LOCUS       NM_152536               5903 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens FYVE, RhoGEF and PH domain containing 5 (FGD5),
            transcript variant 1, mRNA.
ACCESSION   NM_152536 XM_371619
VERSION     NM_152536.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5903)
  AUTHORS   Gui,H., Tang,W.H.W., Francke,S., Li,J., She,R., Bazeley,P.,
            Pereira,N.L., Adams,K., Luzum,J.A., Connolly,T.M., Hernandez,A.F.,
            McNaughton,C.D., Williams,L.K. and Lanfear,D.E.
  TITLE     Common Variants on FGD5 Increase Hazard of Mortality or
            Rehospitalization in Patients With Heart Failure From the ASCEND-HF
            Trial
  JOURNAL   Circ Heart Fail 16 (9), e010438 (2023)
   PUBMED   37725680
  REMARK    GeneRIF: Common Variants on FGD5 Increase Hazard of Mortality or
            Rehospitalization in Patients With Heart Failure From the ASCEND-HF
            Trial.
REFERENCE   2  (bases 1 to 5903)
  AUTHORS   Azad,A.K., Farhan,M.A., Murray,C.R., Suzuki,K., Eitzen,G.,
            Touret,N., Moore,R.B. and Murray,A.G.
  TITLE     FGD5 regulates endothelial cell PI3 kinase-beta to promote
            neo-angiogenesis
  JOURNAL   FASEB J 36 (1), e22080 (2022)
   PUBMED   34882832
  REMARK    GeneRIF: FGD5 regulates endothelial cell PI3 kinase-beta to promote
            neo-angiogenesis.
REFERENCE   3  (bases 1 to 5903)
  AUTHORS   You,H., Gao,S., Xu,X. and Yuan,H.
  TITLE     Faciogenital dysplasia 5 confers the cancer stem cell-like traits
            of gastric cancer cells through enhancing Sox2 protein stability
  JOURNAL   Environ Toxicol 36 (12), 2426-2435 (2021)
   PUBMED   34427968
  REMARK    GeneRIF: Faciogenital dysplasia 5 confers the cancer stem cell-like
            traits of gastric cancer cells through enhancing Sox2 protein
            stability.
REFERENCE   4  (bases 1 to 5903)
  AUTHORS   Chen,N., Han,X., Yin,B., Bai,X. and Wang,Y.
  TITLE     FGD5 facilitates tumor growth by regulating EGFR ubiquitination in
            gastric cancer
  JOURNAL   Biochem Biophys Res Commun 562, 43-49 (2021)
   PUBMED   34034092
  REMARK    GeneRIF: FGD5 facilitates tumor growth by regulating EGFR
            ubiquitination in gastric cancer.
REFERENCE   5  (bases 1 to 5903)
  AUTHORS   Liu,L., Zhang,C., Wang,J., Liu,X., Qu,H., Zhang,G., Liang,T.,
            Wang,J. and Zhang,J.
  TITLE     A high level of lncFGD5-AS1 inhibits epithelial-to-Mesenchymal
            transition by regulating the miR-196a-5p/SMAD6/BMP axis in gastric
            Cancer
  JOURNAL   BMC Cancer 21 (1), 453 (2021)
   PUBMED   33892661
  REMARK    GeneRIF: A high level of lncFGD5-AS1 inhibits
            epithelial-to-Mesenchymal transition by regulating the
            miR-196a-5p/SMAD6/BMP axis in gastric Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5903)
  AUTHORS   Niu,X., Chang,W., Liu,R., Hou,R., Li,J., Wang,C., Li,X. and
            Zhang,K.
  TITLE     Expression of pro-angiogenic genes in mesenchymal stem cells
            derived from dermis of patients with psoriasis
  JOURNAL   Int J Dermatol 55 (5), e280-e288 (2016)
   PUBMED   26748901
  REMARK    GeneRIF: We provide the first report that pro-angiogenic genes
            PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological
            dermal angiogenesis disorders of psoriasis.
REFERENCE   7  (bases 1 to 5903)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   8  (bases 1 to 5903)
  AUTHORS   Nakhaei-Nejad,M., Haddad,G., Zhang,Q.X. and Murray,A.G.
