LOCUS       NM_033137               3616 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 1 (FGF1), transcript variant
            3, mRNA.
ACCESSION   NM_033137
VERSION     NM_033137.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3616)
  AUTHORS   Jamal,S.B. and Hockman,D.
  TITLE     FGF1.
  JOURNAL   Differentiation 139, 100802 (2024)
   PUBMED   39074995
  REMARK    GeneRIF: FGF1.
            Review article
REFERENCE   2  (bases 1 to 3616)
  AUTHORS   Tarapongpun,T., Onlamoon,N., Tabu,K., Chuthapisith,S. and Taga,T.
  TITLE     The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells
  JOURNAL   Genes Cells 29 (3), 231-253 (2024)
   PUBMED   38253356
  REMARK    GeneRIF: The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells.
REFERENCE   3  (bases 1 to 3616)
  AUTHORS   Lampart,A., Krowarsch,D., Biadun,M., Sorensen,V., Szymczyk,J.,
            Sluzalska,K., Wiedlocha,A., Otlewski,J. and Zakrzewska,M.
  TITLE     Intracellular FGF1 protects cells from apoptosis through direct
            interaction with p53
  JOURNAL   Cell Mol Life Sci 80 (10), 311 (2023)
   PUBMED   37783936
  REMARK    GeneRIF: Intracellular FGF1 protects cells from apoptosis through
            direct interaction with p53.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3616)
  AUTHORS   Li,Y.X., Shu,J., Kou,N.N., Chen,H.B., Guo,L.M., Yuan,Y., He,S.X.
            and Zhao,G.
  TITLE     FGF1 reduces cartilage injury in osteoarthritis via regulating
            AMPK/Nrf2 pathway
  JOURNAL   J Mol Histol 54 (5), 427-438 (2023)
   PUBMED   37659992
  REMARK    GeneRIF: FGF1 reduces cartilage injury in osteoarthritis via
            regulating AMPK/Nrf2 pathway.
REFERENCE   5  (bases 1 to 3616)
  AUTHORS   Wang,D., Wang,C., Sun,L., Lu,X., Shi,J., Chen,J. and Zhang,X.
  TITLE     MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells
            Through FGF1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 256-262 (2022)
   PUBMED   35818245
  REMARK    GeneRIF: MiR-143-3p Increases the Radiosensitivity of Breast Cancer
            Cells Through FGF1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3616)
  AUTHORS   Beenken,A. and Mohammadi,M.
  TITLE     The FGF family: biology, pathophysiology and therapy
  JOURNAL   Nat Rev Drug Discov 8 (3), 235-253 (2009)
   PUBMED   19247306
  REMARK    Review article
REFERENCE   7  (bases 1 to 3616)
  AUTHORS   Yu,Y.L., Kha,H., Golden,J.A., Migchielsen,A.A., Goetzl,E.J. and
            Turck,C.W.
  TITLE     An acidic fibroblast growth factor protein generated by alternate
            splicing acts like an antagonist
  JOURNAL   J Exp Med 175 (4), 1073-1080 (1992)
   PUBMED   1372643
REFERENCE   8  (bases 1 to 3616)
  AUTHORS   Zhu,X., Komiya,H., Chirino,A., Faham,S., Fox,G.M., Arakawa,T.,
            Hsu,B.T. and Rees,D.C.
  TITLE     Three-dimensional structures of acidic and basic fibroblast growth
            factors
  JOURNAL   Science 251 (4989), 90-93 (1991)
   PUBMED   1702556
REFERENCE   9  (bases 1 to 3616)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 3616)
  AUTHORS   Chiu,I.M., Wang,W.P. and Lehtoma,K.
  TITLE     Alternative splicing generates two forms of mRNA coding for human
            heparin-binding growth factor 1
  JOURNAL   Oncogene 5 (5), 755-762 (1990)
   PUBMED   1693186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005592.1 and AC005370.1.
