LOCUS       NM_000800               3748 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens fibroblast growth factor 1 (FGF1), transcript variant
            1, mRNA.
ACCESSION   NM_000800 NM_013394
VERSION     NM_000800.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3748)
  AUTHORS   Jamal,S.B. and Hockman,D.
  TITLE     FGF1.
  JOURNAL   Differentiation 139, 100802 (2024)
   PUBMED   39074995
  REMARK    GeneRIF: FGF1.
            Review article
REFERENCE   2  (bases 1 to 3748)
  AUTHORS   Tarapongpun,T., Onlamoon,N., Tabu,K., Chuthapisith,S. and Taga,T.
  TITLE     The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells
  JOURNAL   Genes Cells 29 (3), 231-253 (2024)
   PUBMED   38253356
  REMARK    GeneRIF: The optimized priming effect of FGF-1 and FGF-2 enhances
            preadipocyte lineage commitment in human adipose-derived
            mesenchymal stem cells.
REFERENCE   3  (bases 1 to 3748)
  AUTHORS   Lampart,A., Krowarsch,D., Biadun,M., Sorensen,V., Szymczyk,J.,
            Sluzalska,K., Wiedlocha,A., Otlewski,J. and Zakrzewska,M.
  TITLE     Intracellular FGF1 protects cells from apoptosis through direct
            interaction with p53
  JOURNAL   Cell Mol Life Sci 80 (10), 311 (2023)
   PUBMED   37783936
  REMARK    GeneRIF: Intracellular FGF1 protects cells from apoptosis through
            direct interaction with p53.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3748)
  AUTHORS   Li,Y.X., Shu,J., Kou,N.N., Chen,H.B., Guo,L.M., Yuan,Y., He,S.X.
            and Zhao,G.
  TITLE     FGF1 reduces cartilage injury in osteoarthritis via regulating
            AMPK/Nrf2 pathway
  JOURNAL   J Mol Histol 54 (5), 427-438 (2023)
   PUBMED   37659992
  REMARK    GeneRIF: FGF1 reduces cartilage injury in osteoarthritis via
            regulating AMPK/Nrf2 pathway.
REFERENCE   5  (bases 1 to 3748)
  AUTHORS   Wang,D., Wang,C., Sun,L., Lu,X., Shi,J., Chen,J. and Zhang,X.
  TITLE     MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells
            Through FGF1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 256-262 (2022)
   PUBMED   35818245
  REMARK    GeneRIF: MiR-143-3p Increases the Radiosensitivity of Breast Cancer
            Cells Through FGF1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3748)
  AUTHORS   Beenken,A. and Mohammadi,M.
  TITLE     The FGF family: biology, pathophysiology and therapy
  JOURNAL   Nat Rev Drug Discov 8 (3), 235-253 (2009)
   PUBMED   19247306
  REMARK    Review article
REFERENCE   7  (bases 1 to 3748)
  AUTHORS   Yu,Y.L., Kha,H., Golden,J.A., Migchielsen,A.A., Goetzl,E.J. and
            Turck,C.W.
  TITLE     An acidic fibroblast growth factor protein generated by alternate
            splicing acts like an antagonist
  JOURNAL   J Exp Med 175 (4), 1073-1080 (1992)
   PUBMED   1372643
REFERENCE   8  (bases 1 to 3748)
  AUTHORS   Zhu,X., Komiya,H., Chirino,A., Faham,S., Fox,G.M., Arakawa,T.,
            Hsu,B.T. and Rees,D.C.
  TITLE     Three-dimensional structures of acidic and basic fibroblast growth
            factors
  JOURNAL   Science 251 (4989), 90-93 (1991)
   PUBMED   1702556
REFERENCE   9  (bases 1 to 3748)
  AUTHORS   Dionne,C.A., Crumley,G., Bellot,F., Kaplow,J.M., Searfoss,G.,
            Ruta,M., Burgess,W.H., Jaye,M. and Schlessinger,J.
  TITLE     Cloning and expression of two distinct high-affinity receptors
            cross-reacting with acidic and basic fibroblast growth factors
  JOURNAL   EMBO J 9 (9), 2685-2692 (1990)
   PUBMED   1697263
REFERENCE   10 (bases 1 to 3748)
  AUTHORS   Chiu,I.M., Wang,W.P. and Lehtoma,K.
