LOCUS       NM_001195755            3605 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens free fatty acid receptor 4 (FFAR4), transcript variant
            2, mRNA.
ACCESSION   NM_001195755
VERSION     NM_001195755.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3605)
  AUTHORS   Wang,Z., Li,J., Wang,L., Liu,Y., Wang,W., Chen,J., Liang,H.,
            Chen,Y.Q. and Zhu,S.
  TITLE     FFAR4 activation inhibits lung adenocarcinoma via blocking
            respiratory chain complex assembly associated mitochondrial
            metabolism
  JOURNAL   Cell Mol Biol Lett 29 (1), 17 (2024)
   PUBMED   38243188
  REMARK    GeneRIF: FFAR4 activation inhibits lung adenocarcinoma via blocking
            respiratory chain complex assembly associated mitochondrial
            metabolism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3605)
  AUTHORS   Di Petrillo,A., Kumar,A., Onali,S., Favale,A. and Fantini,M.C.
  TITLE     GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory
            Bowel Disease
  JOURNAL   Inflamm Bowel Dis 29 (12), 1981-1989 (2023)
   PUBMED   37542525
  REMARK    GeneRIF: GPR120/FFAR4: A Potential New Therapeutic Target for
            Inflammatory Bowel Disease.
            Review article
REFERENCE   3  (bases 1 to 3605)
  AUTHORS   He,Q., Lin,M., Wu,Z. and Yu,R.
  TITLE     Predictive value of first-trimester GPR120 levels in gestational
            diabetes mellitus
  JOURNAL   Front Endocrinol (Lausanne) 14, 1220472 (2023)
   PUBMED   37842292
  REMARK    GeneRIF: Predictive value of first-trimester GPR120 levels in
            gestational diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3605)
  AUTHORS   Karmokar,P.F. and Moniri,N.H.
  TITLE     Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates
            migration, invasion, proliferation and tumor growth of papillary
            renal cell carcinoma cells
  JOURNAL   Biochem Pharmacol 213, 115590 (2023)
   PUBMED   37201877
  REMARK    GeneRIF: Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially
            regulates migration, invasion, proliferation and tumor growth of
            papillary renal cell carcinoma cells.
REFERENCE   5  (bases 1 to 3605)
  AUTHORS   Duah,M., Zhang,K., Liang,Y., Ayarick,V.A., Xu,K. and Pan,B.
  TITLE     Immune regulation of poly unsaturated fatty acids and free fatty
            acid receptor 4
  JOURNAL   J Nutr Biochem 112, 109222 (2023)
   PUBMED   36402250
  REMARK    GeneRIF: Immune regulation of poly unsaturated fatty acids and free
            fatty acid receptor 4.
            Review article
REFERENCE   6  (bases 1 to 3605)
  AUTHORS   Burns,R.N. and Moniri,N.H.
  TITLE     Agonism with the omega-3 fatty acids alpha-linolenic acid and
            docosahexaenoic acid mediates phosphorylation of both the short and
            long isoforms of the human GPR120 receptor
  JOURNAL   Biochem Biophys Res Commun 396 (4), 1030-1035 (2010)
   PUBMED   20471368
  REMARK    GeneRIF: These are the first results which demonstrate specific
            phosphorylation of GPR120 isoforms upon agonism by free fatty acids
            and the first which distinguish the phosphorylation profiles of the
            two GPR120 isoforms.
REFERENCE   7  (bases 1 to 3605)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   8  (bases 1 to 3605)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   9  (bases 1 to 3605)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 3605)
  AUTHORS   Dong,C., Wang,S., Li,W.D., Li,D., Zhao,H. and Price,R.A.
  TITLE     Interacting genetic loci on chromosomes 20 and 10 influence extreme
            human obesity
  JOURNAL   Am J Hum Genet 72 (1), 115-124 (2003)
   PUBMED   12478478
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM757151.1, BC101175.2,
            AK301525.1, AI469384.1, AL356214.20, DA986310.1 and AI732606.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001195755.1.
            
            Summary: This gene encodes a G protein-coupled receptor (GPR) which
            belongs to the rhodopsin family of GPRs. The encoded protein
            functions as a receptor for free fatty acids, including omega-3,
            and participates in suppressing anti-inflammatory responses and
            insulin sensitizing. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2012].
