LOCUS       NM_005102               1993 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens fasciculation and elongation protein zeta 2 (FEZ2),
            transcript variant 1, mRNA.
ACCESSION   NM_005102
VERSION     NM_005102.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Butland,S.L., Sanders,S.S., Schmidt,M.E., Riechers,S.P., Lin,D.T.,
            Martin,D.D., Vaid,K., Graham,R.K., Singaraja,R.R., Wanker,E.E.,
            Conibear,E. and Hayden,M.R.
  TITLE     The palmitoyl acyltransferase HIP14 shares a high proportion of
            interactors with huntingtin: implications for a role in the
            pathogenesis of Huntington's disease
  JOURNAL   Hum Mol Genet 23 (15), 4142-4160 (2014)
   PUBMED   24705354
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Spang,N., Feldmann,A., Huesmann,H., Bekbulat,F., Schmitt,V.,
            Hiebel,C., Koziollek-Drechsler,I., Clement,A.M., Moosmann,B.,
            Jung,J., Behrends,C., Dikic,I., Kern,A. and Behl,C.
  TITLE     RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced
            autophagy
  JOURNAL   Autophagy 10 (12), 2297-2309 (2014)
   PUBMED   25495476
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Alborghetti,M.R., Furlan,A.S. and Kobarg,J.
  TITLE     FEZ2 has acquired additional protein interaction partners relative
            to FEZ1: functional and evolutionary implications
  JOURNAL   PLoS One 6 (3), e17426 (2011)
   PUBMED   21408165
  REMARK    GeneRIF: FEZ2 interacted with 59 proteins and that of these only 40
            interacted with FEZ1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1993)
  AUTHORS   Surpili,M.J., Delben,T.M. and Kobarg,J.
  TITLE     Identification of proteins that interact with the central
            coiled-coil region of the human protein kinase NEK1
  JOURNAL   Biochemistry 42 (51), 15369-15376 (2003)
   PUBMED   14690447
REFERENCE   7  (bases 1 to 1993)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   8  (bases 1 to 1993)
  AUTHORS   Kolle,G., Georgas,K., Holmes,G.P., Little,M.H. and Yamada,T.
  TITLE     CRIM1, a novel gene encoding a cysteine-rich repeat protein, is
            developmentally regulated and implicated in vertebrate CNS
            development and organogenesis
  JOURNAL   Mech Dev 90 (2), 181-193 (2000)
   PUBMED   10642437
REFERENCE   9  (bases 1 to 1993)
  AUTHORS   Bloom,L. and Horvitz,H.R.
  TITLE     The Caenorhabditis elegans gene unc-76 and its human homologs
            define a new gene family involved in axonal outgrowth and
            fasciculation
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3414-3419 (1997)
   PUBMED   9096408
REFERENCE   10 (bases 1 to 1993)
  AUTHORS   Ranes-Goldberg,M.G., Hori,T., Mohan-Peterson,S. and Spits,H.
  TITLE     Identification of human pre-T/NK cell-associated genes
  JOURNAL   J Immunol 151 (10), 5810-5821 (1993)
   PUBMED   8228263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007401.4 and BC037566.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005102.2.
