LOCUS       NM_005303               5597 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens free fatty acid receptor 1 (FFAR1), mRNA.
ACCESSION   NM_005303
VERSION     NM_005303.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5597)
  AUTHORS   Nakamoto,K. and Tokuyama,S.
  TITLE     [The involvement of brain fatty acid-GPR40/FFAR1 signaling in the
            stress-induced chronic pain]
  JOURNAL   Nihon Yakurigaku Zasshi 158 (6), 449-453 (2023)
   PUBMED   37914321
  REMARK    GeneRIF: [The involvement of brain fatty acid-GPR40/FFAR1 signaling
            in the stress-induced chronic pain].
            Review article
REFERENCE   2  (bases 1 to 5597)
  AUTHORS   Karmokar,P.F. and Moniri,N.H.
  TITLE     Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4
            in human breast carcinoma cells
  JOURNAL   Biochem Pharmacol 206, 115328 (2022)
   PUBMED   36309079
  REMARK    GeneRIF: Oncogenic signaling of the free-fatty acid receptors FFA1
            and FFA4 in human breast carcinoma cells.
            Review article
REFERENCE   3  (bases 1 to 5597)
  AUTHORS   Guzman-Silva,A., Martinez-Morales,J.C., Medina,L.D.C.,
            Romero-Avila,M.T., Villegas-Comonfort,S., Solis,K.H. and
            Garcia-Sainz,J.A.
  TITLE     Mutation of putative phosphorylation sites in the free fatty acid
            receptor 1: Effects on signaling, receptor phosphorylation, and
            internalization
  JOURNAL   Mol Cell Endocrinol 545, 111573 (2022)
   PUBMED   35065200
  REMARK    GeneRIF: Mutation of putative phosphorylation sites in the free
            fatty acid receptor 1: Effects on signaling, receptor
            phosphorylation, and internalization.
REFERENCE   4  (bases 1 to 5597)
  AUTHORS   Konigs,V., Pierre,S., Schicht,M., Welss,J., Hahnefeld,L.,
            Rimola,V., Lutjen-Drecoll,E., Geisslinger,G. and Scholich,K.
  TITLE     GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by
            Suppressing VEGF-A Expression
  JOURNAL   Diabetes 71 (4), 774-787 (2022)
   PUBMED   35061031
  REMARK    GeneRIF: GPR40 Activation Abolishes Diabetes-Induced Painful
            Neuropathy by Suppressing VEGF-A Expression.
REFERENCE   5  (bases 1 to 5597)
  AUTHORS   Cho,Y.J., Choi,S.H., Lee,R., Hwang,H., Rhim,H., Cho,I.H., Kim,H.C.,
            Lee,J.I., Hwang,S.H. and Nah,S.Y.
  TITLE     Ginseng Gintonin Contains Ligands for GPR40 and GPR55
  JOURNAL   Molecules 25 (5), 1102 (2020)
   PUBMED   32121640
  REMARK    GeneRIF: Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5597)
  AUTHORS   Hamid,Y.H., Vissing,H., Holst,B., Urhammer,S.A., Pyke,C.,
            Hansen,S.K., Glumer,C., Borch-Johnsen,K., Jorgensen,T.,
            Schwartz,T.W., Pedersen,O. and Hansen,T.
  TITLE     Studies of relationships between variation of the human G
            protein-coupled receptor 40 Gene and Type 2 diabetes and insulin
            release
  JOURNAL   Diabet Med 22 (1), 74-80 (2005)
   PUBMED   15606695
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5597)
  AUTHORS   Briscoe,C.P., Tadayyon,M., Andrews,J.L., Benson,W.G.,
            Chambers,J.K., Eilert,M.M., Ellis,C., Elshourbagy,N.A., Goetz,A.S.,
            Minnick,D.T., Murdock,P.R., Sauls,H.R. Jr., Shabon,U.,
            Spinage,L.D., Strum,J.C., Szekeres,P.G., Tan,K.B., Way,J.M.,
            Ignar,D.M., Wilson,S. and Muir,A.I.
