LOCUS       NM_033136               3644 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 1 (FGF1), transcript variant
            2, mRNA.
ACCESSION   NM_033136
VERSION     NM_033136.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3644)
  AUTHORS   Jamal,S.B. and Hockman,D.
  TITLE     FGF1.
  JOURNAL   Differentiation 139, 100802 (2024)
   PUBMED   39074995
  REMARK    GeneRIF: FGF1.
            Review article
REFERENCE   2  (bases 1 to 3644)
  AUTHORS   Tarapongpun,T., Onlamoon,N., Tabu,K., Chuthapisith,S. and Taga,T.
  TITLE     The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells
  JOURNAL   Genes Cells 29 (3), 231-253 (2024)
   PUBMED   38253356
  REMARK    GeneRIF: The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells.
REFERENCE   3  (bases 1 to 3644)
  AUTHORS   Lampart,A., Krowarsch,D., Biadun,M., Sorensen,V., Szymczyk,J.,
            Sluzalska,K., Wiedlocha,A., Otlewski,J. and Zakrzewska,M.
  TITLE     Intracellular FGF1 protects cells from apoptosis through direct
            interaction with p53
  JOURNAL   Cell Mol Life Sci 80 (10), 311 (2023)
   PUBMED   37783936
  REMARK    GeneRIF: Intracellular FGF1 protects cells from apoptosis through
            direct interaction with p53.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3644)
  AUTHORS   Li,Y.X., Shu,J., Kou,N.N., Chen,H.B., Guo,L.M., Yuan,Y., He,S.X.
            and Zhao,G.
  TITLE     FGF1 reduces cartilage injury in osteoarthritis via regulating
            AMPK/Nrf2 pathway
  JOURNAL   J Mol Histol 54 (5), 427-438 (2023)
   PUBMED   37659992
  REMARK    GeneRIF: FGF1 reduces cartilage injury in osteoarthritis via
            regulating AMPK/Nrf2 pathway.
REFERENCE   5  (bases 1 to 3644)
  AUTHORS   Wang,D., Wang,C., Sun,L., Lu,X., Shi,J., Chen,J. and Zhang,X.
  TITLE     MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells
            Through FGF1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 256-262 (2022)
   PUBMED   35818245
  REMARK    GeneRIF: MiR-143-3p Increases the Radiosensitivity of Breast Cancer
            Cells Through FGF1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3644)
  AUTHORS   Beenken,A. and Mohammadi,M.
  TITLE     The FGF family: biology, pathophysiology and therapy
  JOURNAL   Nat Rev Drug Discov 8 (3), 235-253 (2009)
   PUBMED   19247306
  REMARK    Review article
REFERENCE   7  (bases 1 to 3644)
  AUTHORS   Yu,Y.L., Kha,H., Golden,J.A., Migchielsen,A.A., Goetzl,E.J. and
            Turck,C.W.
  TITLE     An acidic fibroblast growth factor protein generated by alternate
            splicing acts like an antagonist
  JOURNAL   J Exp Med 175 (4), 1073-1080 (1992)
   PUBMED   1372643
REFERENCE   8  (bases 1 to 3644)
  AUTHORS   Zhu,X., Komiya,H., Chirino,A., Faham,S., Fox,G.M., Arakawa,T.,
            Hsu,B.T. and Rees,D.C.
  TITLE     Three-dimensional structures of acidic and basic fibroblast growth
            factors
  JOURNAL   Science 251 (4989), 90-93 (1991)
   PUBMED   1702556
REFERENCE   9  (bases 1 to 3644)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 3644)
  AUTHORS   Chiu,I.M., Wang,W.P. and Lehtoma,K.
  TITLE     Alternative splicing generates two forms of mRNA coding for human
            heparin-binding growth factor 1
  JOURNAL   Oncogene 5 (5), 755-762 (1990)
   PUBMED   1693186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA326831.1, AC005370.1 and
            AI283639.1.
