LOCUS       NM_001024613            2435 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens FEZ family zinc finger 1 (FEZF1), transcript variant
            1, mRNA.
ACCESSION   NM_001024613 XM_371948 XM_374517
VERSION     NM_001024613.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Zhang,T., Yu,S. and Zhao,S.
  TITLE     LncRNA FEZF1-AS1 promotes colorectal cancer progression through
            regulating the miR-363-3p/PRRX1 pathway
  JOURNAL   Adv Clin Exp Med 30 (8), 839-848 (2021)
   PUBMED   34286520
  REMARK    GeneRIF: LncRNA FEZF1-AS1 promotes colorectal cancer progression
            through regulating the miR-363-3p/PRRX1 pathway.
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Liu,X., Li,X. and Li,J.
  TITLE     Long Non-coding RNA FEZF1-AS1 Promotes Growth and Reduces Apoptosis
            Through Regulation of miR-363-3p/PAX6 Axis in Retinoblastoma
  JOURNAL   Biochem Genet 59 (3), 637-651 (2021)
   PUBMED   33432525
  REMARK    GeneRIF: Long Non-coding RNA FEZF1-AS1 Promotes Growth and Reduces
            Apoptosis Through Regulation of miR-363-3p/PAX6 Axis in
            Retinoblastoma.
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Liu,W., Li,Y., Zhang,Y., Shen,X., Su,Z., Chen,L., Cai,W., Wang,F.
            and Ju,S.
  TITLE     Circulatinglong non-coding RNA FEZF1-AS1 and AFAP1-AS1 serve as
            potential diagnostic biomarkers for gastric cancer
  JOURNAL   Pathol Res Pract 216 (1), 152757 (2020)
   PUBMED   31785996
  REMARK    GeneRIF: Circulatinglong non-coding RNA FEZF1-AS1 and AFAP1-AS1
            serve as potential diagnostic biomarkers for gastric cancer.
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Kotan,L.D., Hutchins,B.I., Ozkan,Y., Demirel,F., Stoner,H.,
            Cheng,P.J., Esen,I., Gurbuz,F., Bicakci,Y.K., Mengen,E., Yuksel,B.,
            Wray,S. and Topaloglu,A.K.
  TITLE     Mutations in FEZF1 cause Kallmann syndrome
  JOURNAL   Am J Hum Genet 95 (3), 326-331 (2014)
   PUBMED   25192046
  REMARK    GeneRIF: Mutations in FEZF1 cause Kallmann syndrome.
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Eckler,M.J. and Chen,B.
  TITLE     Fez family transcription factors: controlling neurogenesis and cell
            fate in the developing mammalian nervous system
  JOURNAL   Bioessays 36 (8), 788-797 (2014)
   PUBMED   24913420
  REMARK    GeneRIF: Fezf1 and Fezf2 accomplish both independent and redundant
            functions across diverse tissue and cell types. [Review]
            Review article
REFERENCE   7  (bases 1 to 2435)
  AUTHORS   Song,I.S., Ha,G.H., Kim,J.M., Jeong,S.Y., Lee,H.C., Kim,Y.S.,
            Kim,Y.J., Kwon,T.K. and Kim,N.S.
  TITLE     Human ZNF312b oncogene is regulated by Sp1 binding to its promoter
            region through DNA demethylation and histone acetylation in gastric
            cancer
  JOURNAL   Int J Cancer 129 (9), 2124-2133 (2011)
   PUBMED   21170990
  REMARK    GeneRIF: the aberrant expression of ZNF312b promotes gastric
            tumorigenesis through epigenetic modification of its promoter
            region and provides a molecular mechanism for ZNF312b expression to
            contribute to the progression of gastric cancer.
REFERENCE   8  (bases 1 to 2435)
  AUTHORS   Maestrini,E., Pagnamenta,A.T., Lamb,J.A., Bacchelli,E., Sykes,N.H.,
            Sousa,I., Toma,C., Barnby,G., Butler,H., Winchester,L.,
            Scerri,T.S., Minopoli,F., Reichert,J., Cai,G., Buxbaum,J.D.,
            Korvatska,O., Schellenberg,G.D., Dawson,G., de Bildt,A.,
            Minderaa,R.B., Mulder,E.J., Morris,A.P., Bailey,A.J. and
            Monaco,A.P.
