LOCUS       NM_004112               2578 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens fibroblast growth factor 11 (FGF11), transcript
            variant 1, mRNA.
ACCESSION   NM_004112
VERSION     NM_004112.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2578)
  AUTHORS   Seong,M.S., Jang,J.A., Jeong,Y.R., Kim,Y.B., Kyaw,Y.Y., Kong,H.J.,
            Lee,J.H. and Cheong,J.
  TITLE     Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus Gene
            Expression Through FXRalpha Suppression
  JOURNAL   J Microbiol 61 (7), 693-702 (2023)
   PUBMED   37646922
  REMARK    GeneRIF: Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus
            Gene Expression Through FXRalpha Suppression.
REFERENCE   2  (bases 1 to 2578)
  AUTHORS   Lee,K.W., An,Y.J., Lee,J., Jung,Y.E., Ko,I.Y., Jin,J., Park,J.H.,
            Lee,W.K., Cha,K., Ko,S.C., Lee,J.H. and Yim,H.S.
  TITLE     Expression and purification of intracrine human FGF 11 and study of
            its FGFR-dependent biological activity
  JOURNAL   J Microbiol 60 (11), 1086-1094 (2022)
   PUBMED   36318359
  REMARK    GeneRIF: Expression and purification of intracrine human FGF 11 and
            study of its FGFR-dependent biological activity.
REFERENCE   3  (bases 1 to 2578)
  AUTHORS   Chen,B., Feng,M., Yao,Z., Zhang,Z., Zhang,K. and Zhou,L.
  TITLE     Hypoxia promotes thyroid cancer progression through HIF1alpha/FGF11
            feedback loop
  JOURNAL   Exp Cell Res 416 (1), 113159 (2022)
   PUBMED   35430272
  REMARK    GeneRIF: Hypoxia promotes thyroid cancer progression through
            HIF1alpha/FGF11 feedback loop.
REFERENCE   4  (bases 1 to 2578)
  AUTHORS   Wu,X., Li,M., Li,Y., Deng,Y., Ke,S., Li,F., Wang,Y. and Zhou,S.
  TITLE     Fibroblast growth factor 11 (FGF11) promotes non-small cell lung
            cancer (NSCLC) progression by regulating hypoxia signaling pathway
  JOURNAL   J Transl Med 19 (1), 353 (2021)
   PUBMED   34404435
  REMARK    GeneRIF: Fibroblast growth factor 11 (FGF11) promotes non-small
            cell lung cancer (NSCLC) progression by regulating hypoxia
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2578)
  AUTHORS   Rudakou,U., Yu,E., Krohn,L., Ruskey,J.A., Asayesh,F.,
            Dauvilliers,Y., Spiegelman,D., Greenbaum,L., Fahn,S., Waters,C.H.,
            Dupre,N., Rouleau,G.A., Hassin-Baer,S., Fon,E.A., Alcalay,R.N. and
            Gan-Or,Z.
  TITLE     Targeted sequencing of Parkinson's disease loci genes highlights
            SYT11, FGF20 and other associations
  JOURNAL   Brain 144 (2), 462-472 (2021)
   PUBMED   33349842
  REMARK    GeneRIF: Targeted sequencing of Parkinson's disease loci genes
            highlights SYT11, FGF20 and other associations.
REFERENCE   6  (bases 1 to 2578)
  AUTHORS   Zhang,X., Bao,L., Yang,L., Wu,Q. and Li,S.
  TITLE     Roles of intracellular fibroblast growth factors in neural
            development and functions
  JOURNAL   Sci China Life Sci 55 (12), 1038-1044 (2012)
   PUBMED   23233218
  REMARK    Review article
REFERENCE   7  (bases 1 to 2578)
  AUTHORS   Popovici,C., Conchonaud,F., Birnbaum,D. and Roubin,R.
  TITLE     Functional phylogeny relates LET-756 to fibroblast growth factor 9
  JOURNAL   J Biol Chem 279 (38), 40146-40152 (2004)
   PUBMED   15199049
REFERENCE   8  (bases 1 to 2578)
  AUTHORS   Cousin,P., Billotte,J., Chaubert,P. and Shaw,P.
  TITLE     Physical map of 17p13 and the genes adjacent to p53
  JOURNAL   Genomics 63 (1), 60-68 (2000)
   PUBMED   10662545
REFERENCE   9  (bases 1 to 2578)
  AUTHORS   Verdier,A.S., Mattei,M.G., Lovec,H., Hartung,H., Goldfarb,M.,
            Birnbaum,D. and Coulier,F.
  TITLE     Chromosomal mapping of two novel human FGF genes, FGF11 and FGF12
  JOURNAL   Genomics 40 (1), 151-154 (1997)
   PUBMED   9070933
REFERENCE   10 (bases 1 to 2578)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113189.11.
            
            On Nov 23, 2018 this sequence version replaced NM_004112.3.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. The function of this gene has not yet been determined.