            
            On May 31, 2019 this sequence version replaced NM_033136.3.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein functions as a modifier of endothelial cell
            migration and proliferation, as well as an angiogenic factor. It
            acts as a mitogen for a variety of mesoderm- and
            neuroectoderm-derived cells in vitro, thus is thought to be
            involved in organogenesis. Multiple alternatively spliced variants
            encoding different isoforms have been described. [provided by
            RefSeq, Jan 2009].
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, which results in a frameshift, compared to variant 1. The
            encoded isoform (2) is shorter and has a distinct C-terminus,
            compared to isoform 1. Variants 2 and 23-27 encode the same isoform
            (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.99747.1,
                                           SRR1803616.113439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               DA326831.1         64-529
            467-3302            AC005370.1         63798-66633
            3303-3644           AI283639.1         10-351              c
FEATURES             Location/Qualifiers
     source          1..3644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3644
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="fibroblast growth factor 1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
     exon            1..134
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..337
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..351
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     endothelial cell growth factor, alpha; endothelial cell
                     growth factor, beta; heparin-binding growth factor 1;
                     beta-endothelial cell growth factor; fibroblast growth
                     factor 1 (acidic)"
                     /codon_start=1
                     /product="fibroblast growth factor 1 isoform 2"
                     /protein_id="NP_149127.1"
                     /db_xref="CCDS:CCDS4276.1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
                     /translation="MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDG
                     TVDGTRDRSDQHTDTK"
     exon            338..3644
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3621..3626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="hexamer: AATAAA"
     polyA_site      3644
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcag tagcctggag gttcagagag ccgggctact ctgagaagaa gacaccaagt
       61 ggattctgct tcccctggga cagcactgag cgagtgtgga gagaggtaca gccctcggcc
      121 tacaagctct ttagtcttga aagcgccaca agcagcagct gctgagccat ggctgaaggg
      181 gaaatcacca ccttcacagc cctgaccgag aagtttaatc tgcctccagg gaattacaag
      241 aagcccaaac tcctctactg tagcaacggg ggccacttcc tgaggatcct tccggatggc
      301 acagtggatg ggacaaggga caggagcgac cagcacacag acaccaaatg aggaatgttt
      361 gttcctggaa aggctggagg agaaccatta caacacctat atatccaaga agcatgcaga
      421 gaagaattgg tttgttggcc tcaagaagaa tgggagctgc aaacgcggtc ctcggactca
      481 ctatggccag aaagcaatct tgtttctccc cctgccagtc tcttctgatt aaagagatct
      541 gttctgggtg ttgaccactc cagagaagtt tcgaggggtc ctcacctggt tgacccaaaa
      601 atgttccctt gaccattggc tgcgctaacc cccagcccac agagcctgaa tttgtaagca
      661 acttgcttct aaatgcccag ttcacttctt tgcagagcct tttacccctg cacagtttag
      721 aacagaggga ccaaattgct tctaggagtc aactggctgg ccagtctggg tctgggtttg
      781 gatctccaat tgcctcttgc aggctgagtc cctccatgca aaagtggggc taaatgaagt
