LOCUS       NM_001139500           19158 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens fibroblast growth factor 13 (FGF13), transcript
            variant 2, mRNA.
ACCESSION   NM_001139500
VERSION     NM_001139500.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 19158)
  AUTHORS   Dong,Z.S., Zhang,X.R., Xue,D.Z., Liu,J.H., Yi,F., Zhang,Y.Y.,
            Xian,F.Y., Qiao,R.Y., Liu,B.Y., Zhang,H.L. and Wang,C.
  TITLE     FGF13 enhances the function of TRPV1 by stabilizing microtubules
            and regulates acute and chronic itch
  JOURNAL   FASEB J 38 (10), e23661 (2024)
   PUBMED   38733310
  REMARK    GeneRIF: FGF13 enhances the function of TRPV1 by stabilizing
            microtubules and regulates acute and chronic itch.
REFERENCE   2  (bases 1 to 19158)
  AUTHORS   Yang,H., Zhou,J., Li,D., Zhou,S., Dai,X., Du,X., Mao,H. and Wang,B.
  TITLE     The inhibitory role of microRNA-141-3p in human cutaneous melanoma
            growth and metastasis through the fibroblast growth factor
            13-mediated mitogen-activated protein kinase axis
  JOURNAL   Melanoma Res 33 (6), 492-505 (2023)
   PUBMED   36988403
  REMARK    GeneRIF: The inhibitory role of microRNA-141-3p in human cutaneous
            melanoma growth and metastasis through the fibroblast growth factor
            13-mediated mitogen-activated protein kinase axis.
REFERENCE   3  (bases 1 to 19158)
  AUTHORS   Han,D., Guan,L., Zhang,Y., Yang,H., Si,L., Jia,T., Wu,Y., Lv,K.,
            Song,T. and Yang,G.
  TITLE     FGF13A interacts with NPM1 and UBF and inhibits the invasion of
            bladder cancer cells
  JOURNAL   Biochem Biophys Res Commun 678, 1-10 (2023)
   PUBMED   37603967
  REMARK    GeneRIF: FGF13A interacts with NPM1 and UBF and inhibits the
            invasion of bladder cancer cells.
REFERENCE   4  (bases 1 to 19158)
  AUTHORS   Fan,X., Huang,J., Jin,X. and Yan,N.
  TITLE     Cryo-EM structure of human voltage-gated sodium channel Nav1.6
  JOURNAL   Proc Natl Acad Sci U S A 120 (5), e2220578120 (2023)
   PUBMED   36696443
REFERENCE   5  (bases 1 to 19158)
  AUTHORS   Cheng,H., Miao,P., Wang,Y., Guo,Y., Gao,L., Lou,Y., Yang,F.,
            Liang,M. and Feng,J.
  TITLE     A Heterozygous Variant of FGF13 Caused X-Linked Developmental and
            Epileptic Encephalopathy 90 in a Chinese Family
  JOURNAL   Cytogenet Genome Res 163 (1-2), 36-41 (2023)
   PUBMED   37536293
  REMARK    GeneRIF: A Heterozygous Variant of FGF13 Caused X-Linked
            Developmental and Epileptic Encephalopathy 90 in a Chinese Family.
REFERENCE   6  (bases 1 to 19158)
  AUTHORS   Yao,D.L., Masonic,K., Petullo,D., Li,L.Y., Lincoln,C.,
            Wibberley,L., Alderson,R.F. and Antonaccio,M.
  TITLE     Pretreatment with intravenous FGF-13 reduces infarct volume and
            ameliorates neurological deficits following focal cerebral ischemia
            in rats
  JOURNAL   Brain Res 818 (1), 140-146 (1999)
   PUBMED   9914447
REFERENCE   7  (bases 1 to 19158)
  AUTHORS   Gecz,J., Baker,E., Donnelly,A., Ming,J.E., McDonald-McGinn,D.M.,
            Spinner,N.B., Zackai,E.H., Sutherland,G.R. and Mulley,J.C.
  TITLE     Fibroblast growth factor homologous factor 2 (FHF2): gene
            structure, expression and mapping to the Borjeson-Forssman-Lehmann
            syndrome region in Xq26 delineated by a duplication breakpoint in a
            BFLS-like patient
  JOURNAL   Hum Genet 104 (1), 56-63 (1999)
   PUBMED   10071193
REFERENCE   8  (bases 1 to 19158)
  AUTHORS   Munoz-Sanjuan,I., Simandl,B.K., Fallon,J.F. and Nathans,J.
  TITLE     Expression of chicken fibroblast growth factor homologous factor
            (FHF)-1 and of differentially spliced isoforms of FHF-2 during
            development and involvement of FHF-2 in chicken limb development
  JOURNAL   Development 126 (2), 409-421 (1999)
   PUBMED   9847253
REFERENCE   9  (bases 1 to 19158)
  AUTHORS   Greene,J.M., Li,Y.L., Yourey,P.A., Gruber,J., Carter,K.C.,
            Shell,B.K., Dillon,P.A., Florence,C., Duan,D.R., Blunt,A.,
            Ornitz,D.M., Ruben,S.M. and Alderson,R.F.
  TITLE     Identification and characterization of a novel member of the
            fibroblast growth factor family
  JOURNAL   Eur J Neurosci 10 (5), 1911-1925 (1998)
   PUBMED   9751161
REFERENCE   10 (bases 1 to 19158)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z81007.1, Z82204.1, Z82193.1,
            AL031386.1 and AL357123.11.
