LOCUS       NM_004465               6113 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 10 (FGF10), mRNA.
ACCESSION   NM_004465
VERSION     NM_004465.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6113)
  AUTHORS   Zhao,J., Zhang,L., Zhang,Y., Cao,M., Wang,C., Hu,A., Cao,L.,
            Luo,Q., You,Z., Ma,X., Gong,L., Zhang,C. and Li,H.
  TITLE     FGF7 and FGF10 Promote Fate Transition of Human Epidermal
            Cell-derived Organoids to an Eccrine Gland Phenotype
  JOURNAL   Int J Biol Sci 20 (11), 4162-4177 (2024)
   PUBMED   39247826
  REMARK    GeneRIF: FGF7 and FGF10 Promote Fate Transition of Human Epidermal
            Cell-derived Organoids to an Eccrine Gland Phenotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6113)
  AUTHORS   Peng,W., Song,Y., Zhu,G., Zeng,Y., Cai,H., Lu,C., Abuduxukuer,Z.,
            Song,X., Gao,X., Ye,L., Wang,J. and Jin,M.
  TITLE     FGF10 attenuates allergic airway inflammation in asthma by
            inhibiting PI3K/AKT/NF-kappaB pathway
  JOURNAL   Cell Signal 113, 110964 (2024)
   PUBMED   37956773
  REMARK    GeneRIF: FGF10 attenuates allergic airway inflammation in asthma by
            inhibiting PI3K/AKT/NF-kappaB pathway.
REFERENCE   3  (bases 1 to 6113)
  AUTHORS   Oeurn,K., Jusakul,A., Jaidee,R., Kukongviriyapan,V.,
            Senggunprai,L., Prawan,A. and Kongpetch,S.
  TITLE     FGF10/FGFR2 Signaling: Therapeutically Targetable Vulnerability in
            Ligand-responsive Cholangiocarcinoma Cells
  JOURNAL   In Vivo 37 (4), 1628-1637 (2023)
   PUBMED   37369494
  REMARK    GeneRIF: FGF10/FGFR2 Signaling: Therapeutically Targetable
            Vulnerability in Ligand-responsive Cholangiocarcinoma Cells.
REFERENCE   4  (bases 1 to 6113)
  AUTHORS   Jiang,T., Hu,W., Zhang,S., Ren,C., Lin,S., Zhou,Z., Wu,H., Yin,J.
            and Tan,L.
  TITLE     Fibroblast growth factor 10 attenuates chronic obstructive
            pulmonary disease by protecting against glycocalyx impairment and
            endothelial apoptosis
  JOURNAL   Respir Res 23 (1), 269 (2022)
   PUBMED   36183124
  REMARK    GeneRIF: Fibroblast growth factor 10 attenuates chronic obstructive
            pulmonary disease by protecting against glycocalyx impairment and
            endothelial apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6113)
  AUTHORS   Hubert,F., Payan,S.M., Pelce,E., Bouchard,L., Sturny,R.,
            Lenfant,N., Mottola,G., Collart,F., Kelly,R.G. and Rochais,F.
  TITLE     FGF10 promotes cardiac repair through a dual cellular mechanism
            increasing cardiomyocyte renewal and inhibiting fibrosis
  JOURNAL   Cardiovasc Res 118 (12), 2625-2637 (2022)
   PUBMED   34755840
  REMARK    GeneRIF: FGF10 promotes cardiac repair through a dual cellular
            mechanism increasing cardiomyocyte renewal and inhibiting fibrosis.
REFERENCE   6  (bases 1 to 6113)
  AUTHORS   Sekine,K., Ohuchi,H., Fujiwara,M., Yamasaki,M., Yoshizawa,T.,
            Sato,T., Yagishita,N., Matsui,D., Koga,Y., Itoh,N. and Kato,S.
