LOCUS       NM_001303460            2345 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens fibroblast growth factor 11 (FGF11), transcript
            variant 2, mRNA.
ACCESSION   NM_001303460
VERSION     NM_001303460.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2345)
  AUTHORS   Seong,M.S., Jang,J.A., Jeong,Y.R., Kim,Y.B., Kyaw,Y.Y., Kong,H.J.,
            Lee,J.H. and Cheong,J.
  TITLE     Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus Gene
            Expression Through FXRalpha Suppression
  JOURNAL   J Microbiol 61 (7), 693-702 (2023)
   PUBMED   37646922
  REMARK    GeneRIF: Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus
            Gene Expression Through FXRalpha Suppression.
REFERENCE   2  (bases 1 to 2345)
  AUTHORS   Lee,K.W., An,Y.J., Lee,J., Jung,Y.E., Ko,I.Y., Jin,J., Park,J.H.,
            Lee,W.K., Cha,K., Ko,S.C., Lee,J.H. and Yim,H.S.
  TITLE     Expression and purification of intracrine human FGF 11 and study of
            its FGFR-dependent biological activity
  JOURNAL   J Microbiol 60 (11), 1086-1094 (2022)
   PUBMED   36318359
  REMARK    GeneRIF: Expression and purification of intracrine human FGF 11 and
            study of its FGFR-dependent biological activity.
REFERENCE   3  (bases 1 to 2345)
  AUTHORS   Chen,B., Feng,M., Yao,Z., Zhang,Z., Zhang,K. and Zhou,L.
  TITLE     Hypoxia promotes thyroid cancer progression through HIF1alpha/FGF11
            feedback loop
  JOURNAL   Exp Cell Res 416 (1), 113159 (2022)
   PUBMED   35430272
  REMARK    GeneRIF: Hypoxia promotes thyroid cancer progression through
            HIF1alpha/FGF11 feedback loop.
REFERENCE   4  (bases 1 to 2345)
  AUTHORS   Wu,X., Li,M., Li,Y., Deng,Y., Ke,S., Li,F., Wang,Y. and Zhou,S.
  TITLE     Fibroblast growth factor 11 (FGF11) promotes non-small cell lung
            cancer (NSCLC) progression by regulating hypoxia signaling pathway
  JOURNAL   J Transl Med 19 (1), 353 (2021)
   PUBMED   34404435
  REMARK    GeneRIF: Fibroblast growth factor 11 (FGF11) promotes non-small
            cell lung cancer (NSCLC) progression by regulating hypoxia
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2345)
  AUTHORS   Rudakou,U., Yu,E., Krohn,L., Ruskey,J.A., Asayesh,F.,
            Dauvilliers,Y., Spiegelman,D., Greenbaum,L., Fahn,S., Waters,C.H.,
            Dupre,N., Rouleau,G.A., Hassin-Baer,S., Fon,E.A., Alcalay,R.N. and
            Gan-Or,Z.
  TITLE     Targeted sequencing of Parkinson's disease loci genes highlights
            SYT11, FGF20 and other associations
  JOURNAL   Brain 144 (2), 462-472 (2021)
   PUBMED   33349842
  REMARK    GeneRIF: Targeted sequencing of Parkinson's disease loci genes
            highlights SYT11, FGF20 and other associations.
REFERENCE   6  (bases 1 to 2345)
  AUTHORS   Zhang,X., Bao,L., Yang,L., Wu,Q. and Li,S.
  TITLE     Roles of intracellular fibroblast growth factors in neural
            development and functions
  JOURNAL   Sci China Life Sci 55 (12), 1038-1044 (2012)
   PUBMED   23233218
  REMARK    Review article
REFERENCE   7  (bases 1 to 2345)
  AUTHORS   Popovici,C., Conchonaud,F., Birnbaum,D. and Roubin,R.
  TITLE     Functional phylogeny relates LET-756 to fibroblast growth factor 9
  JOURNAL   J Biol Chem 279 (38), 40146-40152 (2004)
   PUBMED   15199049
REFERENCE   8  (bases 1 to 2345)
  AUTHORS   Cousin,P., Billotte,J., Chaubert,P. and Shaw,P.
  TITLE     Physical map of 17p13 and the genes adjacent to p53
  JOURNAL   Genomics 63 (1), 60-68 (2000)
   PUBMED   10662545
REFERENCE   9  (bases 1 to 2345)
  AUTHORS   Verdier,A.S., Mattei,M.G., Lovec,H., Hartung,H., Goldfarb,M.,
            Birnbaum,D. and Coulier,F.
  TITLE     Chromosomal mapping of two novel human FGF genes, FGF11 and FGF12
  JOURNAL   Genomics 40 (1), 151-154 (1997)
   PUBMED   9070933
REFERENCE   10 (bases 1 to 2345)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113189.11.
            
            On Jun 1, 2019 this sequence version replaced NM_001303460.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. The function of this gene has not yet been determined.