            The expression pattern of the mouse homolog implies a role in
            nervous system development. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032502.1, SRR1803617.150276.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293829.9/ ENSP00000293829.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC113189.11        89595-89896
            303-413             AC113189.11        91554-91664
            414-517             AC113189.11        91859-91962
            518-716             AC113189.11        92677-92875
            717-2578            AC113189.11        93159-95020
FEATURES             Location/Qualifiers
     source          1..2578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2578
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /note="fibroblast growth factor 11"
                     /db_xref="GeneID:2256"
                     /db_xref="HGNC:HGNC:3667"
                     /db_xref="MIM:601514"
     exon            1..302
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..787
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fibroblast growth factor homologous factor 3"
                     /codon_start=1
                     /product="fibroblast growth factor 11 isoform 1"
                     /protein_id="NP_004103.1"
                     /db_xref="CCDS:CCDS11105.1"
                     /db_xref="GeneID:2256"
                     /db_xref="HGNC:HGNC:3667"
                     /db_xref="MIM:601514"
                     /translation="MAALASSLIRQKREVREPGGSRPVSAQRRVCPRGTKSLCQKQLL
                     ILLSKVRLCGGRPARPDRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFT
                     HFNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASA
                     LYRQRRSGRAWYLGLDKEGQVMKGNRVKKTKAAAHFLPKLLEVAMYQEPSLHSVPEAS
                     PSSPPAP"
     exon            303..413
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     exon            414..517
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..716
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     exon            717..2578
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2554..2559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /note="hexamer: ATTAAA"
     polyA_site      2578
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /note="major polyA site"
ORIGIN      
        1 gagtcggggc ctgagcgtca agagcatgcc ctagtgagcg ggctcctctg ggggagccca
       61 gcgcgctccg ggcgcctgcc ggtttggggg tgtctcctcc cggggcgcta tggcggcgct
      121 ggccagtagc ctgatccggc agaagcggga ggtccgcgag cccgggggca gccggccggt
      181 gtcggcgcag cggcgcgtgt gtccccgcgg caccaagtcc ctttgccaga agcagctcct
      241 catcctgctg tccaaggtgc gactgtgcgg ggggcggccc gcgcggccgg accgcggccc
      301 ggagcctcag ctcaaaggca tcgtcaccaa actgttctgc cgccagggtt tctacctcca
      361 ggcgaatccc gacggaagca tccagggcac cccagaggat accagctcct tcacccactt
      421 caacctgatc cctgtgggcc tccgtgtggt caccatccag agcgccaagc tgggtcacta
      481 catggccatg aatgctgagg gactgctcta cagttcgccg catttcacag ctgagtgtcg
      541 ctttaaggag tgtgtctttg agaattacta cgtcctgtac gcctctgctc tctaccgcca
      601 gcgtcgttct ggccgggcct ggtacctcgg cctggacaag gagggccagg tcatgaaggg
      661 aaaccgagtt aagaagacca aggcagctgc ccactttctg cccaagctcc tggaggtggc
      721 catgtaccag gagccttctc tccacagtgt ccccgaggcc tccccttcca gtccccctgc
      781 cccctgaaat gtagtccctg gactggaggt tccctgcact cccagtgagc cagccaccac
      841 cacaacctgt ctcccagtcc tgctctcacc cctgctgcca cacacatgcc ctgagcagcc
      901 aggtcccact aggtgctcta ccctgaggga gcctaggggc tgactgtgac ttccgaggct
      961 gctgagaccc ttagatcttt gggcctagga gggagtcaga gagggggatg tctgaagatg
     1021 gtcctggctg atcacttctt tctttccaca ctcacacaac gccatgcctt ttcctgagat
     1081 ggcgctggga gttcccacat ggacagccag ggcataaaca cttcccaccc cggctcagcc
     1141 agttcctgga gtcctgtgcc ccttttcatt gccactgagc catttctaga ttcactggag
     1201 ctcaggattc atgtgtcctt ctttccctac tctaccttct accttggtct ggacacattc
     1261 tggaacactg gacaccctcg ccagggccac ttctgcacta gggctctgtg ctggaaccca
     1321 ggcatgctgc cagccttttc tctggatctg tcaggcctct gtcattgact cagatggacc
     1381 cctggtttcc aagtagaaag aggctagatt tgggccttgt ctagctgttg gctttggcct
     1441 gaaccggaac cagtctcaga tgaccacggg tttaaccttc ttatcccaga gacacccaat
     1501 tctagagctt tatggagccg tacttccccc tgaatcctag ctctaggaca tagatcatga
     1561 ctctcagccc ttttacccag gatggagctg gggcctgtat agccatatta ttgttctaag
     1621 taagttctag ccccaccctc ccgccttctt gagtgatacc tattacggat gagttctgga
     1681 aaagacccag ctatgattca taaaaacact tctggatgaa tcaagaacca tttcttgttt
     1741 ttcctagata attctctaaa aatatgattc ttccatatag aatgctaagc ttatttttac
     1801 atgcagtttc tagctccttc aacccagctg aggtcgtgcc agggagacag agtctggaga
     1861 agggcagagg aattttggaa ggatccctgg ctcatagtag ggaagctggg atgggggagg
     1921 ggtcaaaatt atggcatgac tgaacctgca tctgtgttgg gtggacatga atacttagct
     1981 acctcagcag gaattccttc caggtcccct ttaaagctga ggtccttaga gtaatatgtc
     2041 cttaataaaa aggacaaatg gatacagcct tgaccctccc agtgaggaga ccccaattca
     2101 gcaataagtc tcacccttct cccctacagg tcaggccaag aagggtgaag gcctcttgca
     2161 ctccagacct catacgcccc aacagcttct aattggatag aacttgcttt accttacagc
     2221 tcacaacctc agctgggttt taggtaccca aaaagggcct gtctagattt tttcagaaaa
     2281 acgtggagtg ctaggggcag cctggaaaag atggggaacc tgctagtgaa ctaggaggga
     2341 gacttccata gcctcagact tggatagggt aggctgaggg ggccctaagg gagggactaa
     2401 ggctccaagg caggtcactt ttccttaggc tgttctactt ctggcttgtt gcaagaggag
     2461 tagatgcccc ctcacccaca caaaccccac tcagtctcca cccaactcct ggcactgctc
     2521 ccaggggatc gggtctccac tccagctttc tcaattaaag acgatttata caactgaa
//