            
            On Jul 10, 2019 this sequence version replaced NM_001139500.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth, and
            invasion. This gene is located in a region on chromosome X, which
            is associated with Borjeson-Forssman-Lehmann syndrome (BFLS),
            making it a possible candidate gene for familial cases of the BFLS,
            and for other syndromal and nonspecific forms of X-linked cognitive
            disability mapping to this region. Alternative splicing of this
            gene at the 5' end results in several transcript variants encoding
            different isoforms with different N-termini. [provided by RefSeq,
            Nov 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2695141.1,
                                           SRR18074967.713617.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               Z81007.1           64865-64967         c
            104-316             Z81007.1           64003-64215         c
            317-484             Z82204.1           6448-6615           c
            485-595             Z82193.1           49709-49819         c
            596-699             Z82193.1           43875-43978         c
            700-898             AL031386.1         14494-14692         c
            899-12821           AL031386.1         101-12023           c
            12822-19158         AL357123.11        66018-72354         c
FEATURES             Location/Qualifiers
     source          1..19158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3-q27.1"
     gene            1..19158
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="fibroblast growth factor 13"
                     /db_xref="GeneID:2258"
                     /db_xref="HGNC:HGNC:3670"
                     /db_xref="MIM:300070"
     exon            1..103
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            104..316
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1035
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="isoform 2 is encoded by transcript variant 2;
                     fibroblast growth factor homologous factor 2"
                     /codon_start=1
                     /product="fibroblast growth factor 13 isoform 2"
                     /protein_id="NP_001132972.1"
                     /db_xref="CCDS:CCDS55513.1"
                     /db_xref="GeneID:2258"
                     /db_xref="HGNC:HGNC:3670"
                     /db_xref="MIM:300070"
                     /translation="MSGKVTKPKEEKDASKVLDDAPPGTQEYIMLRQDSIQSAELKKK
                     ESPFRAKCHEIFCCPLKQVHHKENTEPEEPQLKGIVTKLYSRQGYHLQLQADGTIDGT
                     KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFEN
                     YYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPS
                     LHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST"
     exon            317..484
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            485..595
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            596..699
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            700..898
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     exon            899..19158
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="hexamer: AATAAA"
     polyA_site      2309
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="major polyA site"
     regulatory      19129..19134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
                     /note="hexamer: AATAAA"
     polyA_site      19158
                     /gene="FGF13"
                     /gene_synonym="DEE90; FGF-13; FGF2; FHF-2; FHF2;
                     LINC00889; XLID110"
ORIGIN      
        1 gtggctctct aggaccggag agttctttgg aaggagagcg cgagcgaggg agcgggcgag
       61 ctccgagggg gtgtgggtgt agggagagag agaaagagag caggcagcgg cggcggcggc
      121 agcggtgggg aaaagcggat tccgccccga accacaccga ggggagctcg tggtcgagac
      181 ttgccgccct aagcactctc ccaagtccga cccgctcggc gaggacttcc gtcttctgag
