LOCUS       NM_001257211            3778 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens fibroblast growth factor 1 (FGF1), transcript variant
            13, mRNA.
ACCESSION   NM_001257211
VERSION     NM_001257211.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3778)
  AUTHORS   Jamal,S.B. and Hockman,D.
  TITLE     FGF1.
  JOURNAL   Differentiation 139, 100802 (2024)
   PUBMED   39074995
  REMARK    GeneRIF: FGF1.
            Review article
REFERENCE   2  (bases 1 to 3778)
  AUTHORS   Tarapongpun,T., Onlamoon,N., Tabu,K., Chuthapisith,S. and Taga,T.
  TITLE     The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells
  JOURNAL   Genes Cells 29 (3), 231-253 (2024)
   PUBMED   38253356
  REMARK    GeneRIF: The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells.
REFERENCE   3  (bases 1 to 3778)
  AUTHORS   Lampart,A., Krowarsch,D., Biadun,M., Sorensen,V., Szymczyk,J.,
            Sluzalska,K., Wiedlocha,A., Otlewski,J. and Zakrzewska,M.
  TITLE     Intracellular FGF1 protects cells from apoptosis through direct
            interaction with p53
  JOURNAL   Cell Mol Life Sci 80 (10), 311 (2023)
   PUBMED   37783936
  REMARK    GeneRIF: Intracellular FGF1 protects cells from apoptosis through
            direct interaction with p53.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3778)
  AUTHORS   Li,Y.X., Shu,J., Kou,N.N., Chen,H.B., Guo,L.M., Yuan,Y., He,S.X.
            and Zhao,G.
  TITLE     FGF1 reduces cartilage injury in osteoarthritis via regulating
            AMPK/Nrf2 pathway
  JOURNAL   J Mol Histol 54 (5), 427-438 (2023)
   PUBMED   37659992
  REMARK    GeneRIF: FGF1 reduces cartilage injury in osteoarthritis via
            regulating AMPK/Nrf2 pathway.
REFERENCE   5  (bases 1 to 3778)
  AUTHORS   Wang,D., Wang,C., Sun,L., Lu,X., Shi,J., Chen,J. and Zhang,X.
  TITLE     MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells
            Through FGF1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 256-262 (2022)
   PUBMED   35818245
  REMARK    GeneRIF: MiR-143-3p Increases the Radiosensitivity of Breast Cancer
            Cells Through FGF1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3778)
  AUTHORS   Beenken,A. and Mohammadi,M.
  TITLE     The FGF family: biology, pathophysiology and therapy
  JOURNAL   Nat Rev Drug Discov 8 (3), 235-253 (2009)
   PUBMED   19247306
  REMARK    Review article
REFERENCE   7  (bases 1 to 3778)
  AUTHORS   Yu,Y.L., Kha,H., Golden,J.A., Migchielsen,A.A., Goetzl,E.J. and
            Turck,C.W.
  TITLE     An acidic fibroblast growth factor protein generated by alternate
            splicing acts like an antagonist
  JOURNAL   J Exp Med 175 (4), 1073-1080 (1992)
   PUBMED   1372643
REFERENCE   8  (bases 1 to 3778)
  AUTHORS   Zhu,X., Komiya,H., Chirino,A., Faham,S., Fox,G.M., Arakawa,T.,
            Hsu,B.T. and Rees,D.C.
  TITLE     Three-dimensional structures of acidic and basic fibroblast growth
            factors
  JOURNAL   Science 251 (4989), 90-93 (1991)
   PUBMED   1702556
REFERENCE   9  (bases 1 to 3778)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 3778)
  AUTHORS   Chiu,I.M., Wang,W.P. and Lehtoma,K.
  TITLE     Alternative splicing generates two forms of mRNA coding for human
            heparin-binding growth factor 1
  JOURNAL   Oncogene 5 (5), 755-762 (1990)
   PUBMED   1693186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB220987.1, DA388578.1,
            AC005370.1 and AI283639.1.
            
            On May 31, 2019 this sequence version replaced NM_001257211.1.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein functions as a modifier of endothelial cell
            migration and proliferation, as well as an angiogenic factor. It
            acts as a mitogen for a variety of mesoderm- and
            neuroectoderm-derived cells in vitro, thus is thought to be
            involved in organogenesis. Multiple alternatively spliced variants
            encoding different isoforms have been described. [provided by
            RefSeq, Jan 2009].