            
            On May 31, 2019 this sequence version replaced NM_033137.3.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein functions as a modifier of endothelial cell
            migration and proliferation, as well as an angiogenic factor. It
            acts as a mitogen for a variety of mesoderm- and
            neuroectoderm-derived cells in vitro, thus is thought to be
            involved in organogenesis. Multiple alternatively spliced variants
            encoding different isoforms have been described. [provided by
            RefSeq, Jan 2009].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            and lacks a coding exon in the coding region, which results in a
            frameshift, compared to variant 1. The encoded isoform (3) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.112940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC005592.1         50169-50277
            110-312             AC005370.1         44992-45194
            313-3616            AC005370.1         63672-66975
FEATURES             Location/Qualifiers
     source          1..3616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3616
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="fibroblast growth factor 1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
     exon            1..109
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..312
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..323
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     endothelial cell growth factor, alpha; endothelial cell
                     growth factor, beta; heparin-binding growth factor 1;
                     beta-endothelial cell growth factor; fibroblast growth
                     factor 1 (acidic)"
                     /codon_start=1
                     /product="fibroblast growth factor 1 isoform 3"
                     /protein_id="NP_149128.1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
                     /translation="MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDG
                     TVDGTRDRSDQHNTK"
     exon            313..3616
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3593..3598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="hexamer: AATAAA"
     polyA_site      3616
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcatac cagtgtcagc tgcacttgta ggggcccaag tgcctcatga cccactcggc
       61 agccttcctc tccaggatcc ccaaggctag gaggccaacc tactaacagt cttgaaagcg
      121 ccacaagcag cagctgctga gccatggctg aaggggaaat caccaccttc acagccctga
      181 ccgagaagtt taatctgcct ccagggaatt acaagaagcc caaactcctc tactgtagca
      241 acgggggcca cttcctgagg atccttccgg atggcacagt ggatgggaca agggacagga
      301 gcgaccagca caacaccaaa tgaggaatgt ttgttcctgg aaaggctgga ggagaaccat
      361 tacaacacct atatatccaa gaagcatgca gagaagaatt ggtttgttgg cctcaagaag
      421 aatgggagct gcaaacgcgg tcctcggact cactatggcc agaaagcaat cttgtttctc
      481 cccctgccag tctcttctga ttaaagagat ctgttctggg tgttgaccac tccagagaag
      541 tttcgagggg tcctcacctg gttgacccaa aaatgttccc ttgaccattg gctgcgctaa
      601 cccccagccc acagagcctg aatttgtaag caacttgctt ctaaatgccc agttcacttc
      661 tttgcagagc cttttacccc tgcacagttt agaacagagg gaccaaattg cttctaggag
      721 tcaactggct ggccagtctg ggtctgggtt tggatctcca attgcctctt gcaggctgag
      781 tccctccatg caaaagtggg gctaaatgaa gtgtgttaag gggtcggcta agtgggacat
      841 tagtaactgc acactatttc cctctactga gtaaacccta tctgtgattc ccccaaacat
