgatta
     8641 tttcctttgc tgggcagata atttttttat tttatttttt gaaacagtgt ctcactctgt
     8701 cacccaggct ggagtgcagt ggtgtgatca tgtctcacca cagccttgac ctccccagga
     8761 tcaggtgatc ctcccacctc agtttttgta tttttagtag agatggagtt tcaccctgtt
     8821 gcccaggctg gtctaaaact cctgggctca agccatcttg cccaccttgg gacctcccaa
     8881 agtgttagga ttagaggcat gggccaccat gcctggcttt gaaacttttt aatttaatgt
     8941 agtctgactt gtttattttt actttgttgc atgtgctttt ggtgttacag ccaaaaaagt
     9001 tattgccaag accaatgcca tagacattat ttcttattct agtaatttta caattttagg
     9061 tcttatgttt aagtttttaa tcgattttga gttgattttt gtgtatggta taggataaag
     9121 gtccaatttc attattttgt atttggatat tcaatgttta aaatacgatt tattgaatgg
     9181 actatatttc cccatgatgt gtttttagtg cctttgttga agatttgttg atcatatatg
     9241 tgtggatttg tttcttggct ttctattctg ttccattggt ctatgtgtct gcttctatgc
     9301 caataccata ctgttttgat tactatagct ttacaatata atttgaaatc aggaaatgtt
     9361 ctaaacttct ttctcaagat tgttttagat ctttggggac ttaggtggtt ccataaggtt
     9421 ttaagaattt tttttctatt tctgtaaaaa attatattaa gattttgata gtgcttgcat
     9481 tgactctgta gatcactttg gttagtatca acatttttgc aaaattaatt cttccaaact
     9541 atgaacacag gatactgttg cacttatttc tcttcttcaa ttcctttcat cagtatctta
     9601 tagtttttaa tgtacagatt tttcacctcc ttggttaaac ttattcctaa gtacattttc
     9661 ctttttgatg caattgcaaa tgggattgtt tttctaattt attttatttt gtttgtttgt
     9721 ttgtttgttt gtttttgaga tggagtcttg ctctgtcacc caggctggag tgcagtggtg
     9781 tgatcttggc tcaccacaac ctctgcctcc cgagttaaag ggattctctt gcctcagcct
     9841 cccgagtagc tgggattata ggcgcctacc accatgcctg gctaattttt gtatttttag
     9901 tagatagaga tggggtttca ccatgttggc caggctagtc tcaaactcct gacctcaggt
     9961 gatccacctt cctcggcctc ccaaagcgct gggattacag gcgtgagcca ctgcacccag
    10021 ccactaattt attttttgga tagttcattg ttagtgtaca gaaacaactg attttttatg
    10081 ttgattttgt atcaacattg gtgaattcca cccaacattt gaggaaaaac taataccaat
    10141 ccttctcaaa atcttccaaa aaaatgaaga ggaaggagca cttccaaact cattttatga
    10201 agccagcatt attctcatac cattccagac aaggacacta caagaaaaaa aattacaggc
    10261 ccaaatccct gttgaacata gatgcaaaaa tccacaacaa aatactagct aaaagaactt
    10321 aacatcacat ttaaaggatc attcaccata atcaagtggg atttcaccaa tttcacttgg
    10381 gtagaattca ccaatgttga taaaaaaatc aacataaaaa tcagttgttt cttcacacga
    10441 acaatgaact atccaaaaaa taaagaacac aatcccattt gcaattgcaa aaaaatactt
    10501 agaaataaat ttagcaaagg aggtgaaaga tctttatatt aaaaactata aaatattgat
    10561 gaaagtaatt gaagaagaca aatggaacag atccctttgt tcatagattg gaagaattaa
    10621 tattacagaa atgttaatac taactaaagt gatctacaga gtcaatgcaa gccctatcaa
    10681 aatcttaatc gaatctttta cagaaataaa aaaaaattct aaaattcata tggcaccaca
    10741 taagtcccca aaaatcttta caacttcact gaatttattt atcacttcta acatttttct
    10801 gttggagtca ttgggtttct gtattgaaga gcatgtgatt tgaaacagac cattttactt
    10861 cttccgtcct gatttgcatg cattttattt ctttttctcg acttattgct ctaagcagaa
    10921 cttcaagtac catgtggaat agaagtggca agagtgagca ttctcttctt catcctgatt
    10981 tcagaagaaa agctttcagc atttcactac tgactatcac gttagatgtg agtttgtcat
    11041 atatatggcc tttgttatat ttagggatat tccttctcta cctaatgttt tgaatgtttt
    11101 catcatgaaa gggtgttgat tttttttcaa atgccttttc tgtatctgtt aaaatgatca
