LOCUS       NM_001370087            2177 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens free fatty acid receptor 2 (FFAR2), transcript variant
            2, mRNA.
ACCESSION   NM_001370087 XM_017026710
VERSION     NM_001370087.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Buchynskyi,M., Oksenych,V., Kamyshna,I., Vorobets,I., Halabitska,I.
            and Kamyshnyi,O.
  TITLE     Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in
            Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes
  JOURNAL   Viruses 16 (6), 985 (2024)
   PUBMED   38932276
  REMARK    GeneRIF: Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene
            Expression in Metabolic-Associated Fatty Liver Disease and COVID-19
            Outcomes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Ruhnke,N., Beyer,A.L., Kaemmerer,D., Sanger,J., Schulz,S. and
            Lupp,A.
  TITLE     Expression of free fatty acid receptor 2 in normal and neoplastic
            tissues
  JOURNAL   Exp Mol Pathol 137, 104902 (2024)
   PUBMED   38788249
  REMARK    GeneRIF: Expression of free fatty acid receptor 2 in normal and
            neoplastic tissues.
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   Sa,A.K., Olimpio,F., Vasconcelos,J., Rosa,P., Faria Neto,H.C.,
            Rocha,C., Camacho,M.F., Barcick,U., Zelanis,A. and Aimbire,F.
  TITLE     Involvement of GPR43 Receptor in Effect of Lacticaseibacillus
            rhamnosus on Murine Steroid Resistant Chronic Obstructive Pulmonary
            Disease: Relevance to Pro-Inflammatory Mediators and Oxidative
            Stress in Human Macrophages
  JOURNAL   Nutrients 16 (10), 1509 (2024)
   PUBMED   38794746
  REMARK    GeneRIF: Involvement of GPR43 Receptor in Effect of
            Lacticaseibacillus rhamnosus on Murine Steroid Resistant Chronic
            Obstructive Pulmonary Disease: Relevance to Pro-Inflammatory
            Mediators and Oxidative Stress in Human Macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Fang,C., Zuo,K., Liu,Z., Xu,L. and Yang,X.
  TITLE     Disordered GPR43/NLRP3 expression in peripheral leukocytes of
            patients with atrial fibrillation is associated with intestinal
            short chain fatty acids levels
  JOURNAL   Eur J Med Res 29 (1), 233 (2024)
   PUBMED   38622672
  REMARK    GeneRIF: Disordered GPR43/NLRP3 expression in peripheral leukocytes
            of patients with atrial fibrillation is associated with intestinal
            short chain fatty acids levels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2177)
  AUTHORS   Wu,J., Chen,N., Grau,E., Johnson,L., Liu,Y., Li,C., Scott,P.A.,
            Kim,C., Sun,D., Kaplan,H.J. and Shao,H.
  TITLE     Short chain fatty acids inhibit corneal inflammatory responses to
            TLR ligands via the ocular G-protein coupled receptor 43
  JOURNAL   Ocul Surf 32, 48-57 (2024)
   PUBMED   38224777
  REMARK    GeneRIF: Short chain fatty acids inhibit corneal inflammatory
            responses to TLR ligands via the ocular G-protein coupled receptor
            43.
REFERENCE   6  (bases 1 to 2177)
  AUTHORS   Brown,A.J., Jupe,S. and Briscoe,C.P.
  TITLE     A family of fatty acid binding receptors
  JOURNAL   DNA Cell Biol 24 (1), 54-61 (2005)
   PUBMED   15684720
  REMARK    Review article
REFERENCE   7  (bases 1 to 2177)
  AUTHORS   Le Poul,E., Loison,C., Struyf,S., Springael,J.Y., Lannoy,V.,
            Decobecq,M.E., Brezillon,S., Dupriez,V., Vassart,G., Van Damme,J.,
            Parmentier,M. and Detheux,M.