      841 gtgttaaggg gtcggctaag tgggacatta gtaactgcac actatttccc tctactgagt
      901 aaaccctatc tgtgattccc ccaaacatct ggcatggctc ccttttgtcc ttcctgtgcc
      961 ctgcaaatat tagcaaagaa gcttcatgcc aggttaggaa ggcagcattc catgaccaga
     1021 aacagggaca aagaaatccc cccttcagaa cagaggcatt taaaatggaa aagagagatt
     1081 ggattttggt gggtaactta gaaggatggc atctccatgt agaataaatg aagaaaggga
     1141 ggcccagccg caggaaggca gaataaatcc ttgggagtca ttaccacgcc ttgaccttcc
     1201 caaggttact cagcagcaga gagccctggg tgacttcagg tggagagcac tagaagtggt
     1261 ttcctgataa caagcaagga tatcagagct gggaaattca tgtggatctg gggactgagt
     1321 gtgggagtgc agagaaagaa agggaaactg gctgagggga taccataaaa agaggatgat
     1381 ttcagaagga gaaggaaaaa gaaagtaatg ccacacattg tgcttggccc ctggtaagca
     1441 gaggctttgg ggtcctagcc cagtgcttct ccaacactga agtgcttgca gatcatctgg
     1501 ggacctggtt tgaatggaga ttctgattca gtgggttggg ggcagagttt ctgcagttcc
     1561 atcaggtccc ccccaggtgc aggtgctgac aatactgctg ccttacccgc catacattaa
     1621 ggagcagggt cctggtccta aagagttatt caaatgaagg tggttcgacg ccccgaacct
     1681 cacctgacct caactaaccc ttaaaaatgc acacctcatg agtctacctg agcattcagg
     1741 cagcactgac aatagttatg cctgtactaa ggagcatgat tttaagaggc tttggcccaa
     1801 tgcctataaa atgcccattt cgaagatata caaaaacata cttcaaaaat gttaaaccct
     1861 taccaacagc ttttcccagg agaccatttg tattaccatt acttgtataa atacacttcc
     1921 tgcttaaact tgacccaggt ggctagcaaa ttagaaacac cattcatctc taacatatga
     1981 tactgatgcc atgtaaaggc ctttaataag tcattgaaat ttactgtgag actgtatgtt
     2041 ttaattgcat ttaaaaatat atagcttgaa agcagttaaa ctgattagta ttcaggcact
     2101 gagaatgata gtaataggat acaatgtata agctactcac ttatctgata cttatttacc
     2161 tataaaatga gatttttgtt ttccactgtg ctattacaaa ttttcttttg aaagtaggaa
     2221 ctcttaagca atggtaattg tgaataaaaa ttgatgagag tgttagctcc tgtttcatat
     2281 gaaattgaag taattgttaa ctaaaaacaa ttccttagta actgaactgt catatttaga
     2341 atggaaggaa aatgacagtt tgtgaaagtt caaagcaata gtgcaattga agaattgacc
     2401 taagtaagct gacattatgg ttaataatag tattttagat ttgtgcagca aaataatttc
     2461 ataacttttt tgtttttgtt acttggataa gatcaatctg ttttatttta gtaaatcttt
     2521 gcaggcaagt tagagaaaat gcagtgtggc ttaacgtctc tttagtatga agatttggcc
     2581 agaaaaagat acccagagag gaaatctaag ataattataa tggtccatac tttttattgt
     2641 atgaatcaaa ctcaagcata acattggcca aggaaaatta aataccattg ctaacttgtg
     2701 aaatggaagt ctgtgatttc ggagatgcaa agcattgtag taaaaacacc aatgtgacct
     2761 cgaccatctc agcccagata tcattcatat atctgttcaa tgactattaa ggtgcctact
     2821 gtgtgctagg cactgtactg gatactgggg accttgtctg tctggtttgc tgctgtatct
     2881 tctcccaggg cattatattt atgatgaaag atgctgtgga ttcaattctt tcagtcaaga
     2941 ataaacacag actttgtagg ttcctgctga ataaagcaaa tcccagaaac ccagattttg
     3001 gaagaatcag caaccccagc ataaaataaa cccctatcaa aatgtcagag gacatggcaa
     3061 ggtaaactta gcattttcaa ctttagaacc gggtcagctt cagggggact gctttcaaat
     3121 cagccaaaga gcctgtcaga tcttcttaga aggaagaggt tggtagttcc ctgctctgtt
     3181 ttgaacatgc tctagtttat taacctgggg acattcccat tgctgtctta agtaagtctc
     3241 atagccagct cctgtcacgt gactctcata tggattcatt ttcgggccag ctctgaacaa
     3301 agcatcatga acatatgtgc ttttggtcgt ttgcaatgtg atggtggtgg aggtaggtat
     3361 tggtttcctt ggaaggcatg ataagaaaga ttcacaatgg ccaacagtgt gtatgaacaa
     3421 aaaactgatt ggagcatcag ctagtactga aggtccttgc tttgtgtcag aggcaaagga
     3481 acccaaggcg ccaagtcctc agccttgagt gtactgctga caactaaact cacaggctgc
     3541 aaagcagacc tctgatgaag atgcctgtta tttcacatca ctgtcttttt gtgtatcata
     3601 gtctgcacct tacaaatatt aataaatgtt ccaataatag gtga
//