      241 cgaaccttgt caagcaagct gggatctatg agtggaaagg tgaccaagcc caaagaggag
      301 aaagatgctt ctaaggttct ggatgacgcc ccccctggca cacaggaata cattatgtta
      361 cgacaagatt ccatccaatc tgcggaatta aagaaaaaag agtccccctt tcgtgctaag
      421 tgtcacgaaa tcttctgctg cccgctgaag caagtacacc acaaagagaa cacagagccg
      481 gaagagcctc agcttaaggg tatagttacc aagctataca gccgacaagg ctaccacttg
      541 cagctgcagg cggatggaac cattgatggc accaaagatg aggacagcac ttacactctg
      601 tttaacctca tccctgtggg tctgcgagtg gtggctatcc aaggagttca aaccaagctg
      661 tacttggcaa tgaacagtga gggatacttg tacacctcgg aacttttcac acctgagtgc
      721 aaattcaaag aatcagtgtt tgaaaattat tatgtgacat attcatcaat gatataccgt
      781 cagcagcagt caggccgagg gtggtatctg ggtctgaaca aagaaggaga gatcatgaaa
      841 ggcaaccatg tgaagaagaa caagcctgca gctcattttc tgcctaaacc actgaaagtg
      901 gccatgtaca aggagccatc actgcacgat ctcacggagt tctcccgatc tggaagcggg
      961 accccaacca agagcagaag tgtctctggc gtgctgaacg gaggcaaatc catgagccac
     1021 aatgaatcaa cgtagccagt gagggcaaaa gaagggctct gtaacagaac cttacctcca
     1081 ggtgctgttg aattcttcta gcagtccttc acccaaaagt tcaaatttgt cagtgacatt
     1141 taccaaacaa acaggcagag ttcactattc tatctgccat tagaccttct tatcatccat
     1201 actaaagccc cattatttag attgagcttg tgcataagaa tgccaagcat tttagtgaac
     1261 taaatctgag agaaggactg ccaaattttc tcatgatctc acctatactt tggggatgat
     1321 aatccaaaag tatttcacag cactaatgct gatcaaaatt tgctctccca ccaagaaaat
     1381 gtaaaagacc acaattgttc ttcaaaaaca aacaaaacaa aacaaaacaa aattaactgc
     1441 ttaaatgttt tgtcggggca aacaaaatta tgtgaattgt gttgttttct tggcttgatg
     1501 ttttctatct acgcttgatt cacatgtact cttttctttg gcatagtgca actttatgat
     1561 ttctgaaatt caatggttct attgactttt tgcgtcactt aatccaaatc aaccaaattc
     1621 agggttgaat ctgaattggc ttctcaggct caaggtaaca gtgttcttgt ggtttgacca
     1681 attgtttttc tttctttttt ttttttttta gatttgtggt attctggtca agttattgtg
     1741 ctgtactttg tgcgtagaaa ttgagttgta ttgtcaaccc cagtcagtaa agagaacttc
     1801 aaaaaattat cctcaagtgt agatttctct taattccatt tgtgtatcat gttaaactat
     1861 tgttgtggct tcttgtgtaa agacaggaac tgtggaactg tgatgttgtc ttttgtgttg
     1921 ttaaaataag aaatgtctta tctgtatatg tatgagtctt cctgtcattg tatttggcac
     1981 atgaatattg tgtacaagga attgttaaga ctggttttcc ctcaacaaca tatattatac
     2041 ttgctactgg aaaagtgttt aagacttagc taggtttcca tttagatctt catatctgtt
     2101 gcatggaaga aagttgggtt cttggcatag agttgcatga tatgtaagat tttgtgcatt
     2161 cataattgtt aaaaatctgt gttccaaaag tggacatagc atgtacaggc agttttctgt
     2221 cctgtgcaca aaaagtttaa aaaagttgtt taatatttgt tgttgtatac ccaaatacgc
     2281 accgaataaa ctctttatat tcattcaaag aataatcttc caacatgtat ttattgagcg
     2341 tccattatgt gccagtaact gaagtagcaa ctggaagtaa acattgtata atgcagataa
     2401 ggtcactgtc ctcagatagt ctacagtcta gagagtcata ttaacatgaa cactttaaag
     2461 tgtgtttatt ttactagtta ctgtacttgc acttcagatt ggtacaaagg aattcacatt
     2521 cccgttcagt agtcaaatta tacaaatgag gcgtttgtgc tagtattttc tctgccactc
     2581 acagtgtcat ttcccctctc tgttgcttat ttctctcctc tctagaggga atacacagga
     2641 ctaaatagtg tcctttctac ctttgagaac tgaaggaaaa tgtaaatttt tttaaatgtt
     2701 gatgactttt ctctagctcc ccaaagctgc attgtctggc aatgaacact ttgagaacag
     2761 tcaatacaga tggtctctga cttacagtag ttcaacttac attttttcgg gggctttaca
     2821 gtggtacaga agcaataggc atttagtaga actcatactt taccatacaa ccattttgct
     2881 ttttatttcc agtacactat tcaataaatg acatgagcta ttcaacactt tttaattaca
     2941 aaatttgctt tgtagtacat gattttgtcc aactgtaagc taatataagc gttctaagca
     3001 catttaaagt aggctaggct aagctatgat gtttgctagg ttaggtgtat taaatgcatt
     3061 ttcaacttaa gatgggttta ttggtatgtg acccccatcg taagtgaagg atcatctgta
     3121 tatggaggga agaattgtga aatacataaa acgtagttga ctagtgcttt tcagagcatc
     3181 tgcaaataaa attactgggg ccccaaacag cctgcttttg caaggagggg agactcctca
     3241 tttctaagat gtttggacca gattcagcat gagctcctat ccctgcccac cccagcccag
     3301 tctaagtcac cttgtaattt catgagataa gtcctcctca tcctgcttca tcctgcctga