  TITLE     Alternative splicing generates two forms of mRNA coding for human
            heparin-binding growth factor 1
  JOURNAL   Oncogene 5 (5), 755-762 (1990)
   PUBMED   1693186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA189432.1, AC005370.1 and
            AI283639.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000800.4.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor (FGF) family. FGF family members possess
            broad mitogenic and cell survival activities, and are involved in a
            variety of biological processes, including embryonic development,
            cell growth, morphogenesis, tissue repair, tumor growth and
            invasion. This protein functions as a modifier of endothelial cell
            migration and proliferation, as well as an angiogenic factor. It
            acts as a mitogen for a variety of mesoderm- and
            neuroectoderm-derived cells in vitro, thus is thought to be
            involved in organogenesis. Multiple alternatively spliced variants
            encoding different isoforms have been described. [provided by
            RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) encodes the full-length
            isoform (1). Variants 1, 4-7, 9-12, and 15-20 encode the same
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.34102.1,
                                           SRR1803615.135343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMN03267763
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337706.7/ ENSP00000338548.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               DA189432.1         36-574
            540-3406            AC005370.1         63767-66633
            3407-3748           AI283639.1         10-351              c
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3748
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="fibroblast growth factor 1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
     exon            1..134
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..337
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..636
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; endothelial cell growth factor, alpha;
                     endothelial cell growth factor, beta; heparin-binding
                     growth factor 1; beta-endothelial cell growth factor;
                     fibroblast growth factor 1 (acidic)"
                     /codon_start=1
                     /product="fibroblast growth factor 1 isoform 1 precursor"
                     /protein_id="NP_000791.1"
                     /db_xref="CCDS:CCDS4275.1"
                     /db_xref="GeneID:2246"
                     /db_xref="HGNC:HGNC:3665"
                     /db_xref="MIM:131220"
                     /translation="MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDG
                     TVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLE
                     RLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD"
     exon            338..441
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..3748
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3725..3730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="hexamer: AATAAA"
     polyA_site      3748
                     /gene="FGF1"
                     /gene_synonym="AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1;
                     FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcag tagcctggag gttcagagag ccgggctact ctgagaagaa gacaccaagt
       61 ggattctgct tcccctggga cagcactgag cgagtgtgga gagaggtaca gccctcggcc
      121 tacaagctct ttagtcttga aagcgccaca agcagcagct gctgagccat ggctgaaggg
      181 gaaatcacca ccttcacagc cctgaccgag aagtttaatc tgcctccagg gaattacaag
      241 aagcccaaac tcctctactg tagcaacggg ggccacttcc tgaggatcct tccggatggc
      301 acagtggatg ggacaaggga caggagcgac cagcacattc agctgcagct cagtgcggaa
      361 agcgtggggg aggtgtatat aaagagtacc gagactggcc agtacttggc catggacacc
      421 gacgggcttt tatacggctc acagacacca aatgaggaat gtttgttcct ggaaaggctg
      481 gaggagaacc attacaacac ctatatatcc aagaagcatg cagagaagaa ttggtttgtt