            The expression pattern of the mouse homolog implies a role in
            nervous system development. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start site compared to variant 1. The encoded isoform (2)
            has a distinct N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293131.1, DC297659.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC113189.11        90851-90899
            50-180              AC113189.11        91534-91664
            181-284             AC113189.11        91859-91962
            285-483             AC113189.11        92677-92875
            484-2345            AC113189.11        93159-95020
FEATURES             Location/Qualifiers
     source          1..2345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2345
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /note="fibroblast growth factor 11"
                     /db_xref="GeneID:2256"
                     /db_xref="HGNC:HGNC:3667"
                     /db_xref="MIM:601514"
     exon            1..49
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     exon            50..180
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..554
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     fibroblast growth factor homologous factor 3"
                     /codon_start=1
                     /product="fibroblast growth factor 11 isoform 2"
                     /protein_id="NP_001290389.1"
                     /db_xref="GeneID:2256"
                     /db_xref="HGNC:HGNC:3667"
                     /db_xref="MIM:601514"
                     /translation="MSLSPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFTH
                     FNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASAL
                     YRQRRSGRAWYLGLDKEGQVMKGNRVKKTKAAAHFLPKLLEVAMYQEPSLHSVPEASP
                     SSPPAP"
     exon            181..284
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     exon            285..483
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     exon            484..2345
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /note="hexamer: ATTAAA"
     polyA_site      2345
                     /gene="FGF11"
                     /gene_synonym="FGF-11; FHF-3; FHF3"
                     /note="major polyA site"
ORIGIN      
        1 gactcagcct gcctctccat ctcctcagct cccacccccc atatccttga tgaatgtctc
       61 tctctccaga gcctcagctc aaaggcatcg tcaccaaact gttctgccgc cagggtttct
      121 acctccaggc gaatcccgac ggaagcatcc agggcacccc agaggatacc agctccttca
      181 cccacttcaa cctgatccct gtgggcctcc gtgtggtcac catccagagc gccaagctgg
      241 gtcactacat ggccatgaat gctgagggac tgctctacag ttcgccgcat ttcacagctg
      301 agtgtcgctt taaggagtgt gtctttgaga attactacgt cctgtacgcc tctgctctct
      361 accgccagcg tcgttctggc cgggcctggt acctcggcct ggacaaggag ggccaggtca
      421 tgaagggaaa ccgagttaag aagaccaagg cagctgccca ctttctgccc aagctcctgg
      481 aggtggccat gtaccaggag ccttctctcc acagtgtccc cgaggcctcc ccttccagtc
      541 cccctgcccc ctgaaatgta gtccctggac tggaggttcc ctgcactccc agtgagccag
      601 ccaccaccac aacctgtctc ccagtcctgc tctcacccct gctgccacac acatgccctg
      661 agcagccagg tcccactagg tgctctaccc tgagggagcc taggggctga ctgtgacttc
      721 cgaggctgct gagaccctta gatctttggg cctaggaggg agtcagagag ggggatgtct
      781 gaagatggtc ctggctgatc acttctttct ttccacactc acacaacgcc atgccttttc
      841 ctgagatggc gctgggagtt cccacatgga cagccagggc ataaacactt cccaccccgg
      901 ctcagccagt tcctggagtc ctgtgcccct tttcattgcc actgagccat ttctagattc
      961 actggagctc aggattcatg tgtccttctt tccctactct accttctacc ttggtctgga
     1021 cacattctgg aacactggac accctcgcca gggccacttc tgcactaggg ctctgtgctg
     1081 gaacccaggc atgctgccag ccttttctct ggatctgtca ggcctctgtc attgactcag
     1141 atggacccct ggtttccaag tagaaagagg ctagatttgg gccttgtcta gctgttggct
     1201 ttggcctgaa ccggaaccag tctcagatga ccacgggttt aaccttctta tcccagagac
     1261 acccaattct agagctttat ggagccgtac ttccccctga atcctagctc taggacatag
     1321 atcatgactc tcagcccttt tacccaggat ggagctgggg cctgtatagc catattattg
     1381 ttctaagtaa gttctagccc caccctcccg ccttcttgag tgatacctat tacggatgag
     1441 ttctggaaaa gacccagcta tgattcataa aaacacttct ggatgaatca agaaccattt
     1501 cttgtttttc ctagataatt ctctaaaaat atgattcttc catatagaat gctaagctta
     1561 tttttacatg cagtttctag ctccttcaac ccagctgagg tcgtgccagg gagacagagt
     1621 ctggagaagg gcagaggaat tttggaagga tccctggctc atagtaggga agctgggatg
     1681 ggggaggggt caaaattatg gcatgactga acctgcatct gtgttgggtg gacatgaata
     1741 cttagctacc tcagcaggaa ttccttccag gtccccttta aagctgaggt ccttagagta
     1801 atatgtcctt aataaaaagg acaaatggat acagccttga ccctcccagt gaggagaccc
     1861 caattcagca ataagtctca cccttctccc ctacaggtca ggccaagaag ggtgaaggcc
     1921 tcttgcactc cagacctcat acgccccaac agcttctaat tggatagaac ttgctttacc
     1981 ttacagctca caacctcagc tgggttttag gtacccaaaa agggcctgtc tagatttttt
     2041 cagaaaaacg tggagtgcta ggggcagcct ggaaaagatg gggaacctgc tagtgaacta
     2101 ggagggagac ttccatagcc tcagacttgg atagggtagg ctgagggggc cctaagggag
     2161 ggactaaggc tccaaggcag gtcacttttc cttaggctgt tctacttctg gcttgttgca
     2221 agaggagtag atgccccctc acccacacaa accccactca gtctccaccc aactcctggc
     2281 actgctccca ggggatcggg tctccactcc agctttctca attaaagacg atttatacaa
     2341 ctgaa
//
