LOCUS       NM_004114              19575 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens fibroblast growth factor 13 (FGF13), transcript
            variant 1, mRNA.
ACCESSION   NM_004114 XM_001129150
VERSION     NM_004114.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 19575)
  AUTHORS   Dong,Z.S., Zhang,X.R., Xue,D.Z., Liu,J.H., Yi,F., Zhang,Y.Y.,
            Xian,F.Y., Qiao,R.Y., Liu,B.Y., Zhang,H.L. and Wang,C.
  TITLE     FGF13 enhances the function of TRPV1 by stabilizing microtubules
            and regulates acute and chronic itch
  JOURNAL   FASEB J 38 (10), e23661 (2024)
   PUBMED   38733310
  REMARK    GeneRIF: FGF13 enhances the function of TRPV1 by stabilizing
            microtubules and regulates acute and chronic itch.
REFERENCE   2  (bases 1 to 19575)
  AUTHORS   Yang,H., Zhou,J., Li,D., Zhou,S., Dai,X., Du,X., Mao,H. and Wang,B.
  TITLE     The inhibitory role of microRNA-141-3p in human cutaneous melanoma
            growth and metastasis through the fibroblast growth factor
            13-mediated mitogen-activated protein kinase axis
  JOURNAL   Melanoma Res 33 (6), 492-505 (2023)
   PUBMED   36988403
  REMARK    GeneRIF: The inhibitory role of microRNA-141-3p in human cutaneous
            melanoma growth and metastasis through the fibroblast growth factor
            13-mediated mitogen-activated protein kinase axis.
REFERENCE   3  (bases 1 to 19575)
  AUTHORS   Han,D., Guan,L., Zhang,Y., Yang,H., Si,L., Jia,T., Wu,Y., Lv,K.,
            Song,T. and Yang,G.
  TITLE     FGF13A interacts with NPM1 and UBF and inhibits the invasion of
            bladder cancer cells
  JOURNAL   Biochem Biophys Res Commun 678, 1-10 (2023)
   PUBMED   37603967
  REMARK    GeneRIF: FGF13A interacts with NPM1 and UBF and inhibits the
            invasion of bladder cancer cells.
REFERENCE   4  (bases 1 to 19575)
  AUTHORS   Fan,X., Huang,J., Jin,X. and Yan,N.
  TITLE     Cryo-EM structure of human voltage-gated sodium channel Nav1.6
  JOURNAL   Proc Natl Acad Sci U S A 120 (5), e2220578120 (2023)
   PUBMED   36696443
REFERENCE   5  (bases 1 to 19575)
  AUTHORS   Cheng,H., Miao,P., Wang,Y., Guo,Y., Gao,L., Lou,Y., Yang,F.,
            Liang,M. and Feng,J.
  TITLE     A Heterozygous Variant of FGF13 Caused X-Linked Developmental and
            Epileptic Encephalopathy 90 in a Chinese Family
  JOURNAL   Cytogenet Genome Res 163 (1-2), 36-41 (2023)
   PUBMED   37536293
  REMARK    GeneRIF: A Heterozygous Variant of FGF13 Caused X-Linked
            Developmental and Epileptic Encephalopathy 90 in a Chinese Family.
REFERENCE   6  (bases 1 to 19575)
  AUTHORS   Yao,D.L., Masonic,K., Petullo,D., Li,L.Y., Lincoln,C.,
            Wibberley,L., Alderson,R.F. and Antonaccio,M.
  TITLE     Pretreatment with intravenous FGF-13 reduces infarct volume and
            ameliorates neurological deficits following focal cerebral ischemia
            in rats
  JOURNAL   Brain Res 818 (1), 140-146 (1999)
   PUBMED   9914447
REFERENCE   7  (bases 1 to 19575)
  AUTHORS   Gecz,J., Baker,E., Donnelly,A., Ming,J.E., McDonald-McGinn,D.M.,
            Spinner,N.B., Zackai,E.H., Sutherland,G.R. and Mulley,J.C.
  TITLE     Fibroblast growth factor homologous factor 2 (FHF2): gene
            structure, expression and mapping to the Borjeson-Forssman-Lehmann
            syndrome region in Xq26 delineated by a duplication breakpoint in a
            BFLS-like patient
  JOURNAL   Hum Genet 104 (1), 56-63 (1999)
   PUBMED   10071193
REFERENCE   8  (bases 1 to 19575)
  AUTHORS   Munoz-Sanjuan,I., Simandl,B.K., Fallon,J.F. and Nathans,J.
  TITLE     Expression of chicken fibroblast growth factor homologous factor
            (FHF)-1 and of differentially spliced isoforms of FHF-2 during
            development and involvement of FHF-2 in chicken limb development
  JOURNAL   Development 126 (2), 409-421 (1999)
   PUBMED   9847253
REFERENCE   9  (bases 1 to 19575)
  AUTHORS   Greene,J.M., Li,Y.L., Yourey,P.A., Gruber,J., Carter,K.C.,
            Shell,B.K., Dillon,P.A., Florence,C., Duan,D.R., Blunt,A.,
            Ornitz,D.M., Ruben,S.M. and Alderson,R.F.
  TITLE     Identification and characterization of a novel member of the
            fibroblast growth factor family
  JOURNAL   Eur J Neurosci 10 (5), 1911-1925 (1998)
   PUBMED   9751161
REFERENCE   10 (bases 1 to 19575)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z82193.1, AL031386.1 and
            AL357123.11.