  TITLE     The orphan G protein-coupled receptor GPR40 is activated by medium
            and long chain fatty acids
  JOURNAL   J Biol Chem 278 (13), 11303-11311 (2003)
   PUBMED   12496284
REFERENCE   8  (bases 1 to 5597)
  AUTHORS   Itoh,Y., Kawamata,Y., Harada,M., Kobayashi,M., Fujii,R.,
            Fukusumi,S., Ogi,K., Hosoya,M., Tanaka,Y., Uejima,H., Tanaka,H.,
            Maruyama,M., Satoh,R., Okubo,S., Kizawa,H., Komatsu,H.,
            Matsumura,F., Noguchi,Y., Shinohara,T., Hinuma,S., Fujisawa,Y. and
            Fujino,M.
  TITLE     Free fatty acids regulate insulin secretion from pancreatic beta
            cells through GPR40
  JOURNAL   Nature 422 (6928), 173-176 (2003)
   PUBMED   12629551
  REMARK    GeneRIF: Free fatty acids regulate insulin secretion from
            pancreatic beta cells through GPR40
REFERENCE   9  (bases 1 to 5597)
  AUTHORS   Kotarsky,K., Nilsson,N.E., Flodgren,E., Owman,C. and Olde,B.
  TITLE     A human cell surface receptor activated by free fatty acids and
            thiazolidinedione drugs
  JOURNAL   Biochem Biophys Res Commun 301 (2), 406-410 (2003)
   PUBMED   12565875
REFERENCE   10 (bases 1 to 5597)
  AUTHORS   Sawzdargo,M., George,S.R., Nguyen,T., Xu,S., Kolakowski,L.F. and
            O'Dowd,B.F.
  TITLE     A cluster of four novel human G protein-coupled receptor genes
            occurring in close proximity to CD22 gene on chromosome 19q13.1
  JOURNAL   Biochem Biophys Res Commun 239 (2), 543-547 (1997)
   PUBMED   9344866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U62631.2 and KF511268.1.
            
            On Jun 22, 2021 this sequence version replaced NM_005303.2.
            
            Summary: This gene encodes a member of the GP40 family of G
            protein-coupled receptors that are clustered together on chromosome
            19. The encoded protein is a receptor for medium and long chain
            free fatty acids and may be involved in the metabolic regulation of
            insulin secretion. Polymorphisms in this gene may be associated
            with type 2 diabetes. [provided by RefSeq, Apr 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.837343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246553.4/ ENSP00000246553.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2937              U62631.2           22398-25334
            2938-5313           U62631.2           25701-28076
            5314-5597           KF511268.1         111-394             c
FEATURES             Location/Qualifiers
     source          1..5597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..5597
                     /gene="FFAR1"
                     /gene_synonym="FFA1R; GPCR40; GPR40"
                     /note="free fatty acid receptor 1"
                     /db_xref="GeneID:2864"
                     /db_xref="HGNC:HGNC:4498"
                     /db_xref="MIM:603820"
     exon            1..2937
                     /gene="FFAR1"