      901 ctggcatggc tcccttttgt ccttcctgtg ccctgcaaat attagcaaag aagcttcatg
      961 ccaggttagg aaggcagcat tccatgacca gaaacaggga caaagaaatc cccccttcag
     1021 aacagaggca tttaaaatgg aaaagagaga ttggattttg gtgggtaact tagaaggatg
     1081 gcatctccat gtagaataaa tgaagaaagg gaggcccagc cgcaggaagg cagaataaat
     1141 ccttgggagt cattaccacg ccttgacctt cccaaggtta ctcagcagca gagagccctg
     1201 ggtgacttca ggtggagagc actagaagtg gtttcctgat aacaagcaag gatatcagag
     1261 ctgggaaatt catgtggatc tggggactga gtgtgggagt gcagagaaag aaagggaaac
     1321 tggctgaggg gataccataa aaagaggatg atttcagaag gagaaggaaa aagaaagtaa
     1381 tgccacacat tgtgcttggc ccctggtaag cagaggcttt ggggtcctag cccagtgctt
     1441 ctccaacact gaagtgcttg cagatcatct ggggacctgg tttgaatgga gattctgatt
     1501 cagtgggttg ggggcagagt ttctgcagtt ccatcaggtc ccccccaggt gcaggtgctg
     1561 acaatactgc tgccttaccc gccatacatt aaggagcagg gtcctggtcc taaagagtta
     1621 ttcaaatgaa ggtggttcga cgccccgaac ctcacctgac ctcaactaac ccttaaaaat
     1681 gcacacctca tgagtctacc tgagcattca ggcagcactg acaatagtta tgcctgtact
     1741 aaggagcatg attttaagag gctttggccc aatgcctata aaatgcccat ttcgaagata
     1801 tacaaaaaca tacttcaaaa atgttaaacc cttaccaaca gcttttccca ggagaccatt
     1861 tgtattacca ttacttgtat aaatacactt cctgcttaaa cttgacccag gtggctagca
     1921 aattagaaac accattcatc tctaacatat gatactgatg ccatgtaaag gcctttaata
     1981 agtcattgaa atttactgtg agactgtatg ttttaattgc atttaaaaat atatagcttg
     2041 aaagcagtta aactgattag tattcaggca ctgagaatga tagtaatagg atacaatgta
     2101 taagctactc acttatctga tacttattta cctataaaat gagatttttg ttttccactg
     2161 tgctattaca aattttcttt tgaaagtagg aactcttaag caatggtaat tgtgaataaa
     2221 aattgatgag agtgttagct cctgtttcat atgaaattga agtaattgtt aactaaaaac
     2281 aattccttag taactgaact gtcatattta gaatggaagg aaaatgacag tttgtgaaag
     2341 ttcaaagcaa tagtgcaatt gaagaattga cctaagtaag ctgacattat ggttaataat
     2401 agtattttag atttgtgcag caaaataatt tcataacttt tttgtttttg ttacttggat
     2461 aagatcaatc tgttttattt tagtaaatct ttgcaggcaa gttagagaaa atgcagtgtg
     2521 gcttaacgtc tctttagtat gaagatttgg ccagaaaaag atacccagag aggaaatcta
     2581 agataattat aatggtccat actttttatt gtatgaatca aactcaagca taacattggc
     2641 caaggaaaat taaataccat tgctaacttg tgaaatggaa gtctgtgatt tcggagatgc
     2701 aaagcattgt agtaaaaaca ccaatgtgac ctcgaccatc tcagcccaga tatcattcat
     2761 atatctgttc aatgactatt aaggtgccta ctgtgtgcta ggcactgtac tggatactgg
     2821 ggaccttgtc tgtctggttt gctgctgtat cttctcccag ggcattatat ttatgatgaa
     2881 agatgctgtg gattcaattc tttcagtcaa gaataaacac agactttgta ggttcctgct
     2941 gaataaagca aatcccagaa acccagattt tggaagaatc agcaacccca gcataaaata
     3001 aacccctatc aaaatgtcag aggacatggc aaggtaaact tagcattttc aactttagaa
     3061 ccgggtcagc ttcaggggga ctgctttcaa atcagccaaa gagcctgtca gatcttctta
     3121 gaaggaagag gttggtagtt ccctgctctg ttttgaacat gctctagttt attaacctgg
     3181 ggacattccc attgctgtct taagtaagtc tcatagccag ctcctgtcac gtgactctca
     3241 tatggattca ttttcgggcc agctctgaac aaagcatcat gaacatatgt gcttttggtc
     3301 gtttgcaatg tgatggtggt ggaggtaggt attggtttcc ttggaaggca tgataagaaa
     3361 gattcacaat ggccaacagt gtgtatgaac aaaaaactga ttggagcatc agctagtact
     3421 gaaggtcctt gctttgtgtc agaggcaaag gaacccaagg cgccaagtcc tcagccttga
     3481 gtgtactgct gacaactaaa ctcacaggct gcaaagcaga cctctgatga agatgcctgt
     3541 tatttcacat cactgtcttt ttgtgtatca tagtctgcac cttacaaata ttaataaatg
     3601 ttccaataat aggtga
//