  TITLE     Functional characterization of human receptors for short chain
            fatty acids and their role in polymorphonuclear cell activation
  JOURNAL   J Biol Chem 278 (28), 25481-25489 (2003)
   PUBMED   12711604
  REMARK    GeneRIF: the highly selective expression of GPR43 in leukocytes,
            particularly polymorphonuclear cells, suggests a role in the
            recruitment of these cell populations toward sites of bacterial
            infection
REFERENCE   8  (bases 1 to 2177)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
  REMARK    GeneRIF: FFA2R is expressed on leukocytes and activated by
            short-chain fatty acids.
REFERENCE   9  (bases 1 to 2177)
  AUTHORS   Brown,A.J., Goldsworthy,S.M., Barnes,A.A., Eilert,M.M., Tcheang,L.,
            Daniels,D., Muir,A.I., Wigglesworth,M.J., Kinghorn,I., Fraser,N.J.,
            Pike,N.B., Strum,J.C., Steplewski,K.M., Murdock,P.R., Holder,J.C.,
            Marshall,F.H., Szekeres,P.G., Wilson,S., Ignar,D.M., Foord,S.M.,
            Wise,A. and Dowell,S.J.
  TITLE     The Orphan G protein-coupled receptors GPR41 and GPR43 are
            activated by propionate and other short chain carboxylic acids
  JOURNAL   J Biol Chem 278 (13), 11312-11319 (2003)
   PUBMED   12496283
REFERENCE   10 (bases 1 to 2177)
  AUTHORS   Sawzdargo,M., George,S.R., Nguyen,T., Xu,S., Kolakowski,L.F. and
            O'Dowd,B.F.
  TITLE     A cluster of four novel human G protein-coupled receptor genes
            occurring in close proximity to CD22 gene on chromosome 19q13.1
  JOURNAL   Biochem Biophys Res Commun 239 (2), 543-547 (1997)
   PUBMED   9344866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002511.1.
            
            On Apr 26, 2019 this sequence version replaced XM_017026710.2.
            
            Summary: This gene encodes a member of the GP40 family of G
            protein-coupled receptors that are clustered together on chromosome
            19. The encoded protein is a receptor for short chain free fatty
            acids and may be involved in the inflammatory response and in
            regulating lipid plasma levels. [provided by RefSeq, Apr 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138517.119558.1,
                                           DRR138517.507566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000599180.3/ ENSP00000473159.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC002511.1         94824-94946
            124-2177            AC002511.1         96281-98334
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..2177
                     /gene="FFAR2"
                     /gene_synonym="FFA2R; GPR43"
                     /note="free fatty acid receptor 2"
                     /db_xref="GeneID:2867"
                     /db_xref="HGNC:HGNC:4501"
                     /db_xref="MIM:603823"
     exon            1..123
                     /gene="FFAR2"
                     /gene_synonym="FFA2R; GPR43"
                     /inference="alignment:Splign:2.1.0"
     exon            124..2177
                     /gene="FFAR2"
                     /gene_synonym="FFA2R; GPR43"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1117
                     /gene="FFAR2"
                     /gene_synonym="FFA2R; GPR43"
                     /note="free fatty acid activated receptor 2; G-protein
                     coupled receptor 43; fatty acid receptor 2"
                     /codon_start=1
                     /product="free fatty acid receptor 2"
                     /protein_id="NP_001357016.1"
                     /db_xref="CCDS:CCDS12461.1"
                     /db_xref="GeneID:2867"