  CONSRTM   IMGSAC
  TITLE     High-density SNP association study and copy number variation
            analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4
            gene region in autism susceptibility
  JOURNAL   Mol Psychiatry 15 (9), 954-968 (2010)
   PUBMED   19401682
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2435)
  AUTHORS   Song,I.S., Oh,N.S., Kim,H.T., Ha,G.H., Jeong,S.Y., Kim,J.M.,
            Kim,D.I., Yoo,H.S., Kim,C.H. and Kim,N.S.
  TITLE     Human ZNF312b promotes the progression of gastric cancer by
            transcriptional activation of the K-ras gene
  JOURNAL   Cancer Res 69 (7), 3131-3139 (2009)
   PUBMED   19318583
  REMARK    GeneRIF: Study is the first to report that ZNF312b, a novel
            transcription factor, was associated with tumorigenicity of gastric
            cancer.
            Erratum:[Cancer Res. 2009 May 1;69(9):4092]
REFERENCE   10 (bases 1 to 2435)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015983.7, AK300742.1,
            AY726588.1 and HY206093.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001024613.3.
            
            Summary: This gene encodes a transcriptional repressor that belongs
            to the zinc finger double domain protein family. The encoded
            protein is thought to play a role in the embryonic migration of
            gonadotropin-releasing hormone neurons into the brain. Mutations in
            this gene are associated with hypogonadotropic hypogonadism-22 with
            anosmia. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.12056.1, AY726588.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442488.7/ ENSP00000411145.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC015983.7         140856-141094       c
            240-1224            AK300742.1         130-1114
            1225-2232           AY726588.1         907-1914
            2233-2429           HY206093.1         1-197               c
            2430-2435           AC015983.7         137647-137652       c
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..2435
                     /gene="FEZF1"
                     /gene_synonym="FEZ; HH22; ZNF312B"
                     /note="FEZ family zinc finger 1"
                     /db_xref="GeneID:389549"
                     /db_xref="HGNC:HGNC:22788"
                     /db_xref="MIM:613301"
     exon            1..1114
                     /gene="FEZF1"
                     /gene_synonym="FEZ; HH22; ZNF312B"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1741
                     /gene="FEZF1"
                     /gene_synonym="FEZ; HH22; ZNF312B"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 312B; fez family zinc finger protein 1"
                     /codon_start=1
                     /product="fez family zinc finger protein 1 isoform 1"
                     /protein_id="NP_001019784.2"
                     /db_xref="CCDS:CCDS34741.2"
                     /db_xref="GeneID:389549"
                     /db_xref="HGNC:HGNC:22788"
                     /db_xref="MIM:613301"
                     /translation="MDSSCHNATTKMLATAPARGNMMSTSKPLAFSIERIMARTPEPK
                     ALPVPHFLQGALPKGEPKHSLHLNSSIPCMIPFVPVAYDTSPKAGVTGSEPRKASLEA
                     PAAPAAVPSAPAFSCSDLLNCALSLKGDLARDALPLQQYKLVRPRVVNHSSFHAMGAL
                     CYLNRGDGPCHPAAGVNIHPVASYFLSSPLHPQPKTYLAERNKLVVPAVEKYPSGVAF
                     KDLSQAQLQHYMKESAQLLSEKIAFKTSDFSRGSPNAKPKVFTCEVCGKVFNAHYNLT
                     RHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQEKPHKCNQCGKAFNRSSTLNTH
                     TRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTHSGEKQFKCNICNKAFHQVYNLTFHMH
                     THNDKKPFTCPTCGKGFCRNFDLKKHVRKLHDSSLGLARTPAGEPGTEPPPPLPQQPP
                     MTLPPLQPPLPTPGPLQPGLHQGHQ"
     exon            1115..1249