     3361 gctctaaaca cacctacatg aggtacgctc acctgcctag ctatcttgga tgcaggatcc
     3421 tttgtaccat gttttaaaaa tcaggagatg ctcactcaac cacctctccc tattaactct
     3481 tactaatttt caatcagtag ggaaaagtag tgcattgtct ccctctttct ctaagaactt
     3541 taaagtttgg tcactgacta cttcagttgc tggtcttgct ttttctgttg ttcagaaata
     3601 gtgtaggtct gctggtagta agcaaattag cactatgtgg gtctcaggga tgcctgcgtt
     3661 aataggatgg agtcaaaatg cccaggaaga atcctttacc cccagcattc tttttgagct
     3721 gccttaaagt tgctttaaac agacagtggt gttaaaataa attaataagt aaataaatag
     3781 tcctcaaacc ttcctacaag tgatgatatc aatactttca cacatcttca ttacacacac
     3841 acatacacac acaccctttc ccaccccatc ccctcatgca catcctttag tagcattcct
     3901 cctggcagaa aatactagtc ctgccacata actgatgaaa gaaaaaaaga ctctagtcaa
     3961 atagttgtgg gaaacacttc aaatactatt gggtctcaga tattagctca catcagaatc
     4021 acctggaagg cttgtaagac tcagatcact ggacttcacc ttcagagttt ctgattgagt
     4081 gagtcttgtg tgggcccaaa acttggcatt tctaacaagt ttccaggtga tgctgaggct
     4141 gttgatcctc gggactttga gaaccactgg tattagttca ttctcacgct gctataaaga
     4201 tactacctga gactgggtaa tttataaagg aaagaggttt aattgactca cagttctgca
     4261 tggctgggga ggcctcagga aacttaccat catggcagaa gatgaagggg aagcaaggac
     4321 cttttccacg tggcagcagg agagagaatg ggaaagcgcc acttatcaaa cagatttagt
     4381 gagaacttcc tcactatatg agacagcatg gggaaaccgc cccgaggatc caatcacctc
     4441 ccaccaggtc cctccctcaa cacattggga ttacaactct aaatgagatt taggtgggga
     4501 cacagagcca aaccatatca cactggcata cactattcct ttcttcagga ttagcgtgca
     4561 ttagcaaatt aatttctgaa aagtcttgtg ttaaagaaat ctgtttaact tttacaaatg
     4621 ctgagacaaa cttattgggc cacaaagcca cattttcatg gagcgtctat taacattgca
     4681 gtagagtggt agtcctcaag ctttttatgt gtacctgaat cacctgtggt gttttatatg
     4741 cttcttttgt tttaagcttg gcctgggaat ctcctgaatc tgatacctac tgttctatgc
     4801 cacagcactt aatgtcagtg ttctatggca tggcacttaa tgtcagtttt ccaccccatc
     4861 tgtgaacgtg tattcaatca ttatactgta tttagcctga gaatgaatat ggaaaagaaa
     4921 acaacacttt cttcaggctt tttgcaactt tttaaaagca aaacaggctc caattccccc
     4981 tcccaggagt tttgtttgta tccaaagaga ggacatgctc attgccatgg aatccttaaa
     5041 ggactgagag ggaagtgatc tgtggcactc ctcccctccc taaccagtac atttgttcca
     5101 gttttaagcc agtcaagctc accgaagagt ttttcaaaga ccttagctac atggatttaa
     5161 ctttaccaag catccattgt ccaaatgaac atatgaggga aaatgaatat ctcttcatct
     5221 acatcagctg accataacta tgctgtggat aaggggtggt gggatcagaa ctgataacca
     5281 ttttcaacaa atttcatacg aatgtgtctt agaagcctca tttagatgcg atgtcattca
     5341 tgggtaaaat tgaaatgtgc cttcactggc agagtcttta acaatctctg caagacaatc
     5401 tacgcttttt tctattgttt ctgaaaatcc tttcaacctc tattcaaagc cattttctca
     5461 ctttagaaat tgattacagc agggctgtga ttgtcagtac aaaaatctgt acagggatat
     5521 ggcagtggta taatagatga ccatttccaa ttataaaaca attagcaaag tatagctagg
     5581 tcaggccact agtacccttc aaattcttaa ccatatttac aaagacagct tttcataact
     5641 tttattgctc tgtccacaaa gatgtggtct catggtttca cacgattgag aatgctacaa
     5701 gtaatagtat actgaaaaga acatgtctct aattctggac tgctctttat ctccaagaaa
     5761 cagagagaga gagaatgaaa aaaaatccca gcttagagga attttggaag ttactctttc
     5821 atgaaccatc acattttctg ggcctttgta atctttaaac actgttactc tttagaggtt
     5881 ggtttgaatt tgttgcacag agaacaataa tctatgacaa attaatgaac ccttttgcta
     5941 atatcacatg agtacaagta tcttgtattt ctcatcacat ttaccgtaat aaagaatgca
     6001 gacaagtata atacatggca tcattttggg gattttccaa tttctatgtg ggcatactgg
     6061 aagaagtttg taacagttgc aattctgtca caatgcagga agtctttcta gaacacacaa
     6121 tgtggatgat tttcagtttt agaattgtaa actaaccaaa tgtcaattca gtttctcatt
     6181 ttatattagt ttttgttaca aacactgcct atttctcttt tgtacaaaca cttcacacac
     6241 acacacacac acacgcgcac acacacacac acacacacac acacacaggc acacacacac
     6301 tagatgggcc tccaaaagaa ctcagagctg ctgtcttcct ctgggaggtt gatcatatgt
     6361 ctattcagtt gggagaatgg agcagtcaag ttcaaaatcc atgtggctct ctggcttcag
     6421 aagctatcct ttcagctatg acacacacac taaatagtat tgcccaggtt tgccctacaa
     6481 catgttagca tatctacata ttttgtactg taataatgtg tacgctctta ataatttgtt