                     /db_xref="HGNC:HGNC:4501"
                     /db_xref="MIM:603823"
                     /translation="MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPV
                     HILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAG
                     ISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGN
                     EITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRR
                     RAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFS
                     SSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE"
     regulatory      2155..2160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FFAR2"
                     /gene_synonym="FFA2R; GPR43"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="FFAR2"
                     /gene_synonym="FFA2R; GPR43"
                     /note="major polyA site"
ORIGIN      
        1 accatttttt cctgcatggc atggacagaa gcaggggcta aagctctgtt cctctctcct
       61 ggaagcttgc agacctccct tcagaaccaa tcccaagaag ccacctatcc ggaacaacac
      121 aaggatgctg ccggactgga agagctcctt gatcctcatg gcttacatca tcatcttcct
      181 cactggcctc cctgccaacc tcctggccct gcgggccttt gtggggcgga tccgccagcc
      241 ccagcctgca cctgtgcaca tcctcctgct gagcctgacg ctggccgacc tcctcctgct
      301 gctgctgctg cccttcaaga tcatcgaggc tgcgtcgaac ttccgctggt acctgcccaa
      361 ggtcgtctgc gccctcacga gttttggctt ctacagcagc atctactgca gcacgtggct
      421 cctggcgggc atcagcatcg agcgctacct gggagtggct ttccccgtgc agtacaagct
      481 ctcccgccgg cctctgtatg gagtgattgc agctctggtg gcctgggtta tgtcctttgg
      541 tcactgcacc atcgtgatca tcgttcaata cttgaacacg actgagcagg tcagaagtgg
      601 caatgaaatt acctgctacg agaacttcac cgataaccag ttggacgtgg tgctgcccgt
      661 gcggctggag ctgtgcctgg tgctcttctt catccccatg gcagtcacca tcttctgcta
      721 ctggcgtttt gtgtggatca tgctctccca gccccttgtg ggggcccaga ggcggcgccg
      781 agccgtgggg ctggctgtgg tgacgctgct caatttcctg gtgtgcttcg gaccttacaa
      841 cgtgtcccac ctggtggggt atcaccagag aaaaagcccc tggtggcggt caatagccgt
      901 ggtgttcagt tcactcaacg ccagtctgga ccccctgctc ttctatttct cttcttcagt
      961 ggtgcgcagg gcatttggga gagggctgca ggtgctgcgg aatcagggct cctccctgtt
     1021 gggacgcaga ggcaaagaca cagcagaggg gacaaatgag gacaggggtg tgggtcaagg
     1081 agaagggatg ccaagttcgg acttcactac agagtagcag tttccctgga ccttcagagg
     1141 tcgcctgggt tacacaggag ctgggaagcc tgggagaggc ggagcaggaa ggctcccatc
     1201 cagattcaga aatccttaga cccagcccag gactgcgact ttgaaaaaaa tgcctttcac
     1261 cagcttggta tcccttcctg actgaattgt cctactcaaa ggagcataag tcagagatgc
     1321 acgaagaagt agttaggtat agaagcacct gccgggtgtg gtggctcatg cctataatcc
     1381 cagaactttg ggaggctgag gcaggtggat cacttgaggt cgggagattg agaacatcct
     1441 ggtcaacatg ggaaaacccc gtctctacta aaaatacaaa aaaattagct gggcatggtg
     1501 gcacatgcct ataatcccag ctactctgga ggctgaggca ggagaatcct tgaacccggg
     1561 agttggaggt tgcagtgagc tgagatcacg ccactgcact ccagcctagc gacagagcaa
     1621 gactccattt aaaaaaaaaa aaaaaaaaaa aaagaagcac cttcaggctg gagaagcagc
     1681 gtagctaaca caagtccagt ccttgtgatg tggctggtag ttggggatgg ccaggctgaa
     1741 gcagagagtc ctagagaaat ctcgatacaa gcttcaaagc aacacctaga cactgctcta
     1801 gcggttgatc ctggagataa accaacaaga gagagatgga agagaaatac taaatgaggt
     1861 caaagaagac tcagaaaggt tctgagcctg gagatgagca gggaggcctc agggcttaga
     1921 cctttaatga taggggtttc cctgcattgg tttgacctgt tgcctttttg atgtgctctg
     1981 tttgttttca tgtgttgtct tgtctcccct gctaaactgg gagctgccag gggtctgggt
     2041 cttatctcct tcctccatgg taccccacac aggccaggat gtggtttggt acccagcaat
     2101 cagagattgg cactccctca tacaggggaa agcaacctgg tctagcaaat tgaaaataaa
     2161 gatgataaaa ctctgaa
//