  TITLE     Facio-genital dysplasia-5 regulates matrix adhesion and survival of
            human endothelial cells
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (11), 2694-2701 (2012)
   PUBMED   22922960
  REMARK    GeneRIF: FGD5 regulates endothelial adhesion, survival, and
            angiogenesis by modulating phosphatidylinositol 3-kinase signaling.
REFERENCE   9  (bases 1 to 5903)
  AUTHORS   Cheng,C., Haasdijk,R., Tempel,D., van de Kamp,E.H., Herpers,R.,
            Bos,F., Den Dekker,W.K., Blonden,L.A., de Jong,R., Burgisser,P.E.,
            Chrifi,I., Biessen,E.A., Dimmeler,S., Schulte-Merker,S. and
            Duckers,H.J.
  TITLE     Endothelial cell-specific FGD5 involvement in vascular pruning
            defines neovessel fate in mice
  JOURNAL   Circulation 125 (25), 3142-3158 (2012)
   PUBMED   22661514
  REMARK    GeneRIF: FGD5 inhibits neovascularization, indicated by in vitro
            tube-formation, aortic-ring, and coated-bead assays and by in vivo
            coated-bead plug assays and studies in the murine retina model.
            Erratum:[Circulation. 2012 Sep 18;126(12):e194]
REFERENCE   10 (bases 1 to 5903)
  AUTHORS   Kurogane,Y., Miyata,M., Kubo,Y., Nagamatsu,Y., Kundu,R.K.,
            Uemura,A., Ishida,T., Quertermous,T., Hirata,K. and Rikitake,Y.
  TITLE     FGD5 mediates proangiogenic action of vascular endothelial growth
            factor in human vascular endothelial cells
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (4), 988-996 (2012)
   PUBMED   22328776
  REMARK    GeneRIF: Suggest that FGD5 regulates proangiogenic action of VEGF
            in vascular endothelial cells, including network formation,
            permeability, directional movement, and proliferation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087591.2 and AC090937.2.
            
            On May 17, 2019 this sequence version replaced NM_152536.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132816.1, AK131078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285046.10/ ENSP00000285046.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2635              AC087591.2         100078-102712
            2636-2768           AC087591.2         145244-145376
            2769-2827           AC090937.2         10810-10868
            2828-2858           AC090937.2         10980-11010
            2859-3019           AC090937.2         27747-27907
            3020-3176           AC090937.2         28177-28333
            3177-3264           AC090937.2         28977-29064
            3265-3315           AC090937.2         30641-30691
            3316-3374           AC090937.2         31241-31299
            3375-3446           AC090937.2         37878-37949
            3447-3515           AC090937.2         41099-41167
            3516-3599           AC090937.2         47487-47570
            3600-3679           AC090937.2         48992-49071
            3680-3779           AC090937.2         52156-52255
            3780-3917           AC090937.2         52649-52786
            3918-4047           AC090937.2         53284-53413
            4048-4178           AC090937.2         54246-54376
            4179-4307           AC090937.2         56308-56436
            4308-4462           AC090937.2         62815-62969
            4463-5897           AC090937.2         63369-64803
            5898-5903           AC090937.2         64804-64809
FEATURES             Location/Qualifiers
     source          1..5903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..5903
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /note="FYVE, RhoGEF and PH domain containing 5"
                     /db_xref="GeneID:152273"
                     /db_xref="HGNC:HGNC:19117"
                     /db_xref="MIM:614788"
     exon            1..2635
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..4499
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /note="isoform 1 is encoded by transcript variant 1; FYVE,
                     RhoGEF and PH domain-containing protein 5; zinc finger