     6541 tttaatgctg tgtaaagtta gcaattagag taagagaaac gtatgggata atgattgagt
     6601 aaaatctcag ctccttttga gtcaatcact cagcttgttg gcacagtaga tatttatgac
     6661 cttaaatact gtcagcgctt cacagcacat tactgaggcc tggataaagc attcacacaa
     6721 agataaatgg attgaaactg tgtcaatttt gtagaaaaag atattctggg gtttagtaac
     6781 agagaatttt tctttcctta ctgcgattaa taaagtggaa ctccaattgc aagtaactat
     6841 tcagttttat gttcttcaca tatggaaacc tctctgtcac taataccctg ggacaaactg
     6901 gatgattacc atccaagtgt tattttcttc ctcgaaaatt tcaaaaccag aatgaattag
     6961 ttctccaagt ctggctatac tatagttttc ttcttaatgt aaaacagctg aataaaacag
     7021 cttgaacaat atttgacttt catgggtctt aagaacgttt caaaatacac caccaatata
     7081 tttaccaaca tatttagtgc cagatataca cagaacaaac actaccctat tgtttctgtg
     7141 tgcgtgtgtg tgtgtctgtg tctgtgtgtg tgtgtagcag gacactaaat aaacaagtca
     7201 tgttgctgtt cttagggaag ttttggtaaa gagagcttca aagttccttg gagtcacctg
     7261 caaggctaac tgtactaaaa gcggaatttg catgatcttt ctacaaactc tcagtgtaaa
     7321 gtggtagata gacatgcaag catcacactt agattgcaat aaatgctgtg atgtaaaaaa
     7381 tacaatggag gaaaaatttt tgattaggga aatttaaaca ttttcaaaga agagttaatg
     7441 tttcagtgga gtcttaaaag atgagtagga attcaacagc cagaagggaa gtgtagacgc
     7501 tctgtgtcac ataaaacaaa acagaacaga atagtataag tgaaggcata gagcttcaca
     7561 tgaaaggcac atgaaatagc actgggtatc tctaaaatat taattagcct agtgtagctg
     7621 gacaatgagg ggcagagccc ctggtatgca agtgatgtct gggaaaggag caatctttct
     7681 acagtgcctc attccatcat acctcattac cagaaaaaca ttatgagcca cttaggcctg
     7741 tattatttga gcatctctga aatggagttg ctctacatgt tttgtagaaa cctaatgagt
     7801 aatttattct catcagtaga caaaatgaaa gaaagaaaat agactctgag caaagtatga
     7861 ttcacaacct tgcctattag gctatagaag attgccctac taattcctcc ttttcgtctg
     7921 ttgaacaatc tgtattttgc ctgctcaaaa aggaattcct caagttatag gggcagtttg
     7981 accagtacaa tcatatcaga aaaaaatcag caaaattatg ttctaacaac atcttcccat
     8041 ctaaagtgca cattttattt ttttaaggta acataattac tacgaacaac cgaaatggta
     8101 tataaaggtg aaaaattaaa ataatttttt ttacagctcc acgttacctc accccctaga
     8161 ccctggtaac caccattcaa ctctctgttt ccattagttc aactttttaa gattcttttt
     8221 atacaaagga tgtcatgtag catttttttc ttttttcatc tggcttattt cacttagttt
     8281 gcttatttca acgtgctctg aagtttcatc catgtttatg taaatggaag gagctccctc
     8341 tttatatggc taagatatat atatatatta tattatatat atatatgtat atatatatat
     8401 tatatatata tatgtatata tatataattt tctttcttca ttcatctgtc cgtgggcact
     8461 taggttgttc cataacttat ctattgtgaa taatggtgca atgggaatga atgggagtgc
     8521 agatgtctgt ttggcatact gatttaattt cctttggata tataaccaga agtgggaatg
     8581 ctggatcata cagtagttct atttttactt ttatgaggat ctccatactg ttttacataa
     8641 tggcttacta atttacattc ccataaacag tgtacaagaa tacctccttg ccaacacatt
     8701 atcttttaag ttttggataa tattattcct attaataaca tgtgtgatat tacattgtgg
     8761 ttttgatttg catttccctt atgattaatg atgttaagta ccttttcaga tatatgttgg
     8821 ccatttgtat gtcttccttg gagagatgtc tattcagctc cttggtccat ttttcaaaat
     8881 acagtttact tgtatttttg ctattgactt gtatgagttc cttatatatt ttggatatta
     8941 accccttatg agaaatatgg tttgcaaata ttttctccta ttctgcaggt tgccttttcg
     9001 ttttgtcgat tatttccttt gctgggcaga taattttttt attttatttt ttgaaacagt
     9061 gtctcactct gtcacccagg ctggagtgca gtggtgtgat catgtctcac cacagccttg
     9121 acctccccag gatcaggtga tcctcccacc tcagtttttg tatttttagt agagatggag
     9181 tttcaccctg ttgcccaggc tggtctaaaa ctcctgggct caagccatct tgcccacctt
     9241 gggacctccc aaagtgttag gattagaggc atgggccacc atgcctggct ttgaaacttt
     9301 ttaatttaat gtagtctgac ttgtttattt ttactttgtt gcatgtgctt ttggtgttac
     9361 agccaaaaaa gttattgcca agaccaatgc catagacatt atttcttatt ctagtaattt
     9421 tacaatttta ggtcttatgt ttaagttttt aatcgatttt gagttgattt ttgtgtatgg
     9481 tataggataa aggtccaatt tcattatttt gtatttggat attcaatgtt taaaatacga
     9541 tttattgaat ggactatatt tccccatgat gtgtttttag tgcctttgtt gaagatttgt
     9601 tgatcatata tgtgtggatt tgtttcttgg ctttctattc tgttccattg gtctatgtgt
     9661 ctgcttctat gccaatacca tactgttttg attactatag ctttacaata taatttgaaa