    11161 tatgattatt atccttcatt gtcttattgt tcatatttat tgatttgagt atgttgagcc
    11221 atccttttat cccagggata actctcactt gattatggtg aatgatcttt ttaatgtgat
    11281 gttaagttct tttagctagt attttgttgt ggatttttgc atctatgttc aacagggatt
    11341 tgggactgta ttcctttttt ttcttgtagt gtccttgcct ggctttggta ggagaataat
    11401 gctggtttca tagaaaaatg agtttagaag tgttcctcac tcttcttttt tttttggaag
    11461 atttgagaag gattgatatt agattttctt taaatgttgg gtagaattca ccactgaagc
    11521 catctggttc tgggctttac tttgttggga agttcttttt taaaaaattg ctgattcaat
    11581 attctttttc attattgctc tctacagatt ctctattcat gattcagtct tgctaggttg
    11641 tggtatgttt ctagaaattt atctgtttct tctagattac ccaacttgtg tataattgtt
    11701 cataatagtc tctaatgatc atttatattt ctatggtatc agttgtaatg tcttctcttt
    11761 catttctgat tttatttgtt tatgtctttt ctctttcact ctcagttact ctagctaaag
    11821 gcttgtctgt tttttaatct tttcaaaaaa caactcagtt ttattgctct tttttatttt
    11881 tctagtttct atttcacttt tttctgttct gatatttact tcattccttc ttccgacttt
    11941 gggattagtt tatggttctt ttatagttcc ttgaggtgta aagttaggtc gtttatttga
    12001 tttttttttt cttaatgtag gcatttatca ctataaactt ccttcttaga aatgcctttt
    12061 gctgcatccc atatattttg gtatgttgtt tttccacttt tgtttgtctc aagtttttta
    12121 aatttttctt ttgatttgct ctttgattct ttggctattt aggagtgtat tgtttaattt
    12181 tacagttttc ctccctttac tgatttccag tttcttagca ttgtggtcag aaaagatatt
    12241 tggtatgatt tcaatcttct tagttttgtt aacacttgtt ttgtggccta acagttgatg
    12301 tatcttcaaa atgtacctgc gcaattactt gggacgaatg tacattctat tgcttttgga
    12361 gggaatgttt tgtatctgtt aggtccattt ggtctaaagt gtagttcaag tcaattccct
    12421 attgattttc tgtctgggtg atctgtccat tgttgaaagc tgggtatcaa agtcttctac
    12481 tactatacta ttacagtcta tatttcctgt tcatatctat taatacctgc tttatatatt
    12541 taggtgatcc aatgttgggt gtgtatatat tcaaaattgc atcttgttga tgaattgact
    12601 catttatttt tatataatgg cattctttgt ctcttgttac agtttgtgac tttaagtctg
    12661 ttttgtctga tatagtatag gtgtctctgc ttctttctgg tttctattta catgcaatat
    12721 ctttttaatc tcttcacttt cagtttatac gtgtccttgc agctaaagtg actatcttat
    12781 agatagcaag tacttagttc ttcctttttc atccattcag ccactcactg tcttttgatt
    12841 agagaattta atctacttac attaaaatta attatttata ggtaaagaca tactattgct
    12901 actttgttaa atgtttttca gctgttttgt aagttttttt gtttctttct tcctctcttg
    12961 ctgtctttct ttgtgattga tgattttcct gtagtactat ggtttgattt cttttttttt
    13021 aataattttt atttttattt taagttccag ggtacatgtg caggatatgc aggtttgtta
    13081 cataggtaaa catgtgccat ggtggtttgc tgcaccttca acccatcact gaggtgttca
    13141 gccaagcatg cattagctat ttttcctaat agtatctctc cccacacccc accccccttg
    13201 acaggcccca gtgtgtattg ttcccctccc tgtgtccatg tgttctcatg ttcagctctc
    13261 acttataagt gagaatacgc agtgtttggt tttctgttcc tgcaatagct tgctaagaat
    13321 aatggcttcc agcgccatgt gtgtccctga aaatgacatg atctcattcc tttttatggc
    13381 tgcatagtat cccatggtgt atatgtgcca cattttcttt atccactgta tcattgatgg
    13441 gcatttgggt tgattccaca tctttgctct tttgaacagt gctgcagtga acatatgcgt
    13501 gcatgtatct ttgtaataga atgatttata ttcctttggg tatataccta gtaatgggat
    13561 tgctgggtca aatgttattt ctggttctag atctcggaga aatcaccaca ctgtcttcca
    13621 caatgtttga actaatttac tttcccacca gcagtgtaaa agtgttccta tttctctgca
    13681 accttgccag catctgtcat tttttgactt tttaataatc accattgtga ctggcatgag