                     FYVE domain-containing protein 23"
                     /codon_start=1
                     /product="FYVE, RhoGEF and PH domain-containing protein 5
                     isoform 1"
                     /protein_id="NP_689749.3"
                     /db_xref="CCDS:CCDS46767.1"
                     /db_xref="GeneID:152273"
                     /db_xref="HGNC:HGNC:19117"
                     /db_xref="MIM:614788"
                     /translation="MFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDR
                     GLDEGPRSIPKCSESETDEDYIVVPRVPLREDEPKDEGSVGNKALVSPESSAEEEEER
                     EEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQV
                     SRSEEEEKLVQPHRECSLEDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDE
                     EGCASTDPAGADEGSGPDRPTEDMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLE
                     EGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFENDC
                     MEDFVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVGA
                     LCGQCGSLQGGAAEGPAAPDVVVVLEEEALDDALANPYVMGVGLPGQAAPGEGGQAAS
                     DALGGYGSKEELNCEAEGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSS
                     APGIGGAAEEVGKTLLSLEGKPLEASRALPAKPRAFTLYPRSFSVEGREIPVSVYQEP
                     EGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNHLPSSGTSTPSSMVDIPPPFDLACI
                     TKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALTFKKKTENKLHVDVNVSSSRSSS
                     ESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASESPSSLIFYRDGKRKGVPFSRTVS
                     RVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAMNSDYENIQIPPRRPARAG
                     AFTKLFEDQSRALSTANENDGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPISSA
                     APKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHL
                     NLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWES
                     QQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQ
                     TAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQG
                     ENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQ
                     KDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYGCLSR
                     ALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRH
                     HCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRERPVSMSF
                     PLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAISGYLSRCKRGKR
                     HWKKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEVGPIFHLYHKKT
                     LFYSFKAEDTNSAQRWIEAMEDASVL"
     exon            2636..2768
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2827
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2858
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3019
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3176
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3264
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3315
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3374
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3446
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3515
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3599
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3679
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3779
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3917
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4047
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4178
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4307
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4462
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     exon            4463..5903
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4748..4753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /note="hexamer: AATAAA"
     polyA_site      4771
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /note="major polyA site"
