LOCUS       NM_018351               9291 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens FYVE, RhoGEF and PH domain containing 6 (FGD6), mRNA.
ACCESSION   NM_018351 XM_370702
VERSION     NM_018351.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9291)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 9291)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9291)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 9291)
  AUTHORS   Huang,L., Zhang,H., Cheng,C.Y., Wen,F., Tam,P.O., Zhao,P., Chen,H.,
            Li,Z., Chen,L., Tai,Z., Yamashiro,K., Deng,S., Zhu,X., Chen,W.,
            Cai,L., Lu,F., Li,Y., Cheung,C.M., Shi,Y., Miyake,M., Lin,Y.,
            Gong,B., Liu,X., Sim,K.S., Yang,J., Mori,K., Zhang,X.,
            Cackett,P.D., Tsujikawa,M., Nishida,K., Hao,F., Ma,S., Lin,H.,
            Cheng,J., Fei,P., Lai,T.Y., Tang,S., Laude,A., Inoue,S., Yeo,I.Y.,
            Sakurada,Y., Zhou,Y., Iijima,H., Honda,S., Lei,C., Zhang,L.,
            Zheng,H., Jiang,D., Zhu,X., Wong,T.Y., Khor,C.C., Pang,C.P.,
            Yoshimura,N. and Yang,Z.
  TITLE     A missense variant in FGD6 confers increased risk of polypoidal
            choroidal vasculopathy
  JOURNAL   Nat Genet 48 (6), 640-647 (2016)
   PUBMED   27089177
  REMARK    GeneRIF: data suggest that oxidized phospholipids and FGD6-Arg329
            might act synergistically to increase susceptibility to PCV
REFERENCE   5  (bases 1 to 9291)
  AUTHORS   Low,S.K., Chung,S., Takahashi,A., Zembutsu,H., Mushiroda,T.,
            Kubo,M. and Nakamura,Y.
  TITLE     Genome-wide association study of chemotherapeutic agent-induced
            severe neutropenia/leucopenia for patients in Biobank Japan
  JOURNAL   Cancer Sci 104 (8), 1074-1082 (2013)
   PUBMED   23648065
REFERENCE   6  (bases 1 to 9291)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 9291)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127165.4, AK124904.1, AK128492.1 and AC011598.33.
            
            On Nov 22, 2018 this sequence version replaced NM_018351.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124904.1, SRR11853567.7653.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343958.9/ ENSP00000344446.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC127165.4         53985-53987         c
            4-2614              AK124904.1         1-2611
            2615-3118           AK128492.1         1489-1992
            3119-4999           AK124904.1         3116-4996
            5000-9291           AC011598.33        18892-23183
FEATURES             Location/Qualifiers
     source          1..9291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..9291
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /note="FYVE, RhoGEF and PH domain containing 6"
                     /db_xref="GeneID:55785"
                     /db_xref="HGNC:HGNC:21740"
                     /db_xref="MIM:613520"
     exon            1..243
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..4520
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /note="zinc finger FYVE domain-containing protein 24"
                     /codon_start=1
                     /product="FYVE, RhoGEF and PH domain-containing protein 6"
                     /protein_id="NP_060821.3"
                     /db_xref="CCDS:CCDS31878.1"
                     /db_xref="GeneID:55785"
                     /db_xref="HGNC:HGNC:21740"
                     /db_xref="MIM:613520"
                     /translation="MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQS
                     TKKMKPAIAPKPKVLKTSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQS
                     NDYISPMCSCSSECIHKLGHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCD
                     LYGEKAKNQGGVVLKASVLEEELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQF
                     RIEFADLSPSPSSFEKVPDHHSCHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALE
                     NGKRSTLISSDGVSKKSEVKDLGPLEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTP
                     SESTEEPGNSDSSSSCLTENSLKINKISVLHQNVLCKQEQVDKMKLGNKSELNMESNS
                     DAQDLVNSQKAMCNETTSFEKMAPSFDKDSNLSSDSTTVDGSSMSLAVDEGTGFIRCT
                     VSMSLPKQLKLTCNEHLQSGRNLGVSAPQMQKESVIKEENSLRIVPKKPQRHSLPATG
                     VLKKAASEELLEKSSYPSSEEKSSEKSLERNHLQHLCAQNRGVSSSFDMPKRASEKPV
                     WKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTKPRAKSLSAMDVEKCTKPCKDSTKK
                     NSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTGHLSSGEQKGIESDWQGLLVGEE
                     KRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAESLDDQMLSRESSSQAPYKSV
                     TSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNSSSMEDADANVYEVEEPYE
                     APDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSESSKGEPD
                     PLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIE
                     DRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTYIKE
                     FDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYL
                     KNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGR
                     VFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQE
                     AYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSE
                     NKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGL
                     DYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI
                     PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQP
                     LLGFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL"
     exon            244..2668
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2813
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2881
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2912
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3064
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3221
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3309
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3360
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3419
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3491
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3560
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3644
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3724
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3827
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3974
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4077
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4205
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            4206..4334
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4483
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..9291
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4711..4716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /note="hexamer: ATTAAA"
     polyA_site      4729
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /note="major polyA site"
     regulatory      5000..5005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /note="hexamer: AATAAA"
     polyA_site      5023
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /note="major polyA site"
     regulatory      9272..9277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /note="hexamer: AATAAA"
     polyA_site      9291
                     /gene="FGD6"
                     /gene_synonym="ZFYVE24"
                     /note="major polyA site"
ORIGIN      
        1 gctagtgctc gcccgcccga ccccggcggc tcgcgcccgg gagcgccgca gggtcgctag
       61 agtcggccgc gtcctttgtg tggcgctcag gctgcgccgc ggggcggcgg gacggaatgt
      121 gggcgctgcg ggggcttttc tctcctaccc gaactgtggg aacaatggac tgaaagggga