            
            Summary: This gene is an ortholog of the C. elegans unc-76 gene,
            which is necessary for normal axonal bundling and elongation within
            axon bundles. Other orthologs include the rat gene that encodes
            zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the more abundant
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.440719.1, AB076184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405912.8/ ENSP00000385112.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC007401.4         27961-27974
            15-1993             BC037566.1         1-1979
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..1993
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /note="fasciculation and elongation protein zeta 2"
                     /db_xref="GeneID:9637"
                     /db_xref="HGNC:HGNC:3660"
                     /db_xref="MIM:604826"
     exon            1..292
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1088
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pre-T/NK cell associated protein (3Cl); zygin 2; zygin II"
                     /codon_start=1
                     /product="fasciculation and elongation protein zeta-2
                     isoform 1"
                     /protein_id="NP_005093.2"
                     /db_xref="CCDS:CCDS46257.1"
                     /db_xref="GeneID:9637"
                     /db_xref="HGNC:HGNC:3660"
                     /db_xref="MIM:604826"
                     /translation="MAADGDWQDFYEFQEPARSLLDQENCNASPEPGAEAGAEAGGGA
                     DGFPAPACSLEEKLSLCFRPSDPGAEPPRTAVRPITERSLLQGDEIWNALTDNYGNVM
                     PVDWKSSHTRTLHLLTLNLSEKGVSDSLLFDTSDDEELREQLDMHSIIVSCVNDEPLF
                     TADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSTGSYEERVKRLSV
                     SELNEILEEIETAIKEYSEELVQQLALRDELEFEKEVKNSFISVLIEVQNKQKEHKET
                     AKKKKKLKNGSSQNGKNERSHMPGTYLTTVIPYEKKNGPPSVEDLQILTKILRAMKED
                     SEKVPSLLTDYILKVLCPT"
     exon            293..401
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            402..518
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            519..660
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            661..929
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1005
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1071
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1993
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1970..1975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /note="hexamer: AATAAA"
     polyA_site      1993
                     /gene="FEZ2"
                     /gene_synonym="HUM3CL"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcgcg actgctccgg gcggcgatgg cggcggacgg ggactggcag gatttctatg
       61 agttccagga gccggcccgg agcctcctgg accaggagaa ctgtaacgcg agccccgagc
      121 ctggggcgga ggcgggggcc gaggcgggtg ggggcgccga cggtttcccg gccccggcct
      181 gcagcttgga ggagaagctg agcctgtgct tccgcccctc ggatccgggc gccgagcccc
      241 cgaggacggc cgtgcggccc atcacggagc gcagcctcct gcagggggac gagatttgga
      301 atgccctgac agataattat gggaatgtga tgcctgtaga ctggaagtca tcgcatacta
      361 ggaccttgca cttgcttact ctgaacctct cagaaaaagg ggtaagtgac agtttgctct
      421 ttgatacatc agatgatgaa gagctgagag aacagctgga tatgcactca atcatcgtct
      481 cctgtgttaa tgatgaaccc ctcttcacgg cagaccaggt tattgaagaa attgaagaaa
      541 tgatgcagga atcaccggac ccagaagatg atgaaacccc tacacagtca gatcggcttt
      601 caatgctttc ccaggaaatt caaactctca agaggtctag taccggcagt tatgaagaga
      661 gagtgaaaag gctctcagtg tctgagttaa atgaaatcct ggaagaaatt gagactgcca
      721 ttaaggagta ctctgaggag ctggtgcagc agttggcttt acgagatgaa ctggagtttg
      781 aaaaggaagt gaaaaacagc tttatttctg ttcttattga agtgcaaaac aaacagaaag
      841 agcacaaaga aacagcaaaa aagaaaaaga aactaaaaaa tggcagctct cagaatggga
      901 agaatgagag aagtcatatg cccggcacat atttgactac agtcattcct tatgagaaaa
      961 aaaacggacc accgtctgtt gaagatcttc aaatattaac aaaaattctt cgtgccatga
     1021 aggaggacag tgaaaaagtt ccgagcttgt taactgatta tattctgaaa gttctgtgtc
     1081 ctacatagag cagcaacttt atctgcggtg ggctccaagc tagatttccg acagcattat
     1141 tctgagagct ggctaccatt acccttcttg ctattggaaa ctcagcacat ttgaacttgg
     1201 gtttgattca gtattaacag atcttgacta cactaattct ttatattata gaaccaacgg
     1261 aaatatgggc actattttga attctagaga tggtttttgt taaatctact aataaactgt
     1321 tctcttagta gattaagaga gagtaatatt aattgtgcat gtgcagttgt atttctcatt
     1381 aactgacagt atgcccattt gtttttatgg ctttcttatc taaactgcac tgatgaacta
     1441 gattaaagcc ttgggagatt tatactataa attcagtgat ggcaagaacc aacactgttt
     1501 ttttgtgaga attgtcagtg taactattac ctaccagtat tgttcagaga gattgaaaca
     1561 gaataaacgg gctgttcttg aagaagcaaa accagaatat gcattacttt ggtttaatac
     1621 ttagtgctaa cattgaaact gttggtggtg atggattttg tagcttgctg cttgtttcac
     1681 cactggtcaa attttaacca ttaaattgcc attcactttt agaatcttgt atttaagttt
     1741 tgattttcaa atgttctgct tcatgtgtct gtgaagaatt gtactttaag tgtgtgtcct
     1801 ctgaggtgct tgagaaagtg tacactgcag aactgcccat tctcattact gtgtcctatt
     1861 ttattcatgc ctgtgtgttt ttcttaagta tgaattctag atacagctac ttatggattc
     1921 atcaatatca tgagcacttt tgctggttcc agtcaaatca atggcattta ataaattttt
     1981 taagaagtaa aaa
//