     regulatory      5700..5705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /note="hexamer: AATAAA"
     polyA_site      5719
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /note="major polyA site"
     regulatory      5816..5821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /note="hexamer: ATTAAA"
     polyA_site      5835
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
     regulatory      5874..5879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
                     /note="hexamer: ATTAAA"
     polyA_site      5903
                     /gene="FGD5"
                     /gene_synonym="ZFYVE23"
ORIGIN      
        1 caaaaccacc tgtcgctccc aagccaaaga ctaccagtcc actgacgcca gtgaccgcgc
       61 ccaaattccc ttcctcagcc aggcccgaga gtcttcacag tccaaactcc atgttcaggg
      121 gtccgaagcc ccccattgcc cccaagccca ggctgactgc cccaaacgag tggagagcca
      181 gtgtgtacct gaatgacagc ttgaacaaat gcagcaacgg gcggctgccc tgtgtagaca
      241 gggggcttga tgaggggccc cggtccatcc caaagtgctc tgagtcggag accgacgagg
      301 attacatcgt ggtccccagg gttccgctga gggaggatga acccaaggac gagggcagtg
      361 tggggaacaa agccctggtg tctcccgagt cctctgcgga agaggaagag gagcgtgaag
      421 agggaggcga ggcatgtggc ctggagggta caggagctgg tgaggattca gtggcccctg
      481 ctgctccggg tgcaggagcg ctgagcaggg agggtgagga aggcacagac cttgctcttg
      541 aggatgaagg ggagggctgc gctgatgagc cagggacact ggagcaggtg tccagaagtg
      601 aggaggaaga gaagctagtg cagccacaca gggagtgcag cctggaggac agtgggcctt
      661 gggctggaga gggggtcttc cagagcgacc tcctcctgcc tcacatccat ggagaggacc
      721 aggagccccc cgacaccccc ggggaggcag aggaggatga tgaggaaggc tgtgccagca
      781 cagacccagc aggggcagat gagggttcgg gtcctgacag gcccacggag gacatgggac
      841 aggatgctga ggacaccagt gaggagcccc ctgagaagga ggagctggcc ggggtccagg
      901 aggcagagac agccacagac tgccctgaag ttcttgagga gggatgtgaa gaggccacgg
      961 gtgtcacagg tggggaacag gttgacctca gtgaaccacc tgaccacgag aagaaaacca
     1021 accaagaagt ggcagccgcc accctggagg accatgcaca ggatgagtcc gccgaggaga
     1081 gctgccagat tgtccctttt gagaatgact gcatggagga cttcgtgact tccctcacag
     1141 gaagccccta tgagttcttc ccaactgaga gcacctcttt ttgcagcgag agctgttctc
     1201 ctctttctga atcagcgaaa ggtttagaat cagagcaggc accaaagctg gggctgcgtg
     1261 cggaggagaa ccccatggtg ggggctttgt gtggccagtg tggctcccta cagggtggag
     1321 cggccgaggg tcccgcagcc cctgatgtgg tggtcgtgct ggaggaggag gccttggatg
     1381 atgcactggc caacccctat gtgatgggag tgggcctgcc cggtcaggcg gcccctggag
     1441 aaggagggca ggctgcatcg gacgccctgg gtggttatgg ctcgaaagaa gaattgaact
     1501 gtgaggcaga gggtggcctg gttcccgcgg acaggaagaa caccagcacg agggtccggc
     1561 cccactctgg gaaggtggcc ggctatgtcc cagaaaccgt ccctgaagaa accggacctg
     1621 aggcgggctc gtcagcccct ggcattggag gtgccgcaga ggaggtggga aagacgcttt
     1681 tgtcattgga ggggaagccc ttggaagcca gcagggcctt gccagcaaag cccagggcct
     1741 ttactttata ccctcggtcg ttctccgtgg aaggccgaga gattccagtg tccgtgtacc
     1801 aggagcctga ggggtcaggg ttggatgacc acaggataaa gaggaaagag gacaatctct
     1861 ctctgtcgtg tgtaattggc tcctctggga gtttctccca gagaaaccac cttccgtcca
     1921 gcggcacctc cacgccttct tccatggtcg acatcccacc tcctttcgac ctggcctgca
     1981 tcaccaagaa gcccatcaca aagagctctc cctcactcct gatcgagagc gactccccgg
     2041 acaagtacaa gaagaagaag tcatccttta agcgcttcct ggcactgacg tttaagaaga
     2101 agacggagaa caaattgcat gtggatgtga acgtgtcttc ctctaggtcc tcttcagagt
     2161 ccagctacca cgggccttcc aggattctgg aagttgaccg gagaagcctc agcaactccc
     2221 ctcagcttaa gtctcggact gggaagctcc gggcttctga atccccctcc tccctcatct
     2281 tttatagaga tggcaagagg aaaggtgtcc ccttcagcag gacggtgtcc agagtggagt
     2341 cctttgaaga ccgctcccgg ccgcccttcc tgcccttgcc actgaccaag ccacggtcca
     2401 tctccttccc cagcgctgac acttcagact atgagaacat tccagccatg aactcggact
     2461 atgagaatat ccagattcca ccccggagac ctgccagggc tggcgcgttc acgaagctgt
     2521 ttgaagatca gagcagagcc ctgtccacag caaacgaaaa tgatggctac gtggacatga
     2581 gcagcttcaa cgcctttgag agcaaacagc agagtgcaga ccaggacgca gaaagcgcct
     2641 acacagagcc ctacaaagtc tgtcccatct cgtcggcagc ccccaaagag gaccttacgt
