LOCUS       NM_005304               1800 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens free fatty acid receptor 3 (FFAR3), mRNA.
ACCESSION   NM_005304
VERSION     NM_005304.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1800)
  AUTHORS   Carbone,A.M., Borges,J.I., Suster,M.S., Sizova,A., Cora,N.,
            Desimine,V.L. and Lymperopoulos,A.
  TITLE     Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse
            Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty
            Acid Receptor FFAR3 Signaling
  JOURNAL   Int J Mol Sci 23 (10), 5803 (2022)
   PUBMED   35628613
  REMARK    GeneRIF: Regulator of G-Protein Signaling-4 Attenuates Cardiac
            Adverse Remodeling and Neuronal Norepinephrine Release-Promoting
            Free Fatty Acid Receptor FFAR3 Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1800)
  AUTHORS   Zamarbide,M., Martinez-Pinilla,E., Gil-Bea,F., Yanagisawa,M.,
            Franco,R. and Perez-Mediavilla,A.
  TITLE     Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes
            Behavioral Deficits and Pathological Hallmarks in the APPswe
            Alzheimer's Disease Mouse Model
  JOURNAL   Int J Mol Sci 23 (7), 3533 (2022)
   PUBMED   35408893
  REMARK    GeneRIF: Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes
            Behavioral Deficits and Pathological Hallmarks in the APPswe
            Alzheimer's Disease Mouse Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1800)
  AUTHORS   Lorza-Gil,E., Kaiser,G., Rexen Ulven,E., Konig,G.M., Gerst,F.,
            Oquendo,M.B., Birkenfeld,A.L., Haring,H.U., Kostenis,E., Ulven,T.
            and Ullrich,S.
  TITLE     FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a
            comparative study with mouse islets and rat INS-1E cells
  JOURNAL   Sci Rep 10 (1), 16497 (2020)
   PUBMED   33020504
  REMARK    GeneRIF: FFA2-, but not FFA3-agonists inhibit GSIS of human
            pseudoislets: a comparative study with mouse islets and rat INS-1E
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1800)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1800)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1800)
  AUTHORS   Le Poul,E., Loison,C., Struyf,S., Springael,J.Y., Lannoy,V.,
            Decobecq,M.E., Brezillon,S., Dupriez,V., Vassart,G., Van Damme,J.,
            Parmentier,M. and Detheux,M.
  TITLE     Functional characterization of human receptors for short chain
            fatty acids and their role in polymorphonuclear cell activation
  JOURNAL   J Biol Chem 278 (28), 25481-25489 (2003)
   PUBMED   12711604
  REMARK    GeneRIF: characterization of GP41 in human tissue as a receptor for
            short chain fatty acids
REFERENCE   7  (bases 1 to 1800)
  AUTHORS   Brown,A.J., Goldsworthy,S.M., Barnes,A.A., Eilert,M.M., Tcheang,L.,
            Daniels,D., Muir,A.I., Wigglesworth,M.J., Kinghorn,I., Fraser,N.J.,
            Pike,N.B., Strum,J.C., Steplewski,K.M., Murdock,P.R., Holder,J.C.,
            Marshall,F.H., Szekeres,P.G., Wilson,S., Ignar,D.M., Foord,S.M.,
            Wise,A. and Dowell,S.J.
  TITLE     The Orphan G protein-coupled receptors GPR41 and GPR43 are
            activated by propionate and other short chain carboxylic acids
  JOURNAL   J Biol Chem 278 (13), 11312-11319 (2003)
   PUBMED   12496283
REFERENCE   8  (bases 1 to 1800)
  AUTHORS   Sawzdargo,M., George,S.R., Nguyen,T., Xu,S., Kolakowski,L.F. and
            O'Dowd,B.F.
  TITLE     A cluster of four novel human G protein-coupled receptor genes
            occurring in close proximity to CD22 gene on chromosome 19q13.1
  JOURNAL   Biochem Biophys Res Commun 239 (2), 543-547 (1997)
   PUBMED   9344866
REFERENCE   9  (bases 1 to 1800)
  AUTHORS   Wilson,G.L., Najfeld,V., Kozlow,E., Menniger,J., Ward,D. and
            Kehrl,J.H.
  TITLE     Genomic structure and chromosomal mapping of the human CD22 gene
  JOURNAL   J Immunol 150 (11), 5013-5024 (1993)
   PUBMED   8496602
REFERENCE   10 (bases 1 to 1800)
  AUTHORS   Wilson,G.L., Fox,C.H., Fauci,A.S. and Kehrl,J.H.
  TITLE     cDNA cloning of the B cell membrane protein CD22: a mediator of B-B
            cell interactions
  JOURNAL   J Exp Med 173 (1), 137-146 (1991)
   PUBMED   1985119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR004234.1, BC035657.1 and AC002511.1.