            
            Transcript Variant: This variant (2) is missing an in-frame coding
            exon compared to variant 1, resulting in a shorter isoform
            (GPR120-S) lacking a 16 aa protein segment compared to isoform
            GPR120-L.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.244792.1, AK301525.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371481.9/ ENSP00000360536.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               BM757151.1         1-254
            255-1142            BC101175.2         199-1086
            1143-1362           AK301525.1         1116-1335
            1363-1470           AI469384.1         271-378             c
            1471-1579           AK301525.1         1444-1552
            1580-1965           AL356214.20        104197-104582
            1966-2522           DA986310.1         1-557
            2523-3151           AL356214.20        105140-105768
            3152-3605           AI732606.1         5-458               c
FEATURES             Location/Qualifiers
     source          1..3605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..3605
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /note="free fatty acid receptor 4"
                     /db_xref="GeneID:338557"
                     /db_xref="HGNC:HGNC:19061"
                     /db_xref="MIM:609044"
     exon            1..623
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1142
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /note="isoform GPR120-S is encoded by transcript variant
                     2; G-protein coupled receptor 120; omega-3 fatty acid
                     receptor 1; G-protein coupled receptor 129; G-protein
                     coupled receptor GT01; G-protein coupled receptor PGR4;
                     Obesity, susceptibility to, on chromosome 10q"
                     /codon_start=1
                     /product="free fatty acid receptor 4 isoform GPR120-S"
                     /protein_id="NP_001182684.1"
                     /db_xref="CCDS:CCDS55720.1"
                     /db_xref="GeneID:338557"
                     /db_xref="HGNC:HGNC:19061"
                     /db_xref="MIM:609044"
                     /translation="MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVET
                     TVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTE
                     AWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLA
                     LIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLV
                     PGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIM
                     WSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIF
                     CCFWFPEKGAILTDTSVKRNDLSIISG"
     exon            624..752
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..3605
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1705..1710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /note="hexamer: AATAAA"
     polyA_site      1734
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /note="major polyA site"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /note="hexamer: ATTAAA"
     polyA_site      3605
                     /gene="FFAR4"
                     /gene_synonym="BMIQ10; GPR120; GPR129; GT01; O3FAR1;
                     OB10Q; PGR4"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcctcc cagatgagca ctctctcaga ccgctgcggg ccgccaggcg ccgggaatgt
       61 cccctgaatg cgcgcgggca gcgggcgacg cgcccttgcg cagcctggag caagccaacc
      121 gcacccgctt tcccttcttc tccgacgtca agggcgacca ccggctggtg ctggccgcgg
      181 tggagacaac cgtgctggtg ctcatctttg cagtgtcgct gctgggcaac gtgtgcgccc
      241 tggtgctggt ggcgcgccga cgacgccgcg gcgcgactgc ctgcctggta ctcaacctct
      301 tctgcgcgga cctgctcttc atcagcgcta tccctctggt gctggccgtg cgctggactg
      361 aggcctggct gctgggcccc gttgcctgcc acctgctctt ctacgtgatg accctgagcg
      421 gcagcgtcac catcctcacg ctggccgcgg tcagcctgga gcgcatggtg tgcatcgtgc