      181 agatggattg aggggccgag cggggaagcg agctgcaccg gggaatcatg acttctgcag
      241 ccgagataaa gaagccacca gtggccccca agcccaagtt tgttgtggca aataataagc
      301 cagccccacc tcctattgca cctaaacccg acattgtgat ttctagtgtt ccacagtcga
      361 caaagaaaat gaaaccagca atagccccaa aaccaaaagt cctgaagacc tcacctgttc
      421 gagagattgg gcagtcgcca tcaaggaaaa tcatgttgaa cctggaaggg cataaacagg
      481 aattagctga aagcactgac aactttaatt gtaaatatga aggcaatcag agcaatgatt
      541 atatttcacc aatgtgttcc tgcagttctg agtgtatcca taagctgggc catagagaga
      601 atttgtgtgt aaagcagctt gttttagagc ccctggaaat gaatgaaaat ttagaaaaca
      661 gtaaaattga tgagactttg actataaaaa ctaggagtaa atgtgatttg tatggtgaaa
      721 aagccaagaa ccagggtggg gttgttttaa aggcaagcgt tttagaagag gagctcaaag
      781 atgccttaat acaccaaatg ccacctttta tttctgcaca gaagcacagg cccacagaca
      841 gcccagaaat gaatggtggc tgtaattcaa atggacaatt cagaattgaa tttgcggatt
      901 tgtcaccttc cccatccagc tttgaaaaag ttcctgatca tcacagttgc cacttacagc
      961 ttcctagtga tgaatgtgaa cattttgaaa cttgccagga tgacagtgaa aaaagcaata
     1021 attgctttca gtcatctgaa ctagaggctc tggaaaatgg gaaaaggagt actttaatat
     1081 cttcagatgg agttagtaag aaatcagaag tcaaagacct tggtccctta gaaattcatt
     1141 tagtaccata taccccaaaa tttccaactc ccaagcccag aaagacacga actgctcgtc
     1201 tgttacgcca aaagtgtgta gatactccta gtgaaagcac tgaagaaccg gggaattcag
     1261 acagtagctc ttcctgtctt actgaaaata gtttgaaaat caataaaatc agtgttctgc
     1321 atcagaatgt tttgtgtaag caggaacagg tggataaaat gaagctagga aataaaagtg
     1381 aattgaatat ggaatccaac agtgatgcac aggacttagt caattcacag aaagccatgt
     1441 gtaatgaaac aacttccttt gaaaaaatgg caccttcttt tgataaagac tctaatttga
     1501 gttctgacag cacaactgta gatggttcta gtatgtcgct tgctgtggac gaagggaccg
     1561 gttttataag atgtactgta tctatgagcc tgcctaagca gctcaaatta acttgcaatg
     1621 aacatttgca atctgggaga aacctgggag tttctgcccc tcaaatgcaa aaggaatctg
     1681 ttataaaaga ggaaaattct ctacgaattg tccccaaaaa acctcaaaga catagcttgc
     1741 ctgctacagg agtgcttaaa aaggctgcct ccgaggagct tttggaaaaa agttcttatc
     1801 cttcaagtga agaaaaaagt tcagagaaga gtctagaaag aaatcacctt cagcatttgt
     1861 gtgcccaaaa ccgtggtgtg tcatcctcct ttgatatgcc taaacgggct tcagaaaagc
     1921 cagtgtggaa gttacctcat cctattttac ccttttcagg gaacccagaa ttcttaaagt
     1981 ctgtcaccgt atcgtcaaac agtgagcctt caacagccct aaccaagccc agagcaaaat
     2041 cgttatctgc tatggatgtg gaaaagtgca ctaagccttg caaagactct acaaagaaaa
     2101 actcttttaa aaagttgctc agcatgaaac tgtccatctg tttcatgaag agtgactttc
     2161 aaaaattttg gtccaagagt agccaactcg gagacaccac cacaggccac ctctccagtg
     2221 gggagcagaa ggggattgaa agtgattggc aaggcttgtt ggtaggagag gagaagagaa
     2281 gtaaacccat caaggcatat tccacagaaa actatagcct ggaatctcaa aagaagagga
     2341 agaagtctcg gggccagacc agtgcagcta atggtctgag agctgagtct ttggatgacc
     2401 aaatgctctc ccgggagtca tcatctcagg caccttacaa gtctgttaca agcctctgtg
     2461 caccggagta tgaaaatata cgccattatg aggaaatacc agagtacgag aacttgccat
     2521 ttattatggc tatacggaaa actcaagagt tggaatggca gaattccagc agcatggagg
     2581 acgctgatgc aaatgtgtat gaggtagaag agccgtatga agctccagat ggccagctgc
     2641 agcttggacc cagacatcag cattccagtt caggagcatc ccaggaggaa cagaatgatc
     2701 ttggtcttgg tgaccttccc tctgatgagg aggaaatcat caacagttct gatgaagatg
     2761 atgtcagctc tgagtcaagt aaaggagagc ctgacccact ggaagataaa caggatgaag
     2821 ataatggaat gaaaagtaaa gttcatcata ttgccaagga gatcatgagc tcagagaaag
     2881 tgtttgtgga tgtgttaaaa cttttgcata ttgatttccg ggatgcagta gctcatgctt
     2941 ccaggcaact tgggaaacca gtgattgagg accggattct aaatcagatc ctatactact
     3001 tgcctcagct gtatgagctc aaccgggatc tcttgaagga actggaggaa agaatgttgc
     3061 actggactga acaacaaaga attgctgata tctttgtaaa gaagggacca tatctaaaaa
     3121 tgtattccac atacatcaaa gaatttgata agaatatagc cttgctggat gaacagtgca