            
            On May 17, 2019 this sequence version replaced NM_005304.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035657.1, AK290710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327809.5/ ENSP00000328230.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               DR004234.1         7-146
            141-1647            BC035657.1         1-1507
            1648-1648           AC002511.1         6904-6904
            1649-1693           BC035657.1         1509-1553
            1694-1694           AC002511.1         6950-6950
            1695-1769           BC035657.1         1555-1629
            1770-1770           AC002511.1         7026-7026
            1771-1800           BC035657.1         1630-1659
FEATURES             Location/Qualifiers
     source          1..1800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1800
                     /gene="FFAR3"
                     /gene_synonym="FFA3R; GPR41; GPR42"
                     /note="free fatty acid receptor 3"
                     /db_xref="GeneID:2865"
                     /db_xref="HGNC:HGNC:4499"
                     /db_xref="MIM:603821"
     exon            1..190
                     /gene="FFAR3"
                     /gene_synonym="FFA3R; GPR41; GPR42"
                     /inference="alignment:Splign:2.1.0"
     exon            191..1800
                     /gene="FFAR3"
                     /gene_synonym="FFA3R; GPR41; GPR42"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1242
                     /gene="FFAR3"
                     /gene_synonym="FFA3R; GPR41; GPR42"
                     /note="G-protein coupled receptor 41"
                     /codon_start=1
                     /product="free fatty acid receptor 3"
                     /protein_id="NP_005295.1"
                     /db_xref="CCDS:CCDS12459.1"
                     /db_xref="GeneID:2865"
                     /db_xref="HGNC:HGNC:4499"
                     /db_xref="MIM:603821"
                     /translation="MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQ
                     RRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLT
                     ALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDIS
                     HSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHR
                     RQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVY
                     YFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQG
                     CGTGGQVACAES"
ORIGIN      
        1 ccccttttag catgctgacc agccctggca acggagctca aggcatctat gtgccactgc
       61 tcaacagtga gtgacgtcat gggcacggcc aggtctttat cagttctgcc ggataaatag
      121 ccaactgcac taggtctgga gagacagcaa ggtgctgtgc ggcagagcat ttggggtctc
      181 aaagaagcag tggccaccac catggataca ggccccgacc agtcctactt ctccggcaat
      241 cactggttcg tcttctcggt gtaccttctc actttcctgg tggggctccc cctcaacctg
      301 ctggccctgg tggtcttcgt gggcaagctg cagcgccgcc cggtggccgt ggacgtgctc
      361 ctgctcaacc tgaccgcctc ggacctgctc ctgctgctgt tcctgccttt ccgcatggtg
      421 gaggcagcca atggcatgca ctggcccctg cccttcatcc tctgcccact ctctggattc
      481 atcttcttca ccaccatcta tctcaccgcc ctcttcctgg cagctgtgag cattgaacgc
      541 ttcctgagtg tggcccaccc actgtggtac aagacccggc cgaggctggg gcaggcaggt
      601 ctggtgagtg tggcctgctg gctgttggcc tctgctcact gcagcgtggt ctacgtcata
      661 gaattctcag gggacatctc ccacagccag ggcaccaatg ggacctgcta cctggagttc
      721 cggaaggacc agctagccat cctcctgccc gtgcggctgg agatggctgt ggtcctcttt
      781 gtggtcccgc tgatcatcac cagctactgc tacagccgcc tggtgtggat cctcggcaga
      841 gggggcagcc accgccggca gaggagggtg gcggggctgt tggcggccac gctgctcaac
      901 ttccttgtct gctttgggcc ctacaacgtg tcccatgtcg tgggctatat ctgcggtgaa
      961 agcccggcgt ggaggatcta cgtgacgctt ctcagcaccc tgaactcctg tgtcgacccc
     1021 tttgtctact acttctcctc ctccgggttc caagccgact ttcatgagct gctgaggagg
     1081 ttgtgtgggc tctggggcca gtggcagcag gagagcagca tggagctgaa ggagcagaag
     1141 ggaggggagg agcagagagc ggaccgacca gctgaaagaa agaccagtga acactcacag
     1201 ggctgtggaa ctggtggcca ggtggcctgt gctgaaagct aggtcctccg ggggaggagg
     1261 gtgtagctgg catgtcatcc tcagggcgct tcctcgctca cgccaggagg gacttggagt
     1321 ggcgagctgg ggcccgatgg ggcttggggg cagagtagac atctagcctc cctaagggta
     1381 tgcgcgctaa agcccagctc tcgatctcac ctccatcccc atccacccac acactatgga
     1441 ttgggctctg ggaaggggtc agggtgagag gctgctctgg agaacaatga ggtcctcata
     1501 gcagcaggca gctcctgtgt tttcttgagg gtggcagagg agctaagagc agtgcccagg
     1561 gtctgagggg gctgcccagt gagtggcagg ggcaggagag gggagaaccc catcctcaga
     1621 gctgctccca gccagcgagt caggagcggg ggagacaggg ctccagggat gaggccgcat
     1681 tctgctccca cagcgccttt tccagaaagt tcccattgct caataaatgt ggatcatcag
     1741 agacatttat gaacaatgac agaagaaaaa ttacccaaat aaatgtggaa gcaagcaaaa
//