  TITLE     Fgf10 is essential for limb and lung formation
  JOURNAL   Nat Genet 21 (1), 138-141 (1999)
   PUBMED   9916808
  REMARK    Erratum:[Nat Genet. 2019 May;51(5):921. doi:
            10.1038/s41588-019-0396-9. PMID: 30948796]
REFERENCE   7  (bases 1 to 6113)
  AUTHORS   Park,W.Y., Miranda,B., Lebeche,D., Hashimoto,G. and Cardoso,W.V.
  TITLE     FGF-10 is a chemotactic factor for distal epithelial buds during
            lung development
  JOURNAL   Dev Biol 201 (2), 125-134 (1998)
   PUBMED   9740653
REFERENCE   8  (bases 1 to 6113)
  AUTHORS   Igarashi,M., Finch,P.W. and Aaronson,S.A.
  TITLE     Characterization of recombinant human fibroblast growth factor
            (FGF)-10 reveals functional similarities with keratinocyte growth
            factor (FGF-7)
  JOURNAL   J Biol Chem 273 (21), 13230-13235 (1998)
   PUBMED   9582367
REFERENCE   9  (bases 1 to 6113)
  AUTHORS   Emoto,H., Tagashira,S., Mattei,M.G., Yamasaki,M., Hashimoto,G.,
            Katsumata,T., Negoro,T., Nakatsuka,M., Birnbaum,D., Coulier,F. and
            Itoh,N.
  TITLE     Structure and expression of human fibroblast growth factor-10
  JOURNAL   J Biol Chem 272 (37), 23191-23194 (1997)
   PUBMED   9287324
REFERENCE   10 (bases 1 to 6113)
  AUTHORS   Mohammadi,M., Dikic,I., Sorokin,A., Burgess,W.H., Jaye,M. and
            Schlessinger,J.
  TITLE     Identification of six novel autophosphorylation sites on fibroblast
            growth factor receptor 1 and elucidation of their importance in
            receptor activation and signal transduction
  JOURNAL   Mol Cell Biol 16 (3), 977-989 (1996)
   PUBMED   8622701
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA795795.1, BX955123.1,
            DR003252.1, AB002097.1 and AC093537.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 10, 2019 this sequence version replaced NM_004465.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein exhibits mitogenic activity for keratinizing
            epidermal cells, but essentially no activity for fibroblasts, which
            is similar to the biological activity of FGF7. Studies of the mouse
            homolog of suggested that this gene is required for embryonic
            epidermal morphogenesis including brain development, lung
            morphogenesis, and initiation of lim bud formation. This gene is
            also implicated to be a primary factor in the process of wound
            healing. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.154482.1,
                                           SRR1660803.99825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151358, SAMEA2155984
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264664.5/ ENSP00000264664.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DA795795.1         340-394
            56-636              BX955123.1         138-718
            637-738             DR003252.1         9-110
            739-1365            AB002097.1         1-627
            1366-6113           AC093537.2         102922-107669       c
FEATURES             Location/Qualifiers
     source          1..6113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..6113
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /note="fibroblast growth factor 10"
                     /db_xref="GeneID:2255"