     3181 agaaaaatcc aggttttgct gctgttgtta gagaatttga gatgagccct cgctgtgcta
     3241 atctggccct caagcactac ctgctcaagc cggttcagag gatcccccag tacaggctgt
     3301 tgctgacaga ttatttgaag aatctcatag aagatgctgg agattacaga gacactcaag
     3361 atgcccttgc tgttgttata gaggtagcca accacgccaa tgacaccatg aagcaaggag
     3421 acaactttca gaaacttatg caaattcagt acagcttaaa tggacaccat gaaattgtgc
     3481 agcctggtcg ggtttttctc aaagaaggaa ttctgatgaa gctgtctcgg aaagtgatgc
     3541 aacctcgaat gtttttcctg tttaatgatg ccctgctgta tacaacacca gtgcagtctg
     3601 ggatgtataa actgaacaac atgctctcac tggctggaat gaaggtcaga aaacctaccc
     3661 aagaagccta tcagaatgaa ttaaagattg aaagtgtaga acgttccttc attctctcag
     3721 ccagttctgc cacagaaagg gatgaatggc tagaagcgat ttccagggca atagaagagt
     3781 atgccaagaa aagaatcacc ttctgtccta gtaggagtct tgatgaggca gactcagaaa
     3841 ataaagaaga agttagtcct cttggatcga aggctcccat ctggattcct gataccagag
     3901 ccacaatgtg tatgatctgc acaagcgaat tcactctcac ctggagacga caccactgcc
     3961 gggcctgtgg aaagattgta tgccaagctt gttcgtctaa taagtatggc ttagattacc
     4021 tgaaaaatca accagcaaga gtatgtgaac attgtttcca agaactgcag aaattagatc
     4081 accagcactc ccctaggatt ggatctcctg gaaatcacaa atctccttca agtgccttat
     4141 catcagtctt acatagcatt ccatcaggga ggaaacagaa aaaaatccca gctgctctca
     4201 aagaagtatc agcaaacaca gaggattctt ctatgagtgg ctacttgtac agatcaaagg
     4261 gcaataaaaa accctggaaa cacttttggt ttgtcataaa aaataaagta ctatatacat
     4321 atgctgcaag tgaggacgtg gccgctttgg agagtcagcc tttattagga ttcactgtta
     4381 ttcaagttaa agatgagaat tccgagtcta aagtatttca gttactgcac aaaaacatgt
     4441 tattttatgt attcaaagca gaggatgctc attcggctca gaagtggata gaagcatttc
     4501 aggaaggcac aatattgtag cagtattggt ttcatctctt ctgtgattcc aaagaggtgg
     4561 aatttcatca gaatggagta aatgcaattc aaaaattgta taaaaatgaa cactgccaag
     4621 ataaagccaa ccagaccctt catcaaagaa attgttttgt taggtataag caatttttaa
     4681 aaggtgtttg ttttttcatt tatgttattt attaaaattt tgatgtttac ttaatggtca
     4741 gaattatttc tgagacacac tgaattctaa agtaccattt ctttagagac cagaaaaact
     4801 atcttaatac tgtatactgt attaactatt cgtgacatag ttcacactgt tttcttacct
     4861 tacattgtaa caatcttact ggtggaaagt ctttgtaagg aaaaaacaca tagcaaggag
     4921 caaatttcca caaagtgctt ggtttaggaa ttgtgattat tataaaactg ctgatgaaaa
     4981 aaatgcatgt ctttgaatca ataaacttgg gtgaatattt gtatctttta gtggaaaaac
     5041 atggccagct tctacctcag taactgtgaa ctgaaatttc agtaaattat ctaaagtatt
     5101 tctgttgtta ggtacctctt tggcaggagt taatattaca tcatcaaaga attatagcaa
     5161 agagatagaa tctgaatttt ttaaaactgt gagtaggaat gaagatgttt ttatttgcag
     5221 aataccacaa ataaccaact cttccggctt ttaagtccaa tcttttaaaa aatctaccac
     5281 ttcgaaacaa acataaatgt atcatttttt aaaatagcaa aatatagcaa gcattatgtc
     5341 acataatatt ccctgctatt ataagagttc tgagcccaag tcaatgatga tatttgtatc
     5401 tataagtaat gttacatttc caaaaatatt gtgcattaca aatggaactg gaattactat
     5461 atcagaaaag cataattata agccagtaat aactgaaatt ctatagtatt cattttcaaa
     5521 aggtcttttt ctgccagttt gtgatatcct ccctcctaat taaaaaaaaa aacaacaaat
     5581 cctttctcta taagcagcta tcagcacacc tccttaggaa agatttagat tcataattct
     5641 ggtgcactta ctgtttaaca tatgaactac cttgcacata caattgttga ttagcagaag
     5701 aaaatgaaat aacactgtga taaaagccat ccctgatgtt cacaatacac aatttattaa
     5761 ctaagtttaa actataaatt atcttaactg ccatgagcgg tggctcacac ctacaatctc
     5821 agcattttgg gaggccgagg ccgttggacc acctgaggtc aggagatcga gaccagcctg
     5881 gccaatatgg tgaaacccca tctctattaa aaatacaaga attagccggt cgtggtggta
     5941 catggctgta gtcctagcta ttcagcaggc tgaggcagga gcatcgcttg aacccaggag
     6001 gcagaggttg cagtgagccg agatggtgcc actgcactcc agcctgggat gacagagcga
     6061 gactccatct caaaaaaaaa aaaaaaaaaa aaattgaaca gcaaggttat ccatataata
     6121 tttctttaaa gggtacaaga attttccttt ctgcctctaa ataaaggatt tcctaattca
     6181 gtgtgatcct taacagcaac catgaggatt actgagtgcc tttctggggc cttttgaatg