                     /gene_synonym="FFA1R; GPCR40; GPR40"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..5597
                     /gene="FFAR1"
                     /gene_synonym="FFA1R; GPCR40; GPR40"
                     /inference="alignment:Splign:2.1.0"
     CDS             3285..4187
                     /gene="FFAR1"
                     /gene_synonym="FFA1R; GPCR40; GPR40"
                     /note="G-protein coupled receptor 40"
                     /codon_start=1
                     /product="free fatty acid receptor 1"
                     /protein_id="NP_005294.1"
                     /db_xref="CCDS:CCDS12458.1"
                     /db_xref="GeneID:2864"
                     /db_xref="HGNC:HGNC:4498"
                     /db_xref="MIM:603820"
                     /translation="MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVY
                     ALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSA
                     GRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGI
                     NTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRR
                     KLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVT
                     GYLGRGPGLKTVCAARTQGGKSQK"
     regulatory      5279..5284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FFAR1"
                     /gene_synonym="FFA1R; GPCR40; GPR40"
                     /note="hexamer: AATAAA"
     polyA_site      5299
                     /gene="FFAR1"
                     /gene_synonym="FFA1R; GPCR40; GPR40"
                     /note="major polyA site"
     regulatory      5578..5583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FFAR1"
                     /gene_synonym="FFA1R; GPCR40; GPR40"
                     /note="hexamer: ATTAAA"
     polyA_site      5597
                     /gene="FFAR1"
                     /gene_synonym="FFA1R; GPCR40; GPR40"
ORIGIN      
        1 acagcttttc tgtcattcga ggtcctctgc acccgttctc taattctgtt cactgattca
       61 gactttccag ttaggtgccc cagctcccct ctccgcttct cgggtttgat ctttctccac
      121 ccattcacct gcttctgcaa aggggctaaa gcccattctc cttagagggc aggggtgtaa
      181 ttatctgatc atcagggaga ttggctcctg gcacgtggca ggtgtcccca aactgccacc
      241 ttcctctccc accttccttt ccctcccatc tctgctcagt acccggacgg taactctagg
      301 aattatggtt cagggaggcc ttgatcgccc catcaatcca ctttgtccct ggtttgattc
      361 ttgtgagcac cattaacttt tctggaggaa ggtgaggctt taagaactgt ttaaagccca
      421 ggcgtggtgg atcacgcctg taatcacagc actctgggag gccaaggtgg gcagatcacc
      481 tgaggtcagg agttcaagac cagcctagcc aacatggtaa aatcctgtct ctaccaaaaa
      541 tacaaaaatt agctgagcgt ggtgattcac acctgtaatc tcagctactt gggaggctga
      601 ggcaggagag tcgcttgaac ctgggaggcg gaggtagcgg tgagccgaga tcacgccact
      661 gcactccagc ctatgcaaca gagtgagact ccgcctcaaa acaacaacaa caaaaactgt
      721 ttaaatgaga caggagggtg ttggggtgtc tgtgcccaaa atggggtctg gtgtcattca
      781 actctttctt cattcattct gcacacagat actgagcacc tggaaatgca cccagtacag
      841 agccagttgt taggacacca aaaagataag gcgtaggacc aaccttgggg atctctagtc