            
            On May 17, 2019 this sequence version replaced NM_004114.4.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth, and
            invasion. This gene is located in a region on chromosome X, which
            is associated with Borjeson-Forssman-Lehmann syndrome (BFLS),
            making it a possible candidate gene for familial cases of the BFLS,
            and for other syndromal and nonspecific forms of X-linked cognitive
            disability mapping to this region. Alternative splicing of this
            gene at the 5' end results in several transcript variants encoding
            different isoforms with different N-termini. [provided by RefSeq,
            Nov 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012347.1, AF100143.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315930.11/ ENSP00000322390.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-901               Z82193.1           51708-52608         c
            902-1012            Z82193.1           49709-49819         c
            1013-1116           Z82193.1           43875-43978         c
            1117-1315           AL031386.1         14494-14692         c
            1316-13238          AL031386.1         101-12023           c
            13239-19575         AL357123.11        66018-72354         c
FEATURES             Location/Qualifiers
     source          1..19575
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3-q27.1"
     gene            1..19575
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="fibroblast growth factor 13"
                     /db_xref="GeneID:2258"
                     /db_xref="HGNC:HGNC:3670"
                     /db_xref="MIM:300070"
     exon            1..901
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     CDS             715..1452
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fibroblast growth factor homologous factor 2"
                     /codon_start=1
                     /product="fibroblast growth factor 13 isoform 1"
                     /protein_id="NP_004105.1"
                     /db_xref="CCDS:CCDS14665.1"
                     /db_xref="GeneID:2258"
                     /db_xref="HGNC:HGNC:3670"
                     /db_xref="MIM:300070"
                     /translation="MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLN
                     VFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLF
                     NLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIY
                     RQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRS
                     GSGTPTKSRSVSGVLNGGKSMSHNEST"
     exon            902..1012
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1116
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1315
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..19575
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="hexamer: AATAAA"
     polyA_site      2726
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="major polyA site"
     regulatory      19546..19551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="hexamer: AATAAA"
     polyA_site      19575
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
ORIGIN      
        1 gtcgcgctgt tccggagggt gcctgcggcg gctgaattcc tgtgctgcga ctgtgccgcg
       61 cccagagcag cagcaacagc gaagatgcga ggccattacc tgtttgatcc ctgtcggaaa
      121 cctggcacgg gccaactttt cccgattatc acgccaagaa gttgcaagga ctagtcgaag
      181 actcggaggg gccagggcga gggcgcgctc ccccgcgcgc tgcctcgtcc ctcctccgtc
      241 cggccgcccg agctcccggc ctctctcccg cccgcgctca ctccctccgc ccgcctccct
      301 cctctggccc ccatcagaag ggcaacaggg cgagggggtc cggcgaaatt cggaccggag
      361 cagctggaca tgcacggtgt ccgccgggcg caggggccga ccacacgcag tcgcgcagtt
      421 cagcatccgc gtgccagtct cgcccgcgat cccgggcccg gggctgtggc gtcgactccg
      481 acccaggcag ccagcagccc gcgcgggagc cggaccgccg ccggaggagc tcggacggca
      541 tgctgagccc cctccttggc tgaagcccga gtgcggagaa gcccgggcaa acgcaggcta