                     /gene="FEZF1"
                     /gene_synonym="FEZ; HH22; ZNF312B"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1382
                     /gene="FEZF1"
                     /gene_synonym="FEZ; HH22; ZNF312B"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..2435
                     /gene="FEZF1"
                     /gene_synonym="FEZ; HH22; ZNF312B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2400..2405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEZF1"
                     /gene_synonym="FEZ; HH22; ZNF312B"
                     /note="hexamer: AATAAA"
     polyA_site      2435
                     /gene="FEZF1"
                     /gene_synonym="FEZ; HH22; ZNF312B"
                     /note="major polyA site"
ORIGIN      
        1 agtttacctt ctcctcttgg aagttaacga ttggcgagat cttggctgcg ttattgacac
       61 aacactttct attgatagaa ataagtagtg attgtccccg agtcattggt gcgccaagaa
      121 ctctgcgatg ggctggcagg agtccattgg gctgggcagg caggttcggc tggtgatgct
      181 ggggaggagg aggaggagga ggctactggt ggtgatggtg cccgtccccc tctccgcagg
      241 tctgtgacaa gcagggaaca aggcaacgga cggcgcaacc cagccccggc tgacggacgc
      301 tggcgactca gacatggaca gtagctgcca caacgcgact accaaaatgt tagcgactgc
      361 tccagctcgg ggcaacatga tgagcacgtc caaacccttg gctttctcca ttgaacgaat
      421 catggcgcgc accccagagc ccaaggccct gccagtcccc cacttcctgc agggagcctt
      481 acccaagggg gaacccaagc actctctgca tctcaactcg tcgatcccct gcatgatccc
      541 cttcgtgcct gtggcctacg acacgagccc caaggcagga gtgacgggct ccgagccgcg
      601 gaaggccagt ctggaggccc cggcggcgcc cgcggcggtg ccctcggctc ccgcattcag
      661 ctgcagcgac ctgctcaact gcgcactgag tctcaagggc gacctggccc gcgacgcgct
      721 gccgctgcag cagtacaagc tggtaaggcc gcgtgtggtc aaccactctt cattccacgc
      781 catgggcgcc ttgtgctacc tgaaccgagg tgacggccca tgccacccgg cagccggcgt
      841 gaacatccac ccggtggcct cctacttcct cagttcccct ttgcacccgc agccaaaaac
      901 gtatttagcc gaaaggaata aactggtggt cccggcggtg gagaaatacc cttctggagt
      961 agctttcaaa gacctgtccc aggctcagct gcagcattac atgaaagaaa gcgcccagct
     1021 tctgtcggaa aaaatcgcgt tcaaaacctc ggatttcagc cgaggctctc ctaatgccaa
     1081 gcccaaagtt ttcacttgcg aagtgtgtgg aaaggtcttt aatgcgcact ataacttaac
     1141 ccgtcacatg ccagtgcaca caggagccag acccttcgtt tgcaaagtgt gcggaaaagg
     1201 tttcaggcaa gcaagcaccc tgtgcaggca caagatcatt cacacgcagg aaaaacctca
     1261 caaatgtaac cagtgtggca aagcatttaa tagaagttcc actttaaaca ctcatacccg
     1321 aatacacgcg ggctacaaac cgtttgtgtg tgaattctgt ggcaaagggt ttcatcaaaa
     1381 agggaattac aaaaaccaca agttgaccca cagcggggag aagcagttca agtgcaatat
     1441 ctgcaacaag gctttccacc aggtttacaa cctcaccttc cacatgcaca cccacaacga
     1501 caagaagcct ttcacctgcc ccacgtgcgg caagggtttc tgcaggaact ttgacctcaa
     1561 gaagcatgtc cgcaagctgc acgacagcag cctggggctg gcccgcacgc cagctggcga
     1621 accaggcact gaaccgccgc ccccgctacc gcagcagccg ccgatgacgc tgcctcctct
     1681 gcagccgccg ctgccaaccc cggggcccct gcagcccggg ctccaccagg gccaccagtg
     1741 atcgaggcta agggtcctcc cagcctcagc cgtgccccca cgctgaggca gcggcagact
     1801 agagctcctg gtccgagttc gtctgcagac cccagggcat gttgggcccc acacttcagg
     1861 gccgaccaga agcctctgca tcccctggcc tttcgcctct tgcatgcacc tgctaaatgg
     1921 ttttgtgtat tatattctat ataggcacta acaattatga aaaatttgga gggttttgct
     1981 tgttttctgt ttttcttttt cttttttttt aatttggaaa gacttttcat cttgggtgga
     2041 gagatggtgt ttattttgtt ttgttttgtt taaacaaatt tctgctatat ttattgagat
     2101 ctgtattatt ctacccggga atgctgcatc attttaattt tattattgta tatatttcca
     2161 ttgtgttgat tctccggtct caagatgtct gctggatgtt gatcatttcc tctttccctg
     2221 aagtaacaaa acactgtgtg tatgtcatat atacacgcat agatgtgtgc gcccataggg
     2281 gtacattcca cattcgtgag cacacaccca tacacattag ataagggtgg ttcattatgg
     2341 atgattttga attttggttt tgattattgc acgtgaaaat tgattcattg actgttggaa
     2401 ataaatactt ggaacatgct tatttaatca acaaa
//
