LOCUS       NM_018008               2112 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens FEZ family zinc finger 2 (FEZF2), mRNA.
ACCESSION   NM_018008
VERSION     NM_018008.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2112)
  AUTHORS   Garber,A., Weingarten,L.S., Abreu,N.J., Elloumi,H.Z., Haack,T.,
            Hildebrant,C., Martinez-Gil,N., Mathews,J., Muller,A.J., Valenzuela
            Palafoll,I., Steigerwald,C. and Chung,W.K.
  TITLE     Rare predicted deleterious FEZF2 variants are associated with a
            neurodevelopmental phenotype
  JOURNAL   Am J Med Genet A 194 (7), e63578 (2024)
   PUBMED   38425142
  REMARK    GeneRIF: Rare predicted deleterious FEZF2 variants are associated
            with a neurodevelopmental phenotype.
REFERENCE   2  (bases 1 to 2112)
  AUTHORS   Chen,Z., Zhou,L., Liu,X., Wang,L., Kazobinka,G., Zhang,X. and
            Hou,T.
  TITLE     Loss of Fezf2 promotes malignant progression of bladder cancer by
            regulating the NF-kappaB signaling pathway
  JOURNAL   Lab Invest 98 (9), 1225-1236 (2018)
   PUBMED   29925938
  REMARK    GeneRIF: Fezf2 expression is downregulated in bladder cancer
            tissues and cell lines compared to adjacent non-tumor tissues and
            normal urothelial cells. Overexpression of Fezf2 significantly
            inhibited the proliferation, growth, migration, and invasion of
            bladder cancer cells, and attenuated angiogenesis, while knockdown
            of Fezf2 had the opposite effect.
REFERENCE   3  (bases 1 to 2112)
  AUTHORS   Takaba,H., Morishita,Y., Tomofuji,Y., Danks,L., Nitta,T.,
            Komatsu,N., Kodama,T. and Takayanagi,H.
  TITLE     Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for
            Immune Tolerance
  JOURNAL   Cell 163 (4), 975-987 (2015)
   PUBMED   26544942
REFERENCE   4  (bases 1 to 2112)
  AUTHORS   Berberoglu,M.A., Dong,Z., Li,G., Zheng,J., Trejo Martinez Ldel,C.,
            Peng,J., Wagle,M., Reichholf,B., Petritsch,C., Li,H., Pleasure,S.J.
            and Guo,S.
  TITLE     Heterogeneously expressed fezf2 patterns gradient Notch activity in
            balancing the quiescence, proliferation, and differentiation of
            adult neural stem cells
  JOURNAL   J Neurosci 34 (42), 13911-13923 (2014)
   PUBMED   25319688
  REMARK    GeneRIF: FEZF2 expression has a role in cell proliferation and
            differentiation in adult neural stem cells.
REFERENCE   5  (bases 1 to 2112)
  AUTHORS   Eckler,M.J. and Chen,B.
  TITLE     Fez family transcription factors: controlling neurogenesis and cell
            fate in the developing mammalian nervous system
  JOURNAL   Bioessays 36 (8), 788-797 (2014)
   PUBMED   24913420
  REMARK    GeneRIF: Fezf1 and Fezf2 accomplish both independent and redundant
            functions across diverse tissue and cell types. [Review]
            Review article
REFERENCE   6  (bases 1 to 2112)
  AUTHORS   Shu,X.S., Li,L., Ji,M., Cheng,Y., Ying,J., Fan,Y., Zhong,L.,
            Liu,X., Tsao,S.W., Chan,A.T. and Tao,Q.
  TITLE     FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2
            and MDM2 expression and is frequently methylated in nasopharyngeal
            carcinoma
  JOURNAL   Carcinogenesis 34 (9), 1984-1993 (2013)
   PUBMED   23677067
  REMARK    GeneRIF: overexpression of EZH2 was frequently detected in NPC
            tumors. Thus, we have identified FEZF2 as a novel 3p14.2 TSG
            frequently inactivated by promoter methylation in NPC, which
            functions as a repressor downregulating multiple oncogene
            expression
REFERENCE   7  (bases 1 to 2112)
  AUTHORS   Chen,L., Zheng,J., Yang,N., Li,H. and Guo,S.