      481 acctgcagcg cggcgtgcgg ggtcctgggc ggcgggcgcg ggcagtgctg ctggcgctca
      541 tctggggcta ttcggcggtc gccgctctgc ctctctgcgt cttcttccga gtcgtcccgc
      601 aacggctccc cggcgccgac caggaaattt cgatttgcac actgatttgg cccaccattc
      661 ctggagagat ctcgtgggat gtctcttttg ttactttgaa cttcttggtg ccaggactgg
      721 tcattgtgat cagttactcc aaaattttac agatcacaaa ggcatcaagg aagaggctca
      781 cggtaagcct ggcctactcg gagagccacc agatccgcgt gtcccagcag gacttccggc
      841 tcttccgcac cctcttcctc ctcatggtct ccttcttcat catgtggagc cccatcatca
      901 tcaccatcct cctcatcctg atccagaact tcaagcaaga cctggtcatc tggccgtccc
      961 tcttcttctg ggtggtggcc ttcacatttg ctaattcagc cctaaacccc atcctctaca
     1021 acatgacact gtgcaggaat gagtggaaga aaattttttg ctgcttctgg ttcccagaaa
     1081 agggagccat tttaacagac acatctgtca aaagaaatga cttgtcgatt atttctggct
     1141 aatttttctt tatagccgag tttctcacac ctggcgagct gtggcatgct tttaaacaga
     1201 gttcatttcc agtaccctcc atcagtgcac cctgctttaa gaaaatgaac ctatgcaaat
     1261 agacatccac agcgtcggta aattaagggg tgatcaccaa gtttcataat attttccctt
     1321 tataaaagga tttgttggcc aggtgcagtg gttcatgcct gtaatcccag cagtttggga
     1381 ggctgaggtg ggtggatcac ctgaggtcag gagttcgaga ccaacctgac caacatggtg
     1441 agacccccgt ctctactaaa aataaaaaaa aaaattagct gggagtggtg gtgggcacct
     1501 gtaatcctag ctacttggga ggctgaacca ggagaatctc ttgaacctgg gaggcagagg
     1561 ttgcagtgag ccgagatcgt gccattgcac tccaaccagg gcaacaagag tgaaactcca
     1621 tcttaaaaaa aaaaaaaaaa agatttgtta tgggttcctt ttaaatgtga acttttttag
     1681 tgtgtttgta atatgatcaa atttaataaa tatttattta tgactgttca gcaatcacat
     1741 ctcctacata taaagccaca ccatagtggt ttctgaagtg agtcttagaa ccgattcagg
     1801 acgcagattt ctcctctgaa gggtcacagc caccctgtgc cctaccttgg actcgcaagg
     1861 gtttaggatc attcgttgat gtcaagagca attgaagaat ttctaaggaa cagttaaaga
     1921 tgacttactt tttttttttt ttcatttata aaaatgctat ggaccctttt aagagaatcg
     1981 gcatcatgaa atgagagaga aagtaggatg gctctgaaat gtttgagagt gagttcagga
     2041 gtggtttact cctgacgcat ccagcagaga tgcctcttaa gcaccagcca tggcagacag
     2101 tgtcctttgt gctaggaata cagtggtgaa ccagacagcc atggccctct ctcagggaac
     2161 ttaccttcga gtcaggggca gaaaaactaa ataaaagtca ataaactata tctatataca
     2221 gatacctata tatttgagat gagggtcttg ctccaatgcc caggctggag tgcaacggca
     2281 caatcacggc tccctgaagc ctcaaatgcc ttggctcaag caatcctccc gcctcagcct
     2341 cccaagtagc tgggattaca ggcgtgagcc gccacgcctg gctacaagtc aataaatagt
     2401 atagcatcac agagcgaata agcactgtga agaaaatggg acgggggcta tggtagtgat
     2461 gggaatttag atcagatggg gaggggccta aggagacctt tctgaggagt gacaaattgg
     2521 atcaaaaggt aagcgacaag aaagggccac ctgtgtgaat gggggaaggg acacagaaga
     2581 gatgttagtg caaggaggct gacacgcttg aagggagagt ggcgtaagcc gactattgat
     2641 ggagcctcct ctgcactagg cactgccttt aatgctgaga tgaggggtac ccggctgggg
     2701 cctgtcagtt gaggccagag aaattgcagg gttagatcac atagggccta ggagtttatt
     2761 ctgttctcca agcccctgga ggttggcaac tggaggctga cgtgacctga tgaatgtgtg
     2821 caaagattac cctggctgct gggcagggaa tagactctga ggagcatgag tgaaaatgga
     2881 gaccagttgg gcagctgctg aagtgtgaca tggggatggg accttggagg tgagtggcat
     2941 tagggaggga ttgtgagaaa tgacttgtaa atataccttg ggaaggtaaa acaaagatga
     3001 tttattgatg ggaaggatgg aattgataga atgtgaggga aagggagaac tcaaggggaa
     3061 tactctgatt ttttagcctg tcattggttg gatggtgaag caggcaacaa aaatgggggg
     3121 gcctgggcaa agattagggg ggggggagcc aagagtttca tttggagctc atcagtttga
     3181 aatctcagtg agacttccaa attgaatagg cagttggatg cagagatgtg gagcttgggc
     3241 ctggagatgc acattgtttg gagatataaa tggtgtttat agacctatgg ttttataata
     3301 catcccttgg agagatagag agaaaccaga gccaaagacc gaacccaggg tcactccacc
     3361 acttggaggc tgggccagtg gctggaatgc acagcagcac ggggcctggt gtatagtagg
     3421 tgttcaacaa atctttgttg ctgaggaaat cagcaccagc agtagtgact gcttatgcag
     3481 tttctggagc agcttgcttc tgaagtcaga ttcatggata tcacaagctc gaagacaaac
     3541 gaacagagat gttttgctca ctttagttaa tagatttgat caattaaacc tgtttttgga
     3601 agtga
//