      601 aggagaccaa agcggcgaag tcgcgagaca gcggacaagc agcggaggag aaggaggagg
      661 aggcgaaccc agagaggggc agcaaaagaa gcggtggtgg tgggcgtcgt ggccatggcg
      721 gcggctatcg ccagctcgct catccgtcag aagaggcaag cccgcgagcg cgagaaatcc
      781 aacgcctgca agtgtgtcag cagccccagc aaaggcaaga ccagctgcga caaaaacaag
      841 ttaaatgtct tttcccgggt caaactcttc ggctccaaga agaggcgcag aagaagacca
      901 gagcctcagc ttaagggtat agttaccaag ctatacagcc gacaaggcta ccacttgcag
      961 ctgcaggcgg atggaaccat tgatggcacc aaagatgagg acagcactta cactctgttt
     1021 aacctcatcc ctgtgggtct gcgagtggtg gctatccaag gagttcaaac caagctgtac
     1081 ttggcaatga acagtgaggg atacttgtac acctcggaac ttttcacacc tgagtgcaaa
     1141 ttcaaagaat cagtgtttga aaattattat gtgacatatt catcaatgat ataccgtcag
     1201 cagcagtcag gccgagggtg gtatctgggt ctgaacaaag aaggagagat catgaaaggc
     1261 aaccatgtga agaagaacaa gcctgcagct cattttctgc ctaaaccact gaaagtggcc
     1321 atgtacaagg agccatcact gcacgatctc acggagttct cccgatctgg aagcgggacc
     1381 ccaaccaaga gcagaagtgt ctctggcgtg ctgaacggag gcaaatccat gagccacaat
     1441 gaatcaacgt agccagtgag ggcaaaagaa gggctctgta acagaacctt acctccaggt
     1501 gctgttgaat tcttctagca gtccttcacc caaaagttca aatttgtcag tgacatttac
     1561 caaacaaaca ggcagagttc actattctat ctgccattag accttcttat catccatact
     1621 aaagccccat tatttagatt gagcttgtgc ataagaatgc caagcatttt agtgaactaa
     1681 atctgagaga aggactgcca aattttctca tgatctcacc tatactttgg ggatgataat
     1741 ccaaaagtat ttcacagcac taatgctgat caaaatttgc tctcccacca agaaaatgta
     1801 aaagaccaca attgttcttc aaaaacaaac aaaacaaaac aaaacaaaat taactgctta
     1861 aatgttttgt cggggcaaac aaaattatgt gaattgtgtt gttttcttgg cttgatgttt
     1921 tctatctacg cttgattcac atgtactctt ttctttggca tagtgcaact ttatgatttc
     1981 tgaaattcaa tggttctatt gactttttgc gtcacttaat ccaaatcaac caaattcagg
     2041 gttgaatctg aattggcttc tcaggctcaa ggtaacagtg ttcttgtggt ttgaccaatt
     2101 gtttttcttt cttttttttt ttttttagat ttgtggtatt ctggtcaagt tattgtgctg
     2161 tactttgtgc gtagaaattg agttgtattg tcaaccccag tcagtaaaga gaacttcaaa
     2221 aaattatcct caagtgtaga tttctcttaa ttccatttgt gtatcatgtt aaactattgt
     2281 tgtggcttct tgtgtaaaga caggaactgt ggaactgtga tgttgtcttt tgtgttgtta
     2341 aaataagaaa tgtcttatct gtatatgtat gagtcttcct gtcattgtat ttggcacatg
     2401 aatattgtgt acaaggaatt gttaagactg gttttccctc aacaacatat attatacttg
     2461 ctactggaaa agtgtttaag acttagctag gtttccattt agatcttcat atctgttgca
     2521 tggaagaaag ttgggttctt ggcatagagt tgcatgatat gtaagatttt gtgcattcat
     2581 aattgttaaa aatctgtgtt ccaaaagtgg acatagcatg tacaggcagt tttctgtcct
     2641 gtgcacaaaa agtttaaaaa agttgtttaa tatttgttgt tgtataccca aatacgcacc
     2701 gaataaactc tttatattca ttcaaagaat aatcttccaa catgtattta ttgagcgtcc
     2761 attatgtgcc agtaactgaa gtagcaactg gaagtaaaca ttgtataatg cagataaggt
     2821 cactgtcctc agatagtcta cagtctagag agtcatatta acatgaacac tttaaagtgt
     2881 gtttatttta ctagttactg tacttgcact tcagattggt acaaaggaat tcacattccc
     2941 gttcagtagt caaattatac aaatgaggcg tttgtgctag tattttctct gccactcaca
     3001 gtgtcatttc ccctctctgt tgcttatttc tctcctctct agagggaata cacaggacta
     3061 aatagtgtcc tttctacctt tgagaactga aggaaaatgt aaattttttt aaatgttgat
     3121 gacttttctc tagctcccca aagctgcatt gtctggcaat gaacactttg agaacagtca
     3181 atacagatgg tctctgactt acagtagttc aacttacatt ttttcggggg ctttacagtg
     3241 gtacagaagc aataggcatt tagtagaact catactttac catacaacca ttttgctttt
     3301 tatttccagt acactattca ataaatgaca tgagctattc aacacttttt aattacaaaa
     3361 tttgctttgt agtacatgat tttgtccaac tgtaagctaa tataagcgtt ctaagcacat
     3421 ttaaagtagg ctaggctaag ctatgatgtt tgctaggtta ggtgtattaa atgcattttc
     3481 aacttaagat gggtttattg gtatgtgacc cccatcgtaa gtgaaggatc atctgtatat
     3541 ggagggaaga attgtgaaat acataaaacg tagttgacta gtgcttttca gagcatctgc
     3601 aaataaaatt actggggccc caaacagcct gcttttgcaa ggaggggaga ctcctcattt
     3661 ctaagatgtt tggaccagat tcagcatgag ctcctatccc tgcccacccc agcccagtct
     3721 aagtcacctt gtaatttcat gagataagtc ctcctcatcc tgcttcatcc tgcctgagct