    13741 atggtatctc cttgtggttc tgatttgcat ttctttaatg atcagtgatg ttgaactttt
    13801 ttcatatgtt cgttggcctc atgaatgtct ttttttgaga agtgtctgtt catgtccttt
    13861 gcccactttt tgatgcggtt ttttttttct tgtatatttg cttaaattcc ttgtagattc
    13921 tggatattag accgttgtca gatggataga ttgcaaaaat tttctcccac tctgtaggtt
    13981 gcatgttcac tgtgatagtt tctgtctttc tttcttttta tattatactt gaagttctgg
    14041 ggtacatgtg cagaatgtgc aggtttgtta cataggtatg cacgtgccat ggtggtttgc
    14101 tgcacccatc aacccgtcat ctatattaag tgtttctcct aatgctttga cttcattatt
    14161 tctttcattt gattgagtat gctgtggatg ttttctgtta cttttttaat tttattcatt
    14221 gtattcttca gcttcagaat ttgtttgttt gtttgtttgt ttgtttttca cagtttctat
    14281 ctctttgttg aacttattat tttggtcata cattgttttc ctgattctac tgacttcttt
    14341 gtctgtgttc tcatgtagca acccaagctt atttaaaaca attattttta atattttgtc
    14401 aggaaatttg tagatctcca tttttttttg ttggcaactg gaaaattact gagtttcttc
    14461 ggtggtatta tttttgtgtt gtttttggca ggtgttcctt gaaatctcgt gttgccatgt
    14521 tcacatttga agaagtagtc tcctccttca gcctatactg actggcttca gaagagaaac
    14581 agttatacca gttagcctga ctggggatac taagactctt gcacatcttt tctgtagatg
    14641 tgtcactcaa gctctttttg agaaatttta agatcatctg tattttctta atttcataaa
    14701 accaaaccaa attctgagag tttcccattt gttttctcta acgtggtgcc ctgaagtgct
    14761 caagtttttg tgccttctcc cattcccaca gagtcaagct gcctgcttct gcatgcacac
    14821 aagttcacac tcgctgtcag ggtttgggcc gtgtgcaggg agcaagccaa ggtagaggag
    14881 agagggagac atgcaaagtt ttgggagcac ccatgtgtca gcttcggggg tttacagttc
    14941 aggcatccca agccactagt gggtgggcct cctgatggag tctgtgaagt tgttagtagt
    15001 atatgtgtcc ttttgttgaa tttccagtct ctggttgctg tgagccccta ccgctgttcc
    15061 ctgctcacag cctctcagtc actcagacat gatgatcccc tcagtattct gagtggggat
    15121 agaaagaagt aggcctcttg gtcagtgtcc cacgtggcta ggaaagccag gcattcattt
    15181 actacactct ccctttcacc caatggagaa atcatgagtc aaagttgtat ctcttggtgt
    15241 tgagttctgc tagcttgaga gacggttgac ataagtagtg aaactatttt ctggttcttt
    15301 tcaatgtgcc tattctcgta attgttttgc tccatctgtg agctggacta ccagactccc
    15361 acaaaggtac tctcatactt gagtggttgt caaaattgta gatagtgggg aaatgacagg
    15421 agaaaattcc tgttctgcca tcttgctgac atcaccccaa tatctaaaat gcatatttta
    15481 attatttttt tccttgaata aagtttattt tggaattgtt gagttttaca aaataattta
    15541 aaatattctc tctctctctc tctctctctg gggttgaggt ctcactctgt cacccaggat
    15601 ggattacagt ggcacaatcg cagctcactg cagcctcgaa tttcttgggt caagtgatcc
    15661 tcccacttca gcctcccaag tagctgggac tacaaggcgt gtgccaccat gcccagctaa
    15721 tatttttaca ttttttgtag agatggggtc tcactatgtt gcccaggtgg gtcttgaact
    15781 cctggcatca tgtggtcctc ccacctccac ctcccaagtc ctgaggatac caattgtgag
    15841 tcactgtgcc cagctatccc cttctcactc tctttttctc tcacacacat gtgtgcatgc
    15901 acagacacac acacctcatg ttcattctct ttaccatgat gatccttggt tcttttacac
    15961 agcttctttc agtttacctt acaatttagc tcaacacaaa ttttaaaaaa cttatagtta
    16021 caatttaatt tggcttggtc cacacctcta acaaatttga tacaatctcc aacttacggt
    16081 tgcaagttag ttgattatat tcacttccaa gtatttcccc caacatttca ttatgaaaat
    16141 atatccatca attaatgctc ttatctataa aataattatt tttttgcatt tcaaaataag
    16201 ttacagacat caatgcactt catctttaaa ccctttatca tgcatatcag gaagtagagt