     6241 ctgtttggta cagcaccaga gtccctacta gatctagagt tggctgctat agttttttgt
     6301 ggcgattttt tgccatggag tcatttgaac ctcatacaca atcctaacat gccatcccct
     6361 ttctgtcata gcaggtacac taaaatttct ttgtagctca attttatata atcaagatca
     6421 cataaataag gcttccatgt tagaatcgtt gcagttttta gtgtattcct ttttggaggc
     6481 taaagttgta ccttataaac tgtttctgcg tctggcattt agcaagacaa gttatttggg
     6541 ttttctttcc ctcctcttga gctctcagcc ttctgactac aaggtttggc ttaagcctta
     6601 taatctaaaa aatatcagcc aggctattct atcttctaag acctggctga atcatgagcc
     6661 agttctaaat ctaaagagag tgagagaggg aagaaatctg gcacaaactt acagtctctt
     6721 taattacatg taaaatgcat gtgactgtat tacctattgg cttagcccca tggagggttt
     6781 agaaaaatgt gtagtctttg tggaagctat ccaattatcc ttctcccaaa aagatgtttt
     6841 aaatgtggaa tagtattaca ttcccctgcc cctttatgag tccttcataa cttactaaag
     6901 ctgaccaatt gttatttatg taacctggct cattcattgt caactaagaa cctaattata
     6961 tgcaatttat tgtaaaaaaa gctataaaaa tatattttgc tagtatttta gaggaaaaat
     7021 gatattgggc acagtctata aatggggaga aaagttaagt agtatctaga ttccaaggat
     7081 actatattta ttatacagat atgtgtgcct gtgcttccat caaacccttt ttcaggtatc
     7141 tccttttaat tcataaggag gaaagagtag ggcatttata aagctaagct aaaaatgatg
     7201 ctaagcataa cgtagatgag acgccaggct gaaccagggg aaggctggca ttgttagtgt
     7261 ccccaactag cagtccacct ttatctgtgg cagctataaa tgtacaggac ccatcagagt
     7321 cctaagaaaa tgagagtaat tatctctggc atcatccaca tttccgactc tttccaatct
     7381 cttttccctt tttctgtaat gtacccagca tccccctatt gtattttggt tgcccaagat
     7441 tcttgattct ttgagtgtgt agtagcattt cttaaaatga gatcatcaga ccaacccttg
     7501 attcacatga aagctgtaat gacacaacaa agagaaggcg acagttttaa agtataattg
     7561 tcagccaaat gtgtatttta tatttggttc atagaatata tctagatgtg gggaaagtct
     7621 cctatttggt aatttagtta aaatgtaaat gttatatcac agcatatgtt ggtatgtttt
     7681 ggagtgtgct tccattgtgc tcagcttttg aaaagtttga aatccacttt agtcaaatgt
     7741 agtcaatggg atttccagag atacatattg tttttcttag tgtaccacac actccttgaa
     7801 ggcagatact gtacttaata tatcactgtc ttccataata ctgccctagg tctttttagt
     7861 ttttaagaga ccgggtctcg ctatgtttcc catgctgaac tcaaatgcct gggcttaagc
     7921 aatcctccca cctcagcctc tggagtagct gggactacag gggcatgcac caccaggcct
     7981 ggcttcctag gagggtcttt aaagagaaaa tatttgttca attgaaaaca ggattcttgt
     8041 catctacaac tccaacacag cctgaaaata tccacattat aacctggacc ttagacctac
     8101 tttctccact atcctgcaaa gctacatctg taactaccta ttggctatct atatgagtcc
     8161 tcaagcatct cagactttac atgaataaaa ctcaacttcc ttcccattca aatctgttta
     8221 ttttcttctg taagagaaag ataccatttg agactccaga atctgcctct aactctcaac
     8281 aagactctgc aattactcaa gtatcctttc catcctcatt gccctgctgt tattacatag
     8341 gccctggttc aagtccttgt tacttgttcc cattattgca ataacttcta attccaatgc
     8401 cgttgtgtga tcccatttta aacacggcca gagcagtctt ccaacaacat agctctaatc
     8461 tagtttcatc cccactttta catgcctcag tggctttccc agtgacttgg catggaacac
     8521 gtcctcagtt gccatacatt ccagctaact cttacccaac ctttctttgt tcacacagtt
     8581 tccttttcct tcctcattga cccatccgca tctctgttta tccaagactt ctctgtgata
     8641 gctgaccctt agtctttctc tcccctattc ctccagacta gatcctgtct ccttcctgca
     8701 gccccgacac agccttcagt tcatatcttt tgcatgatgc ttagcacctt ctatccctaa
     8761 ggacaactta ctcatttgag atttctggca gggtaccttg catgcagtgg acactcagta
     8821 tttgctgaat taaattcctt cctatggatc ccttctgatt ttttttaagt gcctctaata
     8881 cacatatcat tctagggctc atgccacttt taatgtcatt ttctaaagga aaatcttatc
     8941 tatgatattt tcccttataa gagatagttg ttttgagtag ggttttttaa aagataaagg
     9001 tagtaggaaa ttttttaaag cctaaatatc aaattccttt ccctttggag ttgggggaag
     9061 gaatgaaggg ggagcaactt gctctttcat atgagttggt catagcatgt aagaaccaat
     9121 cttgaaatat cgtttttttt ttaatggctt ataatgtatt tctagaaata ctttgtactt
     9181 aaaatgataa cagtttgtat ctttttgtcc atatatactt tataaataaa aaaattagca
     9241 ttgtaaataa tgttaatatg tatttataca aaataaattt actataatat a
//