            
            Transcript Variant: This variant (13) differs in the 5' UTR and
            uses an alternate splice site in the 3' coding region, but
            maintains the reading frame, compared to variant 1. Variants 8, 13,
            14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA388578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2151887
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB220987.1         24-35
            13-581              DA388578.1         1-569
            582-3436            AC005370.1         63779-66633
            3437-3778           AI283639.1         10-351              c
FEATURES             Location/Qualifiers
     source          1..3778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3778
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="fibroblast growth factor 1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
     exon            1..167
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..370
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..666
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="isoform 4 is encoded by transcript variant 13;
                     endothelial cell growth factor, alpha; endothelial cell
                     growth factor, beta; heparin-binding growth factor 1;
                     beta-endothelial cell growth factor; fibroblast growth
                     factor 1 (acidic)"
                     /codon_start=1
                     /product="fibroblast growth factor 1 isoform 4"
                     /protein_id="NP_001244140.1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
                     /translation="MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDG
                     TVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSTPNEECLFLER
                     LEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD"
     exon            371..474
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..3778
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3755..3760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="hexamer: AATAAA"
     polyA_site      3778
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="major polyA site"
ORIGIN      
        1 agtttagaga ctgcaaaaat atgaatgcac catgccgcca cattatctcc attcctccag
       61 tgcccgcctg acactggccc tgaatcaggg ctggaggggg caggcatttc tcatttacta
      121 aagtgctgga tgcagccctt gaggttcggc agaagcagaa agctgcgtct tgaaagcgcc
      181 acaagcagca gctgctgagc catggctgaa ggggaaatca ccaccttcac agccctgacc
      241 gagaagttta atctgcctcc agggaattac aagaagccca aactcctcta ctgtagcaac
      301 gggggccact tcctgaggat ccttccggat ggcacagtgg atgggacaag ggacaggagc
      361 gaccagcaca ttcagctgca gctcagtgcg gaaagcgtgg gggaggtgta tataaagagt
      421 accgagactg gccagtactt ggccatggac accgacgggc ttttatacgg ctcaacacca
      481 aatgaggaat gtttgttcct ggaaaggctg gaggagaacc attacaacac ctatatatcc
      541 aagaagcatg cagagaagaa ttggtttgtt ggcctcaaga agaatgggag ctgcaaacgc
      601 ggtcctcgga ctcactatgg ccagaaagca atcttgtttc tccccctgcc agtctcttct
      661 gattaaagag atctgttctg ggtgttgacc actccagaga agtttcgagg ggtcctcacc
      721 tggttgaccc aaaaatgttc ccttgaccat tggctgcgct aacccccagc ccacagagcc
      781 tgaatttgta agcaacttgc ttctaaatgc ccagttcact tctttgcaga gccttttacc
      841 cctgcacagt ttagaacaga gggaccaaat tgcttctagg agtcaactgg ctggccagtc
      901 tgggtctggg tttggatctc caattgcctc ttgcaggctg agtccctcca tgcaaaagtg
      961 gggctaaatg aagtgtgtta aggggtcggc taagtgggac attagtaact gcacactatt