                     /db_xref="HGNC:HGNC:3666"
                     /db_xref="MIM:602115"
     exon            1..1063
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             739..1365
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /note="keratinocyte growth factor 2; produced by
                     fibroblasts of urinary bladder lamina propria; FGF-10"
                     /codon_start=1
                     /product="fibroblast growth factor 10 precursor"
                     /protein_id="NP_004456.1"
                     /db_xref="CCDS:CCDS3950.1"
                     /db_xref="GeneID:2255"
                     /db_xref="HGNC:HGNC:3666"
                     /db_xref="MIM:602115"
                     /translation="MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDM
                     VSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTK
                     KENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENG
                     YNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS"
     exon            1064..1167
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..6113
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2801..2806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /note="hexamer: AATAAA"
     polyA_site      2819
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /note="major polyA site"
     regulatory      3977..3982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /note="hexamer: AAGAAA"
     polyA_site      4003
                     /gene="FGF10"
                     /gene_synonym="LADD3"
     regulatory      4478..4483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /note="hexamer: AATAAA"
     polyA_site      4501
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /note="major polyA site"
     regulatory      6091..6096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF10"
                     /gene_synonym="LADD3"
                     /note="hexamer: AATAAA"
     polyA_site      6113
                     /gene="FGF10"
                     /gene_synonym="LADD3"
ORIGIN      
        1 gacatttaga ctccaggctt caacctgttt acaagcggac tttccaaagg aagggggtgg
       61 gagatagggc catacaaaac accagccgcc gtcccccaaa acaaaaagtg actttcggca
      121 gccttcaaat cggcaggcac cactaaaaac agaaaggaag agagggaaga aaacaacggc
      181 gactgggcag ctgcctccac ttctgacaac tccaaaggga tatacttgta gaagtggctc
      241 gcaggctggg gctccgcaga gagagaccag aaggtgccaa ccgcagaggg gtgcagatat
      301 ctccccctat tccccacccc acctcccttg ggttttgttc accgtgctgt catctgtttt
      361 tcagaccttt ttggcatcta acatggtgaa gaaaggagta aagaagagaa caaagtaact
      421 cctgggggag cgaagagcgc tggtgaccaa caccaccaac gccaccacca gctcctgctg
      481 ctgcggccac ccacgtccac catttaccgg gaggctccag aggcgtaggc agcggatccg
      541 agaaaggagc gaggggagtc agccggcttt tccgaggagt tatggatgtt ggtgcattca
      601 cttctggcca gatccgcgcc cagagggagc taaccagcag ccaccacctc gagctctctc
      661 cttgccttgc atcgggtctt acccttccag tatgttcctt ctgatgagac aatttccagt
      721 gccgagagtt tcagtacaat gtggaaatgg atactgacac attgtgcctc agcctttccc
      781 cacctgcccg gctgctgctg ctgctgcttt ttgttgctgt tcttggtgtc ttccgtccct
      841 gtcacctgcc aagcccttgg tcaggacatg gtgtcaccag aggccaccaa ctcttcttcc
      901 tcctccttct cctctccttc cagcgcggga aggcatgtgc ggagctacaa tcaccttcaa