     3781 ctaaacacac ctacatgagg tacgctcacc tgcctagcta tcttggatgc aggatccttt
     3841 gtaccatgtt ttaaaaatca ggagatgctc actcaaccac ctctccctat taactcttac
     3901 taattttcaa tcagtaggga aaagtagtgc attgtctccc tctttctcta agaactttaa
     3961 agtttggtca ctgactactt cagttgctgg tcttgctttt tctgttgttc agaaatagtg
     4021 taggtctgct ggtagtaagc aaattagcac tatgtgggtc tcagggatgc ctgcgttaat
     4081 aggatggagt caaaatgccc aggaagaatc ctttaccccc agcattcttt ttgagctgcc
     4141 ttaaagttgc tttaaacaga cagtggtgtt aaaataaatt aataagtaaa taaatagtcc
     4201 tcaaaccttc ctacaagtga tgatatcaat actttcacac atcttcatta cacacacaca
     4261 tacacacaca ccctttccca ccccatcccc tcatgcacat cctttagtag cattcctcct
     4321 ggcagaaaat actagtcctg ccacataact gatgaaagaa aaaaagactc tagtcaaata
     4381 gttgtgggaa acacttcaaa tactattggg tctcagatat tagctcacat cagaatcacc
     4441 tggaaggctt gtaagactca gatcactgga cttcaccttc agagtttctg attgagtgag
     4501 tcttgtgtgg gcccaaaact tggcatttct aacaagtttc caggtgatgc tgaggctgtt
     4561 gatcctcggg actttgagaa ccactggtat tagttcattc tcacgctgct ataaagatac
     4621 tacctgagac tgggtaattt ataaaggaaa gaggtttaat tgactcacag ttctgcatgg
     4681 ctggggaggc ctcaggaaac ttaccatcat ggcagaagat gaaggggaag caaggacctt
     4741 ttccacgtgg cagcaggaga gagaatggga aagcgccact tatcaaacag atttagtgag
     4801 aacttcctca ctatatgaga cagcatgggg aaaccgcccc gaggatccaa tcacctccca
     4861 ccaggtccct ccctcaacac attgggatta caactctaaa tgagatttag gtggggacac
     4921 agagccaaac catatcacac tggcatacac tattcctttc ttcaggatta gcgtgcatta
     4981 gcaaattaat ttctgaaaag tcttgtgtta aagaaatctg tttaactttt acaaatgctg
     5041 agacaaactt attgggccac aaagccacat tttcatggag cgtctattaa cattgcagta
     5101 gagtggtagt cctcaagctt tttatgtgta cctgaatcac ctgtggtgtt ttatatgctt
     5161 cttttgtttt aagcttggcc tgggaatctc ctgaatctga tacctactgt tctatgccac
     5221 agcacttaat gtcagtgttc tatggcatgg cacttaatgt cagttttcca ccccatctgt
     5281 gaacgtgtat tcaatcatta tactgtattt agcctgagaa tgaatatgga aaagaaaaca
     5341 acactttctt caggcttttt gcaacttttt aaaagcaaaa caggctccaa ttccccctcc
     5401 caggagtttt gtttgtatcc aaagagagga catgctcatt gccatggaat ccttaaagga
     5461 ctgagaggga agtgatctgt ggcactcctc ccctccctaa ccagtacatt tgttccagtt
     5521 ttaagccagt caagctcacc gaagagtttt tcaaagacct tagctacatg gatttaactt
     5581 taccaagcat ccattgtcca aatgaacata tgagggaaaa tgaatatctc ttcatctaca
     5641 tcagctgacc ataactatgc tgtggataag gggtggtggg atcagaactg ataaccattt
     5701 tcaacaaatt tcatacgaat gtgtcttaga agcctcattt agatgcgatg tcattcatgg
     5761 gtaaaattga aatgtgcctt cactggcaga gtctttaaca atctctgcaa gacaatctac
     5821 gcttttttct attgtttctg aaaatccttt caacctctat tcaaagccat tttctcactt
     5881 tagaaattga ttacagcagg gctgtgattg tcagtacaaa aatctgtaca gggatatggc
     5941 agtggtataa tagatgacca tttccaatta taaaacaatt agcaaagtat agctaggtca
     6001 ggccactagt acccttcaaa ttcttaacca tatttacaaa gacagctttt cataactttt
     6061 attgctctgt ccacaaagat gtggtctcat ggtttcacac gattgagaat gctacaagta
     6121 atagtatact gaaaagaaca tgtctctaat tctggactgc tctttatctc caagaaacag
     6181 agagagagag aatgaaaaaa aatcccagct tagaggaatt ttggaagtta ctctttcatg
     6241 aaccatcaca ttttctgggc ctttgtaatc tttaaacact gttactcttt agaggttggt
     6301 ttgaatttgt tgcacagaga acaataatct atgacaaatt aatgaaccct tttgctaata
     6361 tcacatgagt acaagtatct tgtatttctc atcacattta ccgtaataaa gaatgcagac
     6421 aagtataata catggcatca ttttggggat tttccaattt ctatgtgggc atactggaag
     6481 aagtttgtaa cagttgcaat tctgtcacaa tgcaggaagt ctttctagaa cacacaatgt
     6541 ggatgatttt cagttttaga attgtaaact aaccaaatgt caattcagtt tctcatttta
     6601 tattagtttt tgttacaaac actgcctatt tctcttttgt acaaacactt cacacacaca
     6661 cacacacaca cgcgcacaca cacacacaca cacacacaca cacaggcaca cacacactag
     6721 atgggcctcc aaaagaactc agagctgctg tcttcctctg ggaggttgat catatgtcta
     6781 ttcagttggg agaatggagc agtcaagttc aaaatccatg tggctctctg gcttcagaag
     6841 ctatcctttc agctatgaca cacacactaa atagtattgc ccaggtttgc cctacaacat
     6901 gttagcatat ctacatattt tgtactgtaa taatgtgtac gctcttaata atttgttttt