     2701 cggatgaaga gcagagaagc tcggaggagg aggacagtgc ttcaagagac cccagtgtca
     2761 cccacaaggt ggaaggacag tccagagccc ttgtcatcgc acaggaactg ctatcttcag
     2821 agaaagcata cgtggagatg ctccagcact taaatctgga tttccatgga gctgtcatga
     2881 gggccttgga tgacatggac catgaaggca gagacacatt ggcccgggag gagctgaggc
     2941 agggcctgag tgaactccca gccatccacg accttcatca aggcatcctg gaggagctgg
     3001 aggaaaggct gtcaaattgg gagagccagc agaaggtagc tgacgtcttc ctggcccggg
     3061 agcaggggtt tgatcaccac gccactcaca tcctgcagtt cgacaggtac ctaggtctgc
     3121 tcagtgagaa ttgcctccac tctccccggc tggcagctgc tgtccgtgaa tttgagcaga
     3181 gtgtacaagg aggcagccag actgcgaagc atcggctgct gcgggtggtt caacgcctct
     3241 tccagtacca agtgctcctc acagactatt taaacaacct ttgtccggac tccgccgagt
     3301 acgacaacac acagggtgca ctgagcctca tctccaaagt cacagaccgt gccaacgaca
     3361 gcatggagca aggggaaaac ctgcagaagc tggtccacat tgagcacagc gtccggggcc
     3421 aaggggatct cctccagcca ggaagggagt ttctgaagga agggacgctg atgaaagtaa
     3481 cagggaaaaa cagacggccc cggcacctat ttctgatgaa cgatgtgctc ctgtacacct
     3541 atccccagaa ggatgggaag taccggctga agaacacatt ggctgtggcc aacatgaagg
     3601 tcagccgccc tgtgatggag aaagtgccct acgctctaaa gattgagact tccgagtcct
     3661 gcctgatgct gtctgcgagc tcctgtgcag agagggacga gtggtatggc tgtctgagca
     3721 gagccctccc tgaggactac aaggcccagg cgctggctgc attccaccat agcgtggaga
     3781 tacgagagag gctgggggtt agccttgggg agaggccccc caccctggtg cctgtcacac
     3841 acgtcatgat gtgcatgaac tgcggctgcg acttctccct caccctgcgg cgtcatcact
     3901 gtcacgcctg tggcaagatc gtgtgccgga actgttcgcg gaacaagtac ccgctgaagt
     3961 acctgaagga caggatggcc aaggtctgcg acggctgctt cggggagctg aagaagcggg
     4021 gcagggctgt cccgggcctg atgagagagc ggcctgtgag catgagcttc ccgctgtctt
     4081 caccccgctt ctcgggcagt gccttttcat ccgtcttcca gagcattaac ccctcgacct
     4141 tcaagaagca gaagaaagtc ccttcagccc tgacagaggt ggctgcctct ggagagggct
     4201 ctgccatcag tggctatctc agccggtgta agaggggcaa gcggcactgg aagaagctct
     4261 ggtttgtcat caaaggcaaa gttctctaca cctacatggc cagtgaggac aaagtggcct
     4321 tggagagtat gcctctgcta ggcttcacca ttgctccaga aaaggaagag ggcagcagtg
     4381 aagtaggacc tatttttcac ctttaccaca agaaaaccct attttatagc ttcaaagcag
     4441 aagataccaa ttcagctcag aggtggatcg aggccatgga agatgcgagt gtgttatagc
     4501 agttatcaag catgtggact tgtaacaaat tcttaggtca atatgtgaat gcttttagaa
     4561 gctaagctgt ggctcaactc atccggacac acacctggat tcagcaatga ggcctgacct
     4621 tttttgctat aaccgcccca ccactcccct gcccttgcca acatcttcat gaatggaatc
     4681 cttaagggat atttatggac ctctcctttt ctgtgttttc cacccctacc cccacccgcc
     4741 acccagtaat aaactatttc cttaccccgc agtgagttaa aatttagtaa gatgaagatg
     4801 tggaaaccaa tgaaaagtac atttagaaat gcaggctttt tagtagaaag aagctcttac
     4861 agtttttact catgataaat cttatcacct ttcaaaaatt gattgtggtg cctcaggtga
     4921 aatgagaagc tatcagtaac agctactctc atcgaaagca ctttattatt ttacggagct
     4981 gcaacctcca attttgtgtt ttctaagtga tttacttaag tcaataacag atggaatcct
     5041 gtggactaat gtgccaccag ttttctaaca agggtgtaca taaaatggat ttgtgcagac
     5101 ctggctgtgg cttgctggtg tgcaagcaca catcacttta gaggggctgc gccccaccag
     5161 ataggaaggg gaggattttc tcctccagtc gaccttgtga cctgtatact aacataactt
     5221 attaaaggag gggtccctcc tcccccagag cagtcctcaa cactatgtca gtgctggaaa
     5281 tgcagccact ggcagatctg gccccccaga cgtcaccgca gggcctctga agagtcaagg
     5341 tctgctttaa tttattgtgt gcctttctgt gtttacctca ctcaagctga caacattgtt
     5401 tatgggaatc tatccttctt ttagacacac ggtaatcctt gggctgtatt actgaaggct
     5461 ttttattttt tgagaggtga aaaaaagaga aaacaagtta gactccaaag gtgaattcct
     5521 ggtcttggca gatggctctg ggaacagcga gggagcacag aagtcgtggc ctgaggctgt
     5581 tctatgggca cttggggcta aatcgcctcc tgagggtgac tgttgcttat tctgctggac
     5641 aggtttttac ataaagcaaa gggcatgtga ggggtgggat tccttgttac tcttactgca
     5701 ataaaaatca attgtttgat atcctgtccc cattctgttg ctgccctgtc ccctacaaaa
     5761 aagggaattt gctgacaaac tttttgtaaa aagcaccatc tctggactta cttgcattaa
     5821 atattttcag gggaattttt ttttccagtt tgcagttctt ttaaaatgtt tgcattaaac
     5881 atgtaactaa tggttcacac taa
//