      901 gagagccgcc aagggttttt aaggcaagat accctggagg gagctgaggc agtcctaagc
      961 ctgaagggcc tggcttaagc tccctggcaa ccatcgagca tcttcccctt cccaccctgt
     1021 ccctcagcac agctgctgac ataaacctac tacatggctg attgaccatg agatatggcc
     1081 atcaatagac attgctgagg cgtgaagagc aggtgaagag caggtggcca ggaagctagg
     1141 gggccaggac tccagacgca ggccgccctc cacaacccca gctctcacag tcctcccagg
     1201 gtccagacaa tggatcgtgc atttaggttc ccaaacacct gctgtgcaac gtgtagtaga
     1261 caaagcagac caaagccttt gccctcagga ggccggcatt ctagctcagg agccagccaa
     1321 gacgatgtcg cactgaagaa agacaacaaa agtgagattc acaggaggga tgagtgtggc
     1381 tgaggcaccc gggaaggccc tcggagaagg tgaccttggg caaagatcca gacgccaggt
     1441 gggtggggcc aaagcagaga agatctggaa aacccaatgg ctccccaggg cttcgctctt
     1501 gctgcaggag gggaaaccac actgctgtgg attcttcctc cattctgtcc atttctcagt
     1561 tcccaacaac acactgaaca gtaggaggcc agttctccgc tcacagcggg cgctgcaccc
     1621 caggtgctgc tctcgagaaa aaggcgagca tggaccaatt tagtggctcc gaggtatgaa
     1681 aagcagtgag atggtgtctt tgagggagtt agtgataggc tgagaccccc ttgctgtccc
     1741 ccctgaagcc tggtgaccag agctgccagg aggccacaca gagagaggtt tatgatgggg
     1801 gacctggaat tcggaagggg cagagtggtc aggtgaccca tacacgcctg agaaaactga
     1861 tgtggagagc tgtgttgtca ttctgaggca ggaaatagag acagactgac agacagacag
     1921 aaagacacgg gcacattgag agacagagac agaatcacag agcagagctg gcttctcacc
     1981 agcaggcgtg ggcacacctg agagagcatc cagagaggtt agaaatcttc cttaggtcct
     2041 cctgggaggc tcaggtgacc ccagtgggaa acatgaaagg ctgggaggac ttccagggct
     2101 gagagaagga agctacgcag ccggccggtg ccacattccc tgtgccttgg ggagtgtccc
     2161 ccagtgtccc cagccatgca ccctgggggg agtcggcttg gacatctgtg ccaccccttg
     2221 acaggcagag tgggggccac aacctgggcc ctccagtgct ggtcagcaga ggctgccccc
     2281 gccccttgcc ttcctcctcc cgctccttcc tccagccctg ggaaggtcgg aagccaccac
     2341 catggggcta gtgcggaagc agagggagaa cagaggggcc ctcctcgcaa aaactaaaac
     2401 aagcccacag cctgtgcaga accgcacccg ggtgtgatca ctccttaccc cacacaccca
     2461 ctgccacttg gagatggctt catggctgca gtcacagggc accctgtgtt gtcaggggtg
     2521 agccagtgag gcccgggacc tgcccagggg tgcatcaagg gtggagaaga cctggcccca
     2581 gcgcaggtgt gaacaggcag gagggctggg gagggaatag cgctgggttg tggccgagcc
     2641 cccaagccct gctcttgaga ggcactggct acacactcgg cccctaccca gacaggaccc
     2701 caattcctcc ctggcccctc tgtgttcctg catcttccca gcccctcacc tcctctggcg
     2761 tggcctcacc tccagccggg atgccccatt agctgctcac ccaagctgct agaacctcag
     2821 gctaatggcc ctgtcacccg ccctcctccc cttccggctc actgcccatc ccgggcatcc
     2881 tccatcagcc cgctgagggg actgctgagc ctcagagaca tctggcagca ccaggagagt
     2941 ctcagaaatc gagaagcttt cttcctctgg gacctgtgcg ccacatccta tctcctgtga
     3001 cgctgcagga gcttccctgg ttttaagagg tgacatggtg gagagaaagc acaggactgg
     3061 gggccacagg tcctggcttc tcatccaggc tccgctgctc cctgactgct gcctttctct
     3121 gtgggcctcg tttcctccct gatcccacca ggtgaattgt aattctccac acagggctgg
     3181 aacccgcgag tgatcccagg agcccctcct ctccggggcc ccaagatctg aggacaggga