     6961 aatgctgtgt aaagttagca attagagtaa gagaaacgta tgggataatg attgagtaaa
     7021 atctcagctc cttttgagtc aatcactcag cttgttggca cagtagatat ttatgacctt
     7081 aaatactgtc agcgcttcac agcacattac tgaggcctgg ataaagcatt cacacaaaga
     7141 taaatggatt gaaactgtgt caattttgta gaaaaagata ttctggggtt tagtaacaga
     7201 gaatttttct ttccttactg cgattaataa agtggaactc caattgcaag taactattca
     7261 gttttatgtt cttcacatat ggaaacctct ctgtcactaa taccctggga caaactggat
     7321 gattaccatc caagtgttat tttcttcctc gaaaatttca aaaccagaat gaattagttc
     7381 tccaagtctg gctatactat agttttcttc ttaatgtaaa acagctgaat aaaacagctt
     7441 gaacaatatt tgactttcat gggtcttaag aacgtttcaa aatacaccac caatatattt
     7501 accaacatat ttagtgccag atatacacag aacaaacact accctattgt ttctgtgtgc
     7561 gtgtgtgtgt gtctgtgtct gtgtgtgtgt gtagcaggac actaaataaa caagtcatgt
     7621 tgctgttctt agggaagttt tggtaaagag agcttcaaag ttccttggag tcacctgcaa
     7681 ggctaactgt actaaaagcg gaatttgcat gatctttcta caaactctca gtgtaaagtg
     7741 gtagatagac atgcaagcat cacacttaga ttgcaataaa tgctgtgatg taaaaaatac
     7801 aatggaggaa aaatttttga ttagggaaat ttaaacattt tcaaagaaga gttaatgttt
     7861 cagtggagtc ttaaaagatg agtaggaatt caacagccag aagggaagtg tagacgctct
     7921 gtgtcacata aaacaaaaca gaacagaata gtataagtga aggcatagag cttcacatga
     7981 aaggcacatg aaatagcact gggtatctct aaaatattaa ttagcctagt gtagctggac
     8041 aatgaggggc agagcccctg gtatgcaagt gatgtctggg aaaggagcaa tctttctaca
     8101 gtgcctcatt ccatcatacc tcattaccag aaaaacatta tgagccactt aggcctgtat
     8161 tatttgagca tctctgaaat ggagttgctc tacatgtttt gtagaaacct aatgagtaat
     8221 ttattctcat cagtagacaa aatgaaagaa agaaaataga ctctgagcaa agtatgattc
     8281 acaaccttgc ctattaggct atagaagatt gccctactaa ttcctccttt tcgtctgttg
     8341 aacaatctgt attttgcctg ctcaaaaagg aattcctcaa gttatagggg cagtttgacc
     8401 agtacaatca tatcagaaaa aaatcagcaa aattatgttc taacaacatc ttcccatcta
     8461 aagtgcacat tttatttttt taaggtaaca taattactac gaacaaccga aatggtatat
     8521 aaaggtgaaa aattaaaata atttttttta cagctccacg ttacctcacc ccctagaccc
     8581 tggtaaccac cattcaactc tctgtttcca ttagttcaac tttttaagat tctttttata
     8641 caaaggatgt catgtagcat ttttttcttt tttcatctgg cttatttcac ttagtttgct
     8701 tatttcaacg tgctctgaag tttcatccat gtttatgtaa atggaaggag ctccctcttt
     8761 atatggctaa gatatatata tatattatat tatatatata tatgtatata tatatattat
     8821 atatatatat gtatatatat ataattttct ttcttcattc atctgtccgt gggcacttag
     8881 gttgttccat aacttatcta ttgtgaataa tggtgcaatg ggaatgaatg ggagtgcaga
     8941 tgtctgtttg gcatactgat ttaatttcct ttggatatat aaccagaagt gggaatgctg
     9001 gatcatacag tagttctatt tttactttta tgaggatctc catactgttt tacataatgg
     9061 cttactaatt tacattccca taaacagtgt acaagaatac ctccttgcca acacattatc
     9121 ttttaagttt tggataatat tattcctatt aataacatgt gtgatattac attgtggttt
     9181 tgatttgcat ttcccttatg attaatgatg ttaagtacct tttcagatat atgttggcca
     9241 tttgtatgtc ttccttggag agatgtctat tcagctcctt ggtccatttt tcaaaataca
     9301 gtttacttgt atttttgcta ttgacttgta tgagttcctt atatattttg gatattaacc
     9361 ccttatgaga aatatggttt gcaaatattt tctcctattc tgcaggttgc cttttcgttt
     9421 tgtcgattat ttcctttgct gggcagataa tttttttatt ttattttttg aaacagtgtc
     9481 tcactctgtc acccaggctg gagtgcagtg gtgtgatcat gtctcaccac agccttgacc
     9541 tccccaggat caggtgatcc tcccacctca gtttttgtat ttttagtaga gatggagttt
     9601 caccctgttg cccaggctgg tctaaaactc ctgggctcaa gccatcttgc ccaccttggg
     9661 acctcccaaa gtgttaggat tagaggcatg ggccaccatg cctggctttg aaacttttta
     9721 atttaatgta gtctgacttg tttattttta ctttgttgca tgtgcttttg gtgttacagc
     9781 caaaaaagtt attgccaaga ccaatgccat agacattatt tcttattcta gtaattttac
     9841 aattttaggt cttatgttta agtttttaat cgattttgag ttgatttttg tgtatggtat
     9901 aggataaagg tccaatttca ttattttgta tttggatatt caatgtttaa aatacgattt
     9961 attgaatgga ctatatttcc ccatgatgtg tttttagtgc ctttgttgaa gatttgttga
    10021 tcatatatgt gtggatttgt ttcttggctt tctattctgt tccattggtc tatgtgtctg