     9721 tcaggaaatg ttctaaactt ctttctcaag attgttttag atctttgggg acttaggtgg
     9781 ttccataagg ttttaagaat tttttttcta tttctgtaaa aaattatatt aagattttga
     9841 tagtgcttgc attgactctg tagatcactt tggttagtat caacattttt gcaaaattaa
     9901 ttcttccaaa ctatgaacac aggatactgt tgcacttatt tctcttcttc aattcctttc
     9961 atcagtatct tatagttttt aatgtacaga tttttcacct ccttggttaa acttattcct
    10021 aagtacattt tcctttttga tgcaattgca aatgggattg tttttctaat ttattttatt
    10081 ttgtttgttt gtttgtttgt ttgtttttga gatggagtct tgctctgtca cccaggctgg
    10141 agtgcagtgg tgtgatcttg gctcaccaca acctctgcct cccgagttaa agggattctc
    10201 ttgcctcagc ctcccgagta gctgggatta taggcgccta ccaccatgcc tggctaattt
    10261 ttgtattttt agtagataga gatggggttt caccatgttg gccaggctag tctcaaactc
    10321 ctgacctcag gtgatccacc ttcctcggcc tcccaaagcg ctgggattac aggcgtgagc
    10381 cactgcaccc agccactaat ttattttttg gatagttcat tgttagtgta cagaaacaac
    10441 tgatttttta tgttgatttt gtatcaacat tggtgaattc cacccaacat ttgaggaaaa
    10501 actaatacca atccttctca aaatcttcca aaaaaatgaa gaggaaggag cacttccaaa
    10561 ctcattttat gaagccagca ttattctcat accattccag acaaggacac tacaagaaaa
    10621 aaaattacag gcccaaatcc ctgttgaaca tagatgcaaa aatccacaac aaaatactag
    10681 ctaaaagaac ttaacatcac atttaaagga tcattcacca taatcaagtg ggatttcacc
    10741 aatttcactt gggtagaatt caccaatgtt gataaaaaaa tcaacataaa aatcagttgt
    10801 ttcttcacac gaacaatgaa ctatccaaaa aataaagaac acaatcccat ttgcaattgc
    10861 aaaaaaatac ttagaaataa atttagcaaa ggaggtgaaa gatctttata ttaaaaacta
    10921 taaaatattg atgaaagtaa ttgaagaaga caaatggaac agatcccttt gttcatagat
    10981 tggaagaatt aatattacag aaatgttaat actaactaaa gtgatctaca gagtcaatgc
    11041 aagccctatc aaaatcttaa tcgaatcttt tacagaaata aaaaaaaatt ctaaaattca
    11101 tatggcacca cataagtccc caaaaatctt tacaacttca ctgaatttat ttatcacttc
    11161 taacattttt ctgttggagt cattgggttt ctgtattgaa gagcatgtga tttgaaacag
    11221 accattttac ttcttccgtc ctgatttgca tgcattttat ttctttttct cgacttattg
    11281 ctctaagcag aacttcaagt accatgtgga atagaagtgg caagagtgag cattctcttc
    11341 ttcatcctga tttcagaaga aaagctttca gcatttcact actgactatc acgttagatg
    11401 tgagtttgtc atatatatgg cctttgttat atttagggat attccttctc tacctaatgt
    11461 tttgaatgtt ttcatcatga aagggtgttg attttttttc aaatgccttt tctgtatctg
    11521 ttaaaatgat catatgatta ttatccttca ttgtcttatt gttcatattt attgatttga
    11581 gtatgttgag ccatcctttt atcccaggga taactctcac ttgattatgg tgaatgatct
    11641 ttttaatgtg atgttaagtt cttttagcta gtattttgtt gtggattttt gcatctatgt
    11701 tcaacaggga tttgggactg tattcctttt ttttcttgta gtgtccttgc ctggctttgg
    11761 taggagaata atgctggttt catagaaaaa tgagtttaga agtgttcctc actcttcttt
    11821 tttttttgga agatttgaga aggattgata ttagattttc tttaaatgtt gggtagaatt
    11881 caccactgaa gccatctggt tctgggcttt actttgttgg gaagttcttt tttaaaaaat
    11941 tgctgattca atattctttt tcattattgc tctctacaga ttctctattc atgattcagt
    12001 cttgctaggt tgtggtatgt ttctagaaat ttatctgttt cttctagatt acccaacttg
    12061 tgtataattg ttcataatag tctctaatga tcatttatat ttctatggta tcagttgtaa
    12121 tgtcttctct ttcatttctg attttatttg tttatgtctt ttctctttca ctctcagtta
    12181 ctctagctaa aggcttgtct gttttttaat cttttcaaaa aacaactcag ttttattgct
    12241 cttttttatt tttctagttt ctatttcact tttttctgtt ctgatattta cttcattcct
    12301 tcttccgact ttgggattag tttatggttc ttttatagtt ccttgaggtg taaagttagg
    12361 tcgtttattt gatttttttt ttcttaatgt aggcatttat cactataaac ttccttctta
    12421 gaaatgcctt ttgctgcatc ccatatattt tggtatgttg tttttccact tttgtttgtc
    12481 tcaagttttt taaatttttc ttttgatttg ctctttgatt ctttggctat ttaggagtgt
    12541 attgtttaat tttacagttt tcctcccttt actgatttcc agtttcttag cattgtggtc
    12601 agaaaagata tttggtatga tttcaatctt cttagttttg ttaacacttg ttttgtggcc
    12661 taacagttga tgtatcttca aaatgtacct gcgcaattac ttgggacgaa tgtacattct
    12721 attgcttttg gagggaatgt tttgtatctg ttaggtccat ttggtctaaa gtgtagttca
    12781 agtcaattcc ctattgattt tctgtctggg tgatctgtcc attgttgaaa gctgggtatc