     3241 gccaggttgc acacaggagc cgtgcaggcc aggacggcgg ccccatggac ctgcccccgc
     3301 agctctcctt cggcctctat gtggccgcct ttgcgctggg cttcccgctc aacgtcctgg
     3361 ccatccgagg cgcgacggcc cacgcccggc tccgtctcac ccctagcctg gtctacgccc
     3421 tgaacctggg ctgctccgac ctgctgctga cagtctctct gcccctgaag gcggtggagg
     3481 cgctagcctc cggggcctgg cctctgccgg cctcgctgtg ccccgtcttc gcggtggccc
     3541 acttcttccc actctatgcc ggcgggggct tcctggccgc cctgagtgca ggccgctacc
     3601 tgggagcagc cttccccttg ggctaccaag ccttccggag gccgtgctat tcctgggggg
     3661 tgtgcgcggc catctgggcc ctcgtcctgt gtcacctggg tctggtcttt gggttggagg
     3721 ctccaggagg ctggctggac cacagcaaca cctccctggg catcaacaca ccggtcaacg
     3781 gctctccggt ctgcctggag gcctgggacc cggcctctgc cggcccggcc cgcttcagcc
     3841 tctctctcct gctctttttt ctgcccttgg ccatcacagc cttctgctac gtgggctgcc
     3901 tccgggcact ggcccgctcc ggcctgacgc acaggcggaa gctgcgggcc gcctgggtgg
     3961 ccggcggggc cctcctcacg ctgctgctct gcgtaggacc ctacaacgcc tccaacgtgg
     4021 ccagcttcct gtaccccaat ctaggaggct cctggcggaa gctggggctc atcacgggtg
     4081 cctggagtgt ggtgcttaat ccgctggtga ccggttactt gggaaggggt cctggcctga
     4141 agacagtgtg tgcggcaaga acgcaagggg gcaagtccca gaagtaacgc cactgctcgg
     4201 gggaaggagc atggggcagg agggcccggc tgcttctcca ggcccctgcg gggggctgct
     4261 tcggaggaac tgcagggcag cctggcccgg aggcctccct ggagccactc aagcagagag
     4321 cggcgcctgc tgagggcagc accccagtca agagaggagc accgagccag agcacggtgg
     4381 cagggggagg taagtttgcc cctgcacgtg tcgaggaagt ttgtcccttc ctcgcctatc
     4441 tttctctccc ctctgcacgt cctcacctgc ctgtcttccg tgggccgcga gcagaggcct
     4501 tgtacttacg ggaaggagga ggcagtctgt ttctgaccca caggaactgc cactccggtg
     4561 atgcacttga ggacagctac tctgaaatca gttcccagga gagaacattt gatttccgag
     4621 taggagagga ggcaggaggc aggataatga cgctgttata ccatgtgaaa ctcgcaaggg
     4681 ggcagccttg gagcttggaa cggaggctgg caggaaaaga tgcttcagcc ggggagggaa
     4741 aatgcaaggt cccgcagtga tgggcaaagg ctacggagtt gactcttgaa caacgtgggg
     4801 atggggtgcc gaaccccacg cagtggaaaa tctgtgcatg actttgactc ccccaaagtt
     4861 caactactaa tagcctactg ttgaccaaaa gctttaccca gtatataaac aattgagtaa
     4921 gacatatttg aagccaggca cagtggctta tgcctgtaat cccagcactt taggaggccg
     4981 aggcgggaag actgctcgaa gccaggagtt caagagcagc ctgggcaaga tagtgagacc
     5041 cccacctcta caaataataa aaataaaaat aattagctgg gcgtggtggt gcgtgcctgt
     5101 agtcccagct actcaggggt ctgaggtggg aggatccctt gagcccagga ttgaggctgc
     5161 aatgccatga tcgcaccact gcactccagc ctgggtgaca gagcaagatc ctgtctctgg
     5221 aaaaaaaaga aaaaagacat attttgtatg ttatatatat tatgtgctgt attcttacaa
     5281 taaagtaagc tagagaaaag tacatgttac tgaaaacatt attagaaaga gaaaatacct
     5341 tcacagcact gtgctgtatt tatcaatact gtaagttttg ttgtctgttt ataagagaag
     5401 ttgtctgtct caagcggcag taaccgcggc tgcagatctc aatctgtggt agatatcaag
     5461 cagttcaacc cttttttata atgtcatgac ttttctttgc ttcttggaag cagctctggc
     5521 atcactagtg gccccgcatt tggggccaag ggggttattc aaagtttacg gtattgcatt
     5581 aaacatggtg aaacata
//