    16261 ttaatatttc tatatttctt gggggagaaa tggagctaaa attatatact gtatcatata
    16321 caaacctgtt aggtatatca attcatgtgt attgacaaat gcgtgcacca tgtaacagaa
    16381 actcctttca agatatagaa tattcctatc actacaaata ttaatcacca aaacaatggg
    16441 gagaatgtct ctagggcatg tcagagacct tcactgcagc ctctcccatt ataggccagg
    16501 aggccttgaa ggaaaaaaat ggtttagtgg gccaggcctc aggcaccccc ccttgctctt
    16561 tgcagccttg aaacatggta ccctgcgtcc ccagctgctt cagcttcagc tgtggctaaa
    16621 aggggccaac atacagctca ggccattgtt tcagagagtg caatccccaa gctttggcag
    16681 cttacacatg gtgttgggct tgcaggagca cagaagtcaa gaattgaggt ttgggaacct
    16741 ctgcctagat ttcagaggat gtatggaaat gcctggatgt ccagacagaa gtctgctgca
    16801 ggggtagagc tctcagggag aacctctgct agggcagtgc agaagggaaa tgtggggttg
    16861 gagctccccc acagagtctt cactggggca ctgtatagtg gagctctgag aagagggcca
    16921 tagtcctcca gaccccagaa tggtagatcc accaatagct tgcaccatgc acctggaaaa
    16981 gccactggca ctcaacacca gcccatgaaa agagctgtga gggtggctgc atcctgcaaa
    17041 gccacagggg aagagctgcc caaggctgtg ggagcccacc ccttgcatca ttgtgacctg
    17101 gatagatgtg agacatggag cctaaggaga tcattttgga actttaagct ttaacgactg
    17161 ccctattgga ttttggactt gcatgggcct atagcccctt tgttttggcc aacttctccc
    17221 atttggaatg ggtattttta ctcaattcct gtacccccat tgtatcttgg aaataactaa
    17281 cttgctttag attttacagg cttataggtg gaagggactt gctttgtctc agatgagact
    17341 ttggacttgg acttctgggt taatgtttga atgagttaat actttggggg actattggaa
    17401 gggcatgatt gtgttttgaa atgtgagaac atgagatttg ggaggaacta gggtcagaat
    17461 gatatggttt ggttttgtgt tcccacccaa atctctcctt gaattgtaat aatccccatg
    17521 tgtcaggggt gggaccaggt ggaggactga atcatggggg tggtttccct catgctattc
    17581 tcatgatagt gatttataac agatccaatg gttttataag catctggcat ttcccctgct
    17641 ggcactcatt ctctctcctg ccaccctgtg aagaggggcc ttccaccatg attgtaagtc
    17701 tcctgaggcc tccgaagcca tgcggaactg tgagtcagtt aaaactcttt cctttataaa
    17761 ttacctagtc ttgggtattt ctttatggaa gcatgagaat gaactaatgc acagggtaaa
    17821 aatttaaaaa caaacataca aatgcaagta aacaagccaa tatttcaact gttcccattg
    17881 cattatcctt attctttatc tatggtacca gaaaataata catctgaaac aatttttttt
    17941 tcctgccatg atgtacactc aagtgggtcc actggggttt ctttcagttt cccaaatact
    18001 agatatgact cttccctata ccttatcttc atatgaagaa agctatgaga atatattaat
    18061 aactgaatat agtaacacta ctataggaat aagcatgtgt atattccaac tgatctttta
    18121 aaacttttat tttgaaatat ttatagattc aaaggaagat gcaaagagta tagggaagtg
    18181 ctatatgccc tttatctagt tcctctagtg gtatcaactt acataactgc agtatcatat
    18241 ataaaccaag aaattggcat ctgtataatc cacagacatt actcagactt ctctagtttt
    18301 acatacacta atttgtatgt gtgtgtgtgt gtgcgtgcac gtttatgtgt gtaggtctat
    18361 gcaattttac cacatgtgta tatttgggta accactacaa tgatcaagat atggaactgt
    18421 tccgtcacca ctaagatccc ttgtgctatt cctttataaa catctccctg tcatcctttt
    18481 tcacccataa aagctagtaa acactaatct gttcttcatc cttataattt tattatttca
    18541 gaattgttat ataaatgtca tcatacagta tataacacat agagattggc ttttgtcact
    18601 cagcacaatt cccttgagat gcatccaaac tgttgtgtat atcagtaatg caatatgttt
    18661 aatttctgtg tagtattcca tggtagagat gtgccatagt ttaactattc acctgttgaa
    18721 caacatttgt gttctttcta cttttgggct attacaaata aagttgctat gaacattcat
    18781 gtataa
//