    12841 aaagtcttct actactatac tattacagtc tatatttcct gttcatatct attaatacct
    12901 gctttatata tttaggtgat ccaatgttgg gtgtgtatat attcaaaatt gcatcttgtt
    12961 gatgaattga ctcatttatt tttatataat ggcattcttt gtctcttgtt acagtttgtg
    13021 actttaagtc tgttttgtct gatatagtat aggtgtctct gcttctttct ggtttctatt
    13081 tacatgcaat atctttttaa tctcttcact ttcagtttat acgtgtcctt gcagctaaag
    13141 tgactatctt atagatagca agtacttagt tcttcctttt tcatccattc agccactcac
    13201 tgtcttttga ttagagaatt taatctactt acattaaaat taattattta taggtaaaga
    13261 catactattg ctactttgtt aaatgttttt cagctgtttt gtaagttttt ttgtttcttt
    13321 cttcctctct tgctgtcttt ctttgtgatt gatgattttc ctgtagtact atggtttgat
    13381 ttcttttttt ttaataattt ttatttttat tttaagttcc agggtacatg tgcaggatat
    13441 gcaggtttgt tacataggta aacatgtgcc atggtggttt gctgcacctt caacccatca
    13501 ctgaggtgtt cagccaagca tgcattagct atttttccta atagtatctc tccccacacc
    13561 ccacccccct tgacaggccc cagtgtgtat tgttcccctc cctgtgtcca tgtgttctca
    13621 tgttcagctc tcacttataa gtgagaatac gcagtgtttg gttttctgtt cctgcaatag
    13681 cttgctaaga ataatggctt ccagcgccat gtgtgtccct gaaaatgaca tgatctcatt
    13741 cctttttatg gctgcatagt atcccatggt gtatatgtgc cacattttct ttatccactg
    13801 tatcattgat gggcatttgg gttgattcca catctttgct cttttgaaca gtgctgcagt
    13861 gaacatatgc gtgcatgtat ctttgtaata gaatgattta tattcctttg ggtatatacc
    13921 tagtaatggg attgctgggt caaatgttat ttctggttct agatctcgga gaaatcacca
    13981 cactgtcttc cacaatgttt gaactaattt actttcccac cagcagtgta aaagtgttcc
    14041 tatttctctg caaccttgcc agcatctgtc attttttgac tttttaataa tcaccattgt
    14101 gactggcatg agatggtatc tccttgtggt tctgatttgc atttctttaa tgatcagtga
    14161 tgttgaactt ttttcatatg ttcgttggcc tcatgaatgt ctttttttga gaagtgtctg
    14221 ttcatgtcct ttgcccactt tttgatgcgg tttttttttt cttgtatatt tgcttaaatt
    14281 ccttgtagat tctggatatt agaccgttgt cagatggata gattgcaaaa attttctccc
    14341 actctgtagg ttgcatgttc actgtgatag tttctgtctt tctttctttt tatattatac
    14401 ttgaagttct ggggtacatg tgcagaatgt gcaggtttgt tacataggta tgcacgtgcc
    14461 atggtggttt gctgcaccca tcaacccgtc atctatatta agtgtttctc ctaatgcttt
    14521 gacttcatta tttctttcat ttgattgagt atgctgtgga tgttttctgt tactttttta
    14581 attttattca ttgtattctt cagcttcaga atttgtttgt ttgtttgttt gtttgttttt
    14641 cacagtttct atctctttgt tgaacttatt attttggtca tacattgttt tcctgattct
    14701 actgacttct ttgtctgtgt tctcatgtag caacccaagc ttatttaaaa caattatttt
    14761 taatattttg tcaggaaatt tgtagatctc catttttttt tgttggcaac tggaaaatta
    14821 ctgagtttct tcggtggtat tatttttgtg ttgtttttgg caggtgttcc ttgaaatctc
    14881 gtgttgccat gttcacattt gaagaagtag tctcctcctt cagcctatac tgactggctt
    14941 cagaagagaa acagttatac cagttagcct gactggggat actaagactc ttgcacatct
    15001 tttctgtaga tgtgtcactc aagctctttt tgagaaattt taagatcatc tgtattttct
    15061 taatttcata aaaccaaacc aaattctgag agtttcccat ttgttttctc taacgtggtg
    15121 ccctgaagtg ctcaagtttt tgtgccttct cccattccca cagagtcaag ctgcctgctt
    15181 ctgcatgcac acaagttcac actcgctgtc agggtttggg ccgtgtgcag ggagcaagcc
    15241 aaggtagagg agagagggag acatgcaaag ttttgggagc acccatgtgt cagcttcggg
    15301 ggtttacagt tcaggcatcc caagccacta gtgggtgggc ctcctgatgg agtctgtgaa
    15361 gttgttagta gtatatgtgt ccttttgttg aatttccagt ctctggttgc tgtgagcccc
    15421 taccgctgtt ccctgctcac agcctctcag tcactcagac atgatgatcc cctcagtatt
    15481 ctgagtgggg atagaaagaa gtaggcctct tggtcagtgt cccacgtggc taggaaagcc
    15541 aggcattcat ttactacact ctccctttca cccaatggag aaatcatgag tcaaagttgt
    15601 atctcttggt gttgagttct gctagcttga gagacggttg acataagtag tgaaactatt
    15661 ttctggttct tttcaatgtg cctattctcg taattgtttt gctccatctg tgagctggac
    15721 taccagactc ccacaaaggt actctcatac ttgagtggtt gtcaaaattg tagatagtgg
    15781 ggaaatgaca ggagaaaatt cctgttctgc catcttgctg acatcacccc aatatctaaa
    15841 atgcatattt taattatttt tttccttgaa taaagtttat tttggaattg ttgagtttta
    15901 caaaataatt taaaatattc tctctctctc tctctctctc tggggttgag gtctcactct
    15961 gtcacccagg atggattaca gtggcacaat cgcagctcac tgcagcctcg aatttcttgg