    10081 cttctatgcc aataccatac tgttttgatt actatagctt tacaatataa tttgaaatca
    10141 ggaaatgttc taaacttctt tctcaagatt gttttagatc tttggggact taggtggttc
    10201 cataaggttt taagaatttt ttttctattt ctgtaaaaaa ttatattaag attttgatag
    10261 tgcttgcatt gactctgtag atcactttgg ttagtatcaa catttttgca aaattaattc
    10321 ttccaaacta tgaacacagg atactgttgc acttatttct cttcttcaat tcctttcatc
    10381 agtatcttat agtttttaat gtacagattt ttcacctcct tggttaaact tattcctaag
    10441 tacattttcc tttttgatgc aattgcaaat gggattgttt ttctaattta ttttattttg
    10501 tttgtttgtt tgtttgtttg tttttgagat ggagtcttgc tctgtcaccc aggctggagt
    10561 gcagtggtgt gatcttggct caccacaacc tctgcctccc gagttaaagg gattctcttg
    10621 cctcagcctc ccgagtagct gggattatag gcgcctacca ccatgcctgg ctaatttttg
    10681 tatttttagt agatagagat ggggtttcac catgttggcc aggctagtct caaactcctg
    10741 acctcaggtg atccaccttc ctcggcctcc caaagcgctg ggattacagg cgtgagccac
    10801 tgcacccagc cactaattta ttttttggat agttcattgt tagtgtacag aaacaactga
    10861 ttttttatgt tgattttgta tcaacattgg tgaattccac ccaacatttg aggaaaaact
    10921 aataccaatc cttctcaaaa tcttccaaaa aaatgaagag gaaggagcac ttccaaactc
    10981 attttatgaa gccagcatta ttctcatacc attccagaca aggacactac aagaaaaaaa
    11041 attacaggcc caaatccctg ttgaacatag atgcaaaaat ccacaacaaa atactagcta
    11101 aaagaactta acatcacatt taaaggatca ttcaccataa tcaagtggga tttcaccaat
    11161 ttcacttggg tagaattcac caatgttgat aaaaaaatca acataaaaat cagttgtttc
    11221 ttcacacgaa caatgaacta tccaaaaaat aaagaacaca atcccatttg caattgcaaa
    11281 aaaatactta gaaataaatt tagcaaagga ggtgaaagat ctttatatta aaaactataa
    11341 aatattgatg aaagtaattg aagaagacaa atggaacaga tccctttgtt catagattgg
    11401 aagaattaat attacagaaa tgttaatact aactaaagtg atctacagag tcaatgcaag
    11461 ccctatcaaa atcttaatcg aatcttttac agaaataaaa aaaaattcta aaattcatat
    11521 ggcaccacat aagtccccaa aaatctttac aacttcactg aatttattta tcacttctaa
    11581 catttttctg ttggagtcat tgggtttctg tattgaagag catgtgattt gaaacagacc
    11641 attttacttc ttccgtcctg atttgcatgc attttatttc tttttctcga cttattgctc
    11701 taagcagaac ttcaagtacc atgtggaata gaagtggcaa gagtgagcat tctcttcttc
    11761 atcctgattt cagaagaaaa gctttcagca tttcactact gactatcacg ttagatgtga
    11821 gtttgtcata tatatggcct ttgttatatt tagggatatt ccttctctac ctaatgtttt
    11881 gaatgttttc atcatgaaag ggtgttgatt ttttttcaaa tgccttttct gtatctgtta
    11941 aaatgatcat atgattatta tccttcattg tcttattgtt catatttatt gatttgagta
    12001 tgttgagcca tccttttatc ccagggataa ctctcacttg attatggtga atgatctttt
    12061 taatgtgatg ttaagttctt ttagctagta ttttgttgtg gatttttgca tctatgttca
    12121 acagggattt gggactgtat tccttttttt tcttgtagtg tccttgcctg gctttggtag
    12181 gagaataatg ctggtttcat agaaaaatga gtttagaagt gttcctcact cttctttttt
    12241 ttttggaaga tttgagaagg attgatatta gattttcttt aaatgttggg tagaattcac
    12301 cactgaagcc atctggttct gggctttact ttgttgggaa gttctttttt aaaaaattgc
    12361 tgattcaata ttctttttca ttattgctct ctacagattc tctattcatg attcagtctt
    12421 gctaggttgt ggtatgtttc tagaaattta tctgtttctt ctagattacc caacttgtgt
    12481 ataattgttc ataatagtct ctaatgatca tttatatttc tatggtatca gttgtaatgt
    12541 cttctctttc atttctgatt ttatttgttt atgtcttttc tctttcactc tcagttactc
    12601 tagctaaagg cttgtctgtt ttttaatctt ttcaaaaaac aactcagttt tattgctctt
    12661 ttttattttt ctagtttcta tttcactttt ttctgttctg atatttactt cattccttct
    12721 tccgactttg ggattagttt atggttcttt tatagttcct tgaggtgtaa agttaggtcg
    12781 tttatttgat tttttttttc ttaatgtagg catttatcac tataaacttc cttcttagaa
    12841 atgccttttg ctgcatccca tatattttgg tatgttgttt ttccactttt gtttgtctca
    12901 agttttttaa atttttcttt tgatttgctc tttgattctt tggctattta ggagtgtatt
    12961 gtttaatttt acagttttcc tccctttact gatttccagt ttcttagcat tgtggtcaga
    13021 aaagatattt ggtatgattt caatcttctt agttttgtta acacttgttt tgtggcctaa
    13081 cagttgatgt atcttcaaaa tgtacctgcg caattacttg ggacgaatgt acattctatt
    13141 gcttttggag ggaatgtttt gtatctgtta ggtccatttg gtctaaagtg tagttcaagt
    13201 caattcccta ttgattttct gtctgggtga tctgtccatt gttgaaagct gggtatcaaa