      961 ggagatgtcc gctggagaaa gctattctct ttcaccaagt actttctcaa gattgagaag
     1021 aacgggaagg tcagcgggac caagaaggag aactgcccgt acagcatcct ggagataaca
     1081 tcagtagaaa tcggagttgt tgccgtcaaa gccattaaca gcaactatta cttagccatg
     1141 aacaagaagg ggaaactcta tggctcaaaa gaatttaaca atgactgtaa gctgaaggag
     1201 aggatagagg aaaatggata caatacctat gcatcattta actggcagca taatgggagg
     1261 caaatgtatg tggcattgaa tggaaaagga gctccaagga gaggacagaa aacacgaagg
     1321 aaaaacacct ctgctcactt tcttccaatg gtggtacact catagaggaa ggcaacgttt
     1381 gtggatgcag tagaaccaat ggctcttttg ccaagaatag tggatattct tcatgaagac
     1441 agtagattga aaggcaaaga cacgttgcag atgtctgctt gcttaaaaga aagccagcct
     1501 ttgaaggttt ttgtattcac tgctgacata tgatgttctt ttaattagtt ctgtgtcatg
     1561 tcttataatc aagatatagg cagatcgaat gggatagaag ttattcccaa gtgaaaaaca
     1621 ttgtggctgg gttttttgtt gttgttgtca agtttttgtt tttaaacctc tgagatagaa
     1681 cttaaaggac atagaacaat ctgttgaaag aacgatcttc gggaaagtta tttatggaat
     1741 acgaactcat atcaaagact tcattgctca ttcaagccta atgaatcaat gaacagtaat
     1801 acatgcaagc atttactgga aagcacttgg gtcatatcat atgcacaacc aaaggagttc
     1861 tggatgtggt ctcatggaat aattgaatag aatttaaaaa tataaacatg ttagtgtgaa
     1921 actgttctaa caatacaaat agtatggtat gcttgtgcat tctgccttca tccctttcta
     1981 tttctttcta agttatttat ttaataggat gttaaatatc ttttggggtt ttaaagagta
     2041 tctcagcagc tgtcttctga tttatctttt ctttttattc agcacaccac atgcatgttc
     2101 acgacaaagt gtttttaaaa cttggcgaac acttcaaaaa taggagttgg gattagggaa
     2161 gcagtatgag tgcccgtgtg ctatcagttg acttaatttg cacttctgca gtaataacca
     2221 tcaacaataa atatggcaat gctgtgccat ggcttgagtg agagatgtct gctatcattt
     2281 gaaaacatat attactctcg aggcttcctg tctcaagaaa tagaccagaa ggccaaattc
     2341 ttctctttca atacatcagt ttgcctccaa gaatatacta aaaaaaggaa aattaattgc
     2401 taaatacatt taaatagcct agcctcatta tttactcatg atttcttgcc aaatgtcatg
     2461 gcggtaaaga ggctgtccac atctctaaaa accctctgta aattccacat aatgcatctt
     2521 tcccaaagga actatcaaag aatttggtat gaagcgcaac tctcccaggg gcttaaactg
     2581 agcaaatcaa atatatactg gtatatgtgt aaccatatac aaaaacctgt tctagctgta
     2641 tgatctagtc tttacaaaac caaataaaac ttgttttctg taaatttaaa gagctttaca
     2701 aagttccata atgtaaccat atcaaaattc attttgttag agcaggtata gaaaagagta
     2761 cataagagtt taccaatcat catcacattg tattccacta aataaataca taagccttat
     2821 ttgcagtgtc tgtagtgatt ttaaaaatgt agaaaaatac tatttgttct aaatactttt
     2881 aagcaataac tataatagta tattgatgct gcagttttat cttcatattt cttgttttga
     2941 aaaagcattt tattgtttgg acacagtatt ttggtacaaa aaaaaagact cactaaatgt
     3001 gtcttactaa agtttaacct ttggaaatgc tggcgttctg tgattctcca acaaacttat
     3061 ttgtgtcaat acttaaccag cacttccagt taatctgtta tttttaaaaa ttgctttatt
     3121 aagaaatttt ttgtataatc ccataaaagg tcatattttt cccattcttc aaaaaaactg
     3181 tatttcagaa gaaacacatt tgaggcactg tcttttggct tatagtttaa attgcatttc
     3241 atcatacttt gcttccaact tgctttttgg caaatgagat tataaaaatg tttaattttt
     3301 gtggttggaa tctggatgtt aaaatttaat tggtaactca gtctgtgagc tataatgtaa
     3361 tgcattccta tcaaaactag gtatcttttt ttcctttatt ttaaaataat aattgcacct
     3421 gacacataaa catagaccac ccacaaccaa aattaaatgt ttggtaagac aaatacacat
     3481 tggatgacca cagtaacagc aaacagggca caaactggat tcttatttca catagacatt
