LOCUS       NM_001354955            4146 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 1 (FGF1), transcript variant
            19, mRNA.
ACCESSION   NM_001354955
VERSION     NM_001354955.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4146)
  AUTHORS   Jamal,S.B. and Hockman,D.
  TITLE     FGF1.
  JOURNAL   Differentiation 139, 100802 (2024)
   PUBMED   39074995
  REMARK    GeneRIF: FGF1.
            Review article
REFERENCE   2  (bases 1 to 4146)
  AUTHORS   Tarapongpun,T., Onlamoon,N., Tabu,K., Chuthapisith,S. and Taga,T.
  TITLE     The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells
  JOURNAL   Genes Cells 29 (3), 231-253 (2024)
   PUBMED   38253356
  REMARK    GeneRIF: The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells.
REFERENCE   3  (bases 1 to 4146)
  AUTHORS   Lampart,A., Krowarsch,D., Biadun,M., Sorensen,V., Szymczyk,J.,
            Sluzalska,K., Wiedlocha,A., Otlewski,J. and Zakrzewska,M.
  TITLE     Intracellular FGF1 protects cells from apoptosis through direct
            interaction with p53
  JOURNAL   Cell Mol Life Sci 80 (10), 311 (2023)
   PUBMED   37783936
  REMARK    GeneRIF: Intracellular FGF1 protects cells from apoptosis through
            direct interaction with p53.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4146)
  AUTHORS   Li,Y.X., Shu,J., Kou,N.N., Chen,H.B., Guo,L.M., Yuan,Y., He,S.X.
            and Zhao,G.
  TITLE     FGF1 reduces cartilage injury in osteoarthritis via regulating
            AMPK/Nrf2 pathway
  JOURNAL   J Mol Histol 54 (5), 427-438 (2023)
   PUBMED   37659992
  REMARK    GeneRIF: FGF1 reduces cartilage injury in osteoarthritis via
            regulating AMPK/Nrf2 pathway.
REFERENCE   5  (bases 1 to 4146)
  AUTHORS   Wang,D., Wang,C., Sun,L., Lu,X., Shi,J., Chen,J. and Zhang,X.
  TITLE     MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells
            Through FGF1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 256-262 (2022)
   PUBMED   35818245
  REMARK    GeneRIF: MiR-143-3p Increases the Radiosensitivity of Breast Cancer
            Cells Through FGF1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4146)
  AUTHORS   Beenken,A. and Mohammadi,M.
  TITLE     The FGF family: biology, pathophysiology and therapy
  JOURNAL   Nat Rev Drug Discov 8 (3), 235-253 (2009)
   PUBMED   19247306
  REMARK    Review article
REFERENCE   7  (bases 1 to 4146)
  AUTHORS   Yu,Y.L., Kha,H., Golden,J.A., Migchielsen,A.A., Goetzl,E.J. and
            Turck,C.W.
  TITLE     An acidic fibroblast growth factor protein generated by alternate
            splicing acts like an antagonist
  JOURNAL   J Exp Med 175 (4), 1073-1080 (1992)
   PUBMED   1372643
REFERENCE   8  (bases 1 to 4146)
  AUTHORS   Zhu,X., Komiya,H., Chirino,A., Faham,S., Fox,G.M., Arakawa,T.,
            Hsu,B.T. and Rees,D.C.
  TITLE     Three-dimensional structures of acidic and basic fibroblast growth
            factors
  JOURNAL   Science 251 (4989), 90-93 (1991)
   PUBMED   1702556
REFERENCE   9  (bases 1 to 4146)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 4146)
  AUTHORS   Chiu,I.M., Wang,W.P. and Lehtoma,K.
  TITLE     Alternative splicing generates two forms of mRNA coding for human
            heparin-binding growth factor 1
  JOURNAL   Oncogene 5 (5), 755-762 (1990)
   PUBMED   1693186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005592.1 and AC005370.1.
            
            On May 31, 2019 this sequence version replaced NM_001354955.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein functions as a modifier of endothelial cell
            migration and proliferation, as well as an angiogenic factor. It
            acts as a mitogen for a variety of mesoderm- and
            neuroectoderm-derived cells in vitro, thus is thought to be
            involved in organogenesis. Multiple alternatively spliced variants
            encoding different isoforms have been described. [provided by
            RefSeq, Jan 2009].