    16021 gtcaagtgat cctcccactt cagcctccca agtagctggg actacaaggc gtgtgccacc
    16081 atgcccagct aatattttta cattttttgt agagatgggg tctcactatg ttgcccaggt
    16141 gggtcttgaa ctcctggcat catgtggtcc tcccacctcc acctcccaag tcctgaggat
    16201 accaattgtg agtcactgtg cccagctatc cccttctcac tctctttttc tctcacacac
    16261 atgtgtgcat gcacagacac acacacctca tgttcattct ctttaccatg atgatccttg
    16321 gttcttttac acagcttctt tcagtttacc ttacaattta gctcaacaca aattttaaaa
    16381 aacttatagt tacaatttaa tttggcttgg tccacacctc taacaaattt gatacaatct
    16441 ccaacttacg gttgcaagtt agttgattat attcacttcc aagtatttcc cccaacattt
    16501 cattatgaaa atatatccat caattaatgc tcttatctat aaaataatta tttttttgca
    16561 tttcaaaata agttacagac atcaatgcac ttcatcttta aaccctttat catgcatatc
    16621 aggaagtaga gtttaatatt tctatatttc ttgggggaga aatggagcta aaattatata
    16681 ctgtatcata tacaaacctg ttaggtatat caattcatgt gtattgacaa atgcgtgcac
    16741 catgtaacag aaactccttt caagatatag aatattccta tcactacaaa tattaatcac
    16801 caaaacaatg gggagaatgt ctctagggca tgtcagagac cttcactgca gcctctccca
    16861 ttataggcca ggaggccttg aaggaaaaaa atggtttagt gggccaggcc tcaggcaccc
    16921 ccccttgctc tttgcagcct tgaaacatgg taccctgcgt ccccagctgc ttcagcttca
    16981 gctgtggcta aaaggggcca acatacagct caggccattg tttcagagag tgcaatcccc
    17041 aagctttggc agcttacaca tggtgttggg cttgcaggag cacagaagtc aagaattgag
    17101 gtttgggaac ctctgcctag atttcagagg atgtatggaa atgcctggat gtccagacag
    17161 aagtctgctg caggggtaga gctctcaggg agaacctctg ctagggcagt gcagaaggga
    17221 aatgtggggt tggagctccc ccacagagtc ttcactgggg cactgtatag tggagctctg
    17281 agaagagggc catagtcctc cagaccccag aatggtagat ccaccaatag cttgcaccat
    17341 gcacctggaa aagccactgg cactcaacac cagcccatga aaagagctgt gagggtggct
    17401 gcatcctgca aagccacagg ggaagagctg cccaaggctg tgggagccca ccccttgcat
    17461 cattgtgacc tggatagatg tgagacatgg agcctaagga gatcattttg gaactttaag
    17521 ctttaacgac tgccctattg gattttggac ttgcatgggc ctatagcccc tttgttttgg
    17581 ccaacttctc ccatttggaa tgggtatttt tactcaattc ctgtaccccc attgtatctt
    17641 ggaaataact aacttgcttt agattttaca ggcttatagg tggaagggac ttgctttgtc
    17701 tcagatgaga ctttggactt ggacttctgg gttaatgttt gaatgagtta atactttggg
    17761 ggactattgg aagggcatga ttgtgttttg aaatgtgaga acatgagatt tgggaggaac
    17821 tagggtcaga atgatatggt ttggttttgt gttcccaccc aaatctctcc ttgaattgta
    17881 ataatcccca tgtgtcaggg gtgggaccag gtggaggact gaatcatggg ggtggtttcc
    17941 ctcatgctat tctcatgata gtgatttata acagatccaa tggttttata agcatctggc
    18001 atttcccctg ctggcactca ttctctctcc tgccaccctg tgaagagggg ccttccacca
    18061 tgattgtaag tctcctgagg cctccgaagc catgcggaac tgtgagtcag ttaaaactct
    18121 ttcctttata aattacctag tcttgggtat ttctttatgg aagcatgaga atgaactaat
    18181 gcacagggta aaaatttaaa aacaaacata caaatgcaag taaacaagcc aatatttcaa
    18241 ctgttcccat tgcattatcc ttattcttta tctatggtac cagaaaataa tacatctgaa
    18301 acaatttttt tttcctgcca tgatgtacac tcaagtgggt ccactggggt ttctttcagt
    18361 ttcccaaata ctagatatga ctcttcccta taccttatct tcatatgaag aaagctatga
    18421 gaatatatta ataactgaat atagtaacac tactatagga ataagcatgt gtatattcca
    18481 actgatcttt taaaactttt attttgaaat atttatagat tcaaaggaag atgcaaagag
    18541 tatagggaag tgctatatgc cctttatcta gttcctctag tggtatcaac ttacataact
    18601 gcagtatcat atataaacca agaaattggc atctgtataa tccacagaca ttactcagac
    18661 ttctctagtt ttacatacac taatttgtat gtgtgtgtgt gtgtgcgtgc acgtttatgt
    18721 gtgtaggtct atgcaatttt accacatgtg tatatttggg taaccactac aatgatcaag
    18781 atatggaact gttccgtcac cactaagatc ccttgtgcta ttcctttata aacatctccc
    18841 tgtcatcctt tttcacccat aaaagctagt aaacactaat ctgttcttca tccttataat
    18901 tttattattt cagaattgtt atataaatgt catcatacag tatataacac atagagattg
    18961 gcttttgtca ctcagcacaa ttcccttgag atgcatccaa actgttgtgt atatcagtaa
    19021 tgcaatatgt ttaatttctg tgtagtattc catggtagag atgtgccata gtttaactat
    19081 tcacctgttg aacaacattt gtgttctttc tacttttggg ctattacaaa taaagttgct
    19141 atgaacattc atgtataa
//