     3541 tagattacta aagagactat gtgtaaacag tcatcattat agtactcaag acactaaaac
     3601 agcttctagc aaaatatatt aaagcttgca gaggccaaaa atagaaaaca tctccctgtc
     3661 tctcccacat ttccctcaca gaaagacaaa aaacctgcct ggtgcagtag ctcacacctg
     3721 taatcccagc agtttgggag actgtgggaa gatggcttga gtccaggagt tctagacagg
     3781 cctgagaaac ctagtgagac atccttctct taaacaaaac aaaacaaaac aaatgtagcc
     3841 atgcgtggtg gcatatacct gtggtcccaa ctactcagga ggctgaaacg gaaggatctc
     3901 ttgggcccag gagtttgagg ctgcagtgag ctataatctt gccattgcac tccagcctgg
     3961 gtgaaaaaga gccagaaaga aaggaaagag agaaaagaga aaagaaagag agaaaagaca
     4021 gaaagacagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaagcaa
     4081 ggaaagaagg aaggaaggaa agaagggagg gaaggaagga gagagaaaga aagattgttt
     4141 ggtaaggagt aatgacattc tcttgcattt aaaagtggca tatttgcttg aaatggaaat
     4201 agaattctgg tcccttttgc aactactgaa gaaaaaaaaa agcagtttca gccctgaatg
     4261 ttgtagattt gaaaaaaaaa aaaattggag ctattgagag atctgcctct gtaggagtat
     4321 ggtcccaggc ccacaaagtt aaagtgcatc agccacaaat atgtgtccat ttgagttttg
     4381 gttctgagaa tactcctcat aaagatatag aatcactccc tcctcctaac tcgcaaaagg
     4441 ctgaacagtg tatagtatgt tacatttaaa taaaaacaat aaaaatgttg ggaaaagaaa
     4501 attaaaatat tgtccttgtt tgttttatta gtcagaaact ctacctggta ataaagagag
     4561 aagctcaagt gtgtgcatgg caggatgtgg ttaaatgccc cacagcccca aacaacaaca
     4621 acagaaaaaa aaattactca aacatttgta agttttctct aatgtttcac atgtgtgagt
     4681 tagctatctt tactctaata acaaccaaat gctttcaatc ttttctaaat attcaggtcc
     4741 acctaattta cacagtggat aaagaaaaat gaattggaaa cgaggatggc ttatgaaaca
     4801 atggaagact tttggaggaa agccaggtgg ctgcagaatc tgatttcaag gggatgaatg
     4861 accaatgaat ttgatttgaa aattagagag aaaaaataca taataatgca agttgcttcc
     4921 agggcccaag caagtttatg aacccaattt acatagatca gcattaatgc tgcacagttc
     4981 taataatttg gatgctgcca attcaaggtt tgtgattatt cagtgaagta aaatttacct
     5041 ttttcatatt actgaagggt tcagctggtc caaactttgt ctaaataaag ttatatatgt
     5101 agcttaaaat atttaagaga agatgtctag tacattagaa gtaggacata tacatgcaaa
     5161 cagataccat attgattaag agttcttgtt tatttcatga agcaggactt ttccaactta
     5221 aactgaaaaa aaaataaaaa ggaagaggaa tatctttgaa ggatgctcag gagaaaaagg
     5281 aactctgagt tctatgagta cttagaaatg aagtaacgaa gatctgcttc ttctcagaca
     5341 ttcattttct gttacccttc attggtttta tttggttagg ccagattgct tctagtctac
     5401 ttctttccta ctccaaaacc caaaacccca aactccttta ctacaagatc caaaaaggta
     5461 aacatcctag atataactct tattggccag gtttggataa cataccaacc tctagaccaa
     5521 tcagtataag agatttggga attgtgattg accaatcttc agtgacatga ccacagagag
     5581 gcaaggtgaa gattttggca gcccacacaa ccgcaactag tgaagaagag tacaccaagg
     5641 agacagcagt gctgcaggtg caaaaaccaa atggttgttt gctacatctt attaaatgaa
     5701 gctgtgacat aaaaacattt tctattccta tatttcccac caattccaat tattcttcac
     5761 ctgtttgttt gtccaagtta gagaggtttt aagatcattc tctttcatat gttctttacc
     5821 attgaaagat tacatttgca ttgttttgtt ttaagccaag agtagggccc tggatatagc
     5881 taggctcact gtggttttgc aaactttata ttgggatgaa tgcaagtttt cactgaataa
     5941 aaagctggtc ctcctacttc aacctgtatc acaatatgat gttataaatg tttctttcag
     6001 tttatcccaa gagtatgtgc tagtattttc aagtgtatcg acatatagaa aaaatctgaa
     6061 accctgatgt cattcattgt ttaagtgtaa aataaaaaaa aaacagaaaa aaa
//
