LOCUS       NM_005141               3641 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens fibrinogen beta chain (FGB), transcript variant 1,
            mRNA.
ACCESSION   NM_005141
VERSION     NM_005141.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3641)
  AUTHORS   Jia,K., Zeng,M., Zheng,X., Xie,H., Yang,L., Xie,Y. and Wang,M.
  TITLE     A Novel Fibrinogen Mutation p.BbetaAla68Asp Causes an Inherited
            Dysfibrinogenemia
  JOURNAL   Hamostaseologie 43 (6), 426-431 (2023)
   PUBMED   37516116
  REMARK    GeneRIF: A Novel Fibrinogen Mutation p.BbetaAla68Asp Causes an
            Inherited Dysfibrinogenemia.
            Erratum:[Hamostaseologie. 2023 Dec;43(6):e1. doi:
            10.1055/a-2218-6919.. PMID: 38096836]
REFERENCE   2  (bases 1 to 3641)
  AUTHORS   Shao,X., Ma,J., Wang,Z., Sun,M., Huang,Z., Jiang,Z., Liu,X., Li,S.
            and Liu,Y.
  TITLE     [Genetic analysis of a Chinese pedigree affected with Congenital
            dysfibrinogenemia due to variant of FGG gene]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 40 (11), 1324-1329 (2023)
   PUBMED   37906135
  REMARK    GeneRIF: [Genetic analysis of a Chinese pedigree affected with
            Congenital dysfibrinogenemia due to variant of FGG gene].
REFERENCE   3  (bases 1 to 3641)
  AUTHORS   Youyou,Z., Ruirui,J., Hui,W. and Zhaoyang,L.
  TITLE     Association between lipoprotein(a) and ischemic stroke: Fibrinogen
            as a mediator
  JOURNAL   J Neurol Sci 452, 120738 (2023)
   PUBMED   37517272
  REMARK    GeneRIF: Association between lipoprotein(a) and ischemic stroke:
            Fibrinogen as a mediator.
REFERENCE   4  (bases 1 to 3641)
  AUTHORS   Wang,X., Yang,Y., Yu,L., Pang,C., Sun,W., Zang,S. and Li,C.
  TITLE     Association between fibrinogen level and length of stay in patients
            with lower extremity atherosclerotic disease: a retrospective
            cohort study
  JOURNAL   Sci Rep 13 (1), 11872 (2023)
   PUBMED   37481624
  REMARK    GeneRIF: Association between fibrinogen level and length of stay in
            patients with lower extremity atherosclerotic disease: a
            retrospective cohort study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3641)
  AUTHORS   Pahlman,L.I., Morgelin,M., Kasetty,G., Olin,A.I., Schmidtchen,A.
            and Herwald,H.
  TITLE     Antimicrobial activity of fibrinogen and fibrinogen-derived
            peptides--a novel link between coagulation and innate immunity
  JOURNAL   Thromb Haemost 109 (5), 930-939 (2013)
   PUBMED   23467586
REFERENCE   6  (bases 1 to 3641)
  AUTHORS   Doolittle,R.F.
  TITLE     Fibrinogen and fibrin
  JOURNAL   Annu Rev Biochem 53, 195-229 (1984)
   PUBMED   6383194
  REMARK    Review article
REFERENCE   7  (bases 1 to 3641)
  AUTHORS   Chung,D.W., Que,B.G., Rixon,M.W., Mace,M. Jr. and Davie,E.W.
  TITLE     Characterization of complementary deoxyribonucleic acid and genomic
            deoxyribonucleic acid for the beta chain of human fibrinogen
  JOURNAL   Biochemistry 22 (13), 3244-3250 (1983)
   PUBMED   6688356
REFERENCE   8  (bases 1 to 3641)
  AUTHORS   Tarakhovskii,Iu.S., Galushchenko,I.V., Boroviagin,V.L., Ritov,V.B.
            and Komarov,P.G.
  TITLE     [Temperature-dependent changes in the profile of the sarcoplasmic
            reticulum membrane hydrophobic zones]
  JOURNAL   Biokhimiia 44 (5), 897-902 (1979)
   PUBMED   156564
REFERENCE   9  (bases 1 to 3641)
  AUTHORS   Watt,K.W., Takagi,T. and Doolittle,R.F.
  TITLE     Amino acid sequence of the beta chain of human fibrinogen
  JOURNAL   Biochemistry 18 (1), 68-76 (1979)
   PUBMED   420779
REFERENCE   10 (bases 1 to 3641)
  AUTHORS   Gardlund,B., Hessel,B., Marguerie,G., Murano,G. and Blomback,B.
  TITLE     Primary structure of human fibrinogen. Characterization of
            disulfide-containing cyanogen-bromide fragments
  JOURNAL   Eur J Biochem 77 (3), 595-610 (1977)
   PUBMED   891553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312972.1, J00129.1 and
            AC107385.4.