    13261 gtcttctact actatactat tacagtctat atttcctgtt catatctatt aatacctgct
    13321 ttatatattt aggtgatcca atgttgggtg tgtatatatt caaaattgca tcttgttgat
    13381 gaattgactc atttattttt atataatggc attctttgtc tcttgttaca gtttgtgact
    13441 ttaagtctgt tttgtctgat atagtatagg tgtctctgct tctttctggt ttctatttac
    13501 atgcaatatc tttttaatct cttcactttc agtttatacg tgtccttgca gctaaagtga
    13561 ctatcttata gatagcaagt acttagttct tcctttttca tccattcagc cactcactgt
    13621 cttttgatta gagaatttaa tctacttaca ttaaaattaa ttatttatag gtaaagacat
    13681 actattgcta ctttgttaaa tgtttttcag ctgttttgta agtttttttg tttctttctt
    13741 cctctcttgc tgtctttctt tgtgattgat gattttcctg tagtactatg gtttgatttc
    13801 ttttttttta ataattttta tttttatttt aagttccagg gtacatgtgc aggatatgca
    13861 ggtttgttac ataggtaaac atgtgccatg gtggtttgct gcaccttcaa cccatcactg
    13921 aggtgttcag ccaagcatgc attagctatt tttcctaata gtatctctcc ccacacccca
    13981 ccccccttga caggccccag tgtgtattgt tcccctccct gtgtccatgt gttctcatgt
    14041 tcagctctca cttataagtg agaatacgca gtgtttggtt ttctgttcct gcaatagctt
    14101 gctaagaata atggcttcca gcgccatgtg tgtccctgaa aatgacatga tctcattcct
    14161 ttttatggct gcatagtatc ccatggtgta tatgtgccac attttcttta tccactgtat
    14221 cattgatggg catttgggtt gattccacat ctttgctctt ttgaacagtg ctgcagtgaa
    14281 catatgcgtg catgtatctt tgtaatagaa tgatttatat tcctttgggt atatacctag
    14341 taatgggatt gctgggtcaa atgttatttc tggttctaga tctcggagaa atcaccacac
    14401 tgtcttccac aatgtttgaa ctaatttact ttcccaccag cagtgtaaaa gtgttcctat
    14461 ttctctgcaa ccttgccagc atctgtcatt ttttgacttt ttaataatca ccattgtgac
    14521 tggcatgaga tggtatctcc ttgtggttct gatttgcatt tctttaatga tcagtgatgt
    14581 tgaacttttt tcatatgttc gttggcctca tgaatgtctt tttttgagaa gtgtctgttc
    14641 atgtcctttg cccacttttt gatgcggttt tttttttctt gtatatttgc ttaaattcct
    14701 tgtagattct ggatattaga ccgttgtcag atggatagat tgcaaaaatt ttctcccact
    14761 ctgtaggttg catgttcact gtgatagttt ctgtctttct ttctttttat attatacttg
    14821 aagttctggg gtacatgtgc agaatgtgca ggtttgttac ataggtatgc acgtgccatg
    14881 gtggtttgct gcacccatca acccgtcatc tatattaagt gtttctccta atgctttgac
    14941 ttcattattt ctttcatttg attgagtatg ctgtggatgt tttctgttac ttttttaatt
    15001 ttattcattg tattcttcag cttcagaatt tgtttgtttg tttgtttgtt tgtttttcac
    15061 agtttctatc tctttgttga acttattatt ttggtcatac attgttttcc tgattctact
    15121 gacttctttg tctgtgttct catgtagcaa cccaagctta tttaaaacaa ttatttttaa
    15181 tattttgtca ggaaatttgt agatctccat ttttttttgt tggcaactgg aaaattactg
    15241 agtttcttcg gtggtattat ttttgtgttg tttttggcag gtgttccttg aaatctcgtg
    15301 ttgccatgtt cacatttgaa gaagtagtct cctccttcag cctatactga ctggcttcag
    15361 aagagaaaca gttataccag ttagcctgac tggggatact aagactcttg cacatctttt
    15421 ctgtagatgt gtcactcaag ctctttttga gaaattttaa gatcatctgt attttcttaa
    15481 tttcataaaa ccaaaccaaa ttctgagagt ttcccatttg ttttctctaa cgtggtgccc
    15541 tgaagtgctc aagtttttgt gccttctccc attcccacag agtcaagctg cctgcttctg
    15601 catgcacaca agttcacact cgctgtcagg gtttgggccg tgtgcaggga gcaagccaag
    15661 gtagaggaga gagggagaca tgcaaagttt tgggagcacc catgtgtcag cttcgggggt
    15721 ttacagttca ggcatcccaa gccactagtg ggtgggcctc ctgatggagt ctgtgaagtt
    15781 gttagtagta tatgtgtcct tttgttgaat ttccagtctc tggttgctgt gagcccctac
    15841 cgctgttccc tgctcacagc ctctcagtca ctcagacatg atgatcccct cagtattctg
    15901 agtggggata gaaagaagta ggcctcttgg tcagtgtccc acgtggctag gaaagccagg
    15961 cattcattta ctacactctc cctttcaccc aatggagaaa tcatgagtca aagttgtatc
    16021 tcttggtgtt gagttctgct agcttgagag acggttgaca taagtagtga aactattttc
    16081 tggttctttt caatgtgcct attctcgtaa ttgttttgct ccatctgtga gctggactac
    16141 cagactccca caaaggtact ctcatacttg agtggttgtc aaaattgtag atagtgggga
    16201 aatgacagga gaaaattcct gttctgccat cttgctgaca tcaccccaat atctaaaatg
    16261 catattttaa ttattttttt ccttgaataa agtttatttt ggaattgttg agttttacaa
    16321 aataatttaa aatattctct ctctctctct ctctctctgg ggttgaggtc tcactctgtc
    16381 acccaggatg gattacagtg gcacaatcgc agctcactgc agcctcgaat ttcttgggtc