  TITLE     Genomic selection identifies vertebrate transcription factor Fezf2
            binding sites and target genes
  JOURNAL   J Biol Chem 286 (21), 18641-18649 (2011)
   PUBMED   21471212
  REMARK    GeneRIF: the feasibility of employing genomic SELEX to identify
            vertebrate transcription factor binding sites and target genes and
            reveal Fezf2 as a transcription activator and a candidate for
            evaluation in human microcephaly.
REFERENCE   8  (bases 1 to 2112)
  AUTHORS   Zhu,H., Yang,Y., Gao,J., Tao,H., Qu,C., Qu,J. and Chen,J.
  TITLE     Area dependent expression of ZNF312 in human fetal cerebral cortex
  JOURNAL   Neurosci Res 68 (1), 73-76 (2010)
   PUBMED   20570630
  REMARK    GeneRIF: ZNF312 and other brain-layer biomarkers have area
            dependent expressions in the human fetal cortex.
REFERENCE   9  (bases 1 to 2112)
  AUTHORS   Hashimoto,H., Yabe,T., Hirata,T., Shimizu,T., Bae,Y., Yamanaka,Y.,
            Hirano,T. and Hibi,M.
  TITLE     Expression of the zinc finger gene fez-like in zebrafish forebrain
  JOURNAL   Mech Dev 97 (1-2), 191-195 (2000)
   PUBMED   11025224
REFERENCE   10 (bases 1 to 2112)
  AUTHORS   Kleiderlein,J.J., Nisson,P.E., Jessee,J., Li,W.B., Becker,K.G.,
            Derby,M.L., Ross,C.A. and Margolis,R.L.
  TITLE     CCG repeats in cDNAs from human brain
  JOURNAL   Hum Genet 103 (6), 666-673 (1998)
   PUBMED   9921901
  REMARK    Erratum:[Hum Genet 1999 Jan;104(1):113]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092502.2, DA492936.1, DR002892.1, BM930804.1, BC022464.1 and
            H28929.1.
            
            On May 17, 2019 this sequence version replaced NM_018008.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290464.1, HM005703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283268.8/ ENSP00000283268.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC092502.2         143620-143654       c
            36-158              DA492936.1         1-123
            159-500             DR002892.1         129-470
            501-1151            BM930804.1         52-702
            1152-2109           BC022464.1         948-1905
            2110-2112           H28929.1           19-21               c
FEATURES             Location/Qualifiers
     source          1..2112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.2"
     gene            1..2112
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /note="FEZ family zinc finger 2"
                     /db_xref="GeneID:55079"
                     /db_xref="HGNC:HGNC:13506"
                     /db_xref="MIM:607414"
     exon            1..272
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /inference="alignment:Splign:2.1.0"
     exon            273..1182
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1710
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /note="zinc finger protein 312; forebrain embryonic zinc
                     finger-like protein 2; testis tissue sperm-binding protein
                     Li 80P; too few"
                     /codon_start=1
                     /product="fez family zinc finger protein 2"
                     /protein_id="NP_060478.3"
                     /db_xref="CCDS:CCDS2897.1"
                     /db_xref="GeneID:55079"
                     /db_xref="HGNC:HGNC:13506"
                     /db_xref="MIM:607414"
                     /translation="MASSASLETMVPPACPRAGASPATSKTLAFSIERIMAKTSEPRA
                     PFEPRPGALEADGSQGKKLLNLCSPLPCMIPLQPLGYEVPSKTLLSYSELWKSSLRAG
                     GGGGGGGGGGGGGGGAPVCGASGLCKTNCGVCCKAELGLAPSALPAGRVIKPQVINQA