            
            On Feb 27, 2020 this sequence version replaced NM_005141.4.
            
            Summary: The protein encoded by this gene is the beta component of
            fibrinogen, a blood-borne glycoprotein comprised of three pairs of
            nonidentical polypeptide chains. Following vascular injury,
            fibrinogen is cleaved by thrombin to form fibrin which is the most
            abundant component of blood clots. In addition, various cleavage
            products of fibrinogen and fibrin regulate cell adhesion and
            spreading, display vasoconstrictor and chemotactic activities, and
            are mitogens for several cell types. Fibrinogen serves key roles in
            hemostasis and antimicrobial host defense. Mutations in this gene
            lead to several disorders, including afibrinogenemia,
            dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
            [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.349197.1,
                                           SRR14038193.1849025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for disease process
            MANE Ensembl match     :: ENST00000302068.9/ ENSP00000306099.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1484              AK312972.1         32-1515
            1485-1915           J00129.1           1453-1883
            1916-3641           AC107385.4         46820-48545
FEATURES             Location/Qualifiers
     source          1..3641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..3641
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /note="fibrinogen beta chain"
                     /db_xref="GeneID:2244"
                     /db_xref="HGNC:HGNC:3662"
                     /db_xref="MIM:134830"
     exon            1..122
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1484
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; fibrinogen, B beta polypeptide; epididymis
                     secretory sperm binding protein Li 78p; beta-fibrinogen"
                     /codon_start=1
                     /product="fibrinogen beta chain isoform 1 preproprotein"
                     /protein_id="NP_005132.2"
                     /db_xref="CCDS:CCDS3786.1"
                     /db_xref="GeneID:2244"
                     /db_xref="HGNC:HGNC:3662"
                     /db_xref="MIM:134830"
                     /translation="MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSAR
                     GHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDL
                     GVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQK
                     QVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSA
                     QMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTEN
                     GGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTR
                     MGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMG
                     ENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGG
                     QYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ"
     exon            123..314
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /inference="alignment:Splign:2.1.0"
     exon            315..498
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /inference="alignment:Splign:2.1.0"
     exon            499..726
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /inference="alignment:Splign:2.1.0"
     exon            727..840
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /inference="alignment:Splign:2.1.0"
     exon            841..966
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1252
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..3641
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1563..1568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /note="hexamer: ATTATA"
     polyA_site      1586
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /note="major polyA site"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /note="hexamer: ATTAAA"
     polyA_site      1653
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
     regulatory      1896..1901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /note="hexamer: ATTAAA"
     polyA_site      1920
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
     regulatory      3620..3625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
                     /note="hexamer: AATATA"
     polyA_site      3641
                     /gene="FGB"
                     /gene_synonym="HEL-S-78p"
ORIGIN      