            
            Transcript Variant: This variant (19), as well as variants 1, 4-7,
            9-12, 15-18, and 20, encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.248610.1,
                                           SRR1803613.65887.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               AC005592.1         50169-50568
            401-532             AC005592.1         62102-62233
            533-735             AC005370.1         44992-45194
            736-839             AC005370.1         58348-58451
            840-4146            AC005370.1         63669-66975
FEATURES             Location/Qualifiers
     source          1..4146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4146
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="fibroblast growth factor 1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
     exon            1..400
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..532
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..735
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             567..1034
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 19; endothelial cell growth factor, alpha;
                     endothelial cell growth factor, beta; heparin-binding
                     growth factor 1; beta-endothelial cell growth factor;
                     fibroblast growth factor 1 (acidic)"
                     /codon_start=1
                     /product="fibroblast growth factor 1 isoform 1 precursor"
                     /protein_id="NP_001341884.1"
                     /db_xref="CCDS:CCDS4275.1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
                     /translation="MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDG
                     TVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLE
                     RLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD"
     exon            736..839
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..4146
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4123..4128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="hexamer: AATAAA"
     polyA_site      4146
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcatac cagtgtcagc tgcacttgta ggggcccaag tgcctcatga cccactcggc
       61 agccttcctc tccaggatcc ccaaggctag gaggccaacc tactaacagg tgggtgggta
      121 tggtgtgtgg tttcactcag ttcttctcat ggggtttctc tgagctccat tcataccaga
      181 aagggagcag gagagagagg acaagtggat ccaacagcct tcgctccagg ggaatcaggg
      241 catcgcctcc ttttctggga ggacactccc ttctgatggt gaatgggaac tcccttcctc
      301 ctgcagcagc ctgcctgcag ctgtcctggt agaacagtgt ggacattgca gaagctgtca
      361 ctgccccaga aagaaagcac cccagagcca aggcaaagag agctgcagta gcctggaggt
      421 tcagagagcc gggctactct gagaagaaga caccaagtgg attctgcttc ccctgggaca
      481 gcactgagcg agtgtggaga gaggtacagc cctcggccta caagctcttt agtcttgaaa
      541 gcgccacaag cagcagctgc tgagccatgg ctgaagggga aatcaccacc ttcacagccc
      601 tgaccgagaa gtttaatctg cctccaggga attacaagaa gcccaaactc ctctactgta
      661 gcaacggggg ccacttcctg aggatccttc cggatggcac agtggatggg acaagggaca
      721 ggagcgacca gcacattcag ctgcagctca gtgcggaaag cgtgggggag gtgtatataa
      781 agagtaccga gactggccag tacttggcca tggacaccga cgggctttta tacggctcac
      841 agacaccaaa tgaggaatgt ttgttcctgg aaaggctgga ggagaaccat tacaacacct
      901 atatatccaa gaagcatgca gagaagaatt ggtttgttgg cctcaagaag aatgggagct
      961 gcaaacgcgg tcctcggact cactatggcc agaaagcaat cttgtttctc cccctgccag
     1021 tctcttctga ttaaagagat ctgttctggg tgttgaccac tccagagaag tttcgagggg
     1081 tcctcacctg gttgacccaa aaatgttccc ttgaccattg gctgcgctaa cccccagccc
     1141 acagagcctg aatttgtaag caacttgctt ctaaatgccc agttcacttc tttgcagagc