                     VGLPASGSLYYFNYLDSTAYPPSELLSGHLFPSGLLNAQAPAALAAHPKLFLLENAKL
                     AGLAADKFPHPAPYPHKERLPAPLEQVLKENSALTAERGGVKGHSKLPGGSADGKPKN
                     FTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQEKPHK
                     CNQCGKAFNRSSTLNTHIRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTHSGEKQYKCT
                     ICNKAFHQVYNLTFHMHTHNDKKPFTCATCGKGFCRNFDLKKHVRKLHDSVGPAAPSA
                     KDLTRTVQS"
     exon            1183..1317
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1450
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..2112
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /note="hexamer: AATATA"
     polyA_site      2112
                     /gene="FEZF2"
                     /gene_synonym="FEZ; FEZL; FKSG36; TOF; ZFP312; ZNF312"
                     /note="major polyA site"
ORIGIN      
        1 actttcccga gaggagcgcg ggcgccagtt gcctcctttt aaagtttgag gggcggtggt
       61 ggcggcggcc ggcaggcgcg ggggaacaca ggggccgcta cgggagccgc gccgccgccc
      121 atgtcattcc acttcaagtg acttcatgtg atgtcagctg aatgtaaaag acagtgatct
      181 cacgcggagg ggaagatgtt tgccatcaaa atgtgacaga agagacacgc tgcatggctc
      241 ggaacgcatc tccttggtgg tgggggaaag agacttagag gagagaggct gcgccctggc
      301 ccagcctggc tcggctcagc tccgcgcgcc atggcaagct cggcttccct ggagaccatg
      361 gtgcccccgg cctgcccgcg cgccggagcg tcgccggcca cttccaagac actggccttt
      421 tccatcgagc gcatcatggc caagacgtcg gagccccgtg cgccctttga gccccggcct
      481 ggagcgctag aggcggacgg cagccagggc aagaaactgc tcaacctctg ctcgccgctg
      541 ccctgtatga tccccctcca gcccctaggc tacgaggtgc cgtcaaagac actgctcagt
      601 tactcggagc tctggaaaag cagcctccgg gcgggcggcg gcggaggcgg cggcggcggt
      661 ggcggcggcg gcggcggggg ggccccagtg tgcggcgcca gcggcttgtg caaaaccaac
      721 tgtggcgtgt gctgcaaggc cgagctgggc ctggcgccgt ccgcgctgcc cgcgggcagg
      781 gtcatcaagc cgcaggtcat caaccaggct gtggggctgc cggccagcgg ctcgctctac
      841 tacttcaact acctggactc gaccgcgtac ccgccgtctg agctcctcag cggccacctc
      901 ttcccgtctg gcctcctcaa tgcgcaggcc cccgccgccc tggctgctca ccccaagctc
      961 tttctgctgg agaacgccaa gctggccggc ctggctgcgg acaagttccc ccacccggct
     1021 ccctatcccc ataaggagcg cttgccggcg ccgctggagc aggtactgaa ggaaaactcg
     1081 gccctgactg ccgagcgcgg aggcgtcaag ggccacagca agctgccagg aggctccgca
     1141 gatggcaagc ccaaaaactt cacctgcgag gtgtgcggca aggtgtttaa cgctcactat
     1201 aatctcaccc gccacatgcc ggtccacacc ggagccagac cgttcgtgtg caaagtctgc
     1261 ggcaaaggct ttcgccaggc cagcacgctc tgcaggcaca aaattatcca cacccaggaa
     1321 aagccacata aatgcaacca gtgcggcaaa gcgttcaacc gcagctccac gctcaacacg
     1381 catatccgca tccacgcggg ctacaagccc ttcgtctgcg aattttgcgg caaaggcttt
     1441 caccaaaaag ggaactacaa gaaccacaag ctgacccaca gcggcgagaa gcagtacaaa
     1501 tgtaccatct gcaacaaggc cttccaccag gtctacaacc taaccttcca tatgcacacc
     1561 cacaacgaca agaagccttt cacgtgcgcc acttgcggca aagggttttg cagaaacttt
     1621 gacttaaaga aacatgtgcg caaactccac gacagcgtgg gccctgctgc cccctccgca
     1681 aaggacctga ctaggacagt gcagagctga gagctactgc cttgcccttc cttccctccc
     1741 tgtaccacct gaaaacagat cacacatata aacttatttc taaaattaaa agaaaaaaaa
     1801 actatagcag agaggctaaa atctatttat cgaaaccagc atatttttgg aaagctaaat
     1861 gtttcctcga tgactggcag caaactcgtg gcccccacct ttgtatattc aggaaactta
     1921 tttaaatcca gtgcgccgaa acgtatttaa ttccaggcct ccgcttctcc tggggcagcc
     1981 agttttaacc ccagcctgtc accgtgagcg ccccagaaga gcgcggcgcc cctagccatc
     2041 tttatacagc catgtaaatc ctcctgtaca agcgaacacg gaatatatac atatataact
     2101 caataaacag aa
//