     1021 tccctctact gagtaaaccc tatctgtgat tcccccaaac atctggcatg gctccctttt
     1081 gtccttcctg tgccctgcaa atattagcaa agaagcttca tgccaggtta ggaaggcagc
     1141 attccatgac cagaaacagg gacaaagaaa tccccccttc agaacagagg catttaaaat
     1201 ggaaaagaga gattggattt tggtgggtaa cttagaagga tggcatctcc atgtagaata
     1261 aatgaagaaa gggaggccca gccgcaggaa ggcagaataa atccttggga gtcattacca
     1321 cgccttgacc ttcccaaggt tactcagcag cagagagccc tgggtgactt caggtggaga
     1381 gcactagaag tggtttcctg ataacaagca aggatatcag agctgggaaa ttcatgtgga
     1441 tctggggact gagtgtggga gtgcagagaa agaaagggaa actggctgag gggataccat
     1501 aaaaagagga tgatttcaga aggagaagga aaaagaaagt aatgccacac attgtgcttg
     1561 gcccctggta agcagaggct ttggggtcct agcccagtgc ttctccaaca ctgaagtgct
     1621 tgcagatcat ctggggacct ggtttgaatg gagattctga ttcagtgggt tgggggcaga
     1681 gtttctgcag ttccatcagg tcccccccag gtgcaggtgc tgacaatact gctgccttac
     1741 ccgccataca ttaaggagca gggtcctggt cctaaagagt tattcaaatg aaggtggttc
     1801 gacgccccga acctcacctg acctcaacta acccttaaaa atgcacacct catgagtcta
     1861 cctgagcatt caggcagcac tgacaatagt tatgcctgta ctaaggagca tgattttaag
     1921 aggctttggc ccaatgccta taaaatgccc atttcgaaga tatacaaaaa catacttcaa
     1981 aaatgttaaa cccttaccaa cagcttttcc caggagacca tttgtattac cattacttgt
     2041 ataaatacac ttcctgctta aacttgaccc aggtggctag caaattagaa acaccattca
     2101 tctctaacat atgatactga tgccatgtaa aggcctttaa taagtcattg aaatttactg
     2161 tgagactgta tgttttaatt gcatttaaaa atatatagct tgaaagcagt taaactgatt
     2221 agtattcagg cactgagaat gatagtaata ggatacaatg tataagctac tcacttatct
     2281 gatacttatt tacctataaa atgagatttt tgttttccac tgtgctatta caaattttct
     2341 tttgaaagta ggaactctta agcaatggta attgtgaata aaaattgatg agagtgttag
     2401 ctcctgtttc atatgaaatt gaagtaattg ttaactaaaa acaattcctt agtaactgaa
     2461 ctgtcatatt tagaatggaa ggaaaatgac agtttgtgaa agttcaaagc aatagtgcaa
     2521 ttgaagaatt gacctaagta agctgacatt atggttaata atagtatttt agatttgtgc
     2581 agcaaaataa tttcataact tttttgtttt tgttacttgg ataagatcaa tctgttttat
     2641 tttagtaaat ctttgcaggc aagttagaga aaatgcagtg tggcttaacg tctctttagt
     2701 atgaagattt ggccagaaaa agatacccag agaggaaatc taagataatt ataatggtcc
     2761 atacttttta ttgtatgaat caaactcaag cataacattg gccaaggaaa attaaatacc
     2821 attgctaact tgtgaaatgg aagtctgtga tttcggagat gcaaagcatt gtagtaaaaa
     2881 caccaatgtg acctcgacca tctcagccca gatatcattc atatatctgt tcaatgacta
     2941 ttaaggtgcc tactgtgtgc taggcactgt actggatact ggggaccttg tctgtctggt
     3001 ttgctgctgt atcttctccc agggcattat atttatgatg aaagatgctg tggattcaat
     3061 tctttcagtc aagaataaac acagactttg taggttcctg ctgaataaag caaatcccag
     3121 aaacccagat tttggaagaa tcagcaaccc cagcataaaa taaaccccta tcaaaatgtc
     3181 agaggacatg gcaaggtaaa cttagcattt tcaactttag aaccgggtca gcttcagggg
     3241 gactgctttc aaatcagcca aagagcctgt cagatcttct tagaaggaag aggttggtag
     3301 ttccctgctc tgttttgaac atgctctagt ttattaacct ggggacattc ccattgctgt
     3361 cttaagtaag tctcatagcc agctcctgtc acgtgactct catatggatt cattttcggg
     3421 ccagctctga acaaagcatc atgaacatat gtgcttttgg tcgtttgcaa tgtgatggtg
     3481 gtggaggtag gtattggttt ccttggaagg catgataaga aagattcaca atggccaaca
     3541 gtgtgtatga acaaaaaact gattggagca tcagctagta ctgaaggtcc ttgctttgtg
     3601 tcagaggcaa aggaacccaa ggcgccaagt cctcagcctt gagtgtactg ctgacaacta
     3661 aactcacagg ctgcaaagca gacctctgat gaagatgcct gttatttcac atcactgtct
     3721 ttttgtgtat catagtctgc accttacaaa tattaataaa tgttccaata ataggtga
//