    16441 aagtgatcct cccacttcag cctcccaagt agctgggact acaaggcgtg tgccaccatg
    16501 cccagctaat atttttacat tttttgtaga gatggggtct cactatgttg cccaggtggg
    16561 tcttgaactc ctggcatcat gtggtcctcc cacctccacc tcccaagtcc tgaggatacc
    16621 aattgtgagt cactgtgccc agctatcccc ttctcactct ctttttctct cacacacatg
    16681 tgtgcatgca cagacacaca cacctcatgt tcattctctt taccatgatg atccttggtt
    16741 cttttacaca gcttctttca gtttacctta caatttagct caacacaaat tttaaaaaac
    16801 ttatagttac aatttaattt ggcttggtcc acacctctaa caaatttgat acaatctcca
    16861 acttacggtt gcaagttagt tgattatatt cacttccaag tatttccccc aacatttcat
    16921 tatgaaaata tatccatcaa ttaatgctct tatctataaa ataattattt ttttgcattt
    16981 caaaataagt tacagacatc aatgcacttc atctttaaac cctttatcat gcatatcagg
    17041 aagtagagtt taatatttct atatttcttg ggggagaaat ggagctaaaa ttatatactg
    17101 tatcatatac aaacctgtta ggtatatcaa ttcatgtgta ttgacaaatg cgtgcaccat
    17161 gtaacagaaa ctcctttcaa gatatagaat attcctatca ctacaaatat taatcaccaa
    17221 aacaatgggg agaatgtctc tagggcatgt cagagacctt cactgcagcc tctcccatta
    17281 taggccagga ggccttgaag gaaaaaaatg gtttagtggg ccaggcctca ggcacccccc
    17341 cttgctcttt gcagccttga aacatggtac cctgcgtccc cagctgcttc agcttcagct
    17401 gtggctaaaa ggggccaaca tacagctcag gccattgttt cagagagtgc aatccccaag
    17461 ctttggcagc ttacacatgg tgttgggctt gcaggagcac agaagtcaag aattgaggtt
    17521 tgggaacctc tgcctagatt tcagaggatg tatggaaatg cctggatgtc cagacagaag
    17581 tctgctgcag gggtagagct ctcagggaga acctctgcta gggcagtgca gaagggaaat
    17641 gtggggttgg agctccccca cagagtcttc actggggcac tgtatagtgg agctctgaga
    17701 agagggccat agtcctccag accccagaat ggtagatcca ccaatagctt gcaccatgca
    17761 cctggaaaag ccactggcac tcaacaccag cccatgaaaa gagctgtgag ggtggctgca
    17821 tcctgcaaag ccacagggga agagctgccc aaggctgtgg gagcccaccc cttgcatcat
    17881 tgtgacctgg atagatgtga gacatggagc ctaaggagat cattttggaa ctttaagctt
    17941 taacgactgc cctattggat tttggacttg catgggccta tagccccttt gttttggcca
    18001 acttctccca tttggaatgg gtatttttac tcaattcctg tacccccatt gtatcttgga
    18061 aataactaac ttgctttaga ttttacaggc ttataggtgg aagggacttg ctttgtctca
    18121 gatgagactt tggacttgga cttctgggtt aatgtttgaa tgagttaata ctttggggga
    18181 ctattggaag ggcatgattg tgttttgaaa tgtgagaaca tgagatttgg gaggaactag
    18241 ggtcagaatg atatggtttg gttttgtgtt cccacccaaa tctctccttg aattgtaata
    18301 atccccatgt gtcaggggtg ggaccaggtg gaggactgaa tcatgggggt ggtttccctc
    18361 atgctattct catgatagtg atttataaca gatccaatgg ttttataagc atctggcatt
    18421 tcccctgctg gcactcattc tctctcctgc caccctgtga agaggggcct tccaccatga
    18481 ttgtaagtct cctgaggcct ccgaagccat gcggaactgt gagtcagtta aaactctttc
    18541 ctttataaat tacctagtct tgggtatttc tttatggaag catgagaatg aactaatgca
    18601 cagggtaaaa atttaaaaac aaacatacaa atgcaagtaa acaagccaat atttcaactg
    18661 ttcccattgc attatcctta ttctttatct atggtaccag aaaataatac atctgaaaca
    18721 attttttttt cctgccatga tgtacactca agtgggtcca ctggggtttc tttcagtttc
    18781 ccaaatacta gatatgactc ttccctatac cttatcttca tatgaagaaa gctatgagaa
    18841 tatattaata actgaatata gtaacactac tataggaata agcatgtgta tattccaact
    18901 gatcttttaa aacttttatt ttgaaatatt tatagattca aaggaagatg caaagagtat
    18961 agggaagtgc tatatgccct ttatctagtt cctctagtgg tatcaactta cataactgca
    19021 gtatcatata taaaccaaga aattggcatc tgtataatcc acagacatta ctcagacttc
    19081 tctagtttta catacactaa tttgtatgtg tgtgtgtgtg tgcgtgcacg tttatgtgtg
    19141 taggtctatg caattttacc acatgtgtat atttgggtaa ccactacaat gatcaagata
    19201 tggaactgtt ccgtcaccac taagatccct tgtgctattc ctttataaac atctccctgt
    19261 catccttttt cacccataaa agctagtaaa cactaatctg ttcttcatcc ttataatttt
    19321 attatttcag aattgttata taaatgtcat catacagtat ataacacata gagattggct
    19381 tttgtcactc agcacaattc ccttgagatg catccaaact gttgtgtata tcagtaatgc
    19441 aatatgttta atttctgtgt agtattccat ggtagagatg tgccatagtt taactattca
    19501 cctgttgaac aacatttgtg ttctttctac ttttgggcta ttacaaataa agttgctatg
    19561 aacattcatg tataa
//