      541 ggcctcaaga agaatgggag ctgcaaacgc ggtcctcgga ctcactatgg ccagaaagca
      601 atcttgtttc tccccctgcc agtctcttct gattaaagag atctgttctg ggtgttgacc
      661 actccagaga agtttcgagg ggtcctcacc tggttgaccc aaaaatgttc ccttgaccat
      721 tggctgcgct aacccccagc ccacagagcc tgaatttgta agcaacttgc ttctaaatgc
      781 ccagttcact tctttgcaga gccttttacc cctgcacagt ttagaacaga gggaccaaat
      841 tgcttctagg agtcaactgg ctggccagtc tgggtctggg tttggatctc caattgcctc
      901 ttgcaggctg agtccctcca tgcaaaagtg gggctaaatg aagtgtgtta aggggtcggc
      961 taagtgggac attagtaact gcacactatt tccctctact gagtaaaccc tatctgtgat
     1021 tcccccaaac atctggcatg gctccctttt gtccttcctg tgccctgcaa atattagcaa
     1081 agaagcttca tgccaggtta ggaaggcagc attccatgac cagaaacagg gacaaagaaa
     1141 tccccccttc agaacagagg catttaaaat ggaaaagaga gattggattt tggtgggtaa
     1201 cttagaagga tggcatctcc atgtagaata aatgaagaaa gggaggccca gccgcaggaa
     1261 ggcagaataa atccttggga gtcattacca cgccttgacc ttcccaaggt tactcagcag
     1321 cagagagccc tgggtgactt caggtggaga gcactagaag tggtttcctg ataacaagca
     1381 aggatatcag agctgggaaa ttcatgtgga tctggggact gagtgtggga gtgcagagaa
     1441 agaaagggaa actggctgag gggataccat aaaaagagga tgatttcaga aggagaagga
     1501 aaaagaaagt aatgccacac attgtgcttg gcccctggta agcagaggct ttggggtcct
     1561 agcccagtgc ttctccaaca ctgaagtgct tgcagatcat ctggggacct ggtttgaatg
     1621 gagattctga ttcagtgggt tgggggcaga gtttctgcag ttccatcagg tcccccccag
     1681 gtgcaggtgc tgacaatact gctgccttac ccgccataca ttaaggagca gggtcctggt
     1741 cctaaagagt tattcaaatg aaggtggttc gacgccccga acctcacctg acctcaacta
     1801 acccttaaaa atgcacacct catgagtcta cctgagcatt caggcagcac tgacaatagt
     1861 tatgcctgta ctaaggagca tgattttaag aggctttggc ccaatgccta taaaatgccc
     1921 atttcgaaga tatacaaaaa catacttcaa aaatgttaaa cccttaccaa cagcttttcc
     1981 caggagacca tttgtattac cattacttgt ataaatacac ttcctgctta aacttgaccc
     2041 aggtggctag caaattagaa acaccattca tctctaacat atgatactga tgccatgtaa
     2101 aggcctttaa taagtcattg aaatttactg tgagactgta tgttttaatt gcatttaaaa
     2161 atatatagct tgaaagcagt taaactgatt agtattcagg cactgagaat gatagtaata
     2221 ggatacaatg tataagctac tcacttatct gatacttatt tacctataaa atgagatttt
     2281 tgttttccac tgtgctatta caaattttct tttgaaagta ggaactctta agcaatggta
     2341 attgtgaata aaaattgatg agagtgttag ctcctgtttc atatgaaatt gaagtaattg
     2401 ttaactaaaa acaattcctt agtaactgaa ctgtcatatt tagaatggaa ggaaaatgac
     2461 agtttgtgaa agttcaaagc aatagtgcaa ttgaagaatt gacctaagta agctgacatt
     2521 atggttaata atagtatttt agatttgtgc agcaaaataa tttcataact tttttgtttt
     2581 tgttacttgg ataagatcaa tctgttttat tttagtaaat ctttgcaggc aagttagaga
     2641 aaatgcagtg tggcttaacg tctctttagt atgaagattt ggccagaaaa agatacccag
     2701 agaggaaatc taagataatt ataatggtcc atacttttta ttgtatgaat caaactcaag
     2761 cataacattg gccaaggaaa attaaatacc attgctaact tgtgaaatgg aagtctgtga
     2821 tttcggagat gcaaagcatt gtagtaaaaa caccaatgtg acctcgacca tctcagccca
     2881 gatatcattc atatatctgt tcaatgacta ttaaggtgcc tactgtgtgc taggcactgt
     2941 actggatact ggggaccttg tctgtctggt ttgctgctgt atcttctccc agggcattat
     3001 atttatgatg aaagatgctg tggattcaat tctttcagtc aagaataaac acagactttg
     3061 taggttcctg ctgaataaag caaatcccag aaacccagat tttggaagaa tcagcaaccc
     3121 cagcataaaa taaaccccta tcaaaatgtc agaggacatg gcaaggtaaa cttagcattt
     3181 tcaactttag aaccgggtca gcttcagggg gactgctttc aaatcagcca aagagcctgt
     3241 cagatcttct tagaaggaag aggttggtag ttccctgctc tgttttgaac atgctctagt
     3301 ttattaacct ggggacattc ccattgctgt cttaagtaag tctcatagcc agctcctgtc
     3361 acgtgactct catatggatt cattttcggg ccagctctga acaaagcatc atgaacatat
     3421 gtgcttttgg tcgtttgcaa tgtgatggtg gtggaggtag gtattggttt ccttggaagg
     3481 catgataaga aagattcaca atggccaaca gtgtgtatga acaaaaaact gattggagca
     3541 tcagctagta ctgaaggtcc ttgctttgtg tcagaggcaa aggaacccaa ggcgccaagt
     3601 cctcagcctt gagtgtactg ctgacaacta aactcacagg ctgcaaagca gacctctgat
     3661 gaagatgcct gttatttcac atcactgtct ttttgtgtat catagtctgc accttacaaa
     3721 tattaataaa tgttccaata ataggtga
//