        1 aagtctacat gaaaaggatg gtttcttgga gcttccacaa acttaaaacc atgaaacatc
       61 tattattgct actattgtgt gtttttctag ttaagtccca aggtgtcaac gacaatgagg
      121 agggtttctt cagtgcccgt ggtcatcgac cccttgacaa gaagagagaa gaggctccca
      181 gcctgaggcc tgccccaccg cccatcagtg gaggtggcta tcgggctcgt ccagccaaag
      241 cagctgccac tcaaaagaaa gtagaaagaa aagcccctga tgctggaggc tgtcttcacg
      301 ctgacccaga cctgggggtg ttgtgtccta caggatgtca gttgcaagag gctttgctac
      361 aacaggaaag gccaatcaga aatagtgttg atgagttaaa taacaatgtg gaagctgttt
      421 cccagacctc ctcttcttcc tttcagtaca tgtatttgct gaaagacctg tggcaaaaga
      481 ggcagaagca agtaaaagat aatgaaaatg tagtcaatga gtactcctca gaactggaaa
      541 agcaccaatt atatatagat gagactgtga atagcaatat cccaactaac cttcgtgtgc
      601 ttcgttcaat cctggaaaac ctgagaagca aaatacaaaa gttagaatct gatgtctcag
      661 ctcaaatgga atattgtcgc accccatgca ctgtcagttg caatattcct gtggtgtctg
      721 gcaaagaatg tgaggaaatt atcaggaaag gaggtgaaac atctgaaatg tatctcattc
      781 aacctgacag ttctgtcaaa ccgtatagag tatactgtga catgaataca gaaaatggag
      841 gatggacagt gattcagaac cgtcaagacg gtagtgttga ctttggcagg aaatgggatc
      901 catataaaca gggatttgga aatgttgcaa ccaacacaga tgggaagaat tactgtggcc
      961 taccaggtga atattggctt ggaaatgata aaattagcca gcttaccagg atgggaccca
     1021 cagaactttt gatagaaatg gaggactgga aaggagacaa agtaaaggct cactatggag
     1081 gattcactgt acagaatgaa gccaacaaat accagatctc agtgaacaaa tacagaggaa
     1141 cagccggtaa tgccctcatg gatggagcat ctcagctgat gggagaaaac aggaccatga
     1201 ccattcacaa cggcatgttc ttcagcacgt atgacagaga caatgacggc tggttaacat
     1261 cagatcccag aaaacagtgt tctaaagaag acggtggtgg atggtggtat aatagatgtc
     1321 atgcagccaa tccaaacggc agatactact ggggtggaca gtacacctgg gacatggcaa
     1381 agcatggcac agatgatggt gtagtatgga tgaattggaa ggggtcatgg tactcaatga
     1441 ggaagatgag tatgaagatc aggcccttct tcccacagca atagtcccca atacgtagat
     1501 ttttgctctt ctgtatgtga caacattttt gtacattatg ttattggaat tttctttcat
     1561 acattatatt cctctaaaac tctcaagcag acgtgagtgt gactttttga aaaaagtata
     1621 ggataaatta cattaaaata gcacatgatt ttcttttgtt ttcttcattt ctcttgctca
     1681 ccaagaagta acaaaagtat agttttgaca gagttggtgt tcataatttc agttctagtt
     1741 gattgcgaga attttcaaat aaggaagagg ggtcttttat ccttgtcgta ggaaaaccat
     1801 gacggaaagg aaaaactgat gtttaaaagt ccacttttaa aactatattt atttatgtag
     1861 gatctgtcaa agaaaacttc caaaaagatt tattaattaa accagactct gttgcaataa
     1921 gttaatgttt tcttgttttg taatccacac attcaatgag ttaggctttg cacttgtaag
     1981 gaaggagaag cgttcacaac ctcaaatagc taataaaccg gtcttgaata tttgaagatt
     2041 taaaatctga ctctaggacg ggcacggtgg ctcacgacta taatcccaac actttgggag
     2101 gctgaggcgg gcggtcacaa ggtcaggagt tcaagaccag cctgaccaat atggtgaaac
     2161 cccatctcta ctaaaaatac aaaaattagc caggcgtggt ggcaggtgcc tgtagtccca
     2221 gctacctgtg aggtggagat tgcattgagc caagatctca acactgcact ccagcctggg
     2281 caacagcgtg agactccacc tcaaaaaaaa aaaaaaaaga atctgactat ataccatgga
     2341 aaagccacca ctctgccact taaataaaca tcaggatcag agattccaag aggacaatct
     2401 gcatcaagtc ttcaccaagt gttttttaag cgaaataatg aaatagggag cagaatatgc
     2461 ctgttgccca tagaaacgag gtctattctt gtcctcaatt aggctttttt ttcttcatag
     2521 ttacaccaga actaaagtaa aagtggtttt tctgttcttt ctacttctcc ccatgaaatg
     2581 ggcatatcat ctcaacactt cactccaagt cgccacgggc aaccttatga ccctaggtcc
     2641 tccaccccta atgtatcatc attgccaccc atttttatgg tacttattgt tcttaagctt
     2701 atcctcttaa tcttttcatg taagcaaagc tcattaattt ctgtcttgga aatgctacta
     2761 ctctctttaa ttactcacca aatccaactt taacttttga cctggtttct ctgccacaag
     2821 ttctgtccca ctggagccca tactcaccta ccgctttgcc atcacattta acagaaaact
     2881 cttatcaact tacttcctgc ttaacattag ctccttccta tctatatcca aatttcttaa
     2941 attcaaattt tttagctgga gtaaaaatgg tcccagtacc atttcctgtt cccttcacta
     3001 taacctacat ttttgtcaca ttaagttttt ccccattcca ggacaggtca ggccctttaa
     3061 aaatttcaac agctttattg agatataatt gatataattt aaaaaatcct gcacatgtgt
     3121 catgctggag ccctattgat tccaacaggg atggcgcctt gtccaagaag agacccagag
     3181 ccagtgaatg ggacataggg tttatttagg acttaaatac agatgtggtc cagtggcagt
     3241 gggctggaca ggaccgctac tatttgtaaa gagtatgtag tttatataac atttctactt
     3301 agcactctcc acttagcaac ctccatttaa cccaaaataa aaggccttgg ttccttgcac
     3361 atcctgagtt ccaacggaca ggcagggagt tcaagtgtcc ttcacagata agaagtgaat
     3421 ctctctgggt tggccattcc cggattcctt agcttagact ctgaacacat attcttctta
     3481 gaccatacag tcattctcag ggtatgcttg agttaatgct gtcggatgca tctgtcatac
     3541 aaagtgttta acatatacga tttcatgatt ttggaaatat gcatacaccc atgatatcac
     3601 tggcacagtc aagatattaa atatatccat cacctccaaa a
//