     1201 cttttacccc tgcacagttt agaacagagg gaccaaattg cttctaggag tcaactggct
     1261 ggccagtctg ggtctgggtt tggatctcca attgcctctt gcaggctgag tccctccatg
     1321 caaaagtggg gctaaatgaa gtgtgttaag gggtcggcta agtgggacat tagtaactgc
     1381 acactatttc cctctactga gtaaacccta tctgtgattc ccccaaacat ctggcatggc
     1441 tcccttttgt ccttcctgtg ccctgcaaat attagcaaag aagcttcatg ccaggttagg
     1501 aaggcagcat tccatgacca gaaacaggga caaagaaatc cccccttcag aacagaggca
     1561 tttaaaatgg aaaagagaga ttggattttg gtgggtaact tagaaggatg gcatctccat
     1621 gtagaataaa tgaagaaagg gaggcccagc cgcaggaagg cagaataaat ccttgggagt
     1681 cattaccacg ccttgacctt cccaaggtta ctcagcagca gagagccctg ggtgacttca
     1741 ggtggagagc actagaagtg gtttcctgat aacaagcaag gatatcagag ctgggaaatt
     1801 catgtggatc tggggactga gtgtgggagt gcagagaaag aaagggaaac tggctgaggg
     1861 gataccataa aaagaggatg atttcagaag gagaaggaaa aagaaagtaa tgccacacat
     1921 tgtgcttggc ccctggtaag cagaggcttt ggggtcctag cccagtgctt ctccaacact
     1981 gaagtgcttg cagatcatct ggggacctgg tttgaatgga gattctgatt cagtgggttg
     2041 ggggcagagt ttctgcagtt ccatcaggtc ccccccaggt gcaggtgctg acaatactgc
     2101 tgccttaccc gccatacatt aaggagcagg gtcctggtcc taaagagtta ttcaaatgaa
     2161 ggtggttcga cgccccgaac ctcacctgac ctcaactaac ccttaaaaat gcacacctca
     2221 tgagtctacc tgagcattca ggcagcactg acaatagtta tgcctgtact aaggagcatg
     2281 attttaagag gctttggccc aatgcctata aaatgcccat ttcgaagata tacaaaaaca
     2341 tacttcaaaa atgttaaacc cttaccaaca gcttttccca ggagaccatt tgtattacca
     2401 ttacttgtat aaatacactt cctgcttaaa cttgacccag gtggctagca aattagaaac
     2461 accattcatc tctaacatat gatactgatg ccatgtaaag gcctttaata agtcattgaa
     2521 atttactgtg agactgtatg ttttaattgc atttaaaaat atatagcttg aaagcagtta
     2581 aactgattag tattcaggca ctgagaatga tagtaatagg atacaatgta taagctactc
     2641 acttatctga tacttattta cctataaaat gagatttttg ttttccactg tgctattaca
     2701 aattttcttt tgaaagtagg aactcttaag caatggtaat tgtgaataaa aattgatgag
     2761 agtgttagct cctgtttcat atgaaattga agtaattgtt aactaaaaac aattccttag
     2821 taactgaact gtcatattta gaatggaagg aaaatgacag tttgtgaaag ttcaaagcaa
     2881 tagtgcaatt gaagaattga cctaagtaag ctgacattat ggttaataat agtattttag
     2941 atttgtgcag caaaataatt tcataacttt tttgtttttg ttacttggat aagatcaatc
     3001 tgttttattt tagtaaatct ttgcaggcaa gttagagaaa atgcagtgtg gcttaacgtc
     3061 tctttagtat gaagatttgg ccagaaaaag atacccagag aggaaatcta agataattat
     3121 aatggtccat actttttatt gtatgaatca aactcaagca taacattggc caaggaaaat
     3181 taaataccat tgctaacttg tgaaatggaa gtctgtgatt tcggagatgc aaagcattgt
     3241 agtaaaaaca ccaatgtgac ctcgaccatc tcagcccaga tatcattcat atatctgttc
     3301 aatgactatt aaggtgccta ctgtgtgcta ggcactgtac tggatactgg ggaccttgtc
     3361 tgtctggttt gctgctgtat cttctcccag ggcattatat ttatgatgaa agatgctgtg
     3421 gattcaattc tttcagtcaa gaataaacac agactttgta ggttcctgct gaataaagca
     3481 aatcccagaa acccagattt tggaagaatc agcaacccca gcataaaata aacccctatc
     3541 aaaatgtcag aggacatggc aaggtaaact tagcattttc aactttagaa ccgggtcagc
     3601 ttcaggggga ctgctttcaa atcagccaaa gagcctgtca gatcttctta gaaggaagag
     3661 gttggtagtt ccctgctctg ttttgaacat gctctagttt attaacctgg ggacattccc
     3721 attgctgtct taagtaagtc tcatagccag ctcctgtcac gtgactctca tatggattca
     3781 ttttcgggcc agctctgaac aaagcatcat gaacatatgt gcttttggtc gtttgcaatg
     3841 tgatggtggt ggaggtaggt attggtttcc ttggaaggca tgataagaaa gattcacaat
     3901 ggccaacagt gtgtatgaac aaaaaactga ttggagcatc agctagtact gaaggtcctt
     3961 gctttgtgtc agaggcaaag gaacccaagg cgccaagtcc tcagccttga gtgtactgct
     4021 gacaactaaa ctcacaggct gcaaagcaga cctctgatga agatgcctgt tatttcacat
     4081 cactgtcttt ttgtgtatca tagtctgcac cttacaaata ttaataaatg ttccaataat
     4141 aggtga
//
